가임력 보존을 위한 계획적 난자 동결

이다용,김용진 대한의사협회 2022 대한의사협회지 Vol.65 No.6

Background: Oocyte cryopreservation opens up opportunities for women to preserve fertility when it is necessary to postpone pregnancy. After the advent of vitrification, the results of oocyte cryopreservation were significantly improved compared to conventional slow-freezing. Through these improvements, oocyte cryopreservation was introduced to overcome a decline in fecundity due to an increase in age, and this modality is defined as planned oocyte cryopreservation. Current Concepts: Oocytes cryopreserved through vitrification appear to result in similar clinical pregnancy rates and live birth rates compared to fresh oocytes, though the evidence is still limited. It has been reported that the live birth rate increases when the planned oocyte cryopreservation is performed at a younger age. Obstetrical and neonatal outcomes appear similar between vitrified and fresh oocytes. Discussion and Conclusion: Preliminary data supports planned oocyte cryopreservation as a feasible modality resulting in fertility preservation and subsequent live births. The fact that performing the procedure at a younger age can increase the oocyte yield, oocyte efficacy, and live birth rate can be discussed along with patient consultation. However, as there is still a lack of data on the standardized live birth rate, the number of oocytes to be collected, and the long-term effect on the children; more well-designed studies are needed to improve counseling and decision-making in patients seeking this treatment.

일차성 생리통의 특성 및 약물적 치료

이다용,김슬기 대한의사협회 2020 대한의사협회지 Vol.63 No.3

Dysmenorrhea is the most common gynecologic condition in women during the reproductive period. Severe dysmenorrhea pain affects their social activities, sleep, and quality of life. Nevertheless, the proportion of women with dysmenorrhea do not receive adequate medical counseling or pharmacological treatments. Primary dysmenorrhea is diagnosed clinically, and the secondary causes that can cause pelvic pain should be identified. The treatment of choice for primary dysmenorrhea is non-steroidal anti-inflammatory drugs (NSAIDs). In order to maximize the therapeutic effect, it is necessary to ensure that the appropriate medication is administered in a proper way. NSAIDs can cause adverse effects, including gastrointestinal disorders. If side effects occur or are anticipated with NSAIDs, the use of hormonal contraceptives may be recommended when contraception is considered. In addition to these pharmacological treatments, heat, dietary, and behavioral therapies have been tried and reported to have some effects. However, further research is required for robust conclusions.

Donor oocyte bank : worldwide status and application in Korea

이다용 대한산부인과학회 2022 대한산부인과학회 학술대회 Vol.108 No.-

Roles of mTOR Signaling in Brain Development

이다용 한국뇌신경과학회 2015 Experimental Neurobiology Vol.24 No.3

mTOR is a serine/threonine kinase composed of multiple protein components. Intracellular signaling of mTOR complexes is involved in many of physiological functions including cell survival, proliferation and differentiation through the regulation of protein synthesis in multiple cell types. During brain development, mTOR-mediated signaling pathway plays a crucial role in the process of neuronal and glial differentiation and the maintenance of the stemness of neural stem cells. The abnormalities in the activity of mTOR and its downstream signaling molecules in neural stem cells result in severe defects of brain developmental processes causing a significant number of brain disorders, such as pediatric brain tumors, autism, seizure, learning disability and mental retardation. Understanding the implication of mTOR activity in neural stem cells would be able to provide an important clue in the development of future brain developmental disorder therapies.

