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수점산(手拈散)이 심장(心臟)과 소화기(消化器)에 미치는 영향(影響)
이기상,문병순,김세길,Lee, Key-Sang,Mun, Byeong-Sun,Kim, Sah-Gil 대한한방내과학회 1990 大韓韓方內科學會誌 Vol.11 No.2
The Present experiment was designed to investigate the effects of Soo Jeom San on the function of heart and digestive organs. And thus it was analyzed the total acidity, recovery effect, and the other various enzyme activities such as ATPase, Creatine kinase, Aspartate transaminase, and Lactate dehydrogenase. The results were obtained as follows : 1. The Total acidity decreased after Soo JeomSan administration for 6 days, however the total acidity inoreased after the drug administration for 9 days, these phenomena demonstrate that Soo Jeom San acts as a dual factor. The mechanism of decreasing the total acidity was considered to the inhibition of ATPase activity used for HCI active transport from parietal cells. 2. Soo Jeom San recovered the islets of Langerhans which was disrupted by streptozotocin. The recovery mechanism was suggested that Soo Jeom San stimulates the ${\beta}-cell$ proliferation. 3. Soo Jeom San inhibited the enzyme activities such as Creatine kinase and Aspartate transaminase, however the drug activated Lactate dehydrogenase. According to the obtained results, Soo Jeom San may be used for curing gastric ulcer and myocardiac infarction.
H2O2와 Aβ로 유도된 pc12 cell에서 생산조인(生酸棗仁) 수추출물의 항산화 및 항치매 효과
이상원 ( Sang Won Lee ),김대현 ( Dae Hyun Kim ),윤종현 ( Jong Hyun Yun ),김진우 ( Jin Woo Kim ),정은영 ( Ejun Young Jung ),이성근 ( Seoung Geun Lee ),이기상 ( Key Sang Lee ),김태헌 ( Tae Heon Kim ),류영수 ( Yeoung Su Lyu ),강형원 대한한방신경정신과학회 2008 동의신경정신과학회지 Vol.19 No.3
Objective : The antioxidant and anti-Alzheimer effects of Semen Ziziphi Spinosae (SZS) water extract against the amyloid beta peptide (1-42) or H2O2-induced oxidative damage and cell death were investigated in rat pheochromocytoma line PC 12. Methods : The cells were incubated with SZS water extract and oxidative damage-inducing materials, amyloid beta peptide (1-42) or H2O2 for 24 h. The cellular viability was assessed by WST-1 assay, cytotoxic damage by LDH activity assay, oxidative damages of cells by fluorescence spectrophotometric method, and apoptosis by TUNEL staining assay. Results and Conclusions : 1. Preincubation of the cells with SZS water extract prior to amyloid beta peptide (1-42) (2 uM) or H2O2 (30 uM) exposure elevated the cell survival close to the control and decreased the level of LDH activity and the fluorescence from the cell homogenates and TUNEL staining of the cells, compared to only amyloid beta peptide (1-42) (2 uM) or H2O2 (30 uM) treated conditions . 2. Our study suggests that Semen Ziziphi Spinosae (SZS) water extract has protective effects against amyloid beta peptide (1-42) or H2O2-induced cell toxicity through the antioxidation mechanism, which might be beneficial for the treatment of Alzheimer`s disease.
대계(大?)가 LPS로 유도된 Mouse BV2 Microglial cells의 염증반응에 미치는 영향
김영선,이성근,이기상,Kim, Young-Sun,Lee, Seoung-Geun,Lee, Key-Sang 대한한방내과학회 2008 大韓韓方內科學會誌 Vol.29 No.4
Cirsii Japonici Herba(CJ) is a wild perennial herb found in many areas of Korea as well as China and Japan, which has been used to treat bleeding and inflammation. Silibinin is the main flavonoid extracted from milk thistle (Cirsii Japonici Herba). It exhibits potent antioxidant activity and anti-inflammatory effect. In this study, the effect of CJ and silibinin extract on lipopolysaccharide-induced inflammation was investigated using MTS assay, RT-PCR, western blot, and nitric oxide detection on mouse BV2 microglial cell lines. In the present results, CJ and silibinin extract suppressed nitric oxide production by inhibiting the lipopolysaccharide-stimulated enhancement of COX-2 and iNOS gene expression in BV2 cells. Moreover, CJ and silibinin also repressed some lipopolysaccharide-induced signaling molecules. Importantly, catalase-induced COX-2 and iNOS expression needed activations of $NF-{\kappa}B$, PI3K/Akt, and MAPK, which were important for the transcriptional up-regulation of COX-2 and iNOS. CJ and silibinin interaction on BV2 cells down-regulated $NF-{\kappa}B$-dependent proinflammatory cytokine (IL-2,IL-6) expression. They are involved in the regulation of inflammatory responses. These data shows that CJ and silibinin exerts anti-inflammatory and analgesic effects, probably by suppression of COX-2 and iNOS synthase expression in BV2 microglial cells.
