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도파민 발현 세포주 CV(bDAT) 세포에서 항정신병 약물이 도파민 수송체 활성에 미치는 영향
김영미,이용성,이상훈,오동렬,양병환,조석신,남정현,Kim, Young-Mi,Lee, Yong-Sung,Lee, Sang-Hun,Oh, Dong-Yul,Yang, Byung-Hwan,Cho, Suck-Shin,Nam, Jung-Hyun 대한생물정신의학회 1997 생물정신의학 Vol.4 No.1
CV(bDAT) cell line, expressing dopamine transporter stably, has been established by transfection of CV-1 cells with bovine dopamine transporter cDNA. Using CV(bDAT) cells, the effects of various antipsychotic drugs on dopamine uptake activity were investigated. All of antipsychotic drugs tested, inhibited the [$^3H$]dopamine uptake into CV(bDAT) cells with $IC_{50}s$ in the low to mid micromolar range, implying that antipsychotic drugs may produce overflow of dopamine in the synaptic cleft of dopaminergic neuron.
간장및 담도 : 만성간질환 환자의 상부위장관 증상에 대한 Domperidone 효과에 대한 연구
함준수(Joon Soo Hahm),이동후(Dong Hoo Lee),이민호(Min Ho Lee),이종철(Jong Chul Rhee),기춘석(Choon Suck Kee),이오영(Oh Yong Lee),안종훈(Jong Hoon Ahn),박경남(Kung Nam Park),조석신(Suck Shin Cho) 대한소화기학회 1990 대한소화기학회지 Vol.22 No.2
N/A The fact that chronic hepatitis patients with dysfunctional upper gastro-intestinal symptoms have delayed gastric empting time was documented in our previous study. Fifteen patients with chronic hepatitis participated in a assessment of the effects of domperidone on gastric empting time and dysfunctional upper gastrointestinal symptoms such as recurrent nausea, vomiting, postprandial bloating, anorexia and meight loss. They were each given domperidone 10 mg t.i.d. for four weeks. The resu1ts are as folIowing; 1) The total patints with chronic hepatitis are 15 in number, composed of chronic active hepatitis 9, chronic persistant hepatitis 6. 2) The GET (T 1/2) OF 15 patients with chronic hepatitis was delayed significantly than that of the normal control. (Mean +- SE; 135.0 +- 6.0 vs 89.4 +- 5.9 mins) (p<0.05). 3) Follow-up GET (T 1/2) of these patients after domperidone treatment were 116.0 +- 5.5 mins but those results were not statistically significant different from initial GET (T 1/2) (135.0 +- 6.0 mins). 4) Domperidone significantly promote dysfunctional gastrointestinal symptoms such as recurrent nausea, vomiting, postprandial bloating, anorexia, and weight loss. (Mean +- SE; 4.3 +- 0.2 vs 0.8 +- 0.2 symptom scores) (p<0.05). 5) The two side effect seen only with domperidone, diarrhea and mild abdominal pain occurred in one patient each and neither was severe enough to require discontinuing the study. No neurologic problems were noted.
위내시경으로 진단된 Gastric Red Spots(GRS)의 병태생리 및 임상적 의의
박경남,이민호,강인구,양석철,조석신,함준수,이종철,기춘석,성인경 대한소화기학회 1992 대한소화기학회지 Vol.24 No.5
The incidence of GRS in the proximal part of the stomach was investigated in patients with various liver diseases. 477 patients with biopsy proven chronic liver disease underwent endoscopic study and GRS were obaerved in 38 (20.3%) out of 187 patients with liver cirrhosis, in 21 (16.8%) out of l25 patients with chronic active hepatitis, in 9 (15. 5%) out of 58 patients with chronic persietent hepatitis, and in 12 (14.3%) out of 84 patients with other chronic liver pathologies. There were no statistical differences among the groups. The incidence of chronic liver disease among patients with normal liver function tests and abdominal ultrasonography, but exhibiting GRS upon endoscopic study, was also prospectively studied by liver biopsy. 11 of 23 such patients had chronic liver disease: 2 had liver cirrhosis, 3 with chronic persistent hepatitis, and 6 with chronic reactive hepatitis, while 12 patients with no conclusive pathology in liver biopsy in spite of minimal disarray of hepatic lobular architecture and mild inflammatory cell infiltration into periportal area. The heart to liver radioisotope uptake ratios measured by Thallium-201 scan to estimate the portal pressure were 13±3% (mean± SD) in 15 control subjects, 22±7% in 20 patients with chronic persistent hepatitis, 28±13% in 15 patients with chronic active hepatitis, 59±41% in 18 patients with liver cirrhosis, and 27±14% in 50 patients with GRS, but with normal liver function test results and normal abdomial ultrasonography. These results showed statistical difference from normal control (p$lt;0.05). It can thus be concluded that GRS in the proximal part of the stomach could be a stigma of chronic liver disease, and would also indicate the presence of high portal pressure.