웹 서비스 애플리케이션의 동적 성장을 위한 ESB와 에이전트 기반 프레임워크

이창호,김진한,이재정,이병정,Lee, Chang-Ho,Kim, Jin-Han,Lee, Jae-Jeong,Lee, Byung-Jeong 한국정보처리학회 2007 정보처리학회논문지 A Vol.14 No.7

유비쿼터스 컴퓨팅 환경에서는 이기종 플랫폼간의 상호작용과 빠른 환경의 변화에 대처할 수 있는 능력이 필요하다. 웹 서비스는 이러한 문제를 위해 이종의 분산 서비스 또는 자원들을 활용하고 조직하기 위한 방법을 제공한다. 그렇지만 서비스 요청 시, 의미 정보의 부족으로 원하는 서비스를 찾기가 어렵다. 시맨틱 웹 서비스는 의미 정보는 제공하지만 다양한 매칭에 대한 방법은 지원하지 않고 있다. 또한 웹 서비스를 이용해서 소프트웨어에 적응과 확장 능력을 제공할 순 있지만, 서비스들을 관리하고 운영하는 방법이 필요하다. 따라서 본 논문에서는 웹 서비스 애플리케이션의 동적 성장을 위해 ESB(Enterprise Service Bus)와 에이전트 기반의 프레임워크를 제안하고 유용성을 보이기 위한 프로토타입을 제시한다. Software adaptation may be required to interact between heterogeneous platforms and to react to rapid change of environment in ubiquitous computing. Web service provides a way to use heterogeneous and distributed services or resources to utilize and organize them. But it is not easy to retrieve appropriate services when we search services because web service lacks of semantic information. Semantic web service provides additional information of services, but it does not support a method to match them in various ways. We can adapt and extend web applications by using web service, but a method for management and administration is still needed. Therefore in this paper, we propose a framework for dynamic growing of web service applications based on ESB(Enterprise Service Bus) and agent and provide a prototype to show its usefulness.

고속역류크로마토그래프의 분리효율에 미치는 작동조건의 영향

이창호,이부용,이철호 ( Chang Ho Lee,Boo Yong Lee,Cherl Ho Lee ) 한국산업식품공학회 1997 산업 식품공학 Vol.1 No.3

원형제트출구 전단류 조절에 따른 제트충돌면에서의 열전달 특성

이창호,김영석,조형희,Lee, Chang-Ho,Kim, Yeong-Seok,Jo, Hyeong-Hui 대한기계학회 1998 大韓機械學會論文集B Vol.22 No.3

The present experiment is conducted to investigate heat transfer characteristics on the impinging surface with secondary flows around circular nozzle jets. The changed vortex pattern around jet affects significantly the flow characteristics and heat transfer coefficients on the impinging surface. The effects of the jet vortex control are also considered with jet nozzle-to-plate distances and main jet velocities. The vortex pattern around a jet is changed from a convective instability to an absolute instability with a velocity suction ratio of the main jet and the secondary counterflow. With the absolute instability condition, the jet potential core length increases and the heat transfer on the impinging surface is increased by small scale eddies. The region of high heat transfer coefficients is enlarged with the high Reynolds number due to increasing secondary peak values. The effect of suction flows is influenced largely with collars attached the exit of the jet nozzle because the attached collar guides well the counterflow around the main jet.

주민자력의 주택개량을 위한 주거모델 선정 시스템 구축 및 시뮬레이션에 관한 연구

이창호(Lee, Chang-Ho),백혜선(Parik, Hae-Sun) 한국도시설계학회 2009 도시설계 : 한국도시설계학회지 Vol.10 No.4

