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탈미네랄화된 골분/히알루론산을 이용한 조직공학적 지지체의 제조 및 특성분석
임지예 ( Ji Ye Lim ),김순희 ( Soon Hee Kim ),소정원 ( Jeong Won So ),이종문 ( John M. Rhee ),강길선 ( Gil Son Khang ) 한국조직공학·재생의학회 2008 조직공학과 재생의학 Vol.5 No.3
Demineralized bone particle(DBP) that affects to cell proliferation and differentiation has been used to clinical trial as natural material. hyalunonic acid(HA) called natural moisturizer can be used as biomaterials. In this study, we tried to design and characterize novel DBP-HA sponge. DBP-HA sponge were prepared by freeze-drying method after addition of 1 wt% HA solution into fabricated DBP sponge. Sponge was crosslinked with 1-ethyl-(3- 3-dimethyl aminopropyl) carbodiimide hydrochloride(EDC) solution with 50 mM concentration for 24 hrs and lyophilized. We seeded cells in DBP-HA sponge. Cellular attachment was assayed by 3-(4,5-dimethylthiazole-2-yl)- 2,5-diphenyltertazolium-bromide(MTT) test. DBP-HA sponges were characterized by scanning electron microscopy, fourier transeform infrared spectrometer and water ubsorption ability. We demonstrated presence of HA in DBP-HA sponge from C-O functional group observed by the FT-IR analysis. Moreover, we confirmed high water uptake ability and high cell viability in DBP-HA sponge. Therefore, we could expect that DBP-HA scaffolds are applicable for the tissue regeneration.
연구논문 : 서울지역 일부 초등학생의 식이효능감과 아동의 특성 및 어머니 양육효능감과의 관련성 연구
임지예 ( Ji Ye Lim ),민성희 ( Sung Hee Min ),이민준 ( Min June Lee ) 한국식생활문화학회 2015 韓國食生活文化學會誌 Vol.30 No.6
The purpose of this study was to determine the relationship between children’s dietary self-efficacy, general characteristics and mother’s parenting self-efficacy among elementary school students. Mother’s parenting self-efficacy was significantly higher as parents’ educational levels increased (p<0.001), as family monthly income level increased (p<0.001), and when father’s job was professional or managing work (p<0.001). Children’s dietary self-efficacy was meaningfully higher when parents’ educational levels were higher (p<0.01), and family income level was higher (p<0.01). Mother’s parenting selfefficacy showed a correlation with children’s dietary self-efficacy (p<0.001). All factors comprising parenting self-efficacy, such as ‘general parenting self-efficacy’ (p<0.001), ‘healthy parenting self-efficacy’ (p<0.001), ‘communication parenting self-efficacy’ (p<0.001), ‘educational parenting self-efficacy’ (p<0.001), and ‘control parenting self-efficacy’ (p<0.001) showed correlation with children’s dietary self-efficacy. It is suggested that in order to improve children’s dietary self-efficacy and mothers’ parenting self-efficacy, families, schools, and communities must put forth a concerted effort. By complementing existing nutritional programs focusing on nutritional knowledge, one can develop a education program and social support to enhance children’s dietary self-efficacy and mothers’ parenting self-efficacy.
SIS/PLGA 필름에서 SIS 함량이 디스크세포의 증식에 미치는 영향
임지예 ( Ji Ye Lim ),김순희 ( Soon Hee Kim ),소정원 ( Jeong Won So ),최진희 ( Jin Hee Choi ),이종문 ( John M. Rhee ),신형식 ( Hyung Shik Shin ),강길선 ( Gil Son Khang ) 한국조직공학·재생의학회 2008 조직공학과 재생의학 Vol.5 No.3
Porcine small intestine submucosa is accellular tissue and widely used as a biomaterials without immunorejection responses. Poly(lactide-co-glycilide) (PLGA) has controllable biodegradability and good biocompatibility. In this study, we evaluated 2-dimensional porcine small intestine submucosa (SIS)/PLGA hybrid films on adhesion, proliferation and phenotype maintenance of intervertebral disc cells. We prepared natural/synthetic hybrid films using 0, 10, 20, 40 and 80 wt% of SIS by the solvent evaporation method. SIS/PLGA films were characterized by scanning election microscopy (SEM). Disc cells were seeded on PLGA and SIS/PLGA film and we confirmed the effects of adhesion and proliferation on disc cells according to content of SIS by cell count and SEM observation. Contents of 10 wt% SIS positively affected to proliferate and maintain of disc phenotype in SIS/PLGA Film.
PLGA/DBP 하이브리드지지체와 섬유륜세포 및 수핵세포를 이용한 바이오디스크의 재생
임지예 ( Ji Ye Lim ),김순희 ( Soon Hee Kim ),박상욱 ( Sang Wook Park ),소정원 ( Jeong Won So ),백미옥 ( Mi Ock Back ),김문석 ( Moon Suk Kim ),강길선 ( Gilson Khang ),이종문 ( John M. Rhee ),이해방 ( Hai Bang Lee ) 한국조직공학과 재생의학회 2008 조직공학과 재생의학 Vol.5 No.1
We fabricated poly(lactide-co-glycolide)(PLGA) scaffolds impregnated 0, 10, 20, 40, and 80 wt% demieneralized bone particle(DBP)(PLGA/DBP) to investigate the effect of cell viability and proliferation of intervertebral disc(IVD) cells. PLGA is a biodegradable synthetic polymer with acceptable mechanical strength and well-controlled degradation rate. DBP contains bioactive molecules. Annulus fibrosus(AF) and nucleus pulposus (NP) cells were seeded in PLGA and PLGA/DBP scaffold to evaluate mRNA expression and a proliferation of AF and NP cells according to content of DBP. Cellular viability and proliferation were assayed by 3-(4,5-dimethylthiazole- 2-l)-2,5-diphenyltetrazolium-bromide(MTT) test. Reverse transcription polymerase chain reaction(RT-PCR) was assessed to measure mRNA expression for Type I collagen and Type II collagen of IVD cells in scaffolds. Scaffolds were implanted in subcutaneous of athymic nude mouse for histology in vivo. The formation of disc-like tissue appeared in PLGA/DBP scaffold than control. Especially, 40 and 80 wt% of DBP positively affected to proliferation and maintenance of phenotype in scaffold. These information would contribute to design of PLGA/DBP scaffold for tissue engineered IVD regeneration.
