지골피 추출물이 류마티스관절염 관련 매개체에 미치는 영향

장아영,승오탁,이명선 한국응용과학기술학회 2019 한국응용과학기술학회지 Vol.36 No.4

The present study aimed to evaluate the effect of Lycii radicis CORTEX extract on rheumatoid related factors in CIA-induced Rheumatoid Arthritis model of DBA/1 mice. Lycii radicis CORTEX extract was administered orally at doses of 200 mg/kg/day for 4 weeks after direct injection of CIA into the mice’ right paw. We evaluated the treatment effects based on serum biomarkers, morphological and histopathological analyses of the paw. Compared with those in control mice, the Lycii radicis CORTEX extract treatments significantly reduced the serum concentration of cytokine, kemokine and immunoglobulin levels. In addition, the Lycii radicis CORTEX extract treatments effectively preserved the paw bone joint, that in the H&E staining and masson-trichrome staining showed that there were histopathological improvements in Lycii radicis CORTEX extract treated group compared to those of control group. The results indicate that Lycii radicis CORTEX extract alleviated rheumatoid arthritis symptoms. Thus, Lycii radicis CORTEX extract may be a novel therapeutic option for the management of rheumatoid arthritis. 본 연구는 CIA로 유도된 류마티스 관절염 모델에서 지골피 추출물이 류마티스관절염 관련 인자에 미치는 영향을 평가하였다. 동물 모델에 류마티스관절염을 유발한 후 지골피 추출물을 4주간 200 ㎎/㎏/day 용량으로 경구 투여하였다. 이후 혈액, 방사선 및 조직 분석에 기초하여 효과를 평가하 였다. 그 결과, 대조군에 비해 지골피 추출물은 사이토카인, 케모카인 및 면역글로불린 생성을 유의하게 감소시켰다. 또한, 지골피 추출물은 중족골을 효과적으로 보존하였으며, H&E 및 M&T 염색에서도 대조군에 비해 조직 병리학적 개선이 있음을 보여주었다. 이와 같은 결과는 지골피 추출물이 류마티스관절염 증상을 완화시켰음을 나타내고 있다. 따라서 지골피 추출물은 류마티스 관절염 관리를 위한 새로운 치료옵션이 될 수 있다.

도금 용액 관리에 따른 사틴 니켈 수명 연장 연구

장아영,황양진,이규환,우창호,이수언 한국표면공학회 2011 한국표면공학회 학술발표회 초록집 Vol.2011 No.11

필터링 시스템을 통한 사틴 니켈 연속 공정 연구

장아영,황양진,우창호,이수언,황환일,김철,이규환 한국표면공학회 2012 한국표면공학회 학술발표회 초록집 Vol.2012 No.5

학업무기력이 청소년의 삶의 만족도에 미치는 영향: 진로적응력의 조절효과

장아영,김순규 전북대학교 사회과학연구소 2024 지역과 세계 Vol.48 No.3

본 연구는 청소년의 학업무기력이 삶의 만족도에 미치는 영향에서 진로적응력의 조절효과를 살펴보고자 하 였다. 본 연구를 위해 한국청소년정책연구원의 한국아동·청소년패널조사 2018 제5차년도(2022) 중학교 1 학년 데이터를 사용하였다. 본 연구의 결과를 살펴보면, 먼저 학업무기력은 삶의 만족도, 진로 적응력 모두와 부적 상관관계가 나타났다. 다음은 학업무기력은 청소년의 삶의 만족도에 부정적인 영향을 미쳤고, 진로 적 응력은 이를 조절하는 것으로 나타났다. 이러한 결과는 청소년의 진로적응력을 강화하는 것이 학업무기력으 로 인한 부정적 영향을 줄이고, 전반적인 삶의 만족도를 높이는 데 중요한 역할을 한다는 점을 시사한다. 따 라서 청소년의 진로적응력 발달을 위한 교육 및 상담적 개입 방안의 필요성이 강조된다. This study examined the moderating effect of career adaptability on the relationship between adolescents' academic helplessness and life satisfaction. Data from the 2022 first-year middle school students in the Korea Children and Youth Panel Survey 2018 were used. Results showed a negative correlation between academic helplessness and life satisfaction, and between academic helplessness, life satisfaction, and career adaptability. Academic helplessness negatively impacted life satisfaction, while career adaptability moderated this relationship. Strengthening career adaptability is crucial for improving life satisfaction and mitigating academic helplessness.

Immune-modulation effect of Halocynthia aurantium tunic lipid on RAW264.7 cells

장아영,Chaiwat Monmai,Weerawan Rod-in,김지은,유상관,이태호,박우정 한국식품과학회 2022 Food Science and Biotechnology Vol.31 No.1

The current study evaluated the immune-regulatory potential of lipid extract from Halocynthia aurantium tunic on macrophage cells. The results showed that H. aurantium lipid is composed of primarily SFA (68.32%), followed by MUFA and PUFA (17.61% and 14.07%, respectively). Halocynthia aurantium lipid dose-dependently modulated the NO and PGE2 production in RAW264.7 cells without any LPS stimulation. The lipid effectively up-regulated the cytokine expression, including IL-1β, IL-6, and TNF-α in RAW264.7 cells. The COX-2 expression as a key biomarker for inflammation was also significantly increased. Conversely, H. aurantium lipid down-regulated the expression of inflammatory cytokines in LPS-stimulated RAW264.7 cells. Halocynthia aurantium lipid modulated the phosphorylation of NF-κB p-65, p38, ERK, and JNK, indicating that this lipid activated through NF-κB and MAPK pathways. These results provide insight into the immune-regulatory activities of H. aurantium tunic lipid and suggest that H. aurantium tunic may a potential lipid source for immune-regulatory molecules.

