생리적 신호를 이용한 통증 인식을 위한 딥 러닝 네트워크

( Kim Ngan Phan ),이귀상 ( Guee-sang Lee ),양형정 ( Hyung-jeong Yang ),김수형 ( Soo-hyung Kim ) 한국정보처리학회 2021 한국정보처리학회 학술대회논문집 Vol.28 No.2

Pain is an unpleasant experience for the patient. The recognition and assessment of pain help tailor the treatment to the patient, and they are also challenging in the medical. In this paper, we propose an approach for pain recognition through a deep neural network applied to pre-processed physiological. The proposed approach applies the idea of shortcut connections to concatenate the spatial information of a convolutional neural network and the temporal information of a recurrent neural network. In addition, our proposed approach applies the attention mechanism and achieves competitive performance on the BioVid Heat Pain dataset.

해운대 해수욕장의 이안류 발생기구 및 수치모의

김인철(Kim, In-Chul),이주용(Lee, Joo-Yong),이정렬(Lee, Jung-Lyul) 한국해안해양공학회 2011 한국해안해양공학회 논문집 Vol.23 No.1

2009년 8월 13일과 15일, 부산 해운대 해수욕장 앞 해상에서 이안류가 발생하였다. 또한, 올 여름인 2010년 7월 29일과 30일에도 이안류가 발생하여 피서객 들이 조난된 사고가 발생하였다. 해수욕객들은 전원 구조되어 인명 피해는 발생하지 않았지만 최근 이안류 발생이 너무 잦아져 이에 대한 원인파악과 대책마련이 시급한 실정이다. 본 논문에서는 파랑모형과 조류가 결합된 해빈류 모형을 기본으로 튜브거동까지 재현되는 사용자 편의를 위하여 GUI로 개발된 HAECUM 모형(HAEundae CUrrent Model)을 이용, 해운대 해수욕장의 이안류 발생 수치모의를 실시하였다. At Haeundae Beach in Busan, people were swept away by the fast-moving rip current and rescued, on August 13th and 15th, 2009 & July 29th and 30th, 2010. In predicting the wave-induced current and consequent tube movement for public safety, the coastal flows and waves are calculated at each time step and grid point by means of systematic interfacing of hydrodynamic and wave models (Lee, 2001). To provide a user-friendly simulation tool for end-users, the forecasting system has been built in a software package called HAECUM. Outputs from the system are viewed as graphs of tube positions with combined current vectors for easy decision of emergency management officials. The tube-wave interaction is taken into account and the traces of swim tube are simulated by using a Lagrangian random walk (Chorin, 1978; Lee, 1994). In this study, we use the Lee's approach (Lee, 1993) in estimating the surface onshore currents due to wave breaking.

이용자 중심의 스마트공원 조성을 위한 공원서비스의 상대적 중요도 분석

이주용,이형숙,Lee, Ju-Yong,Lee, Hyung-Sook 한국조경학회 2021 韓國造景學會誌 Vol.49 No.4

최근 스마트도시의 급부상에 따라 스마트공원에 대한 관심이 증대되고 전국적으로 확산되고 있으나, 획일적인 시설물 도입과 기술 위주의 스마트공원 개발에 대한 우려 또한 커지고 있다. 본 연구는 향후 이용자 중심의 스마트공원을 개발하기 위해 지향해야 할 가치 및 우선적으로 고려될 공원서비스가 무엇일지 전문가와의 심층인터뷰와 계층분석기법을 통해 그 상대적 중요도를 평가하는 것을 목적으로 하였다. 이를 위해 공원 기능 및 서비스에 대한 선행연구 및 문헌을 고찰하였고, IT전문가 및 조경분야 전문가를 대상으로 전문가 인터뷰를 2차례 실시하여 내용분석을 통해 서비스 항목을 도출하였다. 4개의 가치와 15개의 공원서비스로 구성된 AHP 모델을 구축하고 38명의 조경 전문가들을 대상으로 한 설문조사를 통해 공원서비스의 중요도를 산정하였다. 그 결과, 자연접촉, 휴식, 운동·산책 등 공원의 본질적인 기능 향상을 위한 서비스의 중요도가 높았으며, 미세먼지나 폭염 등 기후변화에 대응하는 재난재해 방지 및 안전성 관련 서비스도 높게 나타났다. 사회통합 관련 서비스의 중요도 값은 상대적으로 낮았으나, 지역주민들의 참여와 체감도 제고에 있어서는 중요한 서비스로 논의되었다. 향후 스마트공원 개발에 있어 과다한 인공시설물과 기술의 도입으로 인해 자연접촉과 휴식이라는 기존의 공원 기능이 퇴색되지 않도록 하며, 이용자의 요구에 근거하고 지역특성을 반영하는 스마트기술의 적용이 필요할 것이다. 스마트공원의 홍보교육 강화를 통해 이용자의 친밀감을 높이고, 스마트공원에 대한 이해도를 제고하는 노력이 요구된다. Interest in smart parks has been increasing due to the recent rapid rise of smart cities, but concerns are growing over the development of technology-oriented smart parks. The purpose of this study is to evaluate the relative importance of park services through Focus Group Interviews and the Analytic Hierarchy Process (AHP) to develop user-oriented smart parks in the future. To this end, literature on park functions and services was reviewed, and interviews with experts in the field of landscape architecture and IT were conducted to derive service items. The AHP model consisted of four values, and 15 park services were established and used to survey 38 landscape experts. As a result, services for improving the park's essential functions, such as contact with nature, relaxation, and exercise-walking, were deemed important. Services related to the environment and safety in response to climate change, such as the amelioration of pollution and heatwaves were also high. The importance of social integration services was relatively low, but it was considered an important service to when enhancing community participation. Future smart parks should enhance the health benefits of contact with nature rather than implementing excessive artificial facilities and technology. Additionally, smart technology will need to be applied based on users' needs while reflecting local characteristics. Efforts should be made to enhance user intimacy and improve the understanding of smart parks by strengthening public relations education.

