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이한별,박시형,이창로 한국미생물학회 2023 미생물학회지 Vol.59 No.3
The inner membrane protein LapB participates in the regulation of proteolysis of lipopolysaccharide (LPS) biosynthesis protein LpxC by the essential membrane protease FtsH. However, the presence of the LpxC-independent phenotype in the lapB mutant implies an additional physiological role of LapB. In this study, we present novel genetic evidence for other cellular functions of LapB in Escherichia coli. We identified several novel phenotypes of the lapB mutant, such as growth defects under energy-poor carbon sources, and demonstrated that most phenotypes were suppressed by the depletion of penicillinbinding protein 1b (PBP1b), an inner membrane protein that participates in peptidoglycan biosynthesis, in an LpxC-independent manner. Additionally, most phenotypes of the lapB mutant were also suppressed by the depletion of YhcB, an inner membrane protein that is associated with the coordinated biosynthesis of peptidoglycan and LPS. Collectively, our genetic experiments imply that LapB may be associated with the regulation of peptidoglycan biosynthesis, as well as LpxC-mediated modulation of LPS levels.
Evaluation of Cellulolytic Enzyme Production by Indigenous Fungi in Korea
이한별,이영민,허영목,이재정,김재진 한국환경생물학회 2017 환경생물 : 환경생물학회지 Vol.35 No.4
The aim of this study was to select various fungal strains indigenous to Korea that have the potential to produce cellulases, including filter paper activity (FPase), endo-β-1,4-glucanase (EG), and β-glucosidase (BGL). Among the 25 species of Ascomycetes and the 32 species of Basidiomycetes tested in this study, the Bjerkandera adusta KUC10565, Heterobasidion orientale KUC10556, Hyphoderma praetermissum KUC10609, and Trichoderma harzianum KUC1716 all exhibited remarkably high FPase activity. In addition, the T. harzianum KUC1716 showed high levels of EG and BGL activity. This strain has been selected for further study because of their enzymatic potential.
Unique Features of Young Age Breast Cancer and Its Management
이한별,한원식 한국유방암학회 2014 Journal of breast cancer Vol.17 No.4
Young age breast cancer (YABC) has unique clinical and biologicalfeatures that are not seen in older patients. Breast tumor biologyis more aggressive and is associated with an unfavorableprognosis in younger women. The diagnosis of breast cancer isoften delayed, resulting in their initial presentation with more advanceddisease. Together, these characteristics lead to a poorerprognosis in younger women than in older women. Young womenwho receive breast-conserving therapy have a higher rate oflocal recurrence. Therefore, it is important to secure sufficient resectionmargins and consider boost radiotherapy to prevent localtreatment failure. Based on age alone, patients with YABCshould be regarded as high-risk cases, and they should be treatedwith adjuvant chemotherapy. Special considerations regardingpsychosocial factors and fertility should be taken into accountfor young patients. This review discusses the major considerationsand principles concerning the management of patientswith YABC
이한별,이수향 대한두개안면성형외과학회 2018 Archives of Craniofacial Surgery Vol.19 No.4
Background: The presence of enophthalmos is an important determinant in the decision of orbital wall fracture surgery. We proposed eyelid drooping as a new anthropometric diagnostic measure and analyzed whether eyelid drooping is associated with enophthalmos. Methods: This retrospective study was performed from January 2014 to December 2016. A total of 75 patients with blowout fractures were studied. One experimenter measured the degree of enophthalmos using a Hertel exophthalmometer at 1 week after trauma and at 3 months after surgery. The height change of the upper eyelid was measured using the marginal reflex distance (MRD) on both sides, and the degree of eyelid drooping was calculated by comparing the two lengths. We analyzed statistically the correlation between enophthalmos and eyelid drooping. Results: We found a highly significant correlation between the degree of enophthalmos and the reduction rate of MRD (RRM, as an indicator of eyelid drooping) at 1 week after trauma (r= 0.845). Approximately 2.0 mm of enophthalmos was associated with a 30.8% reduction in MRD on the affected side as compared with the normal side. At 3 months after surgery, patients showed improved eyelid appearance, with a moderate association between enophthalmos and RRM. Conclusion: We demonstrated that the degree of enophthalmos, measured using an exophthalmometer, is associated with a change in the height of the upper eyelid. Thus, upper eyelid drooping can be used as another indicator for orbital wall fracture surgery. Compared with conventional methods, measurements of eyelid drooping are easy to perform, offering a great advantage and understanding to the patient.
이한별,이정호,이동환 순천향대학교 순천향의학연구소 2018 Journal of Soonchunhyang Medical Science Vol.24 No.2
Thyroid hormone resistance is a rare syndrome of reduced tissue responsiveness to thyroid hormone. We report the case of a 13-month girl with short height and low weight. She was born at 37+6 weeks gestation and weighed 2,470 g. In the neonatal screening test, patients’ thyroid stimulation hormone (TSH) level was increased to 13.1 μIU/mL. In follow-up test after getting levothyroxine medication, patients’ free T4 level continued to increase and TSH level was normalized. After stop medication, the patient visited Soonchunhyang University Seoul Hospital every 2 to 3 months and done laboratory test, and the result was not changed. Despite good feeding, she consistently shows 5–10 percentile weight and 5–10 percentile height. Her bone age was delayed by 5 months compared to the expected age. In suspicious thyroid hormone resistance, THRβ gene study and brain magnetic resonance imaging (MRI), and T3 suppression test was done. Brain MRI and T3 suppression test shows the exception of pituitary thyroid adenoma. Gene study result was THRβ gene mutation, c.1012C>T (p.Arg338Trp), and heterozygous. This gene mutation was reported at thyroid hormone resistance family. After diagnosis of thyroid hormone resistance, because of the patient is asymptomatic, she does not have medication. We are checking developmental delay, growth delay, and other clinical hypothyroid symptoms.