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전자궁적출술과 자궁경부상부 자궁적출술이 성기능에 미치는 영향
조해중 ( Hea Joong Cho ),이제중 ( Je Jung Lee ),박성남 ( Seong Nam Park ),정상훈 ( Sang Hun Jung ),고경희 ( Kyung Hee Ko ),홍기연 ( Gi Yeon Hong ) 대한산부인과학회 2005 Obstetrics & Gynecology Science Vol.48 No.2
목적: 자궁의 양성질환에서 자궁경부상부 자궁적출술 (SCH)과 전자궁적출술 (TAH)이 성기능에 미치는 영향에 대해 평가하고자 하였다. 연구 방법: 자궁경부상부 자궁적출술 (SCH)을 시행 받은 50명과 전자궁적출술 (TAH)를 시행 받은 46명의 환자에서 성 욕구, 성교 횟수, 오르가즘의 질과 빈도의 변화, 수술 후 성교통 발생, 전체적인 성적 만족도에 대해 설문조사 하였다. 결과: 1. 성 욕구는 TAH군에서 SCH군보다 더 많은 수가 감소하였으며 Objective: The aim of this study was to analyze the effects of total abdominal hysterectomy (TAH) versus supracervical hysterectomy (SCH) on sexual function in patients with non-malignant conditions. Methods: We choose fifty patients who were operated by
정재은,조해중,이환봉,한원철,이예리,호정규 대한부인종양학회 2007 Journal of Gynecologic Oncology Vol.18 No.4
평활근육종은 평활근으로부터 생기는 매우 드문 종양이며, 대개 위장관계와 후복막 그리고 비뇨생식기계에서 호발한다. 본 례는 2007년 1월에 복부종괴를 주소로 내원한 49세의 여성의 예로서, 진찰결과 좌하복부에 촉지되는 고형성, 유동성의 종양이 있었고, 골반 및 복부컴퓨터 단층촬영상 11.0×9.2×7.5 cm 크기의 종양이 측정되어, 시험적 개복술을 실시하고 종양을 제거하였다. 종양은 좌측 골반의 후복강내 좌측 총장골정맥에서 기원한 평활근육종, 병기 I (IB)로 판명되었다. 환자는 현재 수술 후 보조적 항암화학요법 시행 중이다. 이와 같은 종양의 최선의 치료는 완벽한 수술적 제거이다. 그러나 완벽한 수술적 제거에도 불구하고 주위장기로의 암 전이와 국소적 재발이 간혹 발생하므로 주의 깊은 추적관찰을 요한다. 저자들은 수술적 절제를 마친 후복막강 기원의 평활근육종 증례를 관련 문헌 고찰과 함께 보고 하는 바이다. The authors report a rare case of retroperitoneal leiomyosarcoma in a 49 year-old woman, with a palpable mass in the left lower abdomen. There is a large neoplasm which was soft and movable, looking a pelvic mass. Abdominal and pelvic CT scan showed a 11.0×9.2×7.5 cm-sized lobulated heterogenous enhancing mass with multifocal necrotic portion near the left ovary. Laparotomy and resection of the mass was performed. Microscopic examination revealed 15 mitoses per 10 high power fields. She was diagnosed as primary leiomyosarcoma originated from the left common iliac vein, stage I (IB). The best treatment of these neoplasms is complete surgical excision, and no therapeutic benefit has been derived from chemotherapy or radiotherapy. Though metastases are occasional, local recurrences can be taken into consideration and, after a careful tumoral re-staging, they can be resected once more. Therefore, careful follow-up is necessary on the basis of neoplastic grading, extension and involvement of the adjacent structures.
적복령 추출물이 파골세포의 분화와 골흡수 억제에 미치는 효과
김주영,조해중,김진숙,이승화,이명수,이창훈,문서영,최민규,김정중,오재민,곽한복 대한골다공증학회 2012 Osteoporosis and Sarcopenia Vol.10 No.3
Objectives: Osteoclast differentiation and bone resorption are considered a potential therapeutic target to the treatment of erosive bone diseases, including osteoporosis and rheumatoid arthritis. Poria cocos Wolf (PCW), commonly used herbal medicine, has previously been reported to induce anti-inflammatory effect and anti-cancer effect, and to modulate immunologic responses. However, the effects of PCW on osteoclasts, and its detailed mechanisms are not proven. Therefore, we examined the inhibitory mechanism of PCW on osteoclast differentiation and bone resorption. Materials and Methods: To analyze the effects of PCW on osteoclast differentiation, we examined osteoclast differentiation in bone marrow macrophages (BMMs) treated with or without of PCW by TRAP staining. The expression of c-Fos, NFATc1, TRAP and OSCAR mRNA was determined by RT-PCR and the protein levels of c-Fos, NFATc1, p38, ERK, JNK, Akt and IκB were assessed by western blot. Also, we evaluated the effect of PCW on bone resorption using hydroxyapatite plate. Results: PCW significantly inhibited RANKL-mediated osteoclast differentiation without any evidence of cytotoxicity. We founded that PCW strongly inhibited RANKL-induced osteoclast formation when added during the early stage of cultures, suggesting that PCW acts on osteoclast precursors to inhibit RANKL/RANK signaling. Among the RANK signaling pathways, PCW inhibited the phosphorylation of p38 and JNK, also inhibited RANKL-induced expression of c-Fos, NFATc1, TRAP and OSCAR. In addition, PCW suppressed the bone resorption of mature osteoclasts. Conclusions: These findings suggest that PCW may be a potential novel drug for bone disorders by targeting the differentiation of osteoclasts as well as their functions.