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이경숙,이옥준,이승영,최미영,Kyoungsook Lee,MD,Ok Jun Lee,MD,Seung Young Lee,MD,Mi Young Choi,MD 대한안과학회 2010 대한안과학회지 Vol.51 No.5
Purpose: Four patients who presented with an upper lid mass were diagnosed with pilomatricoma after excisional biopsy. We report the cases to improve the differential diagnoses of upper lid masses through investigation of the clinical manifestations and radiological findings of pilomatricoma. Case summary: Three females and one male with ages of six, seven, eight and 46 years, respectively, each presented with a slowly growing and painless upper lid mass of a three-month duration. In the six-year-old patient who had a history of trauma related to the mass, the mass was fixed to the skin, although the masses were movable in the other patients. Upon computed tomography (CT), well-circumscribed, enhancing nodules were found. Excisional biopsy was performed for definite diagnosis and treatment. All completely excised masses were hard and encapsulated with a thin membrane. The sizes of the masses were 12 mm, 10 mm, 10 mm, and 7 mm. Histopathologic examination with hematoxylin-eosin staining confirmed the masses to be pilomatricoma. There was no evidence of recurrence at 16, 2, 19, and 21 months after mass excision. Conclusions: In patients presenting with a painless upper lid mass, pilomatricoma should be considered in the differential diagnosis. J Korean Ophthalmol Soc 2010;51(5):758-763
갑상선질환에서 Sonic Hedgehog 단백질 발현의 임상적 의의
유근수,이옥준<SUP>1<,SUP>,김원재<SUP>2<,SUP>,박성수,김동주,박진우,최재운,장이찬,OrloH,Clark<SUP>3<,SUP>,Kuhn-Soo Ryu,M,D,Ok-Jun Lee,M,D,<SUP>1<,SUP>,Wun-Jae Kim,M,D,<SUP>2<,SUP>,Sung Su Park,M,D,Dong-Ju Kim,M,D,Jin- Woo Park 대한갑상선-내분비외과학회 2011 The Koreran journal of Endocrine Surgery Vol.11 No.4
Purpose: The Hedgehog (Hh) signaling pathway is important in embryonic development including cell differentiation and proliferation. Recently, activation of this pathway has been implicated in several forms of solid cancers. We investigated sonic hedgehog (Shh) protein expression and its relation to differentiation and clinicopathologic characteristics in thyroid cancer cell lines and tissues. Methods: We used five thyroid cancer cell lines: TPC-1, FTC-133, FTC-236, FTC-238, and XTC-1. We made tissue microarray slides using 80 thyroid surgical specimen: 40 benign and 40 malignant lesions. Immunohistochemical staining was performed using anti-Shh antibody. mRNA expression of NIS, thyroglobulin, and CD97 were evaluated by RT-PCR. Cyclopamine was used as a Shh signal inhibitor. Results: Shh expression was more prominent in TPC-1, FTC-133, and XTC-1 cell lines than the others. Cyclopamine downregulated CD97 and upregulated thyroglobulin mRNA expression, but did not induce mRNA expression of NIS. Thyroid tissues showed varied expression of Shh in both benign and malignant diseases. Shh expression was detected in 38 of 50 (76%) normal, in 18 of 25 (72%) non-neoplastic benign, in nine of 15 (60%) benign tumors, and in 31 of 40 (77%) malignant tumors. Shh over-expression was significantly less frequent in papillary thyroid carcinomas than in normal or benign thyroid tissues. In addition, Shh protein expression did not relate to clinicopathologic characteristics in papillary thyroid carcinomas. Conclusion: Thyroid tissues and cell lines vary in expression of Shh. Cyclopamine can induce redifferentiation in thyroid cancer cell lines. Shh protein expression, however, is unrelated to clinicopathologic characteristics in papillary thyroid carcinomas. (Korean J Endocrine Surg 2011;11:234-241)
