초음파를 통해 경과관찰한 비복근 부분파열 환자의 한의학적 치료: 증례보고

윤영훈,김혜민,김재수,이현종,임성철,이윤규,Youn, Young Hoon,Kim, Hye Min,Kim, Jae Su,Lee, Hyun Jong,Lim, Sung Chul,Lee, Yun Kyu 경락경혈학회 2022 Korean Journal of Acupuncture Vol.39 No.3

Gastrocnemius muscle partial rupture is a common muscle injury. This case is report on a patient with a gastrocnemius muscle partial rupture who was continuously observed with ultrasonography while receiving Korean medicine treatment. Acupuncture, pharmacoacupuncture, herbal medicine, physical therapy and rehabilitation treatment were performed on a patient diagnosed with gastrocnemius partial rupture. The improvement of symptoms was evaluated using Numeric Rating Scale (NRS), Range of Motion (ROM) of ankle, circumference of calf and size of hematoma by using ultrasonography. NRS decreased more than 90%, ROM of ankle joint gradually improved, calf circumference improved, and hematoma reduced by more than 90% when measured by ultrasonography. In this study, gastrocnemius muscle partial rupture was observed with ultrasonography, and it is considered that the Korean medical treatment is useful for gastrocnemius muscle partial rupture.

임상의학 진료, 연구에서의 이해상충

윤영훈 ( Young Hoon Youn ),이일학 ( Il Hak Lee ) 대한소화기학회 2012 대한소화기학회지 Vol.60 No.3

In recent years, medical professionals are in charge with multiple roles. They have to work as an educator, researcher, and administrator, as well as medical practitioner. In addition, they experience a conflict between the primary responsibilities that each role requires of them. A conflict of interest (COI) is a set of circumstances that creates a risk that professional judgment or actions regarding a primary interest will be unduly influenced by a secondary interest. It occurs when an individual or organization is involved in multiple interests, one of which could possibly corrupt the motivation for an act in the other. The COI should be managed appropriately to preserve the value of public trust, scientific objectivity, and the benefit and safety of patients. Primary interest of medical professionals refers to the principal goals of the medical profession, such as the health and safety of patients, and the integrity of research. Secondary interest includes not only financial gain but also such motives as the desire for professional advancement and the wish to do favors for family and friends, but COI rules usually focus on financial relationships because they are relatively more objective, fungible, and quantifiable. This article will briefly review the COI in medical practice and research, discuss about what is COI, why we should manage it, and how we can manage it. (Korean J Gastroenterol 2012;60:149-154)

놓치기 쉬운 위암 진단의 Tip

윤영훈(Young Hoon Youn) 대한임상노인의학회 2012 대한임상노인의학회지 Vol.13 No.3

Zinc Gallate (ZnGa₂O₄)박막 형광체의 합성과 발광특성

김수연,윤영훈,최성철,Kim, Su-Youn,Yun, Young-Hoon,Choi, Sung-Churl 한국세라믹학회 2007 한국세라믹학회지 Vol.44 No.1

Zinc gallate $(ZnGa_2O_4)$ thin film phosphors have been formed on ITO glass substrates by a sol-gel spinning coating method. For the formation of the film phosphors, the starting materials of zinc acetate dihydrate, gallium nitrate hydrate and 2-methoxyethanol as a solution were used. The thin films deposited were firstly dried at $100^{\circ}C$ and fired at $500^{\circ}C\;or\;600^{\circ}C$ for 30 min and then, annealed $500^{\circ}C\;or\;600^{\circ}C$ at for 30 min under an annealing atmosphere of 3% $H_2/Ar$. The thin films deposited on ITO glass plates showed the (220), (222), (400), (422), (511), and (440) peaks of spinel structure as well as the (311) peak indicating a standard powder diffraction pattern. The surface morphologies of the thin film phosphors were observed with a firing and an annealing condition. The $ZnGa_2O_4$ film phosphors showed the blue emission spectra around 410 nm as well as the emission spectra in the UV region (360-380 nm).

