Genome sequence of Veillonella atypica KHUD-V1 isolated from a human subgingival dental plaque of periodontitis lesion

이재형,신승윤,이한,양석빈,장은영,류재인,이진용,문지회,Lee, Jae-Hyung,Shin, Seung-Yun,Lee, Han,Yang, Seok Bin,Jang, Eun-Young,Ryu, Jae-In,Lee, Jin-Yong,Moon, Ji-Hoi The Microbiological Society of Korea 2019 미생물학회지 Vol.55 No.1

본 논문에서는 한국인 만성 치주염 환자의 치은연하치태에서 분리된 Veillonella atypica KHUD-V1의 유전체 서열을 보고한다. 다른 V. atypica 균주와 달리, KHUD-V1에서는 프로 파지 및 이와 관련된 것으로 추정되는 여러 병독성 인자가 확인되었다. V. atypica KHUD-V1 균주 및 이 균주의 유전체 서열정보는 Veillonella의 유전체 다양성을 진화론적 관점에서 이해하고, V. atypica의 병독성 및 유전적 다양성에 기여하는 프로파지의 역할을 연구하는데 유용할 것이다. Here we report the genome sequence of Veillonella atypica strain KHUD-V1 isolated from subgingival dental plaque of Korean chronic periodontitis patients. Unlike other V. atypica strains, KHUD-V1 carries two prophage regions and prophage remnants, as well as several genes homologous to prophage-associated virulence factors, such as virulence-associated protein E, a Clp protease, and a toxin-antitoxin system. The isolate and its genome sequence obtained here will aid to understand the diversity of the genome architecture of Veillonella within an evolutionary framework and the role of prophages that contribute to the genetic diversity as well as the virulence of V. atypica.

설하 신경 마비로 인한 설마비 환자 치험 1례

이재형,한성준,이엄지,이정은,남성욱,하나연,김진성,Lee, Jae-hyung,Han, Seong-jun,Lee, Eom-jee,Lee, Jung-eun,Nam, Seong-uk,Ha, Na-yeon,Kim, Jin-sung 대한한방내과학회 2016 大韓韓方內科學會誌 Vol.37 No.5

Hypoglossal nerve palsy is an uncommon neurologic disorder. We report a 67-year-old Korean male with tongue paralysis due to hypoglossal nerve palsy. He had complaints associated only with tongue paralysis and was treated with herbal medicine and electric acupuncture for 12 days. We evaluated his tongue paralysis severity by a numeric rating scale (NRS) and the angle of tongue deviation. After 12 days of treatment, the NRS score showed improvement of his complaints, and the angle of tongue deviation was decreased. Korean medicine could therefore be an effective treatment choice for hypoglossal nerve palsy.

Incremental DP에 의한 홍수시 댐군의 연계운영

이재형,이길성,정동국,Lee, Jae-Hyeong,Lee, Gil-Seong,Jeong, Dong-Guk 한국수자원학회 1992 물과 미래(한국수자원학회지) Vol.25 No.2

북한강 수계에 위치한 화천댐과 소양강댐을 홍수시 연계운영을 위하여 Incremental DP를 사용하여 최적운영모형을 개발하였다. 목적함수로는 의암댐 합류점의 첨두 유량을 최소화하는 것으로 하였으며 수리-수문학적 제약조건은 홍수시 댐조작에 관한 법령, 각 댐 및 하도특성을 고려하여 설정하였다. 특히, 2차 홍수에 대비하여 홍수가 끝나는 시점의 수위가 제한수위가 되도록 하였다. 또한 Incremental DP 모형의 운영결과와 Simulation 및 DP에 의한 단일댐 운영결과를 조절률과 이용률의 관점에서 비교하였고, 합류점의 첨두유량을 Feedback Loop를 이용한 Simulation 결과와 비교하였다. 운영결과 조절률과 이용률이 Simulation 및 DP에 의한 단일댐 운영결과보다 다소 낮게 나타났고, 합류점 유량이 Feedback Loop에 결과보다 크게 나타났는데 이는 홍수말기의 수위에 관한 제약조건 때문이다. An optimal operation model for flood control of multi-reservoirs, Hwacheon and Soyanggang, located in the north Han River basin is developed by using the Incremental DP. The objective function is to minimize the peak flow at the confluence point, of Euam dam, and the hydraulic and hydrologic constraints are established by considering the related laws as to the operation of dam in flood season, each reservoir and channel characteristics. In particular, the final elevations of each reservoir are induced to the conservation pool level in order to prepare for the secondary flood. In addition, the results of this model, simulation results and the single reservoir operation by DP are compared in terms of control and utility efficiencies, and also the peak flows at the confluence point for floods with various return periods are compared with the results of simulation suing feedback control. as the results, the control and utility effciencies are more or less low in contrast with the results of simulation and the single reservoir operation by DP, and the peak flows at confluence point are high because of terminal condition of reservoir storage.

