신경근전기자극에 의한 척수운동신경원의 흥분성 변화

이정우,김태열,이인학,이준희,Lee, Jeong-Woo,Kim, Tae-Youl,Lee, In-Hak,Lee, Joon-Hee 대한임상전기생리학회 2003 대한임상전기생리학회지 Vol.1 No.1

The purpose of this study was to determine the effect of neuromuscular electrical stimulation(NMES) on the alteration of spinal motor neuron excitability. In this article, I would like to experiment on a standard capacity of clinical electrophysiology, a difference in applying methods and a clinical efficiency of NMES by Nerve conduction velocity. We used normal eight subjects without neuromuscular disease and all subjects participated 3 session, which at least 1 week between session. Participants classified according to each group in Antagonist, Agonist, Antagonist-Agonist by the NMES. The test was measured continuously pre test, post-test, post 20 minute test by EMG including H reflex, F wave, motor nerve conduction velocity(MNCV). The following results were obtained; 1. H-reflex latencies and H/M intervals were significantly increased in agonist and antagonist-agonist group(p<.01). 2. H-reflex amplitudes and H/M ratios were significantly decreased in agonist and antagonist-agonist group(p<.01). In agonist group, H-reflex amplitudes and H/M ratios were more significantly decreased than antagonist group. 3. F-wave latencies were significantly increased in agonist and antagonist-agonist group(p<.01). F/M intervals were significantly increased in antagonist-agonist group(p<.01). F wave conduction velocities were significantly increased in agonist and antagonist-agonist group(p<.01) but F/M ratios were not significant. 4. MNCV were significantly decreased in agonist(p<.01). These results lead us to the conclusion that agonist and Antagonist-agonist was significantly decreased excitability of spinal motor neuron. Conversely, Antagonist does not decreased. Therefore, A further direction of this study will be to provide more evidence that NMES have an effect on excitability of spinal motor neurons in UMN syndrome.

아동기 자녀의 환경에 대한 관심과 보전행동에 관한 연구

이정우,황경혜 ( Jeong Woo Lee,Kyung Hae Hwang ) 대한가정학회 1998 Family and Environment Research Vol.36 No.5

확장된 쐐기조사야에 의한 조직산란계수의 변화

이정우,조화섭,박성렬,Lee, Jeong-Woo,Cho, Hwa-Seop,Park, Seong-Ryul 대한방사선치료학회 1998 大韓放射線治療技術學會誌 Vol.10 No.1

In recent days, although many kinds of beam modifiers are developing and using for clinical purposes in accordance with progressing medical engineering, physical wedges are preferred to use as a beam modifier by a lot of institutions until now because of cost, complexities of dosimetry and mechanical uncertainties. According to progressing technology, available field size of wedge is more enlarger than that of old model LINAC. Because field size dependence of wedged fields increases in new model LINAC, we was trying to know that how much different PSFs are in enlarged wedged fields compared with open fields. In small or middle size of fields($4{\times}4{\sim}15{\times}15cm$), there are only a few percents of PSF variation between open and wedged fields. But there are $2{\sim}8\%\;variations\;in\;relatively\;large\;fields(20{\times}20{\sim}30{\times}40cm)$.

과다 유두(Supernumerary Nipple) 2례

이정우,양정덕,이정훈,최강영,김귀락,정호윤,조병채,Lee, Jeong-Woo,Yang, Jung-Dug,Lee, Jung-Hun,Choi, Kang-Young,Kim, Gui-Rak,Chung, Ho-Yun,Cho, Byung-Chae 대한성형외과학회 2010 Archives of Plastic Surgery Vol.37 No.5

