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      • KCI등재

        Pulmonary Complications After Hematopoietic Stem Cell Transplantation

        임도형,이지연,Hong Ghi Lee,박병배,백경란,오원섭,Sang Hoon Ji,이세훈,박준오,김기현,김원석,정철원,박영석,Young Hyuck Im,강원기,박근칠 대한의학회 2006 Journal of Korean medical science Vol.21 No.3

        Despite advanced effective prophylaxes, pulmonary complications still occur in a high proportion of all hematopoietic stem cell recipients, accounting for considerable morbidity and mortality. The aim of our study was to describe the causes, incidences and mortality rates secondary to pulmonary complications and risk factors of such complications following hematopoietic stem cell transplantation (HSCT). We reviewed the medical records of 287 patients who underwent either autologous or allogeneic HSCT for hematologic disorders from February 1996 to October 2003 at Samsung Medical Center (134 autografts, 153 allografts). The timing of pulmonary complica-tions was divided into pre-engraftment, early and late period. The spectrum of pul-monary complications included infectious and non-infectious conditions. 73 of the 287 patients (25.4%) developed pulmonary complications. Among these patients, 40 (54.8%) and 29 (39.7%) had infectious and non-infectious conditions, respectively. The overall mortality rate from pulmonary complications was 28.8%. Allogeneic trans-plant, grade II-IV acute graft-versus-host disease (GVHD) and extensive chronic GVHD were the risk factors with statistical significance for pulmonary complications after HSCT. The mortality rates from pulmonary complications following HSCT were high, especially those of viral and fungal pneumonia, diffuse alveolar hemorrhage and idiopathic pneumonia syndrome.

      • KCI등재

        Mapping of the morphological and the material characteristics on the glenoid and estimation of predominant loading condition on the glenoid through the mapping

        임도형,김한성,김중성,Rami Seliktar,이성재 대한기계학회 2009 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.23 No.2

        The aim of this study was to predict and map the regional distribution of the trabecular architecture and the material properties of the glenoid and to estimate the predominant loading condition on the glenoid through the mapping. The morphological and material characteristics of the glenoid were investigated by analyzing digitized trabecular bone images obtained from twelve cadaver scapula specimens. The morphological and material characteristics computed from the cadaver specimens show that the predominant loading on the glenoid generally occurs during shoulder movement, which produces forces directed toward the posterior aspect of the bare region. This study is innovative in its detailed mapping of the morphological and material characteristics of the glenoid and its pioneering approach used to estimate the loading pattern acting on the glenoid through the mapping.

      • KCI등재

        후두편평세포암종에서 Vascular Endothelial Growth Factor의 발현

        임도형,이규석,이강원,홍영호,김훈 대한이비인후과학회 2003 대한이비인후과학회지 두경부외과학 Vol.46 No.3

        Background and Objectives:The growth of tumor is dependent on angiogenesis. Expresions of vascular endothelial growth factor (VEGF) as a prognostic indicator has been documented for various types of human tumors. The purpose of this study was cell carcinoma. Materials and Method:The VEGF expresion was evaluated by imunohistochemical staining with monoclonal anti-VEGF antibody in 28 cases of the laryngeal squamous cell carcinoma. Results:The positive staining for VEGF was observed in 5 (31.3%) out of 16 cases of well differentiated carcinomas and 7 (58.3%) out of 12 cases of moderately differentiated carci-nomas. Comparing with the TNM staging system, no positive staining was found in any of the stage I cases;however, 2 out of 6 cases (33.3%) of stage II, 3 out of 7 cases (42.9%) of stage II and 6 out of 9 cases (66.7%) of stage IV showed positive staining for VEGF. There was statistical relationship betwen the differentiation and positive expression for VEGF, but not betwen the stage of the laryngeal squamous cell carcinoma and the VEGF expression. Conclusion:These results suggest that there is a clinical corelation of VEGF expression to the progres of diferentiation and tumor stages. (Korean J Otolaryngol 2003 ;46 :234-8)

      • KCI등재

        Relationship Between Dual Time Point FDG PET/CTand Clinical Prognostic Indexes in Patients with High Grade Lymphoma: a Pilot Study