대청댐 예비 방류를 위한 홍수 예보

이재형,심명필,전일권,Lee, Jae-Hyeong,Sim, Myeong-Pil,Jeon, Il-Gwon 한국수자원학회 1993 물과 미래(한국수자원학회지) Vol.26 No.2

호우발생전의 기상상태, 유역의 저류상태 그리고 과거의 패턴을 반영한 실용성 있는 홍수 예보모형을 제안하였다. 호우 예보는 구름 물리학을 토대로한 지점 호우 예보 모형을, 유출예측은 저류함수모형을 채택하였다. 홍수 예보 모형의 입력 변수는 예보 발령 시점의 지상 기온, 지상 기압, 지상 이슬점 온도 그리고 유출점의 초기 유량이다. 홍수 예보 모형의 매개 상수는 과거의 홍수 사상이 갖는 최적 상수들의 산술평균값으로 하였다. 유출률은 홍수 초기 유량을 지표로 하여 예측될 수 있게 하였다. A practical flood forecasting model(FFM) is suggested. The output of the model is the results which the initial condition of meteorological parameters and soil moisture are projected on the future. The physically based station model for rainfall forecasting(RF) and the storage function model for runoff prediction(RP) are adopted respectively. Input variables for FFM are air temperature, pressure, and dew-point temperature at the ground level and the flow at the rising limb(FRL). The constant parameters for FFM are average of optimum values which the past storm events have. Also loss rate of rainfall can predicted by FRL.

일본에 있어서 교량구조물의 파괴현상과 역사적, 지역적으로 본 구조물내하력의 추정

이재형,Lee, Jae-Hyeong 한국건설안전협회 1992 建設 安全技術 Vol.2 No.1

RF-Sputtering 법을 이용한 ZnO:Al 박막의 후 열처리에 따른 특성 변화

이재형,이동진,Lee, Jae-Hyeong,Lee, Dong-Jin 한국전기전자재료학회 2008 전기전자재료학회논문지 Vol.21 No.9

Zinc oxide (ZnO) has been widely studied for its practical applications such as transparent conduction electrodes for flat panel displays and solar cells. Especially, ZnO films show good chemical stability against hydrogen plasma, absence of toxicity, abundance in nature, and then suitable for photovoltaic applications. However, the fabrication process of thin film solar cells require a high substrate temperature and/or post heat treatment. Therefore, the layers have to withstand high temperatures, requiring an excellent stability without degrading their electronic and optical properties. In this paper, we investigated the stability of zinc oxide (ZnO) films doped with aluminum and hydrogen. Doped ZnO films were prepared by r.f. magnetron sputter and followed by heat treatment at different temperatures and for various times.