Purpose: Supernumerary nipple or polythelia is one of the developmental anomalies occurring at the embryonic stage and this anomaly usually arises from the milk line. While this atypical feature is determined during early developmental stage, it may not come out obviously or become troublesome until puberty or lactation. Moreover, sometimes it is confused with a pigmented nevus. Methods: Case 1, a 18-year-old woman with intramammary supernumerary breast consisted of another nipple with middle sized areola on the right lower breast was admitted for a $2.8{\times}3.1\;cm$-sized mass on the right breast which was starting appeared 1 year earlier. The preliminary cytological examination of the material obtained by needle aspiration biopsy from the mass was revealed by fibroadenoma with no malignant change. The patient had the surgical excision of the mass and accessory breast. Case 2, a 16 year-old woman admitted for intra-areolar polythelia of the left breast, even she doesn't have any family history of polythelia. Since she wanted surgical correction of her atypical nipple for aesthetic and psychological reasons, we reconstructed the areola using transposition flaps in an S-plasty design. Results: Case 1, the excised supernumerary nipple showed following histological features. In the superficial layer, an acanthotic and hyperpigmented epithelium with elongated rete ridges was found. In the dermis, there were follicles with hairs surrounded by hypertrophic sebaceous glands. In the deepest portion, abundant secretory glomerules and excretory ducts of apocrine gland type were observed. Case 2, follow-up visits 3 months after the procedure showed a satisfactory result with good shape and projection of the nipple. Conclusion: We report two cases of aberrant mammary tissue who underwent surgical correction, including complete breast (with nipple, areola, and glandular tissue) and intra-areolar polythelia according to the Kajava's classification, and the results were satisfactory.

유두상 혈관내막 증식증의 임상적 보고

이정우,정호윤,이석종,김귀락,최강영,양정덕,조병채,Lee, Jeong-Woo,Chung, Ho-Yun,Lee, Seok-Jong,Kim, Gui-Rak,Choi, Kang-Young,Yang, Jung-Dug,Cho, Byung-Chae 대한성형외과학회 2010 Archives of Plastic Surgery Vol.37 No.3

Purpose: Intravascular papillary endothelial hyperplasia (IPEH), also known as Masson's pseudoangiosarcoma, is a rare disease which is now considered as a reactive process of the endothelium rather than a benign neoplasm. It can occur in any blood vessels in the body but more common in the head and neck region as a solitary, often tender, bluish or reddish nodule. IPEH is characterized by the development of endothelial-lined papillary projections in a vascular lumen, usually associated with thrombotic material, the endothelial cells in the papillary structures showing only slight atypia and occasional mitotic Figures, the absence of tissue necrosis. Methods: 8 patients with IPEH were enrolled in the study from 2002 to 2007. All 8 lesions were surgically excised for histopathologic diagnosis. Results: 4 patients were female. The duration of the lesions ranged from 3 months to 15 years. The tumors were first noted between the ages of 20 and 72 years. 4 patients had lesions on the head; 2 on the toe; 1 on the back; and 1 on the finger, respectively. All lesions were solitary, ranged in size from 2 mm to 27 mm. There were no recurrences. Conclusion: The clinical appearance of IPEH is not specific, presented as a primary neoplasm, and the diagnosis can be established by microscopic examination. Complete surgical excision is the best choice of therapy for patients with IPEH, and is both diagnostic and curative. Awareness of this lesion will prevent incorrect diagnosis and overly aggressive treatment.

전기생리학적 기전에 근거한 망막 모델의 제안과 시공간적 응답의 분석

이정우,채승표,조진호,김명남,Lee, Jeong-Woo,Chae, Seung-Pyo,Cho, Jin-Ho,Kim, Myoung-Nam 대한전자공학회 2002 電子工學會論文誌-SC (System and control) Vol.39 No.6