본 연구는 주민들이 자신들의 의지에 따라 손쉽게 주택개량을 추진할 수 있도록 주거모델 선정 시스템을 구축하고, 실제의 대상지에 주거모델을 적용하여 그 변화상을 시뮬레이션 하였다. 연구방법으로서는 첫째, 박스형, 필로티형, 테라스형, 굴곡형, 응용형의 5가지 유형별로 필지단위 주거모델을 제시하였다. 다음으로 과거 15년간의 선행연구로부터 7가지 평가지표를 도출하여 각각의 주거모델에 대한 주거환경을 상대평가 방식으로 평가하였다. 둘째, 주민들이 자력으로 주택개량을 할 때 사업비 및 대지폭, 가구구성으로부터 주거모델의 후보군을 선정한 후, 주거환경을 평가하여 주민들이 자신에게 맞는 최적의 모델을 선정할 수 있는 시스템을 구축하였다. 마지막으로 셋째로는, 충남 서천군사지구의 주민들을 대상으로 설문조사를 실시하여 이를 바탕으로 시뮬레이션의 기본구상을 설정하고, 주거모델을 실제로 적용하여 지구의 변화상을 시뮬레이션 하였다. 도출된 연구성과는 정비지구 주민들이 자신들의 의지에 따라 손쉽게 주택개량을 추진할 수 있도록 해주는 가이드라인의 역할과, 담당공무원 및 사업시행자 등이 주택개량을 원활히 유도할 수 있도록 하는 매뉴얼의 역할을 담당할 수 있다. This study set up a selection system of housing models with self-evaluation results that induce the residents to self-improvement and simulated the changes of the test site with applying the new housing models. The research process and conclusions of this study are as follows. First, it proposes five types of housing models for a lot - Box type, Piloti type, Terrace type, Folded type and Complex type - for residents’ self-improvement, and they are evaluated by the 7 evaluation index based on the literature review over the past 15 years. Second, it suggests the selection system from which residents can judge each housing type with its factors - cost, width of each lot and household feature and select several alternations of housing model, and then select their own housing model with self-evaluation results by the 7 evaluation index, if they improve their housing environment. Third, it suggests the master plan for a test site - Chungnam Seochoen Gunsa area- based on the results of the residents’ survey, designs the site plan with the devised housing types and simulates the changes.

주민자력의 주택개량을 위한 가구단위 주거모델 선정에 관한 연구

이창호(Lee Chang-Ho),백혜선(Paik Hae-Sun) 대한건축학회 2009 대한건축학회논문집 Vol.25 No.10

Korean Government launched the local improvement project on May, 2007 that was a public-based model project for setting up the base for further renewal in terms of social renewal. This study researched 12 deteriorated residential area case for devicing housing types and a selection system with self-evaluation results that induce the residents to self-environment improvement and provides an easy reference. The study is concluded as follows. First, it proposes four types of block housing models for residents' self-environment improvement, and is evaluated by the evaluation index based on the literature review over the past 15 years. Second, it suggests the selecting system from which residents can judge each housing type by its factors-cost, the number of households and layers, and select their own model, if they improve their housing environment. Third, it suggests the master plan for a test site, designs the site plan with the devised housing types and simulates the changes. It can be used as a guideline for inducing the residents to self-environmental improvement and easy improvement in their own way, and also a manual for government officials and professionals to promote the local improvement project in actuality.

PET/CT 검사에서 환자체형에 따른 적정검사 프로토콜에 관한 고찰

조석원,함준철,강천구,반영각,이승재,임한상,이창호,박훈희,Cho, Seok Won,Ham, Joon-Chul,Kang, Chun Goo,Bahn, Young Kag,Lee, Seung Jae,Lim, Han Sang,Lee, Chang-Ho,Park, Hoon-Hee 대한핵의학기술학회 2013 핵의학 기술 Vol.17 No.2

Purpose: Whole-body PET using radiopharmaceutical is one of the imaging study methods for physiological changes of body. High specificity of the PET-CT examination is used to detect an early stages of cancer and metastatic cancer by imaging a physiological changes. During the imaging process, PET image has been characterized by a relatively low image quality due to its low sensitivity and the acquisition of random and scatter coincidences as well as patients figure. Therefore, the image quality as the changes of the acquisition times of patient weight was evaluated in this study. Materials and Methods: Thirty patients who presented to our hospital were enrolled. They were divided to normal, overweight, and obese group using BMI index, respectively. The patients with a liver disease and diabetes were excluded. $^{18}F-FDG$ was administered to the patients as 5.2 MBq per kg. After an hour from an injection, image acquisition was obtained as List mode in a part of liver in 1 bed. SNR (signal-to-noise ratio) of each groups acquisition times were confirmed from the calculated radiation counts and random fractions. The statistical significance of three groups was confirmed through one-way ANOVA test. On the basis of the counts of 2 minutes on normal group, the SNR of overweight group and obese group were compared. Results: The SNR were increased with loger aquisition time in 3 groups. In the condition of same acquisition time, the SNR had a statistical significance (P<0.05). The SNR were decreased to the normal, overweight, and obese, respectively. Liver activity had no significance difference on each group and RF had the significance differences (P<0.05). On the basis of the counts of 2 minutes on normal group, there were no statistical significance in a three minute acquisitions of overweight group and two minute acquisitions of obese group (P=0.150). Conclusion: In this study, the administrated amount of radiation dose did not adjust as the change of the patients weight. Increasing the acquisition time when the administration of the same amount of dose was able to get a good result of SNR. When the Based 2 minute on normal group, if overweight and obese case the increased acquisition time of 3 minute was able to obtain a similar SNR. On the basis of the normal group, the acquisition times of overweight and obese group were increased to 3 minutes per bed and the SNR were similar to the normal group.

