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N-4-[^18F]-풀루오르부틸피리디늄염의 합성과 양이온교환수지와 이온쌍 크로마토그래피를 이용한 on-line 분리
유국현 東國大學校 1995 東國論叢 Vol.34 No.-
[_18F]-Fluorobutylpyridinium salt is synthesized, which is a _18F-labelled potential flow tracer for PET(Positron Emission Tomography). Radiochemical yields of 25%(decay corrected) are achieved in 30 min of reaction time. For separation of [_18F]-Fluorobutylpyridinium salt is developed on-line separation unit with Sp-Sepadex C-25 cation exchanger and ion pair chromatography. With the separation unit, 95% or _18F-labelled Fluoro-butylpyridinium salt are recovered in 30min.
유국현 東國大學校 1999 東國論叢 Vol.38 No.-
In order to develop a ^18F-labelled myocardial perfusion agent (flow tracer) for PET, ^18F-labelled organic ammonium cations were synthesized [^18F]-N,N-Dibenzyl-r(2-fluoroethyl)piperidinium was labelled with ^18F to good yield by direct introduction of ^18F-fluoride. Radiochemical yields have been achieved in 30min by the precursors(tosylates) in Dimethyl sulfoxide(DMSO) 60% (decay corrected).
가스크로마토그라피 분석을 통한 $\alpha$-브로모-$\omega$ -플루오로알칸의 효율적 합성
유국현,Yu, Kook Hyun 대한화학회 1995 대한화학회지 Vol.39 No.5
디브로모알칸, AgF 및 tetrabutylammoniumbromide(TBABr)를 acetonitrile 용매하에서 $82^{\circ}C$에서 20분간 반응시켜 19~55%의 수율로 $\alpha$-브로모-$\omega$-플르오르알칸을 합성하였다. 반응 조건은 가스 크로마토그라피를 이용하여 조절하였으며, 반응 생성물인 $\alpha$-브로모-$\omega$-플르오르알칸, 디플르오로알칸, 플르오로알켄 및 브로모알켄을 1^H$ NMR 및 $19^F$ NMR로 확인하였다. $\alpha$-Bromo-$\omega$-fluoroalkanes are synthesized in 19∼55% yields from the reactions of dibromoalkanes with AgF and TBABr in acetonitrile at $82^{\circ}C$ for 20 minutes. The reaction is monitored with gas-chromatography. 1^H$ NMR and $19^F$ NMR-Spectrometer are used for identification of $\alpha$-Bromo-$\omega$-fluoroalkanes, difluoroalkane, fluoroalken and bromoalkene.
^27Al(p,α pn)핵반응에 의한 무담체 ^22Na 제법 연구
유국현,서용섭,양승대 東國大學校 1998 東國論叢 Vol.37 No.-
A method for the production of no-carrier added(NCA) ^22Na was developed via ^27Al(p, ㄷαpn) nuclear reaction with 50.5MeV protons. the half life of ^22Na is 2.6 years and main γ-energy is 1274.5keV and it is used standard source and sodium catabolism study. The cross-section and thick target yield for the reaction was measured in detail in the energy range of 50.5→20.2MeV in order to determine the optimum conditions for the production of ^22Na. the maximum cross-section for the production of ^22Na was 40.8 mbarn at 43.85MeV. the calculated production yield of ^22Na by 50.5MeV protons on aluminium was 60.9μCi/μAh. The seperation of ^22Na was carried out by ion exchange, precipitation and diffusion. It was found that ion exchange column operation using AG50W-X4 resin was the most efficient method among them.
유국현,서용섭 東國大學校 2000 東國論叢 Vol.39 No.-
The half-life of ^54Mn is 312.2 days and main γ-energy is 835keV, therefore it is used as a standard source for a multi-channel analyzer and a dose calibrator and managanese catabolism study in human body. In this paper, a method for the production of no carrier added ^54Mn was studied via ^54Cr(p,n) and ^59Co(p, αpn), with MC-50 cyclotron and described chemical isolation method of ^54Mn from a irradiated target by ion exchange resin. Chromium and cobalt were used as target materials. The production yields of ^54Mn by 50.5 MeV protons was 4.5 μCi.μ/Ah on chromium target and 11.85 μCi/μAh on cobalt target. The cross-section and thick target yield of ^59Co(p, αpn)^54Mn reaction were measured in the energy range of 50.5→22.2MeV in order to determine the optimum conditions for the production of ^54Mn. the maximum cross-section was 47.48 mbarn at 41.2MeV.