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전자궁적출술과 자궁경부상부 자궁적출술이 성기능에 미치는 영향
조해중 ( Hea Joong Cho ),이제중 ( Je Jung Lee ),박성남 ( Seong Nam Park ),정상훈 ( Sang Hun Jung ),고경희 ( Kyung Hee Ko ),홍기연 ( Gi Yeon Hong ) 대한산부인과학회 2005 Obstetrics & Gynecology Science Vol.48 No.2
Objective: The aim of this study was to analyze the effects of total abdominal hysterectomy (TAH) versus supracervical hysterectomy (SCH) on sexual function in patients with non-malignant conditions. Methods: We choose fifty patients who were operated by
적복령 추출물이 파골세포의 분화와 골흡수 억제에 미치는 효과
김주영,조해중,김진숙,이승화,이명수,이창훈,문서영,최민규,김정중,오재민,곽한복 대한골다공증학회 2012 Osteoporosis and Sarcopenia Vol.10 No.3
Objectives: Osteoclast differentiation and bone resorption are considered a potential therapeutic target to the treatment of erosive bone diseases, including osteoporosis and rheumatoid arthritis. Poria cocos Wolf (PCW), commonly used herbal medicine, has previously been reported to induce anti-inflammatory effect and anti-cancer effect, and to modulate immunologic responses. However, the effects of PCW on osteoclasts, and its detailed mechanisms are not proven. Therefore, we examined the inhibitory mechanism of PCW on osteoclast differentiation and bone resorption. Materials and Methods: To analyze the effects of PCW on osteoclast differentiation, we examined osteoclast differentiation in bone marrow macrophages (BMMs) treated with or without of PCW by TRAP staining. The expression of c-Fos, NFATc1, TRAP and OSCAR mRNA was determined by RT-PCR and the protein levels of c-Fos, NFATc1, p38, ERK, JNK, Akt and IκB were assessed by western blot. Also, we evaluated the effect of PCW on bone resorption using hydroxyapatite plate. Results: PCW significantly inhibited RANKL-mediated osteoclast differentiation without any evidence of cytotoxicity. We founded that PCW strongly inhibited RANKL-induced osteoclast formation when added during the early stage of cultures, suggesting that PCW acts on osteoclast precursors to inhibit RANKL/RANK signaling. Among the RANK signaling pathways, PCW inhibited the phosphorylation of p38 and JNK, also inhibited RANKL-induced expression of c-Fos, NFATc1, TRAP and OSCAR. In addition, PCW suppressed the bone resorption of mature osteoclasts. Conclusions: These findings suggest that PCW may be a potential novel drug for bone disorders by targeting the differentiation of osteoclasts as well as their functions.