Rhizobium sp. SNU 003의 생육에 미치는 Canavanine과 Arginine의 영향 및 Arginine Deiminase의 성질

이주용,권영명,Lee, Ju-Yong,Kwon, Youn-Myung 생화학분자생물학회 1990 한국생화학회지 Vol.23 No.2

해녀콩(Canavalia lineata)의 뿌리에서 분리한 Rhizobium sp. SNU 003은 arginine에 의해서는 생육이 촉진되나 canavanine에 의해서는 생육이 억제된다. 또한 2mM의 canavanine에 의해 억제된 생육은 2~20 mM의 arginine 첨가에 의해 약 78~95%의 회복을 보여주었다. Rhizobium에서 arginine의 대사는 arginine deiminase의 작용으로 시작되며, arginine의 존재로 이 효소의 활성은 약 10배 증가하였다. Arginine deiminase는 protamine sulfate에 의한 침전, DEAE-Sephacel 이온교환 크로마토그래피와 Sephacryl S-300 gel 크로마토그래피에 의하여 45배로 정제되었으며, 회수율은 11%였다. Sephacryl S-300 gel 컬럼 크로마토그래피로 분자량은 190,000임을 알았다. Sodiumacetate 완충용액에서의 활성 최적온도는 $30^{\circ}C$, 최적 pH는 6.0으로 밝혀졌다. Canavanine은 기질로서 이용될 수 없으며, arginine의 이용을 경쟁적으로 억제하였다. 효소의 활성은 $Co^{2+}$, $Al^{3+}$, $Pb^{2+}$ 및 $Zn^{2+}$에 의해서는 억제되었으나, 10 mM의 $Mg^{2+}$와 $Mn^{2+}$에 의해서는 30~40% 증가하였다. The growth of Rhizobium sp. SNU 003 isolated from the nodule of Canaialia lineata was inhibited by canavanine and promoted by arginine. The growth inhibited by 2 mM canavanine was approximately shown 78 - 95% recovery by the addition of 2 - 20 mM arginine. Arginine deiminase of this Rhizobium is an active catabolic enzyme of arginine and the enzyme activity was promoted about 10-times when arginine was added into the medium. Arginine deminase was purified 45-fold and the yield was 11% by the following steps: Protamine sulfate and ammonium sulfate precipitation, DEAE-Sephacel chromatography, and Sephacryl S-300 gel chromatography. The molecular weight of the native enzyme was 190,000 by gel filtration and optimum temperature for activity was $30^{\circ}C$. Enzyme showed the highest activity at pH 6.0 in the sodium-acetate buffer. Canavanine was not catabolized by arginine deiminase and competitively inhibited the degradation of arginine. The activity of enzyme was inhibited by $Co^{2+}$, $Al^{3+}$, $Cu^{2+}$, $Pb^{2+}$ and $Zn^{2+}$, however promoted by 10 mM of $Mg^{2+}$ and $Mn^{2+}$ approximately 30 - 40%.