무릎 뼈관절염의 단파치료 효과 : 무작위임상시험의 메타분석과 체계적 고찰

이재형,조혁신,송인영,Lee, Jae-Hyoung,Cho, Hyuk-Shin,Song, In-Yong 대한물리치료학회 2014 대한물리치료학회지 Vol.26 No.5

Purpose: The purpose of this study is to assess the effectiveness of short-wave therapy (SWT) for treatment of knee osteoarthritis (OA) as compared to placebo and control, and to assess the question of whether the effects are related to the mode, dosage, and application method. Methods: We searched randomized, placebo-controlled trials using electronic databases. We also manually reviewed sources in order to identify additional relevant studies. Results: Eight studies (597 participants) with OA were included in the meta-analysis. Pulse SWT had a significant effect on pain relief compared with control treatment, while did not favour compared with the placebo group. Pulse SWT had a significant effect on functional improvement compared with control and placebo treatment. Continuous SWT had no effect on pain relief and functional improvement. Capacitive SWT a significant effect on pain relief, functional improvement, and muscle strength. Continuous and capacitive SWT had increased muscle strength significantly. We found no clinical significance of all outcomes except pain and functional improvement in pulsed SWT with low dose. There was no difference in adverse events. None of the participants experienced any serious adverse events. Conclusion: Low dose pulsed SWT provided a short-term clinical benefit for pain relief and functional improvement. Pulsed SWD with low and high dose had effects on pain and function. There seems to be a placebo effect. We found significant effects on pain and function in capacitive SWT. Despite some positive findings, this analysis lacked data on how effectiveness is affected by mode, dosage, and application method of SWT. Further well-designed clinical studies are required in order to confirm the effectiveness of SWT.

2단계 추이모형에 의한 금강하구호의 공수도달시간의 평가

이재형,정만,Lee, Jae-Hyoung,Chung, Mahn 한국수자원학회 1993 물과 미래(한국수자원학회지) Vol.26 No.3

본 연구는 금강하구호의 운영정책을 효율적으로 수립할 수 있도록, 2단계 추이모형으로부터 저수지 정상분포와 공수도달시간을 평가하는 데 있다. 이를 위해서 저수량과 유량의 결합분포에 이산 Markov과정을 도입하였으며, 저수지 유입량 분포로는 이항분포를 이용하였다. 계산결과, 대청댐 건설이전인 1952년부터 1980년 유량자료로부터 갈수시 자기 상관계수의 도입에 따른 저수지 정상분포의 공수확률은 0.952에서 0.904로 감소하며, 대청댐 건설이후인 1981-1989년까지는 저수지 정상분포의 공수확률은 0.900에서 0.829로 감소하였다. 한편 평균공수도달시간은 초기 저수량이 1단위에서 댐건설전은 23일에서 37일로 증가하며, 건설후는 29일에서 61일로 증가하는 것으로 나타났다. 이는 비교적 용량이 적은 금강하구호에서 저수율이 낮을 때 정상분포, 공수도달시간 등이 저수지 유입량의 자기상관계수에 따라 변화함을 알 수 있다. 따라서 갈수시 감강하구호의 효율적인 이수관리를 위해서는 유입량의 자기상관성을 고려해야 한다. This study aims at the evaluation of the stationary distribution and the emptiness passage time for the effectiveness of water utility in the Keumgang estuary reservoir by two-step transition model. It was taken discrete Markovian correlated inflows for the joint probability of inflows and storage, and was used binomial distribution for inflows distribution. As the results, it was decreased from 0.952 to 0.904 the emptiness probability of the reservoir stationary distribution during 1952-1980, and from 0.900 to 0.829 during 1981-1989, and the average emptiness passage time was increased from 23 days to 37 days during 1952-1980, and from 29 days to 61 days during 1981-1989 at low state of storage. From this, it is found that the emptiness passage time is varied with the increase of the inflows auto-correlation coefficient in the Keumgang estuary reservoir. Therefore, it is understood that auto-correlation coefficient must be taken into consideration for the evaluation of water utility in a small reservoir at drought time.

나노 소재 기반의 전기장 투과 전극에 관한 연구동향

이재형,신재혁,이상일,박원일,Lee, Jae Hyung,Shin, Jae Hyeok,Lee, Sang Il,Park, Won Il 한국마이크로전자및패키징학회 2020 마이크로전자 및 패키징학회지 Vol.27 No.1

The 'field-effect' underlies the operation of most conventional electronic devices. However, effective control and implementation of the field-effect in semiconductor devices are limited due to screening of the electric-field by conducting electrodes. Thus far, the electronic devices have necessarily been designed to avoid or minimize the electric-field screening effect. As an alternative approach to this, a new type of conducting electrodes which would be transparent to both visible light and electric-field while being electrically conductive have been developed. Here, we define these electrodes as 'electric-field transparent electrodes' and provide a review on related work. Particular attention is paid to the material selection and design strategies to enhance the electric-field transparency of the electrodes while maintaining good electrical conductivity and optical transparency. We then introduce potential applications of the electric-field transparent electrodes in electronic and optoelectronic devices.