무릎 골관절염 노인에게 적용한 운동 중재 지속 효과

장아영,이은주 인문사회 21 2023 인문사회 21 Vol.14 No.2

This study conducted to identify the effect of exercise interventions on the adherence of exercise for the elderly with knee osteoarthritis. As a research method, based on systemic review and meta-analysis, random controlled trials published from Jan. 10 to Jan. 18, 2023 were searched and selected according to the PRISMA reporting guidelines. The effect size was meta-analyzed the risk of bias (RoB2) was evaluated by the Review Manager 5.4 version program. The estimated overall effect size of the intervention programs to exercise for the elderly with knee osteoarthritis was 0.26 (95% CI=0.07-0.45), of which behavior graded activity intervention was statistically significant (SMD=0.53, 95% CI=0.21-0.86). Based on the results of this study, we propose to raise the level of physical activity in consideration of individual abilities when developing a continuous exercise program for the elderly with knee osteoarthritis.

[YTN 보도국 편집회의] “24시간 백지를 채워라…” 하루 3번 대규모 보도국 회의

장아영 (사)방송기자연합회 2020 방송기자 Vol.57 No.-

가로 연결성이 상권의 경제활력에 미치는 영향 : 서울시 상권 단위 매출액 비교를 중심으로

장아영,강명구 대한국토·도시계획학회 2024 國土計劃 Vol.59 No.1

Street connectivity is pivotal in creating vibrant urban environments. Previous studies have shown that street connectivity has a significant impact on urban health and land use, and it promotes commercial interaction and leisure activities by citizens. It is thus important to empirically analyze the influence of street connectivity on the commercial economy as a factor that promotes commercial interaction and leisure activities. Studies on connectivity have developed different approaches depending on the urban, architectural, and transportation contexts, and the majority focus on centrality and accessibility. In addition, previous studies related to the economy of commercial districts have focused on socio-economic variables, with studies based on the spatial characteristics of commercial districts lacking. To address these gaps, this study compared and analyzed how the index of street connectivity in the urban context differs from connectivity indicators used in spatial syntax and transportation, and empirically examined the effect of street connectivity on the commercial economy. The developed commercial district of Seoul was set as the spatial scope, and sales data for the food & beverage (F&B) industry were used, as this is one of the industries most affected by people's activities and interactions. Street connectivity was measured as street density and intersection density. Multiple regression analysis was applied to prove that higher street connectivity causes higher F&B business sales in commercial districts. This study underscores the significance and role of street connectivity, and provides a comparison with architectural and traffic indicators. It also emphasizes the importance of streets as public places in relation to the economy of commercial districts. 본 연구는 서울시 발달상권을 대상으로 공간 투과성 측면에서의 가로 연결성을 측정하여, 권역 단위의 가로 연결성이 상권 경제에 미치는 영향을 증명하였다. 공간에 전반적으로 침투되어 틈틈이 접근 가능하도록 연결하는 망(Network) 특성 기반의 ‘가로연결성’과 타 지표들 간 차이를 비교분석하여 권역적인 접근에서의 가로 연결성의 의미를 규명하였다. 또한, 다중회귀분석을 통해 가로 연결성이 상권 경제에 영향을 미치는 핵심적인 변수임을실증분석하였다. 이를 통해 본 연구는 가로 연결성의 증진이 사람들의 방문 및 상호작용을 촉진하여 상권 내 직접적인 소비로 이어지는 영향을 보였으며, 개별 점포의 매출 활성화를 넘어 상권경제 전체의 활력 증진을 위한 함의를 제시하고자 한다.

Association between Smoking and Periodontal Disease in Korean Adults: The Fifth Korea National Health and Nutrition Examination Survey (2010 and 2012)

장아영,이정권,신진영,이해영 대한가정의학회 2016 Korean Journal of Family Medicine Vol.37 No.2

Background: This study aimed to evaluate an association between smoking, smoking cessation, and periodontaldisease in Korean adults. Methods: The data were collected from 8,336 participants, aged between 20 and 64 years, who participated in thefifth Korea National Health and Nutrition Examination (2010 and 2012). Smoking status was assessed using self-administeredquestionnaires. Periodontal disease was defined as a community periodontal index ≥3 points. Logisticregression analysis was used to evaluate an association between smoking, smoking cessation, and periodontal diseaseafter adjusting for age, sex, education, monthly income, diabetes, obesity, alcohol intake, and frequency oftooth brushing. Results: The risk of periodontal disease was higher among current smokers (odds ratio [OR], 1.49; 95% confidenceinterval [CI], 1.21–1.83) than never smokers. Among current smokers, the risk of periodontal disease was increasedin smokers of ≥10 cigarettes/d, ≥20 years duration, and >10 pack-years compared with never smokers (P<0.05). Among former smokers, the risk of periodontal disease after 10 years since cessation declined to 0.56 (95% CI, 0.42–0.75) compared with current smokers and was indistinguishable statistically from never smokers. Conclusion: Periodontal disease is significantly associated with smoking status in Korean adults.

탐사보도의 ‘최전선’에서 배운다

장아영 (사)방송기자연합회 2016 방송기자 Vol.31 No.-