C형 간염바이러스(HCV)의 NS5B RNA Replicase에 의해 그 활성이 조절되는 HCV지놈 표적 Hammerhead 리보자임 개발

이창호,이성욱,Lee, Chang-Ho,Lee, Seong-Wook 한국미생물학회 2007 미생물학회지 Vol.43 No.3

C형 간염바이러스(hepatitis C virus; HCV)증식을 효과적이며 특이적으로 제어할 수 있는 유전산물을 개발하기 위하여 HCV 중식조절이자인 NS5B RNA replicase 존재에 의해 allosteric하게 그 활성 이 조절될 수 있는 HCV internal ribosome entry site (IRES) 표적 hammerhead 리보자임을 개발하였다. 우선 HCV IRES 염기서열 중+382 nucleotide(nt) 부위가 리보자임에 의해 가장 잘 인식되었음을 관찰하였다. 이러한 allosteric 리보자임은 NS5B RNA replicase와 특이적으로 결합하는 RNA aptamer 부위, aptamer와 NS5B와의 결합에 의해 리보자임 활성을 유도할 수 있도록 구조적 변이를 전달할 수 있는 communication module부위 및 HCV IRES의 +382 nt를 인지하는 hammerhead 리보자임 등으로 구성되도록 설계하였다. 특히 in vitro selection기법을 활용하여 NS5B 의존적으로 리보자임 활성을 증가시킬 수 있는 communication module 염기서열을 밝혀내었다. 이러한 리보자임은 단백질이 없거나 대조 단백질인 bovine serum albumin이 존재할 때에는 절단반응을 유도하지 못하였으나 HCV NS5B 단백질이 존재할 매에만 효과적으로 NS5B 농도 의존적으로 절단 반응을 유도할 수 있음을 관찰하였다. 이러한 allosteric 리보자임은 HCV중식의 효과적인 증식 억제 선도물질 뿐만 아니라 HCV 치료선도물질의 스크리닝용 도구 및 HCV 조절 인자를 탐색할 수 있는 HCV 진단용 리간드로서도 활용될 수 있을 것이다. For the development of basic genetic materials for specific and effective therapeutic approach to suppress multiplication of hepatitis C virus (HCV), HCV internal ribosome entry site (IRES)-targeting hammerhead ribozyme which activity is allosterically regulated by HCV regulatory protein, NS5B RNA replicase, was developed. The ribozyme targeted most effectively to +382 nucleotide (nt) site of HCV IRES RNA. The allosteric ribozyme was designed to be composed of sequence of RNA aptamer to HCV NS5B, communication module sequence which can transfer structural transition for inducing ribozyme activity upon binding NS5B to the aptamer, and sequence of ribozyme targeting +382 nt of HCV IRES. Noticeably, we employed in vitro selection technology to identify the most appropriate communication module sequence which can induce ribozyme activity depending on the US5B protein. We demonstrated that the ribozyme was nonfunctional either in the absence of any proteins or in the presence of control bovine serum albumin. In sharp contrast, the allosteric ribozyme can induce activity of cleavage reaction with HCV IRES RNA in the presence of the HCV NS5B protein. This allosteric ribozyme can be used as lead compound for specific and effective anti-HCV agent, tool for highthroughput screening to isolate lead chemicals for HCV therapeutics, and ligand for biosensor system for HCV diagnosis.

Representation of Interactions in Data Model for Hybrid Structural Experiments

이창호,Lee, Chang-Ho Computational Structural Engineering Institute of 2010 한국전산구조공학회논문집 Vol.23 No.2