메타커머스 스토어 VMD의 특성 연구 - 플레이투게더 스토어를 중심으로 -

이다용 ( Lee Dayong ),김선영 ( Kim Sunyoung ) 한국상품문화디자인학회 2023 상품문화디자인학연구 Vol.72 No.-

메타커머스 스토어는 메타버스에서 상품(아이템)을 구매 또는 경험할 수 있는 상점 형태의 공간으로, 주로 기존 메타버스 플랫폼 내에서 상품 판매나 브랜드 체험을 위해 활용된다. 본 연구는 오프라인과 비교하여 사용자의 경험에 영향을 주는 메타커머스 스토어 VMD의 특성을 규명하고자 하였다. 연구 방법은 문헌연구, 현장 관찰, 인터뷰를 활용한 자료의 삼각화를 통해 동일한 현상에 대한 다각적 관점을 반영하고자 했다. 사례는 오프라인과 메타버스 모두에서 스토어를 운영 중인 ‘라인프렌즈’의 플레이투게더 스토어를 선정하였다. 연구 결과 첫째, 메타커머스 스토어는 오프라인 스토어를 대체할 수는 없으나, 기존에 온라인상에서 경험하지 못한 공간 경험을 제공하여 브랜딩과 마케팅에 도움을 준다. 둘째, 메타커머스 스토어에서 구성요소의 중요 순위는 파사드 > VP > 벽·바닥 순으로 나타났다. 셋째, 메타커머스 스토어 VMD 구성요소에는 기존 오프라인 스토어 요소에 경험적 요소(재미, 상호작용)가 추가되어야 한다. 넷째, 오프라인에서의 시·공간의 물리적 한계를 극복한 경험을 제공하며, 기존 온·오프라인 스토어와 다른 마케팅과 브랜드 경험을 줄 수 있기 때문에 메타커머스 스토어의 지속가능성에 대한 전문가와 일반인들의 평가는 모두 긍정적으로 나타났다. The metacommerce store is a space in the form of a store where you can purchase or experience products or items on Metaverse, and is mainly used for selling products or brand experiences within the existing Metaverse platforms. This study attempted to investigate the characteristics of the metacommerce store VMD that affect the user’s experience compared to offline. The research method attempted to reflect a multilateral perspective on the same phenomenon through triangulation of data using literature research, field observation data, and interviews. We selected the Play Together store of ‘Line Friends’, which operates stores both offline and metaverse as a case. As a result, first, metacommerce stores could not replace offline stores, but they help branding and marketing by providing spatial experiences that have not been experienced online before. Second, the important ranking of components in the meta-commerce store was in the order of facade > VP > wall and floor. Third, it was found that empirical elements (fun, interaction) should be added to the existing offline store elements in the meta-commerce store VMD component. Fourth, both experts and the general public generally evaluated the sustainability of the metacommerce store positively because it provides an experience of overcoming the physical limitations of time and space offline and can give marketing and brand experience different from existing online and offline stores.

K-pop 아이돌 캐릭터 스토리텔링 사례 연구 - BT21을 중심으로 -

이다용 ( Lee Dayong ),김선영 ( Kim Sunyoung ) 한국상품문화디자인학회(구 한국패키지디자인학회) 2021 상품문화디자인학연구 Vol.65 No.-

본 연구는 최근 전 세계적으로 많은 인기를 얻고 있는 K-pop 캐릭터의 성공요인 중 하나가 스토리텔링이라는 점에 주목하여 그 구체적 요인을 도출하고자 하였다. 이를 위해 BTS(방탄소년단)의 캐릭터인 BT21을 사례로 선정하고, 분석틀로는 선행연구를 참고하여 고유성, 매력성, 흥미성, 이해용이성, 감성, 커뮤니케이션성 등의 스토리텔링 요소를 구성하였다. 연구 결과, BT21은 고유성, 매력성, 흥미성, 감성 등의 요소에는 매우 부합한다고 분석된다. 그러나 이해용이성 중 스토리가 캐릭터의 이해를 돕는가, 캐릭터에 대해 적절히 묘사하고 있는가 등의 요인과 커뮤니케이션성 중 상호커뮤니케이션을 통한 관계 구축과 판매 목적이 아닌 가치창출을 위한 장기적 관계 구축 등의 요인에서는 보완점이 발견되었다. 실증적 검증이 이루어지지 못한 한계에도 불구하고 본 연구가 향후 다양한 방식의 아이돌 캐릭터 제작 등 산업적 기여와 더불어 K-pop 아이돌 캐릭터에 대한 학술적 논의가 촉발되는 계기가 되기를 기대한다. This study aimed to derive specific factors, noting that one of the success factors of K-pop characters, which has recently become very popular around the world, is storytelling. To this end, BT21, a character of BTS(BTS) was selected as an example, and for the analysis framework, storytelling elements such as uniqueness, attractiveness, interest, ease of understanding, sensibility, and communication were constructed by referring to prior research. Studies show that BT21 is highly consistent with factors such as uniqueness, attractiveness, interest, sensibility, etc. However, a complement was found in whether the story helps the character understand, appropriately describes the character, and whether the communication establishes a relationship through mutual communication, or a long-term relationship for value creation, not for sales purposes. Despite the limitations of only theoretical research, we hope that this study will trigger academic discussions on K-pop idol characters along with industrial contributions such as idol character production in various ways in the future.