서정훈,이성준,이옥준,최미영,Jeong Hun Seo,MD,Seong Jun Lee,MD,Ok Jun Lee,MD,Mi Young Choi,MD 대한안과학회 2009 대한안과학회지 Vol.50 No.4
Purpose: To investigate the effects of sutureless faden operation to eliminate suture-related perioperative risks in a rabbit model. Methods: Twenty-eighty superior recti muscles of 14 rabbits were subjected to faden operation, at a distance of 6 mm from the insertion of the muscle. They were divided into four groups of 7 muscles each: group A, Beriplast-P ; group B, BardⓇ mesh (12×2 mm); group C, SurgiproⓇ mesh (6×2 mm); group D, SurgiproⓇ mesh (6×6 mm). Rabbits were sacrificed and the eyes were enucleated. The operative field was examined upon dissection, 4 weeks after the surgery. Histopathologic sections were examined for the degree (grade 0 to 4) of inflammation, fibrosis, atrophy and/or degeneration of muscle fiber. Results: Grossly, there was a mild adhesion at the myopexy site in group A, while there was greater adhesion at the myopexy site in groups B, C and D. Group B produced a pronounced adhesion, and the mesh firmly adhered to the sclera as well as to adjacent tissue. Upon histologic examination, group A showed a mild inflammatory reaction and fibrosis, whereas groups B and D showed a moderate inflammatory reaction and fibrosis. The degree of fibrosis in group D was more severe than that in group A (p<0.008), and there was no statistical significance among the other groups (p>0.05). There was atrophy and degeneration in the muscle fiber in all groups, with the exception of group D. Conclusions: In the rabbit model, 6×6 mm sized SurgiproⓇ mesh may be the best material in sutureless faden operation. J Korean Ophthalmol Soc 2009;50(4):603-611
바깥귀길에서 발생한 상피-근상피암종의 세포소견 - 1예 보고 -
이호창,송형근,최영석,이옥준,Lee, Ho-Chang,Song, Hyung-Geun,Choi, Young-Seok,Lee, Ok-Jun The Korean Society for Cytopathology 2008 대한세포병리학회지 Vol.19 No.1
Epithelial-myoepithelial carcinoma (EMC) is a low grade malignant neoplasm that commonly occurs in the parotid gland. Recently, we investigated a case of EMC that occurred in the external auditory canal (EAC) in a 35-year-old male, and this tumor was initially diagnosed as pleomorphic adenoma. The difficulty associated with diagnosing EMC by aspiration cytology arises from both the rare incidence of this tumor and the overlapping spectrum of cytological features found in various salivary gland tumors, such as pleomorphic adenoma, basal cell adenoma and adenoid cystic carcinoma.
인플루엔자 감염 후 말초 신경병증으로 발현한 결절성 다발성 동맥염 1예
이동화 ( Dong Hwa Lee ),한정호 ( Jung Ho Han ),김미경 ( Mi Kyoung Kim ),이옥준 ( Ok Jun Lee ),강귀영 ( Kwi Young Kang ) 대한류마티스학회 2012 대한류마티스학회지 Vol.19 No.3
Polyarteritis nodosa (PAN) is a necrotizing vasculitis of the medium-sized arteries. The symptoms and signs of PAN include purpuric skin lesions, mononeuritis multiplex, symptoms of mesenteric ischemia, and renal involvement. We report the first case of PAN manifesting as a neuropathy after influenza infection in Korea. A 68-year-old woman had fever, myalgia, hyperesthesia of both hand and foot, and lower extremity weakness. EMG findings showed severe sensorimotor polyneuropathy, such as multiple mononeuritis. A sural nerve biopsy showed vasculitis and Influenza A (H1N1) were positive. Our patient was treated by glucocorticoid and oral cyclophosphamide, thereafter, symptoms and signs improved. No recurrence has been observed for five months.