Effective Concentration of Procaine Solution for Inotophoresis

이재형,김주형,제갈승주,Lee Jae-Hyoung,Kim Joo-Young,Jekal Seung-Joo The Korean Society of Physical Therapy 1998 대한물리치료학회지 Vol.10 No.1

The purpose of this study was to determine the of effective concentration of procaine iontophoresis for durarion of cutaneous local anesthesia. Forty-five healthy students with an age range of 19 to 34 years$(21\pm2.7)$, were participated in this study. The subjects were randomly assigned into 5 groups. Bach 9 subjects received iontophoresis on the flexor surface of dominant forearm with soft cotton pad $(3.5\times3.5cm)$ soaked in 2ml of $2\%$ (pH 5.28), $4\%$ (pH 5.12), $8\%$ (pH 4,98), $16\%$ (pH 4.72), $32\%$ (pH 4.52) procaine hydrochloride solution at 4mA for 10 minutes (total current 40mA min) using anodal direct current. The study was performed in a randomized, double-blind design, After procaine iontophoresis, the duration of anesthesia were evaluated at five minute intervals on five random locations in the iontophoretically area using a 21-gauge sterile hypodermic needle pressed with 1mm invagination unitl sharp pin-pricking pain sensation returned. The data were analyzed with one-way ANOVA to determine significant differences between groups. Duncan post hoc was performed at level .01. The relationship between anesthetic duration and procaine concentration was assessed with Pearson Product-Moment Correlation Coefficients. ANOVA tests showed significant differences in the anesthetic duration between the concentration of procaine solution (p<.001). Procaine iontophoresis with $4\%$ concentration produced cutaneous Socal anesthesia of significantly longer duration(15.56 min) than iontophoresis with $2\%,\;8\%,\;16\%$, and $32\%$ of procaine GCl(p<.01). Whereas the anesthetic duration had no correlation with concentration of procaine solution (r=-0.41, NS). These results support the $4\%$ procaine solution was an effective concentration of iontophoresis for induced cutaneous local anesthesia. 효율적으로 국소마취를 유발시키는 procaine이온도입의 효과적인 농도를 조사하였다. 19세에서 34까지의 자원자 45명을 9명씩 무작위로 5군으로 나누어 배치하고, 각군 대상자의 오른쪽 전완 전면에 각각 $2\% (pH\;5.2H),\;4%(pH\;5.12),\;8\%(pH\;4.98),\;16\%(pH\; 4.72),\;32\%(pH\;4.52)$ 염산 procaine용액 2ml를 적신 $3.5\times3.5 cm$의 면패드를 대고 4mA로 10분간 양극 직류전류를 통전시켰다. 이온도입 직후부터 5분 간격으로 21 G주사침으로 이온도입부위를 1mm함몰되게 눌러 바늘로 찌르는 통증을 느낄 때까지 감각검사를 시행하여 국소마취지속시간을 측정하였다. Procaine의 농도에 따른 축소마취지속시간을 일원분산분석한 결과 유의한 차이를 보였으며 (F=5.83; df=4, 40; p<.001). 이를 사후검정한 결과 농도 $4\%$의 국소마취지속시간이 농도 $2\%,\;8\%,\;16\%,\;32\%$보다 유의하게 길었다 (p<.01). 또한 상관분석 결과 약물의 농도는 국소마취지속시간과 상관관계가 없었다 (r=-0.41, NS). 본 연구 결과 $4\%$ 농도의 염산 procaine 용액의 이온도입이 국소마취지속시간을 가장 길게 유지하여 $4\%$ 염산 procaine 용액이 이온도입에 가장 효과적인 농도였음을 알 수 있었다.