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오홍근,한홍무 中央醫學社 1976 中央醫學 Vol.31 No.5
In order to assess that insulin injection can prevent or decrease deglycogenation after portacaval transposition in the rat liver. Lewis and Sprague Dawley rats, weighing 240 to 410gm were used for portacaval transposition and 70%, hepatectomy, and for both. Daily injection of insulin, Lente zinc suspension, was done with 10 units per kg of body eight for portacaval transposion group, and 5 units for hepatectomized rats, respectively. Hepatic glycogen, DNA, and protein contents were analyzed in the each experimental group. According to the results as shown in Table I and II, the following conclusion was made. 1. Even in normal rat, the insulin injection of such doses produced remarkable hepatic deglycogenation during 17 days. 2. Deglycogenation after portacaval transposition was prominent, which could not be prevented with insulin injection, and surprisingly became more severe after insulin injection. The portacaval transplantation group was followed up to postoperative 263 days. 3. Portacaval transposition suggests clinical applicability for glycogen storage disease. 4. The reason for the profound glycogen depletion with insulin injection should be investigated.
오홍근,김철원 한국전자통신학회 2019 한국전자통신학회 논문지 Vol.14 No.2
최근 정부의 에너지 정책에 힘입어 ESS 설비가 증가하고 있으나 더불어 화재·폭발등 다양한 사건사고가 발생하고 있으나 기존 ESS는 PMS 포함하여 모든 시스템이 현장에 설치되어있는 통합형 ESS로 구축되어 있어 사고 발생 시 산화되어 데이터의 부재 가능성이 매우 높을뿐만아니라 외부에 존재하는 관리자가 사고 발생시 신속하게 대응할 수 있는 방법 없는 상황이다. 이에 본 논문에서는 별도의 WAS 및 데이터 스토리지 구축을 통해 기존 시스템에서의 주요 기능을 분리하여 외부에서 EMS 운용이 가능함과 동시에 사고 발생시 원인 및 신속한 대응이 가능한 독립형 PMS 개발을 제안하고자 한다. Recently, ESS facilities have been increased under the government's energy policy, but in addition, various accident incidents such as fire and explosion occurred, but existing ESS, all systems including PMS are on site It is built in integrated ESS installed in the accident, it is oxidized at the occurrence of the accident, not only the absence of data is extremely high, but also the administrator existing outside can respond promptly when accident occurs There is no situation. Therefore, in this paper, by constructing a separate WAS and data storage, it is possible to separate the main functions of the conventional system, to enable external EMS operation, and at the same time to quickly respond to the cause and cause of the accident occurrence We will propose the development of a standalone PMS that is possible.
오홍근,김수희,박종성,김용준 한국임상수의학회 2009 한국임상수의학회지 Vol.26 No.6
An orchiopexy was performed in an 18-month old adult English bulldog with bilateral cryptorchidism. One month postoperatively, the dog was twice-treated with GnRH (50 ug/kg) at an interval of 2 weeks. Semen was collected and evaluated before and after surgery. Fertility was determined by artificial insemination. No spermatozoa were observed before orchiopexy and 2 months postoperatively. However, 6 live sperm were detected 4 months postoperatively and normal sperm characteristics (except sperm concentration) were present 7 months postoperatively. A female bulldog, inseminated with the semen from the bulldog 8 months postoperatively, delivered 6 offsprings. Spermatogenesis and spermatozoa with fertilizing capacity were recovered by postpubertal orchiopexy and GnRH therapy in a bilateral cryptorchid dog.
도라지 추출물 연양갱이 β-amyloid에 의한 세포독성 및 Scopolamine에 의해 유도된 인지능 저하 동물 모델의 개선효과
오홍근,김정훈,신은혜,강영례,이봉근,박상훈,문대인,권이성,김영필,최민휴,김옥진,박광현,이학용 한국자원식물학회 2013 한국자원식물학회지 Vol.26 No.4
The aim of this study was to examine improving effect of Platycodon extracts (PE) and/or Platycodon extracts jelly (PEJ) on cognitive impairment in vitro and in vivo. PC12 (Pheochromocytoma) cells were pretreated with PE for 1hr and than incubated with 50 μM amyloid β (Aβ)25-35 for additional 48hr. Cell viability was assessed by WST-1. Animals for Morris water test and passive avoidance test were divided into normal, control and two Platycodon extracts treated groups that were named Normal (n=7), Control (0 mg/kg, n=7), PE (300 mg/kg, n=7), PEJ (10 g/kg, n=7). Cognitive impairment was induced by scopolamine (1 mg/kg/body weight, i.p.) in the three experimental groups but not the normal group. Pretretment of PE (0.01-1 mg/mL) were not induced cytotoxicity but observed in high dose-treated group (5 and 10 mg/mL)in PC12 cells. Protective effects of PE against Aβ-induced cytotoxicity were increased in dose dependent manner in PC12cells. Administration of PE and PEJ were significantly reduced escape latency time on Morris water maze test and passive avoidance test in copolamine-induced cognitive impairment animal model. These results suggest that Platycodon extracts and its related product available to ameliorative purpose for cognitive ability impairments. 본 연구에서는 도라지 추출물에 대한 세포 독성을 확인하였으며, Aβ에 의한 PC12 세포 독성에 대한 보호효과를관찰하였다. 또한 도라지 추출물과 도라지 추출물 연양갱을 4주간 강제 경구 투여하여 Morris 수중미로시험에서 도달지점까지의 도달시간이 도라지 추출물 및 도라지 추출물연양갱 투여에 의해서 모두에서 유의하게 감소하였다. 이와 유사하게 수동회피시험에서도 자극이 있는 어두운 방을나오는 시간이 도라지 추출물 및 도라지 추출물 연양갱 투여에 의해서 현저하게 감소하였다. 따라서 도라지 추출물및 도라지 추출물 연양갱은 인지능 개선에 도움을 줄 것으로 생각된다.