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각종 간질환 환자에서 HPLC 를 이용한 요중 Neopterin 치의 임상적 의의
심대석(Dae Seok Shim),이옥재(Ok Jae Lee),김영채(Young Chai Kim),하우송(Woo Song Ha),박순태(Soon Tae Park) 대한내과학회 1996 대한내과학회지 Vol.51 No.5
Objectives: In vivo, increased level of urinary neopterin was demonstrated in patients with viral, bacterial infection, autoimmune disease, malignancy, cellular graft rejection in transplantation, and AIDS. Increased serum and urinary neopterin levels have been observed in patients with acute hepatitis, chronic hepatitis, and liver cirrhosis. The aim of this study is to evaluate the clinical significance of urinary neopterin in patients with various liver diseases. Methods: Urinary levels of neopterin were measured by HPLC (High Performance Liquid Chromatography) in 66 patients with various liver disease and 12 healthy controls. Results: 1) Urinary neopterin level increased significantly in AH (1217.82±380.97 μmol/mol creatinine), CPH (263.15±70.48 μmol/mol Cr), CAH (307.93±100.65 μmol/mol Cr), LC (276.67±66.67 μmol/mol Cr), HCC (1003.83±289.06 μmol/mol Cr) than control group (136.63±59.05 μmol/mol Cr) (p<0.001). However, urinary neopterin level in ASC or ALD was not significantly different from control group. 2) In AH, urinary neopterin levels significantly correlated with serum AST (r=0.840, p<0.025) and ALT (r=0.817, p<0.025) level. However, in chronic liver disease, there was no correlation between neopterin levels and liver function tests in chronic liver diseases. 3) According to Pugh`s classification, there was no significant differences between three groups, but urinary neopterin levels increased significantly in HCC than LC (p<0.001). Conclusions: Our data suggest that urinary neopterin level reflects cell mediated immunity and may be useful marker to predict the clinical course of the various chronic liver diseases.
심대석(Dae Seok Shin),원용환(Yong Hwan Won),김건호(Kuen Ho Kim),이옥재(Ok Jae Lee),김명희(Myeong Hee Kim),류경렬(Kyung Ryeol Ryu),황일용(Il Yong Hwang),안인옥(In Oak Ahn),지혜기(Hye Gee Jee) 대한내과학회 1994 대한내과학회지 Vol.47 No.1
We report a case of renal papillary necrosis which has recurrent urinary tract infections, partial unilateral ureteral obstruction, and the classic cavity pattern by I.V.P.. Renal papillary necrosis is defined as an ischemic necrosis involving the renal medulla which, in the absence of localizing obstructive or vascular factors, is generally bilateral and most often is associated with infections of the urinary tract. The clinical course is characterized by lumbar pain, hematuria, pyuria, bacteriuria, and sepsis; occasionally also by the passage of whole renal papillae or sections there of in the urine. The diagnosis can sometimes be made by finding pieces of renal medullary tissue in the urinary sediment. Pyelography may demonstrate cavities and sinuses in the region of the papillae. The classic ring-shadow pattern results from detachment of a papilla and its outline within the contraet-filled cavity.
고인습성 약물인 피리도스티그민의 마이크로캅셀화에 의한 분체 특성의 개선
김대석,김인화,정석재,심창구 한국약제학회 2002 Journal of Pharmaceutical Investigation Vol.32 No.1
The purpose of this study is to microencapsulate a highly hygroscopic drug, pyridostigmine bromide (PB), with a waterproof wall material, in order to increase the flowability of the drug particles. Polyvinylacetaldiethylaminoacetate (AEA), Eugragit E and Eugragit RS were examined as the wall materials. Microcapsules containing PB were prepared by the evaporation technique in an acetone/liquid paraffin system using aluminum tristearate as a core material, and evaluated for drug encapsulation efficiency, surface morphology, particle size and drug dissolution. The encapsulation of PB in the wall material was almost complete. Among the wall materials examined, AEA exhibited the most excellency in shape, surface texture, flowability, size distribution of microcapsules. Above results suggest that AEA would be a potential wall material for microcapsulation of highly hygroscopic drugs, such as PB. Through microencapsulation with AEA, inconvenience of handling of PB powders encountered in the process of weighing and packing the powders to tableting die or capsule body could be greatly improved.
신기능 장애를 동반한 Hereditary Coproporphyria 1예
김정렬,김호철,김성욱,황일용,심대석,함종렬,강재황,정판준,이근홍 대한신장학회 1993 Kidney Research and Clinical Practice Vol.12 No.4
We report a case of hereditary coproporphyria with renal insufficiency in a 20 years old girl who had frequent abdominal pain. The typical clinical and biochemical findings of hepatic porphyria represent the hereditary coproporphyria, most likely. Her symptoms and signs were clearly exacerbated in a relation to the menstrual cycle. During admission, serum creatinine changed up to 3 8 mg/dl. Until 35 days after discharge, she was found to have persistently elevated serum creatinine concentration. On the renal biopsy, there was chronic Tubulo-Interstitial Nephritis, which presented with focal and mild degree interstitial edema, chronic inflammatory cells infiltrtion, and vacuolization of tubular cells. Possible etiologic factors including porphyria or its precursor itself for the renal insufficiency of this patient (HCP) should be discussed.