구연 / 제 4 회의장 / 간 19 : Stage Iva 의 진행성 간암에서 간동맥내 항암제 주입약제에 따른 치료성적과 예후인자

안상훈(Sang Hoon Ahn),한광협(Kwang Hyub Han),윤영훈(Youn Young Hoon),김진석(Jin Suk Kim),전재윤(Chae Yoon Chon),문영명(Young Myung Moon),이도연(Do Yun Lee),이종태(Jong Tae Lee) 대한소화기학회 1999 대한소화기학회 추계학술대회 Vol.1999 No.-

한국인에서 간암발생의 위험요인 분석

안상훈(Sang Hoon Ahn),한광협(Kwang Hyub Han),윤영훈(Young Hoon Youn),홍성필(Sung Pil Hong),백용한(Yong Han Paik),전재윤(Chae Yoon Chon),문영명(Young Myoung Moon),송기준(Ki Jun Song),김동기(Dong Kee Kim),서일(Il Suh) 대한내과학회 2001 대한내과학회지 Vol.60 No.2

Background : Hepatocellular carcinoma (HCC) is one of the most common neoplasms in the world. Although screening test for HCC has been performed, the high risk factors were not well evaluated in Korea. This study was undertaken to evaluate the risk factors of HCC development in Korea. Methods : We studied a total of 2,020 patients who visited Yonsei University Medical Center for regular check-up including ultrasonography (US) and alpha-fetoprotein (AFP) from January 1990 to December 1998. All the detailed data of clinical parameters were obtained by our self-exploited data base system prospectively and analyzed by SAS program. Results : Among 2,020 subjects, 1295 were male and 725 were female (mean age, M: 47 years, F: 50 years). 117 (5.8%) out of 2,020 subjects developed HCC during follow-up period (33months). Annual detection rate of HCC was 1.64%. The independent risk factors by univariate analysis were liver cirrhosis, chronic hepatitis, hepatitis B virus (HBV) or hepatitis C virus (HCV) infection, old age (over 40 years old), heavy alcoholics, severe liver parencymal echogenic pattern in US, initial level of serum AFP (>20 ng/mL) or alanine aminotransferase (ALT) (>40 IU/L). Multivariate analysis with a proportional hazards model showed liver cirrhosis (p=0.000), chronic hepatitis (p=0.014), HCV infection (p=0.007), HBV infection (p=0.049), and old age over 40 years old (p=0.000) to be significant risk factors for HCC. We also found that the more risk factors, the higher HCC development. The development of HCC might not be related to history of smoking, family history of HCC, previous therapy such as interferon (IFN), diet, drugs, and transfusion. Conclusion : Screening test for early detection of HCC should be reconsidered according to the relative risk rate of these risk factors.(Korean J Med 60:123-130, 2001)

크론병과 유사한 내시경 소견의 거대세포바이러스 대장염

허철웅 ( Cheal Wung Huh ),윤영훈 ( Young Hoon Youn ),정다현 ( Da Hyun Jung ),김도환 ( Do Whan Kim ),고보건 ( Bo Gun Kho ),김지현 ( Jie Hyun Kim ),박효진 ( Hyo Jin Park ),이상인 ( Sang In Lee ) 대한소화기학회 2012 대한소화기학회지 Vol.59 No.4

Cytomegalovirus (CMV) colitis is common among immunocompromised patients, and often diagnosed by pathologic confirmation because it is associated with a diverse spectrum of clinical and endoscopic features. However, Crohn`s disease has no definitive diagnostic criteria, but longitudinal ulcers and cobble stone appearance are accepted as typical endoscopic features of Crohn`s disease. An 83 year-old male with a history of radiotherapy for hypopharyngeal cancer visited our hospital with a complaint of melena for 1 week. His colonoscopic exam showed multiple longitudinal ulcers along the entire colon. Most of the ulcers were longer than 4 cm, these endoscopic findings were suspected as typical endoscopic features of Crohn`s disease. Pathologic reports revealed multiple inclusion bodies with CMV on immunohistochemistry. He was finally diagnosed as having CMV colitis, and received a 3 week-course of intravenous ganciclovir. A colonoscopic follow-up showed complete healing of the multiple longitudinal ulcers, and he is doing well now without further treatment. (Korean J Gastroenterol 2012;59:303-307)