뇌경색(腦梗塞)으로 발생한 소양인(少陽人) 반신(半身) 무도병(舞蹈病) 환자(患者) 치험 1례

이주용,이한얼,한경수,안택원,Lee, Joo-Yong,Lee, Han-Eol,Han, Kyung-Su,Ahn, Teak-Won 사상체질의학회 2008 사상체질의학회지 Vol.20 No.2

1. Objectives Purpose of this case is to evaluate the effect of Soyangin Yangkyuksanhwa-tang on the hemichorea caused by hypothalamic infarction. 2. Methods The patient was treated with Yangkyuksanhwa-tang, acupuncture treatment and western medicine. The symptom changes of his hemichorea symptoms were evaluated in hospital. 3. Results and Conclusions After we treated him with Yangkyuksanhwa-tang, his symptoms were decreased.

콜로니 에너지를 이용한 단백질-리간드 결합 문제에서의 엔트로피 효과 계산

이주용,석차옥,Lee, Ju-Yong,Seok, Cha-Ok 한국생물정보시스템생물학회 2006 Bioinformatics and Biosystems Vol.1 No.2

단백질-리간드 결합 예측은 새로운 신약 선도 물질을 발견하고 최적화 하는데 있어서 중요한 도구로 널리 사용되고 있다. 결합의 정확도는 일반적으로 각 결합 계산에서 사용되는 평가 함수(scoring function)에 따라 결정된다. 평가 함수는 그 함수가 가지고 있는 기력 가정에 따라 force-field based, empirical, knowledge-based의 세 가지로 분류할 수 있다. 이 중에서 force-field based 함수는 물리적인 상호작용을 가장 구체적으로 기술한다. 그러나 현재 제시된 대부분의 force-field based 함수들은 분산력과 정전기적인 힘 등의 에너지만을 고려할 뿐 엔트로피의 영향을 포함하지 않는 단점을 가지고 있다. 본 논문에서는 force-field based 평가 함수를 이용하는 경우 기존의 도킹 프로그램이 생성해 내는 구조 정보를 활용하여, 엔트로피를 고려할 수 있는 방법을 제시한다. 또한 이 방법을 DOCK 평가 함수에 적용시켰을 때 decoy discrimination에서 향상된 결과를 얻어낼 수 있음을 보였다. 이는 더 정확한 도킹 계산이 가능함을 의미한다. Computational prediction of protein-ligand binding has been widely used as a tool to discover lead compounds fur new drugs. Prediction accuracy is determined in part by the scoring function used in docking calculations. Diverse scoring functions are available, and these can be classified into force-field based, empirical, and knowledge-based functions depending upon the basic assumptions made in development. Among these, force-field based functions consider physical interactions the most in detail. However, the force-field based functions have the drawback of not including the entropic effect while considering only the energy contribution such as dispersion or electrostatic forces. In this article, a method to take into account of the entropic effect using the colony energy is suggested when force-field based scoring functions is used by extracting conformational information obtained from the pre-existing docking program. An improved result for decoy discrimination is illustrated when the method is applied to the DOCK scoring function, and this implies that more accurate docking calculation is possible.

승양익기탕(升陽益氣湯) 전탕액이 노화쥐의 비장, 췌장, 위장 세포의 항산화능에 미치는 영향

이주용,안택원,Lee, Joo-Yong,Ahn, Taek-Won 사상체질의학회 2010 사상체질의학회지 Vol.22 No.2

1. Objectives: The purpose of this study is to investigate the anti-aging and anti-oxidative effects of Seungyangikki-tang decoction(SY) in spleen, pancreas and stomach cells of Sprague-Dawley(SD) rats. 2. Methods: This experiment was used by the tissue of spleen, pancreas and stomach cells of 6, 52 and 68 weeks old SD rats. We devided each group by three. One group as normal group was non-treated cells, another group as control group was saline-treated cells, and the other group as experimental group was SY treated cells. After culture for 48 hours, each groups measured the level of SOD, GSH, MDA and NO in the tissue of kidney, bladder and spleen cells. 3. Results and Conclusions: SOD activity was significantly increased in spleen cell of 6, 68w-SY group, pancreas cell of 52,68w-SY group and in stomach cell of 52w-SY group compared with those of the control groups. GSH concentration was significantly increased in spleen cell of 6,68w-SY group and in pancreas cell of 6w-SY group compared with those of the control groups. MDA concentration was significantly decreased in spleen cell of 68w-SY group and in stomach cell of 68w-SY group compared with those of the control groups. NO concentration was significantly decreased in spleen cell of 68w-SY group, stomach cell of 68w-SY group compared with those of the control groups.