        임도형,이재현 대한핵의학회 2017 핵의학 분자영상 Vol.51 No.4

        Purpose This study investigated the correlative relationship between metabolic parameters estimated from dual time point 2-deoxy-2-[18F] fluoro-D-glucose (18F-FDG) positron emission tomography/computerized tomography (PET/CT) and the clinical tools predicting the outcome of a lymphoma. We also measured metabolic and volumetric alterations between early and delayed 18F-FDG PET/CT in patients with high grade lymphoma (HGL). Methods The samples were 122 lymph nodes and extralymphatic lesions from 26 patients diagnosed with HGL. All patients were applied to the International Prognostic Index (IPI), Ann Arbor stage, and revised IPI as clinical prognostic parameters. 18F-FDG dual time point PET/ CT (DTPFP) consisted of an early scan 1 h after 18F-FDG injection and a delayed scan 2 h after the early scan. Based on an analysis of DTPFP, we estimated the standardized uptake value (SUV) of tumors from the early and delayed scans, retention index (RI) representing the percentage change between early and delayed SUV, and metabolic volume different index (MVDI) calculated using metabolic tumor volumes (MTV). Results RImax showed a multiple positive correlative relationship with stage and IPI in lesion-by-lesion analysis (p < 0.01). In the case of IPI, the high risk group exhibited higher RImax than the low risk group (p = 0.004). In the case of revised IPI, the RImax of the low risk group were significantly lower than the intermediate and high risk groups, respectively (p < 0.01). The MVDIs of the best outcome group were decreased in comparison to the moderate outcome group (p = 0.029). There was a significant negative correlative relationship between RImax and MVDI, and the inclinations for decreased MVDIs were slightly associated with increased RIs. Conclusions RImax extracted from DTPFP had a significant relationship to extranodal involvement, staging, IPI, and revised IPI. MVDI showed significant negative correlation with RImax. Further large scale studies are warranted to support and extend these preliminary results.

      • 신경망을 사용한 매도/매수 주식 종목 선정

        임도형,이일병 한국경영과학회 2000 한국경영과학회 학술대회논문집 Vol.- No.1

        주가는 시계열 데이터의 일종므로 많은 변수들이 주가의 변동에 영향을 미친다. 그러나몇멸 개의 어떠한 변수가, 이렇게 영향물 미치는 지 정확히 알려져 있지 않다. 그렇기 때문에 주가를 예측하는 것은 쉽지 않으며 단지 등락을 예측하는 것 조차도 쉽지 않다. 본 논문에서는 주가를 신호와 잡음이 혼합된 것으로 가점하고 그 특성을 고려하여, 전 종목에 대한 등락물 예측하지 않고, 예측율이 높은 종목물 선정하는 것을 목표로 하였다 MLP를 BP로 학습시켰으면 밉력으로는 28개의 주가분석 지표값이 사용되었다. 여러 예측 기간므로 실험하몄으며, 예측기간이 60일일 때 77.1%의 예측뮬물 보였고 선정된 좀목의 등락 예측물은 88%였다.

      • KCI등재

        Alterations to the Mechanical Response of the Gastrointestinal Tract Induced by Functional Gastrointestinal Disorders and the Feasibility of Developing an Ultrasonic Diagnostic System

        임도형,Won-Pil Park,우대곤,이용흠,김한성,공인덕 대한기계학회 2008 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.22 No.5

        Functional gastrointestinal disorders (FGIDs) affect millions of people of all ages, regardless of race or gender, but little information related to FGIDs is available and no diagnostic methods exist. Therefore, the aim of this study was to investigate the alterations to gastrointestinal tracts induced by FGIDs, and to identify the feasibility of developing an ultrasonic diagnostic system to detect these alterations. Palpation/percussion examinations and in vitro micro-without FGIDs and 20 SpragueDawley rats with or with-out simulated FGIDs to identify any alterations to the mechanical response of the gastrointestinal tract. A finite differ-ence analysis was performed for three simple models with or without assumed FGIDs to identify the feasibility of de-veloping an ultrasonic diagnostic system. The results obtained from the palpation/percussion examinations and in vitro micro-indentation tests showed that a gastrointestinal tract with an FGID became more rigid than a healthy tract (p < 0.05). The results obtained from the finite difference analysis showed that an ultrasonic diagnostic system for FGIDs effectively detects alterations to the rigidity of the gastrointestinal tract, indicating that the development of an ultrasonic diagnostic system is reasonable and will aid in the diagnosis and treatment of FGIDs.

      • KCI등재

        Stress Analysis of Two-Dimensional Cellular Materials with Thick Cell Struts

        임도형,김한성,김영호,김윤혁,S.T.S Al-Hassani 대한기계학회 2008 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.22 No.5

        Finite element analyses (FEA) were performed to thoroughly validate the collapse criteria of cellular materials presented in our previous companion paper. The maximum stress (von-Mises stress) on the cell strut surface and the plastic collapse stress were computed for two-dimensional (2D) cellular materials with thick cell struts. The results from the FEA were compared with those from theoretical criteria of authors. The FEA results were in good agreement with the theoretical results. The results indicate that when bending moment, axial and shear forces are considered, the maximum stress on the strut surface gives significantly different values in the tensile and compressive parts of the cell wall as well as in the two loading directions. Therefore, for the initial yielding of ductile cellular materials and the fracture of brittle cellular materials, in which the maximum stress on the strut surface is evaluated, it is necessary to consider not only the bending moment but also axial and shear forces. In addition, this study shows that for regular cellular materials with the identical strut geometry for all struts, the initial yielding and the plastic collapse under a biaxial state of stress occur not only in the inclined cell struts but also in the vertical struts. These FEA results support the theoretical conclusion of our previous companion paper that the anisotropic 2D cellular material has a truncated yield surface not only on the compressive quadrant but also on the tensile quadrant.

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