본 논문에서는 망막의 전기생리학적 기전을 바탕으로 실제 망막과 유사한 기능 및 응답 특성을 갖는 망막 모델을 제안하였다. 시세포에서 양극세포까지는 기존에 연구된 여러 망막 모델들을 종합하여 모델링하였고, 3 NDP 기전을 이용하여 움직임 정보를 검출한다고 알려져 있는 아마크린세포와 양극세포 터미널에 관한 새로운 모델을 제안하였다. 이 모델의 평가를 위하여, 공간상의 동적 자극과 정지 자극에 대한 응답 특성을 비교 분석을 하였을 뿐만 아니라 자극의 움직임 속도에 따른 특성에 대한 분석도 수행하여 제안한 망막 모델을 검증하였다. 본 연구결과는 움직임 정보를 검출하기 위한 비전 시스템에 대한 인간 시각 시스템의 적용 및 생체에 이식할 수 있는 인공 망막의 개발을 위한 기초 연구에 이용될 수 있을 것이다. Based on electrophysiological retina mechanism, a retina model is proposed, which has similar response characteristics compared with the real primate retina. Photoreceptors, horizontal cells, and bipolar cells are modeled based on the previously studied retina models. And amacrine cells known to have relation to movements detection, and bipolar cell terminals are newly modeled using 3 NDP mechanism. The proposed model verified by analyzing the spatial response characteristics to stationary and moving stimuli, and characteristics for different speeds. Through this retina model, human vision system could be applied to computer vision systems for movement detection, and it could be the basic research for the implantable artificial retina.

Comparison of Enhanced Dynamic Wedge with Physical Metal Wedge based on the Basic Dosimetric Parameters

이정우,홍세미,최경식,정진범,최보영,장홍석,서태석,Lee Jeong-Woo,Hong Semie,Choi Kyoung-Sik,Chung Jin-Beom,Choe Bo-Young,Jang Hong Seok,Suh Tae-Suk Korean Society of Medical Physics 2005 의학물리 Vol.16 No.2

기능강화동적쐐기는 쐐기 형태의 선량 분포를 만드는 방법과 선량 특성적인 면에서 금속쐐기와 상당한 차이를 가지고 있다. 기능강화동적쐐기의 임상적용을 위해서는 금속쐐기와 다른 선량특성을 분석하고 이에 따른 적절한 커미셔닝이 필수적이다. 본 연구의 목적은 기본 선량계측인자에 기초한 기능강화동적래기와 금속쐐기의 선량특성을 분석하는 데 있다 선량 계측학적 특성을 나타내는 심부선량분포, 조사면 주변 선량, 표면선량, 실효 쐐기인자, 쐐기의 선량측면도를 측정, 분석하였다. 또한 열린 조사면과 금속쐐기와의 비교측정을 통해 기능강화동적쐐기가 가지고 있는 고유한 특성을 분석하였다. 기능강화동적쐐기의 선량측면도 측정은 Chamber Array 24 (CP24)를 이용하였으며, Golden Segmented Treatment Table (Golden-577)로 구현한 치료 계획 장치의 계산 값과 비교하였다. 또한 실호쐐기인자 측정은 각각의 X, Y 콜리메이터에 따른 특성을 분석하였다. 심부 선량 백분율측정에서 열린 조사면과 기능강화쐐기의 비교결과, $0.2\~0.5\%$ 이내로 일치하였고, 금속 쐐기인 경우 약 $2\%$의 비교적 큰 차이를 보였다. 조사면 주변선량측정에서는 금속쐐기가 약 $1\%$ 높았다. 표면선량 측정 결과, 금속쐐기가 약 $10\%$ 낮게 평가되었다 기능강화쐐기의 실효쐐기인자는 Y jaw가 커짐에 따라 연속적으로 감소됨을 알 수 있었다. X jaw에 따른 쐐기인자 의존도 측정에서는 X jaw에 따른 의존도는 거의 없는 것으로 평가되었다. 또한 비대칭 조사면의 쐐기 인자측정에서는 비대칭에 상관없이 Y jaw의 크기만 같으면 실효쐐기인자가 같았다. 선량측면도 측정에서는 CA24를 이용해 얻은 실측값과 Golden STT로 Cadplan에서 구현한 계산 값이 $1\%$이내로 일치하였다. 본 연구를 통해 기능강화동적쐐기가 가지고 있는 특성을 분석하였으며, 금속쐐기를 대체할 수 있는 유용한 도구임을 알 수 있었다. For clinical implementation of Enhanced Dynamic Wedge (EDW), it is necessary to adequately analyze and commission its dosimetric properties in comparison to common physical metal wedge (MTW). This study was implemented with the essential measurements of parameters for clinical application, such as percentage depth dose, peripheral dose, surface dose, effective wedge factor, and wedge profile. In addition, through the comparison study of EDW with open and MTW, the analysis was performed to characterize the EDW. We also compared EDW dose profiles of measured values using chamber array 24 (CA24) with calculated values using radiation treatment planning system. PDDs of EDW showed good agreements between $0.2\~0.5\%$ of open beam, but $2\%$ differences with MTW. In the result of the measurements of peripheral dose, it was shown that MTW was about $1\%$ higher than open field and EDW. The surface doses of $60^{\circ}$ MTW showed 10% lower than the others. We found that effective wedge factor of EDW had linear relationships according to Y jaw sizes and was independent of X jaw sizes and was independent of X jaw sizes and asymmetric Y jaw opening. In comparison with measured values and calculate values from Golden-STT based radiation treatment planning system (RTP system), it showed very good agreement within difference of $1\%$. It could be concluded that EDW is a very reliable and useful tool as a beam modification substitute for conventional MTW.