나노결정질 다이아몬드 seeding 효율 향상을 위한 silicon 표면 texturing

박종천,정옥근,김상윤,박세진,윤영훈,조현,Park, Jong Cheon,Jeong, Ok Geun,Kim, Sang Youn,Park, Se Jin,Yun, Young-Hoon,Cho, Hyun 한국결정성장학회 2013 한국결정성장학회지 Vol.23 No.2

나노결정질 다이아몬드 박막 증착을 위한 전처리 공정으로 $SF_6/O_2$ 유도결합 플라즈마를 이용하여 Si 기판 표면을 texturing하였다. $SF_6/O_2$ 플라즈마 texturing은 2~16 범위의 매우 넓은 정규화된 표면 조도 선택성을 제공할 수 있음을 확인하였다. Texturing된 Si 기판 표면의 나노 다이아몬드 입자 seeding 이후 기존 기계적 연마 전처리에 비해 현저히 향상된 ${\sim}6.5{\times}10^{10}cm^{-2}$의 높은 핵형성 밀도를 확보하였다. $SF_6/O_2$ inductively coupled plasmas were employed to texture Si surface as a pretreatment for nanocrystalline diamond film growth. It was found that the $SF_6/O_2$ plasma texturing provided a very wide process window where normalized roughness values in the range of 2~16 could be obtained. Significantly improved nucleation densities of ${\sim}6.5{\times}10^{10}cm^{-2}$ compared to conventional mechanical abrasion were achieved after seeding for the textured Si substrate.

기능성 소화불량증 환자에 대한 서방형 UIC201609/UIC201610 병용요법의 유효성 및 안전성을 비교평가하기 위한 다기관, 무작위배정, 위약대조 임상시험: 예비 보고

이정원 ( Jung Won Lee ),윤영훈 ( Young Hoon Youn ),최석채 ( Suck Chei Choi ),이광재 ( Kwang Jae Lee ),김나영 ( Nayoung Kim ) 대한소화기학회 2021 대한소화기학회지 Vol.77 No.4

