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      • KCI등재

        한국인 조기난소부전 여성의 배란양상

        김혜민,김재령,최은주,박은주,홍서유,이진용,박원일,Kim, Hye-Min,Kim, Jae-Ryoung,Choi, Eun-Joo,Park, Eun-Joo,Hong, Seo-Yu,Lee, Jin-Yong,Park, Won-Il 대한생식의학회 2008 Clinical and Experimental Reproductive Medicine Vol.35 No.3

        Objective: Significant portion of premature ovarian failure patients ovulate intermittently and even can achieve pregnancy. The clinical features and reproductive potentials of Korean women with premature ovarian failure have never been elucidated. The purpose of this study is to assess ovarian follicular growth and ovulatory potential. Methods: Complete medical records of fifteen women with idiopathic premature ovarian failure were reviewed retrospectively. Subjects with more than 6 ultrasonographic scans and 36 months of follow-up period were included. Once the ovarian follicle was found by ultrasonography, the follicular growth was serially monitored. The result of ovulation induction of 6 cycles in 4 patients were also evaluated. Rate of positive ovarian follicle by ultrasound, rate of natural follicular growth and response of ovulation induction were assessed. Results: Among the 15 patients, 6 women (40%) had ovarian follicle in random ultrasonography. But the chance of positive follicle per ultrasonography scan was 7% (8 out of 115 scans). One out of 6 women eventually ovulated during the follow-up scan. In remaining 5 subjects, size of follicles remained unchanged. None of 6 ovulation induction cycles resulted successful ovulation. Conclusion: Incidence of positive ovarian follicle in Korean premature ovarian failure patients is lower than that of Western counterpart. This result, however, could not be directly compared because of the differences of study design. The ovulation rate by medical ovulation induction in this group is 0%, which is worse than the reported success rate of Western studies. 목 적: 조기난소부전 환자의 10$\sim$20%에서 난소기능이 회복될 수 있다고 하며 간헐적으로 배란이 되고 심지어는 임신이 가능할 수 있다는 보고가 있다. 그러나 한국의 조기난소부전 여성의 임상적 특징과 배란가능성은 논의된 적이 없다. 이 연구의 목적은 한국인 조기난소부전 환자에서 자연 난포의 발생 빈도와 배란유도의 가능성을 평가하는 것이다. 연구방법: 특발성 조기난소부전으로 진단된 15명 여성의 전체 진료기록을 후향적으로 연구하였다. 환자별로 6번 이상의 초음파 검사를 시행하였고 36개월 이상의 기간 동안 추적관찰을 하였다. 또한 4명의 환자에서 6주기의 배란유도시도를 하였다. 조사항목은 초음파 검사에서 난포의 발견율, 자연 난포 성장률과 배란유도를 시행한 경우에 그 반응을 평가하여 결과를 분석하였다. 결 과: 15명 중 6명은 초음파상 난포가 발견되었나 (40%) 초음파 검사 당 난포 발견 빈도는 7%였다 (115회 중 8회). 6명 중 한 명은 초음파 추적관찰 상 배란이 확인되었고 나머지 5명은 크기에 변화가 없었다. 배란유도를 시도한 6명 중 성공적인 난포 성장이 관찰된 예는 없었다. 결 론: 한국인 조기난소부전 환자에서 난포의 발견율은 이전 서양 연구에 비하여 낮다고 생각되지만 관찰 방법에 차이가 있어 직접비교는 불가능하다. 배란유도의 성공율은 0%로서 이전 연구에서 발표된 수준보다 낮았다.

      • KCI등재

        불안장애의 치료추구시간에 대한 공존 정신질환의 영향 : 사회불안장애와 공황장애 간 비교

        김혜민,하주원,임세원,오강섭,Kim, Hye-Min,Ha, Juwon,Lim, Se-Won,Oh, Kang-Seob 대한불안의학회 2012 대한불안의학회지 Vol.8 No.2

        Objective : Individuals with anxiety disorders experience a wide range of time to seeking treatment (TST) as well as various comorbid mental disorders. The present study examined the TST in social anxiety disorder (SAD) and panic disorder. This study aimed to find out the influence of comorbid mental disorder on TST of anxiety disorder through the comparison of SAD and panic disorder. Methods : This study included 311 SAD and 378 panic disorder patients at the initial visit of psychiatric clinic. Contribution of clinical (number of comorbidity, comorbid type and onset age) and demographic (current age) factors to TST were investigated by multivariate analysis. Results : The median length of TST was 14.03 years in SAD and 2.26 years in panic disorder. In social anxiety disorder, fewer comorbidity, younger onset age, and older age were factors associated with delayed TST. In panic disorder, only younger onset age was associated with delayed TST. In both disorders, comorbid depressive disorder was associated with shorter TST. Conclusion : Our data provided the differences in illness behavior needing help based on comorbid mental disorders between SAD and panic disorder. In addition to comorbid disorder, factors affecting TST of anxiety disorder requires future investigation.