세기변조방사선치료 선량분포 확인을 위한 2차원적 이온전리함 배열의 특성분석

이정우,홍세미,김연래,최경식,정진범,이두현,서태석,Lee, Jeong-Woo,Hong, Se-Mie,Kim, Yon-Lae,Choi, Kyoung-Sik,Jung, Jin-Beom,Lee, Doo-Hyun,Suh, Tae-Suk 한국의학물리학회 2006 의학물리 Vol.17 No.3

본 연구의 목적은 2차원적 이온전리함 배열의 특성을 분석하고 세기변조방사선치료 선량분포 확인의 유용성을 평가하기 위함이다. 본 실험에 사용된 2차원적 이온전리함 배열(MatriXX, Scanditronix-Wellhofer, IBA, Germany)은 $24{\times}24cm^2$ 범위에 1,024개의 평판형 전리함(용적: $0.08cm^3$, 직경: 4.5 mm, 높이: 5 mm, 배열간격: 7.62 mm)이 일정한 간격으로 배열되어있다. MatriXX의 특성분석을 위해 선량 직선성, 선량률 의존도, 출력 계수, 단기 선릉재현성을 분석하였으며, 선량분포 확인의 신뢰도를 평가하기 위해 Varian사의 동적쐐기와 세기변조 방사선치료의 선량분포를 분석하였다. 선량 직선성의 범위는 $1{\sim}800$cGy이었으며, 1% 미만의 오차율을 보였다. 선량률 의존성(범위 $100{\sim}600MU/min$)은 300 Mu/min을 기준으로 했을 때 모든 선량률 범위에서 0.4% 미만의 선량변화를 보였다. 또한, 물팬톰에서 0.1 cc 지두형 전리함으로 측정한 출력계수와 폴리스틸렌 팬톰에서 MatriXX로 측정한 출력계수를 비교하였다. 이 실험의 결과, $3{\times}3{\sim}24{\times}24cm^2$ 범위에서 0.5% 미만의 일치를 나타내었다. 단기 출력재현성 확인을 위하여 15분 간격으로 6회 측정한 결과, 0.5% 내의 차이를 보였다. 동적쐐기와 세기변조 방사선 조사면의 일치성 실험에서도 치료계획장치의 계산값과 필름측정값이 비교적 잘 일치함을 알 수 있었다. 본 연구를 통해 MatriXX의 물리적인 특성을 분석하였으며 세기변조방사선치료의 품질관리를 위한 유용성을 확인하였다. A commercial ion chamber matrix was examined the characteristics and its performance for radiotherapy qualify assurance. The device was the I'mRT 2D-MatriXX (Scanditronix-Wellhofer, Schwarzenbruck, Germany). The 2D-MatriXX device consists of a 1020 vented ion chamber array, arranged in $24{\times}24cm^2$ matrix. Each ion chamber has a volume of $0.08cm^3$, spacing of 0.762 cm and minimum sampling time of 20 ms. For the investigation of the characteristics, dose linearity, output factor, short-term reproducibility and dose rate dependency were tested. In the testing of dose linearity. It has shown a good signal linearity within 1% in the range of $1{\sim}800$cGy. Dose rate dependency was found to be lower than 0.4% (Range: 100-600 Mu/min) relative to a dose rate of 300 Mu/min as a reference. Output factors matched very well within 0.5% compared with commissioned beam data using a ionization chamber (CC01, Scanditronix-Wellhofer, Schwarzenbruck, Germany) in the range of field sizes $3{\times}3{\sim}24{\times}24cm^2$. Short-term reproducibility (6 times with a interval of 15 minute) was also shown a good agreement within 0.5%, when the temperature and the pressure were corrected by each time of measurement. in addition, we compared enhanced dynamic wedge (EDW, Varian, Palo Alto, USA) profiles from calculated values in the radiation planning system with those from measurements of the MatriXX. Furthermore, anon-uniform IMRT dose fluence was tested. All the comparison studies have shown good agreements. In this study, the MatriXX was evaluated as a reliable dosimeter, and it could be used as a simplistic and convenient tool for radiotherapy qualify assurance.