미국 부동산 시장을 가다-복합용도 개발이 한창인 미국 필라델피아, 마이애미

이주용,Lee, Ju-Yong 한국주택협회 2007 주택과 사람들 Vol.202 No.-

전 세계적으로 복합 용도 개발이 도시 개발의 트렌드다. 미국의 필라델피아와 마이애미는 흥미로운 도시 개발의 사례로 손꼽힌다. 철도 부지에 수익성 높은 빌딩을 건축한 필라델피아와 마이애미의 복합 용도 개발 사례에 대해 알아보자.

Stiffness of the Central Corpus Cavernosum on Shear-Wave Elastography Is Inversely Correlated with the Penile Rigidity Score in Patients with Erectile Dysfunction

이주용,정대철,Lee Seungsoo,Kang Nam Gyu,오영택,Han Kyunghwa 대한남성과학회 2021 The World Journal of Men's Health Vol.39 No.1

Purpose: To perform real-time quantitative measurements of penile rigidity for patients with erectile dysfunction (ED) using shear-wave elastography (SWE). Materials and Methods: A total of 92 patients with clinically diagnosed ED filled out an abridged five-item version of the International Index of Erectile Function (IIEF-5) questionnaire and underwent SWE as well as penile color Doppler ultrasound (CDUS) after intracavernosal injection for penile erection. Elasticity measurements were repeated on two sites of the corpus cavernosum (central and peripheral elasticity of corpus cavernosum [ECC]) and the glans penis during the erection phase. Correlations between penile elasticity and rigidity scores or IIEF-5 were evaluated statistically. Penile elasticity was also compared with the ED types based on CDUS. Results: The mean age of all patients was 53.5±13.4 years, and the mean IIEF-5 score was 9.78±5.01. The rigidity score and central ECC value demonstrated a significant correlation (r=-0.272; 95% confidence interval: -0.464 to -0.056; p=0.015). The IIEF-5 score was not significantly correlated with penile elasticity. Vascular ED patients showed significantly higher central ECC values than nonvascular ED patients (p<0.001). At a cut-off value of 8.05 kPa, the central ECC had a specificity of 41.5%, a sensitivity of 84.6%, and an area under the ROC curve of 0.720 with a standard error of 0.059 (p=0.019) for predicting vascular ED. Conclusions: Quantitatively measuring Young’s modulus of the corpus cavernosum using SWE could be an objective technique for assessing penile erectile rigidity and the vascular subtype in patients with ED.

Sarmanov형 이변량 일반화이항모형의 적합

이주용,김기영,Lee, Joo-Yong,Kim, Kee-Young 한국통계학회 2009 응용통계연구 Vol.22 No.2

급내/급간상관이 동시에 존재하는 이변량 이항자료에 대한 모형으로 Danaher과 Hardie (2005)는 베타이항분포를 제안한바 있다. 그러나 이 모형은 베타분포에 따르는 성공확률을 통해 급내 상관을 묘사하므로 그 적용범위가 양의 급내상관을 가지는 자료에 제한된다. 이 연구에서는 보다 더 넓은 범위의 급내 상관에 대해 유용성을 가지는 일반화가법/승법이항모형과 확장베타이항모형 등에 Sarmanov형식의 이변량 확장을 고려하고 이들을 기존 모형과 적합도의 측면에서 비교한다. 실제자료인 주식자료와 소비자패널자료에 이변량 일반화이항모형들을 적용한 결과, B-mB와 B-ebB의 성능이 우수한 것으로 나타나며, 그 중 상대적으로 넓은 허용범위의 급내상관을 가지는 B-mB가 선호된다고 할 수 있다. For bivariate binomial data with both intra and inter-class correlation, Danaher and Hardie (2005) proposed a bivariate beta-binomial model. However, the model is limited to the situation where the intra-class correlation is strictly positive. Thus it might be seriously inadequate for data with a negative intra-class correlation. Several authors have considered generalized binomial distributions covering a wider range of intra-class correlation which could relax the possible model restrictions imposed. Among others there are the additive/multiplicative and the beta/extended beta binomial model. In this study, bivariate models of the Sarmanov (1966) type are formed by combining each of those univariate models to take care of the inter-class correlation, and are evaluated in terms of the goodness-of-fit. As a result, B-mB and B-ebB are fitted, successfully, to real data and that B-mB, which has a wider permissible range than B-ebB for the intra-class correlation is relatively preferred.