      • KCI등재

        분자동역학법에 의한 기액계면 분자의 운동특성에 관한 고찰

        김혜민,박권하,최현규,최순호,Kim Hye-Min,Park Kweon-Ha,Choi Hyun-Kue,Choi Soon-Ho 한국마린엔지니어링학회 2005 한국마린엔지니어링학회지 Vol.29 No.1

        An experimental study of molecular motions on a liquid-vapor interface is limited due to micro-scale characteristics of a system with an angstrom or a nanometer size Therefore, in recent, many studies for micro-scale systems have been conducted by a computer simulation because it is free from experimental limitations. In this study, through the molecular dynamic (MD) method. molecular behavior was clarified on a liquid-vapor interface and a criterion to distinguish between liquid and vapor was suggested by a potential energy and the number of neighboring molecules. At an interface. the potential energy of a molecule was increased but the number of neighboring molecules was decreased when the molecule moved into a vapor region from a liquid region, and vice versa.

      • KCI등재후보

        Lignan contents in Acanthopanax senticosus by HPLC

        김혜민,조선행,국순자,이상현,Kim, Hye-Min,Cho, Seon-Haeng,Kook, Soon-Ja,Lee, Sang-Hyun Institute of Agricultural Science 2011 Korean Journal of Agricultural Science Vol.38 No.3

        A reverse-phase system of HPLC using a linear gradient of acetonitrile and deionized water was developed for the quantification lignans, eleutherosides B and E, in Acanthopanax senticosus. The HPLC system consisted of linear gradient of acetonitrile and deionized water, and UV/VIS detection was set at 210 nm. Both eleutherosides B and E contents in different parts of A. senticosus were determined. As a result, the contents of eleutherosides B and E were measured in the leaves (trace amounts and 0.029 mg/g, respectively), stems (0.107 and 1.015 mg/g, respectively), roots (0.026 and 0.390 mg/g, respectively), and fruits (0.022 and 0.043 mg/g, respectively). Moreover, eleutherosides B and E in the water extract were found 0.011 and 0.171 mg/g, respectively.

      • KCI등재후보

        Aldose reductase inhibitory activity of the methanol extracts from Korean folk plants

        김혜민,한샘,최경,구자정,박광우,조은주,이상현,Kim, Hye-Min,Han, Saem,Choi, Kyung,Ku, Ja-Jung,Park, Kwang-Woo,Cho, Eun-Ju,Lee, Sang-Hyun Institute of Agricultural Science 2012 Korean Journal of Agricultural Science Vol.39 No.2

        To search for the aldose reductase (AR) inhibitors from Korean folk plants, the inhibition of rat lens AR in vitro using the methanol (MeOH) extracts from Korean folk plants was investigated. Among fifty four Korean folk plants tested, the MeOH extract of Cedrela sinensis showed highest inhibition of AR ($IC_{50}$ value, 2.52 ${\mu}g/ml$). The plant C. sinensis has a possibility of new natural resources for the development of AR inhibitor for the prevention of diabetic complications.

      • KCI등재후보

        하악 편악 수술 교정 치료: 술후 하악골의 전상방 회전 재발을 고려한 3차원 수술 시뮬레이션의 활용

        김혜민(Hye-Min Kim),임성훈(Sung-Hoon Lim),오지수(Ji-Su Oh),정서린(Seo-Rin Jeong),강신구(Shin-Gu Kang) 대한치과교정학회 2022 대한치과교정학회 임상저널 Vol.12 No.1

        '스콜라' 이용 시 소속기관이 구독 중이 아닌 경우, 오후 4시부터 익일 오전 9시까지 원문보기가 가능합니다.

        Isolated mandibular setback along the occlusal plane inevitably causes the development of the vertical bony step (VBS) between the mesial and distal segments of the mandible due to the angular difference between the occlusal plane and mandibular plane. Because the development of VBS causes postsurgical counterclockwise rotation of the mandible, simulation of this counterclockwise rotation should be incorporated into the simulation of surgery and the determination of surgical occlusion. In this case report, a 27-year-old female was treated to correct mandibular prognathism with asymmetry. During presurgical orthodontic treatment, maxillary molars were intruded to reduce the development of VBS during the isolated mandibular setback surgery. Despite this presurgical molar intrusion, 5.6 mm VBS was still developed at the 3D surgical simulation of single jaw surgery. Ideal jaw position was simulated, reducing this VBS to 2.1 mm, resulting in vertical overlaps of molars. To resolve these vertical overlaps or premature contacts, the distal segment was rotated 3.2° clockwise along the hinge axis. This simulation resulted in a surgical occlusion similar to a Class II open bite. During postsurgical orthodontic treatment, the mandible rotated 5.8° counterclockwise with the center of rotation 13 mm inferior to the hinge axis, resolving the VBS almost completely. This was slightly more than the anticipated amount of postsurgical rotation of the mandible. This case report showed that the isolated mandibular setback surgery can be done more predictably by incorporating the postsurgical counterclockwise rotation of the mandible into the simulation of surgery.