Prognostic factors in neuroendocrine cervical carcinoma

이다용 ( Da Yong Lee ),( Chul Chong ),( Maria Lee ),( Jae Weon Kim ),( Noh Hyun Park ),( Yong Sang Song ),( Sang Yoon Park ) 대한산부인과학회 2017 대한산부인과학회 학술대회 Vol.103 No.-

Objective: To evaluate the clinical and pathologic factors associated with survival in patients with neuroendocrine cervical carcinoma (NECC). Methods: The records of 61 patients with NECC diagnosed between 2000 and 2014 at Seoul National University Hospital and the National Cancer Center were retrospectively reviewed. Kaplan-Meier and Cox regression methods were used for analyses. Results: Of the 61 patients, 67.2% were diagnosed at early stage (I to IIA) with a median age of 49 years. Of those, 78% underwent surgery and 75.6% received postoperative adjuvant treatment. For patients diagnosed at advanced stage, 60.0% received chemotherapy only and 25.0% received concurrent chemoradiation therapy. In the univariate analysis, advanced stage (77 vs. 40 months, P=0.013), tumor size ≥2 cm (133 vs. 47 months, P=0.002) and mixed tumor (101 vs. 34 months, P=0.004) were shown to be poor prognostic factors. In the multivariate analysis, tumor stage, tumor size and tumor homology were shown to be independent prognostic factors for overall survival. Of the total, 39.3% of the patients experienced recurrence, and 54.1% of the patients had metastasis. Of the patients diagnosed at early stage, 51.2% experienced recurrence. Conclusion: Tumor stage, tumor size and tumor homology were found to be independent prognostic factors in patients with NECC. Even in patients diagnosed at early stage, recurrence and distant metastasis were frequently observed.

Successful in Vitro Fertilization and Embryo Transfer after Transplantation of Cryopreserved Ovarian Tissue: Report of the First Korean Case

이정렬,이다용,박수현,백은찬,김슬기,지병철,서창석,김석현 대한의학회 2018 Journal of Korean medical science Vol.33 No.21

For patients at risk of premature ovarian failure with cancer treatment, it is an important option to re-implant the ovarian tissue (OT) after cryopreservation to preserve endocrine function and fertility. With this technique, about 30% of pregnancy success rate and about 90 live births have been reported to date. However, there has been no case report of successful in vitro fertilization (IVF) and embryo transfer (ET) with oocytes collected from transplanted cryopreserved OT in Korea. We report a 30-year old woman with rectal cancer who underwent IVF and ET after cryopreserved OT thawing and re-implantation. She has been diagnosed with stage IIIC rectal cancer after surgery, and right ovary was removed and cryopreserved between cycles of chemotherapy. After completion of chemotherapy and radiotherapy, the patient underwent orthotopic transplantation of cryopreserved OTs. Three months after transplantation, the serum follicle-stimulating hormone level decreased from 91.11 mIU/mL to 43.69 mIU/mL. Thereafter, the patient underwent 11 ovarian stimulation cycles, and in 7 cycles, follicle growth was observed at the OT graft site. In one of these cycles, the oocyte was successfully retrieved and one embryo was transplanted after IVF. The patient was not pregnant, but the cryopreservation of OT can save the fertility after anticancer chemotherapy.