최경석 ( Kyung Suck Cheoi ),이원익 ( Won Yik Lee ),음영욱 ( Young Ook Eum ),김희성 ( Hee Sung Kim ),이옥준 ( Ok Jun Lee ),이기형 ( Ki Hyeong Lee ),김승택 ( Seung Taik Kim ) 대한내과학회 2006 대한내과학회지 Vol.71 No.5
유방암의 위전이는 폐, 골, 림프절, 골 전이보다 그 빈도가 매우 드물다. 본 증례는 4년 전 유방암을 앓은 과거 병력을 가진 56세 여자가 상복부 불편감으로 내원하여 상부위장관 내시경과 조직학적상 원발 위암이 아닌 유방암의 위전이가 확인되어 보고하는 바이다. Metastatic cancer from breast cancer is not uncommon and it often involves multiple organs. Gastric metastasis from breast cancer is much rarer than lung, bone and lymph node metastasis. Most of the symptoms are nonspecific, so it is not easy to differentiate primary gastric cancer from gastric metastasis from the breast. In particular, gastric and breast cancers are the two most common cancers among Korean women, so efforts should be made to distinguish primary gastric cancer from gastric metastasis because treatment and prognosis are very different between two. A few cases have been reported in Korea concerning gastric metastasis from breast cancer. We report here a case of gastric metastasis from infiltrating duct carcinoma of the breast.(Korean J Med 71:567-572, 2006)
소포변이 갑상선유두암 진단에서 초음파검사와 수술 중 동결절편 검사의 역할
공병호(Byeong Ho Ghong),김동주(Dong Ju Kim),이옥준(Ok Jun Lee),박진우(Jin Woo Park) 대한갑상선-내분비외과학회 2016 The Koreran journal of Endocrine Surgery Vol.16 No.3
Purpose: The follicular variant of papillary thyroid carcinoma (FVPTC) is the most common variant of papillary thyroid carcinoma (PTC). Preoperative diagnosis of FVPTC is often confused with cPTC, follicular neoplasm (FN), and benign follicular lesion because of the paucity of nuclear changes of PTC and overlapping features with benign and other neoplastic follicular lesions. The aim of this study is to elucidate whether ultrasonography and/or intraoperative frozen section analysis (FSA) have a supplementary role in the diagnosis of FVPTC. Methods: Fifty-five patients diagnosed with histologically confirmed FVPTC from January 2007 to December 2013 were identified. All patients had undergone either lobectomy with/without completion thyroidectomy or total thyroidectomy. Medical records, final histological reports and sonographic (US) findings were reviewed. All sonographic images, 53 fine needle aspiration cytology (FNAC) slides, and FSA slides for 24 cases were available for reexamination. Results: Three histologic types of FVPTC were identified: encapsulated (n=39); infiltrative (n=15); and diffuse (n=1). There were two distinct sonographic patterns: FN-type (n=28) and PTC-type (n=27). The encapsulated type is more common in the FN-like pattern, compared to the PTC-like one (85.7% vs. 55.6%, P=0.009). Among the 24 cases in which sonographic images and FNAC and FSA slides were available for review, six cases (25%) were diagnosed as either FN in FNAC and suspicious PTC(R/O PTC)/PTC in FSA or R/O PTC/PTC in FNAC and FN in FSA. Among those 24 cases described above, 13 cases (54.2%) were diagnosed as either FN-type in US and R/O PTC/PTC in FNAC/FSA or PTC-type in US and FN in FNAC/FSA. Conclusion: It is difficult to make a correct diagnosis of FVPTC before definitive treatment even with US, FNAC and FSA. However the possibility of FVPTC must be considered, especially when diagnoses in US, FNAC and FSA are different and include R/O PTC/PTC and FN in the same case.
자가 연골세포 이식술 이후에 발생한 이식부의 골 형성 병변 - 증례 보고 -
최의성,박경진,김용민,김동수,손현철,조병기,박지강,이형준,이옥준,Choi, Eui-Sung,Park, Kyoung-Jin,Kim, Yong-Min,Kim, Dong-Soo,Shon, Hyun-Chul,Cho, Byung-Ki,Park, Ji-Kang,Lee, Hyung-Joon,Lee, Ok-Jun 대한관절경학회 2010 대한관절경학회지 Vol.14 No.1
연골 손상에 대한 수술적 치료 방법 중 자가 연골 세포 이식술은 자신의 연골 세포를 실험실에서 배양하여 이것을 다시 관절 내의 연골 결손 부위에 이식하여 증상이 있는 전층의 연골 또는 골 연골 손상을 치료하는 술식이다. 저자들은 자가연골 세포 이식술 이후 발생할 수 있는 매우 드문 합병증으로, 이식부의 골 형성 병변이 있는 1 례를 경험하였기에 보고하는 바이다. Autologous chondrocyte implantation is a widely used technique for treating cartilage defect or osteochondral lesion, which is the method of transplantation of self chondrocytes after cultivation in the laboratory. We experienced the rare case of heterotophic ossification in the recipient site of the knee after autologous chondrocyte implantation. So we want to report this case with review of the relevant literatures.