하이브리드 구조실험에서는 전체구조물을 여러 개의 부분구조물로 나누어서 실험과 해석을 수행한다. 실험을 위한 부분 구조물들과 해석을 위한 부분구조물들은 지역적으로 서로 다른 장소에서 실험과 해석이 수행될 수 있으며, 이 부분구조물들의 실험과 해석은 시뮬레이션 코디네이터에 의하여 통제된다. 하이브리드 구조실험을 수행하는 동안에 시뮬레이션 코디네이터와 부분구조물들은 서로 간에 데이터 교환이 이루어지는 상호작용을 하게 된다. 본 논문은 이러한 상호작용을 기술하고 있는데, 하나의 하이브리드 구조실험 예제에 대하여 시뮬레이션 코디네이터와 부분구조물들 사이의 상호작용을 데이터 모델의 하나인 리하이 모델의 클래스와 객체를 통하여 표현하였다. 시뮬레이션 코디네이터와 부분구조물들은 각자의 데이터 저장을 위한 객체를 가지도록 구성하였고, 서로간의 연결은 동일한 형식의 인터페이스 링크를 사용하여 처리하였다. 본 논문에서 설명한 객체들은 일관된 방법에 의하여 구현하였는데, 하이브리드 구조실험을 위한 컴퓨터 시스템의 개발에 사용할 수 있다. The hybrid structural experiment decomposes a structure into independent substructures that can be tested or simulated. The substructures being tested or simulated may be distributed at different facilities of different locations, and are managed by the simulation coordinator. There exist interactions among the simulation coordinator and the substructures since they give and receive the commands and feedbacks during the experimental process. These interactions are described in this paper for an example hybrid structural experiment using the classes and objects in the Lehigh Model which is one of the data models for structural experiments. The simulation coordinator and the substructures have the objects for the interaction data files, and are linked together through the same types of the interface links. The objects for the interactions presented in this paper can be implemented in a consistent way, and be used for developing the computer system for the hybrid structural experiments.

소표본인 경우 비모수 순위척도를 이용한 정규성 검정

이창호,최성운,Lee, Chang-Ho,Choi, Sung-Woon 대한안전경영과학회 2008 대한안전경영과학회지 Vol.10 No.3

The present study proposes two normality tests using nonparametric rank measures for small sample such as modified normal probability paper(NPP) tests and modified Ryan-Joiner Test. This research also reviews various normality tests such as $X^2$ test, and Kullback-Leibler test. The proposed normality tests can be efficiently applied to the sparsity tests of factor effect or contrast using saturated design in $k^n$ factorial and fractional factorial design.

생약 열수추출물의 근력향상 효능 평가

이창호,김영언,김인호,한대석,성기승,양동흠,송태철,Lee, Chang-Ho,Kim, Young-Eon,Kim, In-Ho,Han, Dae-Seok,Seong, Ki-Seung,Yang, Dong-Heum,Song, Tae-Cheol 한국식품영양과학회 2007 한국식품영양과학회지 Vol.36 No.6

생약 열수추출물의 근력 향상 효능을 평가하기 위하여 근력 측정 및 혈액의 피로요소를 분석한 결과 간 글리코겐 함량은 모든 식이군들이 대조군에 비하여 높은 수치를 나타내었다. 특히 맥문동, 오미자, 오가피, 함초 식이군의 경우 높은 글리코겐 함량을 나타내었다. 4주간 측정한 근력 향상효능은 오가피, 함초, 홍삼 열수추출물 섭취군의 경우 다른 열수추출물 섭취군에 비하여 높은 근력 향상 효과를 보여주었다. 무기인산은 맥문동, 오미자, 오가피, 두충, 구기자, 홍삼 열수추출물 섭취군의 경우 대조군에 비하여 낮은 수준을 나타내었다. 젖산 함량은 모든 생약재 열수추출물 식이군에서 대조군과 비교하여 낮은 함량을 나타내어 생약 열수 추출물을 이용한 근력 향상용 기능성 식품의 개발 가능성을 보여주었다. Effects of medicinal herbs on the improvement of muscular strength along with the related fatigue factors were evaluated in SD rats. Nine types of treatment groups were fed diets supplemented with 1% herb hot-water extracts (Liriope spicata (LS), Schizandra chinensis (SC), Acanthopanax sessiliflorus (AS), Saliconia herbacea (SH), Eucommia ulmoides (EU), Lycium chinensis (LC), Panax ginseng (red ginseng) (PG), Polygonum multifloum (PM), Glycyrrhizae uralensis (GU)) for 4 weeks. The muscular strength of all groups were measured weekly for 4 weeks. After 4 weeks serum was collected and liver dissected out for the analysis of glycogen and fatigue factors. The liver glycogen contents of all treatment groups ($21.0{\sim}25.9mg/g$) were higher than that of control group (18.1 mg/g). A significantly increase of muscular strength in the fourth week were found in the AS (282.5 gf), SH (277.4 gf), PG (287.2 gf) groups (p<0.05). LS (7.88 mg/dL), SC (7.85 mg/dL), AS (7.64 mg/dL), EU (7.54 mg/dL), LC (7.81 mg/dL) and PG (7.75 mg/dL) groups were significantly reduced in serum inorganic phosphorus concentration measured after 4 weeks (p<0.05). Serum lactate levels of treatment groups ($8.61{\sim}12.18{\mu}g/dL$) were significantly lower than that of control group ($17.45{\mu}g/dL$). These results suggest that medicinal herbs enhanced muscular strength of rats by delaying accumulation of muscular fatigue factor.