The Molecular Mechanism of NELL2 Movement and Secretion in Hippocampal Progenitor HiB5 Cells

하창만,박재용,황은미,이다용,장성호,이병주,홍성근 한국분자세포생물학회 2013 Molecules and cells Vol.36 No.6

Neural epidermal growth factor-like protein-like 2 (NELL2) is a secreted glycoprotein that is predominantly expressed in the nervous system, but little is known about the intracellular movement and secretion mechanism of this protein. By monitoring the localization and movements of enhanced green fluorescent protein (EGFP)-labeled NELL2 in living cultured hippocampal neuroprogenitor HiB5 cells, we determined the subcellular localization of NELL2 and its intracellular movement and secretion mechanism. C-terminal EGFP-fused NELL2 showed a typical expression pattern of secreted proteins, especially with respect to its localization in the endoplasmic reticulum, Golgi apparatus, and punctate structures. Vesicles containing NELL2 exhibited bidirectional movement in HiB5 cells. The majority of the vesicles (70.1%) moved in an anterograde direction with an average velocity of 0.454 m/s, whereas some vesicles (28.7%) showed retrograde movement with an average velocity of 0.302 m/s. The movement patterns of NELL2 vesicles were dependent upon the presence of microtubules in HiB5 cells. Anterograde movement of NELL2 did not lead to a detectable accumulation of NELL2 in the peripheral region of the cell, indicating that it was secreted into the culture medium. We also showed that the N-terminal 29 amino acids of NELL2 were important for secretion of this protein. Taken together, these results strongly suggest that the N-terminal region of NELL2 determines both the pattern of its intracellular expression and transport of NELL2 vesicles by high-velocity movement. Therefore, NELL2 may affect the cellular activity of cells in a paracrine or autocrine manner.

모체태아의학 : OB-17 ; 임신 초기에 무증상 갑상선기능저하증의 진단을 위한 주수별 기준이 필요한가? -한국 임신 여성에서 임신 1분기 주수별 TSH의 농도

김혜성,김병재,오소희,이다용,황규리,전혜원,이승미 대한산부인과학회 2014 대한산부인과학회 학술대회 Vol.100 No.-

목적: 임신 제 1 삼분기에 TSH ≥ 2.5 mIU/L 은 무증상 갑상선기능저하증의 보편적인 기준으로 제시되어왔다. 하지만 TSH 수치는 임신 중 지속적으로 변하며 임신 제 1 삼분기에서도 마찬가지이므로 고정된 기준치를 적용하면 임신 주수에 따라 무증상 갑상선기능저하증의 진단율이 달라질 수 있다. 이 연구의 목적은 한국 임신 여성에서 임신 제 1 삼분기동안 TSH의 정상범위를 알아보고 고정된 TSH 기준치를 적용하였을 때 무증상 갑상선기능저하증의 임신 주수별 진단율을 구하는 것이다. 방법: 연구대상은 임신 제 1 삼분기에 TSH를 측정하고 분만한 여성을 대상으로 하였다. 정기검진으로 TSH를 측정한 비임신 여성을 대조군으로 포함하였다. 임신 주수별 TSH 범위를 구했고 TSH 의 주수별 기준과 고정된 기준(TSH > 2.5 μU/mL)에 따른 무증상 갑상선기능저하증의 발생률을 비교하였다. 결과: 492명의 임신여성과 984명의 비임신 여성이 포함되었고 비임신 여성보다 임신 제 1 삼분기 여성에서 TSH의 중앙값이 낮았다. 또한 임신 제 1 삼분기동안 TSH의 지속적인 감소를 보였다 (상위 95백분위수: 3+0 ~ 6+6주, 3.78 mIU/L; 7+0 ~ 7+6주, 3.20 mIU/L; 8+0 ~ 13+6주, 2.97 mIU/L). 고정된 기준치인 TSH >2.5 mIU/L를 사용하는 경우 무증상 갑상선기증저하증의 진단율은 임신 주수에 따라 의미있게 감소했으며 (3+0~ 6+6주, 25%; 7+0 ~ 7+6주, 13%; 8+0~ 13+6주, 9%) 주수별 기준을 사용한 경우 진단율은 모든 주수에서 5% 였다. 결론: 고정된 기준인 TSH >2.5 mIU/L를 사용하는 경우 무증상 갑상선기능저하증의 진단율은 임신주수에 따라 의미 있게 변한다. 따라서 임신 주수별 기준이 무증상 갑상선기능저하증을 진단하는 데에 있어서 더 적절할 것이라고 생각되나 임신과 태아 평가를 포함한 추가 연구가 필요하다.