인공어초어장의 어류 군집상과 어획량 변동

이정우,강영실,LEE Jeong-Woo,KANG Young-Shil 한국수산과학회 1994 한국수산과학회지 Vol.27 No.5

각 해역에 시설된 사각형, 반구형, 원통형 인공어초어장의 어류 군집상 및 어획량 변동을 조사하여 인공어초 모형에 대한 어종 친화성과 해역별 최대효과를 가져 올 수 있는 적정 어초모형에 대해 논의하였다. 1988년 5, 7, 9, 11월에 각 1회씩 삼중자망으로 어획조사를 실시하였으며, 어획된 어류는 종별로 분류하여 계수하였다. 인공어초어장에서 출현한 총 어종수는 45종이며 볼락류, 쥐노래미, 가자미류, 쥐치 및 말쥐치의 출현빈도가 높았다. 사각형 인공어초어장에서는 총 38종이, 원통형 인공어초어장에서는 총 31종이, 그리고 반구형 인공어초어장에서는 총 18종이 출현하였다. 해역별 주요 우점종은 대부분이 가자미류, 가오리류, 쥐치, 말쥐치, 쥐노래미, 볼락류와 같은 연안정착성 혹은 저서성, 암초성어류였으며 남해 외양만이 회유성 어종인 고등어가 최우점종이었다. 인공어초모형에 따라 저서성, 암초성, 회유성 어류의 조성률이 다르게 나타났다. 사각형 인공어초어장에서는 회유성어류의 조성률이 높은 반면 반구형 인공어초어장에서는 저서성 어류 및 부착생물을 주로 먹이로 하는 어류의 조성률이 높았다. 동해 중부연안을 제외한 전 해역의 인공어초어장중 사각형 인공어초어장에서 어획량이 가장 높았으며, 동해 중부연안은 원통형 인공어초어장에서 어획량이 가장 높았다. 인공어초모형별 어류 군집상은 사각형 인공어초어장과 반구형 인공어초어장은 서로 차이가 있으며, 원통형 인공어초어장은 이 두 인공어초어장의 중간적인 성격을 띤 군집상을 나타내었다. 또한 해역별로 보면 남해연안과 서해 남${\cdot}$중부연안의 군집상이 유사했고, 남해외양과 동해 남${\cdot}$중부연안의 군집상이 유사하였다.인 점을 고려하여 볼 때 수은 오염에 주의할 필요가 있음을 알 수 있었다. 6. 카드뮴의 어종별 96hr-LC50은 넙치 28.4mg/l, 숭어 2.55mg/l, 조피볼락 28.7mg/l으로 나타났다. 7. LAS의 96hr-LC50은 0.79mg/l이었고, 숭어에 대한 96hr-LC50은 0.06mg/l, 조피볼락 1.08mg/l으로 기수성 어류인 숭어의 내성이 매우 낮은 점이 특이하였다.치사하지 않으므로, 본 실험의 결과를 기초로 하여서 무수 수송 장치를 만들면 충분히 실용화가 가능할 것으로 생각된다.X>로 상당히 높게 나타났고, EPA, DHA 등 w3 계의 장쇄(長鎖)고도불포화지방산의 조성비가 $22.13\%$로 높게 나타났으며, 양적으로 많은 지방산은 포화산 중에는 palmitic acid($C_{16:0}$), monoene산 중에서는 palmitoleic acid($C_{16:1}$), polyene산 중에서는 hexadecatetraenoic acid($C_{16:4}$), eicosapentaenoic acid ($C_{20:5}$), docosahexaenoic acid($C_{22:6}$) 등이 함량이 많았다. Carotenoprotein으로부터 분리한 총 caroteoid 함량은 $8.80mg\%$였고, 주 carotenoid는 mytiloxanthin($74.79\%$), 3,4,3'-trihydroxy-7',8'-didehydro-${\beta}$-carotene($18.26\%$)였다 Community structures and fish densit were investigated on three different types of artificial reefs, dice, turtle artificial reef and tubes, constructed in the Korean waters. Variations of fish fauna according to type of artificial reef and the proper artificial reef in each area for optimizing harvest were discussed. Fish were captured by trammel gill net during May, June, September and November, 1988 and both identified and counted. Fourty-five fish species were found in the artificial reefs. Of these, Sebastes spp., Hexagrammos otakii, Pleuronectidae, Navodon modestus and Stephanolepis cirrhifer showed high