어린이 영양지수를 이용한 아동의 식행동 특성 평가 - 서울지역 일부 초등학생을 중심으로 -
임지예,김정현,민성희,이명희,이민준,Lim, Ji Ye,Kim, Jung Hyun,Min, Sung Hee,Lee, Myung Hee,Lee, Min June 한국식품조리과학회 2016 한국식품조리과학회지 Vol.32 No.1
This study investigated the food behavior and nutritional status of children using the Nutrition Quotient (NQ). The subjects for this study were 974 students and their parents who lived in Seocho-gu, Gwanak-gu, and Dongjak-gu, Seoul. The average NQ score of the subjects was 68.3, which was a medium grade. The mean scores for balance and moderation were above the thresholds, whereas the mean scores for diversity, regularity, and practice did not reach the thresholds. According to the results of evaluation by NQ, the subjects may have insufficient intake of calcium, iron, potassium, zinc, vitamin A, and vitamin C. NQ and NQ factors were different according to the general characteristics and home background characteristics of the subjects. The mean scores for the moderation factor was significantly lower as the eating out frequency increased (p<0.001). The mean scores for balance, moderation, and regularity factors were significantly higher, with higher parents educational level. It is necessary to choose diverse side dishes, vegetables and also foods with balanced nutrition when eating out.
최경민,황승미,임지예,고은실,박종혁,문정혜,이민정,장지은,차정단,Choi, Kyung-Min,Hwang, Seung-Mi,Lim, Ji-Ye,Ko, Eun-Sil,Park, Jong-Hyuk,Moon, Jung-Hye,Lee, Min-Jung,Jang, Ji-Eun,Cha, Jeong-Dan 한국미생물·생명공학회 2015 한국미생물·생명공학회지 Vol.43 No.2
In this study, we investigated the effects of 40% ethanol extract of Red Ginseng (RGE) on the productions of inflammatory proteins in Antigen I/II (Ag I/II)-N, a recombinant protein isolated from Streptococcus mutans -stimulated in RAW 264.7 cells. RGE inhibited the expression of Ag I/II-N-induced pro-inflammatory mediators, both mRNA and protein synthesis levels, without any cytotoxic effects. Moreover, RGE significantly inhibited Ag I/II-N induced NF-κB translocation into the nucleus by preventing the degradation of inhibitor κB-α. In conclusion, RGE down regulates the expression of pro-inflammatory genes involved in the synthesis of NO and iNOS in Ag I/II-N-stimulated RAW 264.7 cells by suppressing NF-κB activity. 본 연구에서, 우리는 S. mutans Ag I/II 재조합단백질에 의해 유도되어진 염증유발 단백질의 발현에 홍삼 40% 에탄올 추출물의 효과를 알아보고자 하였다. 홍삼에탄올추출물은 Ag I/II 재조합단백질에 의해 유도되어진 염증유발물질들의 mRNA와 단백질의 발현을 억제하였다. 더불어 홍삼에탄올 추출물은 NF-κΒ p65가 핵내로 이용하는 것이 억제하였다. 결론적으로 홍삼 40%에탄올추출물은 NF-κB의 활성에 의해 NO 생성과 iNOS 발현이 조절되어지는 것으로 생각되어지며, 염증유발 관련 유전자들의 낮은 발현을 유도하는 것으로 관찰되어졌다.
덱사메타손을 함유한 SIS/PLGA 필름의 제조 및 평가
이준희 ( Jun Hee Lee ),임지예 ( Ji Ye Lim ),안식일 ( Sik Il Ahn ),박종학 ( Jong Hak Park ),김윤태 ( Yun Tae Kim ),이종문 ( John M. Rhee ),강길선 ( Gilson Khang ) 한국조직공학·재생의학회 2008 조직공학과 재생의학 Vol.5 No.3
Even though the steroid drug dexamethasone is an efficacious antiinflammatory drug, it is difficult to formulate in an injectable formulation because of its poorly water solubility. So, polymeric film containing dexamatasone was designed drug delivery system including small intestinal submucosa (SIS) and sustained release of the drug from the polymeric system. poly(D,L-lactide-co-glycolide)(PLGA) is used for polymeric film that has been widely used as carriers in controlled release delivery system due to its biodegradability and relatively good biocompatibility. Also, the release behavior of dexamethasone on film controlled by adding the additive such as SIS. SIS derived from the submucosa layer of porcine intestine has been widely used as biomaterial due to low immune response and biocompatibility. SIS/PLGA film were manufactured by the method of solvent and characterized by scanning election microscopy (SEM). In vitro release behavior measured by HPLC and the PLGA molecular weight according to degradation of PLGA analyzed by GPC and pH meter. In this study, the films containing natural materials such as SIS according to content showed zero-order release profile. It was confirmed that the release of dexamethasone form films could be easily controlled by adding SIS.