목적: 기능성 소화불량증은 상복부 통증, 소화불량과 같은 다양한 상복부 증상을 포괄하는 질환으로서 다양한 병태 생리에서 유래한 다양한 증상의 발현을 찾아볼 수 있는 질환이다. 현재 이에 대해 효과적이면서 순응도가 높은 치료법을 찾기 어려운 상태로, 본 임상시험에서는 기존 기능성 소화불량증 치료의 두 근간인 프로톤펌프억제제인 라베프라졸과 위장관 운동 촉진제인 모사프라이드 서방정 병용요법인 UIC201609 및 UIC201610의 효과 및 안전성을 시험하고자 하였다. 대상 및 방법: 이 연구는 다기관, 이중눈가림, 무작위 배정으로 시행된 연구로 총 30명이 임상시험에 포함되었다. 부작용으로 유효성 평가가 누락된 시험군 1명을 제외한 29명에 대한 결과가 최종 분석되었다. 대조군으로 라베프라졸 10 mg 1일 1회 복용군, 모사프라이드 15 mg 서방정 1일 1회 복용군을 각각 두었으며, 실험군으로 라베프라졸 10 mg 1일 1회 및 모사 프라이드 15 mg 서방정 병용제제인 UIC201609/UIC201610 1일 1회 실험군을 두었다. 연구의 결과변수로 Nepean Dyspepsia Index-Korean 버전의 8가지 항목의 총점 변화량을 투약 시작 2주, 4주 시점에 분석하였고 안전성에 관한 정보를 수집하였다. 결과: 실험군과 대조군 사이의 나이, 성별, 신체계측, 음주 및 흡연에 있어 인구학적인 차이는 관찰되지 않았다. 또한 기능성 소화불량증 아형인 EPS과 PDS 비율에서도 그룹 간 차 이가 관찰되지 않았다. 약물 순응도에서 세 군 모두에서 평균 95% 이상 실험약물 복용이 완료되었다. 이 연구의 1차 유효성 변수인 투약 4주 시점의 증상 점수 변화량에서 모사프라이드 단일군에서 증상 점수(33.4±15.6) 감소, 라베프라졸 단일군(29.4±17.1)에서, 실험군인 UIC201609/UIC201610 병용군(33.4±11.8)에서 감소를 보였으며, 그룹 간 유의미한 자이는 관찰되지 않았다. UIC201609/UIC201610 병용군은 Nepean Dyspepsia Index-Korean의 상복부의 통증 또는, 상복부 쓰림을 호전시키는 비율이 대조군에 비해 높았으나 통계적으로 유의한 변화를 보이지는 못하였다. 안전성 분석에서도 유의미한 차이는 확인되지 않았다. 결론: UIC201609/UIC201610 1일 1회 병용요법에 대한 예비 연구에서 기능성 소화불량증 환자에서 일부 증상의 호전을 보이는 경향이 있으나 유의미한 차이는 없었다. 향후 UIC201609/UIC201610 병용요법의 효능을 확인하기 위한 발전된 설계를 바탕으로 한 추가적인 연구가 필요하다. Background/Aims: Functional dyspepsia is a disease involving a range of upper gastrointestinal symptoms derived from various pathophysiologies. Tablets containing a combination of rabeprazole and controlled-release (CR) mosapride were recently developed. To investigate a more effective treatment, this trial evaluated the efficacy and safety of UIC201609/UIC201610 as a preliminary study. Methods: A multicenter, double-blind, randomized study was performed on 30 subjects. UIC201609/UIC201610 (combination of rabeprazole and CR mosapride) was the case group, and the two control groups were rabeprazole 10 mg once a day and mosapride 15 mg CR tablet once a day. As a primary efficacy endpoint of the study, the changes in the total score of eight items of the Nepean Dyspepsia Index-Korean version were analyzed at 2 weeks and 4 weeks. The outcomes regarding safety were collected. Results: The total symptom score of Nepean Dyspepsia Index-Korean decreased in the rabeprazole single group (29.4±17.1), mosapride CR single group (33.4±15.6), and UIC201609/UIC201610 group (33.4±11.8) at 4 weeks without significant differences. On the other hand, the UIC201609/UIC201610 combination group showed more score reduction of pain in the upper abdomen, burning in the upper abdomen compared to each control group, but it did not reach statistical significance. No difference was found in safety analysis. Conclusions: UIC201609/UIC201610 once daily showed some improvement in epigastric pain and dyspepsia in patients with functional dyspepsia, but there was no significance. Further study based on the advanced clinical trial design will be needed to confirm the efficacy of UIC201609/UIC201610 combination therapy in the future. (Korean J Gastroenterol 2021;77:171-178)

두침을 중심으로 시행한 외사시 환자 한의복합치료 치험 1례

김혜민 ( Hye Min Kim ),윤영훈 ( Young Hoon Youn ),김재수 ( Jae Soo Kim ),이현종 ( Hyun Jong Lee ),임성철 ( Sung Chul Lim ),이윤규 ( Yun Kyu Lee ) 경락경혈학회 2023 Korean Journal of Acupuncture Vol.40 No.1

Strabismus is a vision disorder in which the eyes do not properly align with each other when looking at an object and it can negatively affect the quality of life. This case is a report on a strabismus patient who received Korean medicine treatment including scalp acupuncture. Scalp acupuncture, body acupuncture, and herbal medicine were performed on a patient diagnosed with strabismus and diplopia. The improvement of symptoms was evaluated by the Numeric Rating Scale (NRS), Scott and Kraft Score (SK score), and change of symptoms and progress of diplopia. NRS decreased by more than 85%, and the SK score gradually changed from -4 to 0, which means strabismus mostly recovered, and the symptom and progress of diplopia were reduced. In this study, it is considered that Korean medical treatment including scalp acupuncture is useful for strabismus patients.