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Endoscopic Repair of Meningoencephalocele:A Case Report
장태영,김대형,이승준,김경태 대한비과학회 2004 Journal of rhinology Vol.11 No.1
Meningoencephalocele is a rare mass, usually occurring in childhood. This is the herniation of a part of an intracranialcomponent through the skull base defect. Embryologically, the defect result from closure failure of the anterior neuropore. This mass may include meninges (meningocele), meninges and brain (meningoencephalocele), or meninges, brain, and ventricles(meningoencephalocystocele). It is classified as occipital, parietal, basal, and sincipital on the basis of its anatomicallocation. In past, the treatment of this mass has been by neurosurgeons. The authors experienced a case of basal type intranasalmeningoencephalocele in 15 year-old male patient in which the mass protruded into the nasal cavity through thecribriform plate. It was excised successfully by the intranasal approach with nasal endoscopy, and the dural defect was closedby septal cartilage, fascia lata, septal mucosa, and fibrin glue.
Effect of Long-Term Antiorthostatic Suspension in a Murine Model of Acute Lung Injury
장태영,정아연,김영효 대한이비인후과학회 2016 Clinical and Experimental Otorhinolaryngology Vol.9 No.4
Objectives. Antiorthostatic suspension (AOS) is ground-based model of simulated microgravity. There is still no study about the effect of long-term microgravity on the clinical course of acute lung injury. We evaluated the effect of simulated microgravity using AOS in a murine model of acute lung injury by lipopolysaccharide (LPS). Methods. Thirty BALB/c mice were used. During 4 weeks, mice were equally allocated to control (free movement), restraint (tail suspended, but hindlimbs not unloaded), and AOS group (hindlimb unloaded). After then, mice got intranasal challenge with LPS (20 mg/kg, 50 μL). We measured: weight gain before and after AOS, the number of inflammatory cells and titers of cytokines (interleukin [IL]-1β, IL-6, IL-10, tumor necrosis factor-α, and interferon-γ) in bronchoalveolar lavage (BAL) fluid, titer of myeloperoxidase (MPO) in serum and lung homogenate, and histopathologic examination of lung tissue. Results. AOS group had significant weight loss compared to control and restraint group (P<0.001). AOS group also showed significantly decreased lymphocytes (P=0.023) compared to control group. In AOS group, titer for IL-1β in BAL fluid was significantly lower than restraint group (P=0.049). Titer for serum MPO was significantly decreased in AOS group compared to restraint group (P=0.004). However, there was no significant difference of MPO titers in lung tissue between groups. Histopathologic examination of lung tissue revealed no significant difference in the degree of pulmonary infiltration between restraint and AOS group. Conclusion. In spite of modest anti-inflammatory effect, prolonged AOS caused no significant change in LPS-induced pulmonary inflammation.
Three ptiliid species (Coleoptera: Ptiliidae) new to Korea
장태영,박종석 국립중앙과학관 2022 Journal of Asia-Pacific Biodiversity Vol.15 No.3
The family Ptiliidae is one of the poorly known groups of beetles. Approximately 70 species are currently recorded in Japan and Russian Far East. In Korea, however, taxonomic studies involving ptiliid beetles were started with the recording of three species in 2020e2021. In this study, three additional ptiliid species, Baeocrara japonica, Cissidium elongatum, and Ptinella mekura are recorded in Korea for the first time. Illustrations of habitus, diagnostic characteristics, a distribution map, and a key to the Korean ptiliid species are provided.
만성 부비동염 환자에서의 중비도와 상악동의 배양균주의 연관성
장태영,신준순,최윤석 대한이비인후과학회 2004 대한이비인후과학회지 두경부외과학 Vol.47 No.5
Background and Objectives:The identification of specific pathogens for chronic sinusitis is important for antibiotic treatment. middle meatal cultures can replace maxillary sinus cultures as a noninvasive alternative. Materials and Method:Twenty-two patients with chronic sinusitis, who didnt respond to medical therapy and recieved endoscopic sinus surgery were selected. We collected preoperative middle meatal samples and intraoperative maxillary sinus samples from twenty two patients under end-oscopic visualization using strile cotton swabs. Results:In 18 of the 22 samples (82% )correlated well with the intraoperative maxillary sinus cultures. In both middle meatus and maxillary sinus samples, most frequently encountered microorganism was Staphylococus aureus. Conclusion:Noninvasive middle meatal cultures correlate well with maxillary sinus cultures, and can be confidently used as an alternative.
장태영,김영효 대한배뇨장애요실금학회 2015 International Neurourology Journal Vol.19 No.3
Interleukin (IL) 33, a member of the IL-1 superfamily, is an “alarmin” protein and is secreted in its active form from damaged cells undergoing necrotic cell death. Mast cells are one of the main effector cell types in allergic disorders. They secrete a variety of mediators, including T helper 2 cytokines. As mast cells have high-affinity IgE receptors (FcεRI) on their surface, they can capture circulating IgE. IgE-bound mast cells degranulate large amounts of histamine, heparin, and proteases when they encounter antigens. As IL-33 is an important mediator of innate immunity and mast cells play an important role in adaptive immune responses, interactions between the two could link innate and adaptive immunity. IL-33 promotes the adhesion of mast cells to laminin, fibronectin, and vitronectin. IL-33 increases the expression of adhesion molecules, such as intracellular adhesion molecule-1 and vascular cell adhesion molecule-1, in endothelial cells, thus enhancing mast cell adhesion to blood vessel walls. IL-33 stimulates mast cell proliferation by activating the ST2/Myd88 pathway; increases mast cell survival by the activation of survival proteins such as Bcl-XL; and promotes the growth, development, and maturation of mast cell progenitors. IL-33 is also involved in the activation of mature mast cells and production of different proinflammatory cytokines. The interaction of IL-33 and mast cells could have important clinical implications in the field of clinical urology. Epithelial dysfunction and mast cells could play an important role in the pathogenesis of interstitial cystitis. Urinary levels of IL-33 significantly increase in patients with interstitial cystitis. In addition, the number of mast cells significantly increase in the urinary bladders of patients with interstitial cystitis. Therefore, inhibition of mast cell activation and degranulation in response to increase in IL-33 is a potential therapeutic target in the treatment of interstitial cystitis.