손지영,이성근,이기상,박준영,윤효진,Son, Ji-Young,Lee, Seong-Geun,Lee, Key-Sang,Park, Joon-Young,Yun, Hyo-Jin 대한동의생리학회 2006 동의생리병리학회지 Vol.20 No.6
This study was designed to evaluate the effects of an oriental medicine(Siryung-tang) on pain caused by Post-herpetic neuralgia. We treated a 70 year-old male patient who suffered left flank pain by Post-herpetic neuralgia. As for treatment, we used Siryung-tang. After seven-day of treatment, all symptoms started to improved. This study suggests that Siryung-tang is effective in treatment of pain by Post-herpetic neuralgia.
고혈압-뜸 임상시험 참여자들의 혈압 관리행동에 대한 질적연구
문아지,김태정,이성근,김남권,이기상,Moon, A-Ji,Kim, Tae-Jung,Lee, Seoung-Geun,Kim, Nam-Kwen,Lee, Key-Sang 대한한방내과학회 2012 大韓韓方內科學會誌 Vol.33 No.4
Objectives : The purpose of this study which adopted a qualitative method was to evaluate blood pressure management behaviors of pre- and stage 1 hypertension patients and to provide fundamental data for developing a strategy about proper oriental medical treatment through analyzing factors related to a moxibustion clinical trial. Methods : Semi-structured interviews that focused on personal experiences with hypertension and its management were conducted with 10 hypertensive patients. The interviews lasted for approximately 50 minutes. Results : Most participants recognized that the direct cause of high blood pressure was unhealthy behavior rather than inheritance. Thus, the hypertensive patient believed they could recover their blood pressure to a normal level through removing the direct cause of hypertension instead of taking drugs. The reasons for these statements were that the drugs for controlling hypertension are not natural and they may have side effects. On future management plan of patients, most of them will continue to keep moxibustion and healthy behavior in the well-controlled blood pressure group. However in the uncontrolled blood pressure group, there was an increasing tendency to begin medication. Conclusions : For developing a strategy for an individual approach to hypertension management, we need to develop a client-centered attitude and strategy. That is, we need to tailor our approach to individual cases to avoid generalizations and stereotyping when developing an adherence increasing strategy.
Hemiballism-Hemichorea-Orofacial dyskinesia가 병발한 환자 치험 1례
손지영,윤효진,이성근,이병주,이기상,Son, Ji-Young,Yoon, Hyo-Jin,Lee, Seung-Geun,Lee, Byung-Ju,Lee, Key-Sang 대한한방내과학회 2006 大韓韓方內科學會誌 Vol.27 No.4
Objectives: This study was to examine diagnosis of dyskinesia by criteria of oriental medicine and to evaluate the effect of oriental medical treatment on the symptoms. Methods: After the patient was treated with Yonggyedeunggyo-tang, the changes in dyskinetic symptoms were evaluated for treatment efficacy every hospital day. Results: The dyskinesia symptoms disappeared. Conclusions: Herbal medicine and Saam Acupuncture therapy is useful for the treatment of Hemiballism- Hemichorea-Orofacial dyskinesia patients.
김영은,김일화,이재화,이성근,이기상,Kim, Young-Eun,Kim, Il-Wha,Lee, Jae-Hwa,Lee, Seoung-Geun,Lee, Key-Sang 대한한방내과학회 2009 大韓韓方內科學會誌 Vol.30 No.4
Parkinson's disease is a slowly progressive degenerative disorder of the central nervous system. It is characterized by tremor when muscles are at rest, increased muscle tone, slowness of voluntary movements, and difficulty maintaining balance. In oriental medicine, these symptoms are diagnosed as yin(陰)-deficiency of liver and kidney, deficiency of qi(氣) and blood, retention of phlegm(痰), qi-stagnation and blood stasis. In this case, we diagnosed patients as deficiency of qi(氣) and blood type according to symptoms and treated by herbs that strengthen yang and benefiting yin for two weeks, while maintaining existing parkinson's western medication. After treatment, clinical symptoms were improved, while UPDRS (Unified Parkinson's Disease Rating Scale) score was decreased. These cases suggest that oriental medicine therapy maybe effective in the treatment of Parkinson's disease.