occurrence-frequency. The dominant species groups were coastal settlement, demersal or rock fishes such as Pleuronectidae, Rajiformes, Stephanolepis cirrhifer, Navodon modestus, Hexagrammos otakii and Sebastes spp. in all of the Artificial reefs except the oceanic area of southern waters. Scomber japonicus was predominant in the oceanic area of southern waters. Composition of demersal, rock and pelagic fishes were different depending on the types of artificial reef. Dice artificial reefs were occupied by rock fish, on the other hand turtle artificial reefs were dominated by dermersal fish. Fish density was high at the dice artificial reef in all survey areas except the middle area of Eastern waters, with high fish density evident in the Tube artificial reef. Fish community structures were remarkably different between Dice and Turtle artificial reefs. The Tube artificial reef showed intermediate characteristics between the above two types of artificial reefs. The coastal areas of Southern waters and the middle and southern areas of Western waters revealed similar fish fauna. Results from the oceanic areas of Southern waters were well associated with the middle and southern areas of Eastern waters.

개인 트레이의 설계와 인상채득방법이 의치 변연의 형태에 미치는 영향에 관한 연구

이정우,오상천,진태호,Lee, Jeong-Woo,Oh, Sang-Chun,Jin, Tai-Ho 대한치과보철학회 1995 대한치과보철학회지 Vol.33 No.1

The purpose of this study is to inquire about the effects of individual tray design and impression method on the border extension and contour of denture. 10 students at the dentistry college who have normal occlusion and symmetric facial form and normal facial muscle activity were selected. The tray was designed three types (large, medium, small tray). After border molding was done by dentist and operator, final impression was taken. The length of impression body and width of border were measured by a vernier caliper on the cast. The obtained results were as follows : 1. As the tray border was shortened, the length of impression body and width of border was short (P<0.01). 2. When the impression was taken with the small tray, the length of impression body was short in passive border molding than active border molding. 3. When the medium tray was used, the width of impression body was short in passive border molding than active border molding.