      • CFD 해석을 이용한 Multi Inner Stage Cyclone 내부의 미세입자제거 효율 예측 및 실험적 검증

        김혜민(Hye-Min Kim),권성안(Sung-An Kwon),이상준(Sang-Jun Lee) 한국컴퓨터정보학회 2012 한국컴퓨터정보학회 학술발표논문집 Vol.20 No.2

        A new multi inner stage(MIS) cyclone was designed to remove the acidic gas and minute particles of harmful materials produced from electronic industry. To characterize gas flow in MIS cyclone, pressure and velocity distribution were calculated by means of computational fluid dynamics(CFD) commercial program. Also, the flow locus of particles and particle removal efficiency were analyzed by Lagrangian method. When outlet pressure condition was -1,000 Pa, the efficiency was the best in this study. Based on the CFD simulation result, the pressure loss and destruction removal efficiency was measured through MIS cyclone experiment.

      • KCI등재

        생활무용 참가자의 재미요인이 몰입경헝 및 중독현상에 미치는 영향

        김혜민(Kim Hye-Min),전병관(Chun, Byung-Kwyan),한혜원(Han, Hea-Won) 한국체육과학회 2012 한국체육과학회지 Vol.21 No.6

        This study aims to find out the effects of sensation seeking of leisure dance participants on dance commitment and addiction to dance. Using a purposive sampling method and the questionnaire based on previous study, 20 years old or over and attend them at least once a week periodically in Seoul and Gyeonggi province. The method of the statistical analysis used in this study were t-test, one-way ANOVA, conclusion analysis and regression analysis. As a result of these data analysis, the conclusion of this study were as follows. : First, there are differences depending on some demographic characteristics for the three dependent variables: sensation elements, commitment experience, and addiction phenomenon. Second, sensation elements are found to have some effects on commitment experiences. Third, sensation elements are found to have some effects on addiction phenomenon. Forth, commitment experiences are found to have effects on addiction phenomena.

      • KCI등재

        동절기 수박 접목묘의 안정적 생산을 위한 나노탄소섬유적외선 램프의 난방효과에 대한 적정 설치간격

        김혜민(Hye Min Kim),정현우(Hyeon Woo Jeong),황희성(Hee Sung Hwang),황승재(Seung Jae Hwang) (사)한국생물환경조절학회 2022 시설원예‧식물공장 Vol.31 No.1

        본 연구는 동절기 공정육묘장의 수박 플러그 묘 생산 시, 난방 에너지 절감에 유리한 난방장치인 나노탄소섬유 적외선 난방등의 효율적인 사용을 위한 적정 전력과 설치 간격을 구명하기 위해 수행되었다. 유리온실 내 소형 베드 6개를 플라스틱 필름으로 구획을 나누었으며, 100cm 높이에 700W와 900W 난방등을 설치하였다. 난방등은 설치 간격을 각각 중앙 1개(Control), 60cm 간격(2개), 40cm 간격(3개)으로 설치하였다. 나노탄소섬유 적외선 난방등을 점등한 후 대조구를 제외한 모든 처리에서 설정한 야간 기온(20℃)을 유지하였다. 엽온은 난방등 설치 간격이 좁을수록 빨리 상승하는 경향을 보였다. 나노탄소섬유 적외선 난방등을 사용함에 따른 처리구간 수박 접목묘의 생육에는 뚜렷한 차이가 없었으나, 엽장과 엽폭은 700W 난방등에서 설치 간격이 짧을수록 길어지는 경향을 보였으며, 700W 난방등을 40cm 간격으로 설치하였을 때 묘의 충실도가 높은 값을 나타내는 것을 확인할 수 있었다. 따라서 야간 기온 유지와 묘의 충실도를 고려하였을 때, 700W 난방등을 40cm 간격으로 설치하는 것이 수박 접목묘를 생산하는데 경제성을 고려하여 효율적인 나노탄소섬유 적외선 난방등의 전력과 설치 간격으로 판단된다. This study was carried out to investigate the proper wattage and installation distance for the efficient use of nano-carbon fiber infrared heating lamp (NCFIHL), a heating device advantageous for heating energy saving, when the production of watermelon plug seedlings in the plug seedling nursery in winter season. Six small beds were divided into plastic film, and 700 W and 900 W nano-carbon fiber infrared heating lamps were installed at 100 cm above the bed. 1 lamp at central (control), 60 cm interval (2 lamps), and 40 cm interval (3 lamps) heating lamps were installed in each bed inside the greenhouse. All treatments, except the control, were set to keep the night air temperature at 20℃ after lighting the NCFIHL. The leaf temperature showed a tendency to increase fast as the install distance was narrow. The leaf length and leaf width tended to increase as the installation distance of the 700 W heating lamp was narrow. The compactness was high in 700 W heating lamp with 40 cm of installation distance. Therefore, in consideration of maintaining the set temperature at night, installing 700 W electric lamps at 40 cm was an efficient power and installation distance for watermelon grafted seedlings considering economic feasibility.

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