베트남인 분변 및 김치로부터 분리된 유산균의 프로바이오틱스 기능성 연구신현수1․유성호1․

신현수,유성호,장진아,원지영,김철현 한국낙농식품응용생물학회 2017 Journal of Dairy Science and Biotechnology (JMSB) Vol.35 No.4

The purpose of this study was to investigate the probiotic properties and antioxidant capacity of lactic acid bacteria isolated from Vietnamese feces and the Korean traditional food kimchi. Six isolated strains were identified as Lactobacillus sp. by 16S rRNA sequencing. All strains showed good resistance to low pH (1.5, 2.0, and 3.0) and 0.3% oxgall bile acids. Culture filtrates from the six strains showed various antioxidant effects, including DPPH, ABTS, reducing power, and metal chelating (Fe2+) activities. Two of the six Lactobacillus strains showed potential probiotic activity. Heat resistance and adhesion assays were conducted by mixing the selected strains, Lactobacillus acidophilus V4, Lactobacillus plantarum V7, and Lactobacillus paracasei DK121 isolated from kimchi. The results showed that the heat resistance of these strains was similar to that of a commercial strain, L. plantarum LP. In addition, a mucin attachment assay using the mixture of selected strains (V4, V7, and DK121) showed high binding activity to the mucous layer. In conclusion, a mixture of V4, V7, and DK121 shows promising probiotic activity and may be useful for the development of health-related products.

다시 민주주의를 생각하다

신현수 한국인문사회과학회 2016 현상과 인식 Vol.40 No.1,2

Treatment Result in Advanced T3 and T4 Glottic Carcinoma: YUMC Experience

신현수,이형식,정은지,김귀언,노준규,서창옥,김광문,홍원표,Shin Hyun Soo,Lee Hyung Sik,Chung Eun Ji,Kim Gwi Eon,Loh Juhn Kyu,Suh Chcng Ok,Kim Kwang Hoon,Hong Won Pyo The Korean Society for Radiation Oncology 1991 Radiation Oncology Journal Vol.9 No.2

1980년 1월부터 1988년 9월사이에 연세대학병원, 연세암센터 치료방사선과 및 이비인후과에서 치료받았던 68예의 T3, T4병기의 성문암 환자를 대상으로 후향적분석을 하였다. 이 중 34명은 방사선 치료 단독으로 치료하였고 34명은 성문절제술후 방사선치료를 하였으며 이들 환자의 최소 추적기간은 2년이었고 54명 $(79\%)$에서 5년 추적조사가 가능하였다. 치료후 국소관해율은 방사선치료 단독군에서는 $51\%$, 수술 및 수술후 방사선치료군에서는 $79\%$이었고 임파절 음성군에서는$72\%,\;76\%$였으며 임파절 양성군에서는$31\%,\;81\%$이었다. 이들의 치료실패요인은 대부분 국소 국한적 이었고 30명 $(44\%)$에서 관찰되었다. 치료에 따른 5년 생존율은 방사선치료 단독군에서는 $37\%$, 수술 및 수술후 방사선치료군에서는 $76\%$로서 T3, T5병기의 성문암환자에 있어서 수술시 행후 방사선치료를 병용하는 복합요법 이 더 좋은 치료결과를 얻을 수 있음을 알았다. 그러나 임파절 음성군에서는 방사선치료 단독군과 수술 및 수술 후 방사선치료군을 비교해 본 결과 5년 생존율이 $55\%$와 $73\%$로 통계학적으로 유의한 차이를 보이지는 않았다. 따라서 본 저자들은 T3, T4병기의 성문암치료시 수술 및 방사선치료 병용요법이 더 좋은 치료결과 를 얻을 수 있지만 임파절 음성군에서는 기능적인 보존측면에서 방사선치료가 일차적 차료방법으로서 효과적이리라 사료된다. Between January 1980 and September 1988,08 patients with advanced T3 & T4 glottic carcinoma were treated with RT and surgery/RT in the Department of Radiation Oncology, Yonsei Cancer Center and ENT, Yonsei University College of Medicine. The mean age was 60 years old (range 33 to 79 years old). The 34 patients were treated with irradiation alone, and the remaining 34 patients with surgery and irradiation. Initial nodal presentation was $37\% (25/68);\;31\%$ (l1/34) in RT alone group and $41\%$ (14/34) in combined treatment group. The minimum follow-up was 2 years. The local control rate after treatment was $47\%$ in RT alone group and $65\%$ in combined treatment group; $57\%$ for node negative and $27\%$ for node positive patients treated with RT alone; $65\%$ for node negative and $54\%$ for node positive patients treated with combined treatment. The treatment failure was observed in 30 patients; 14 patients for primary local failure, 6 patients for regional nodal failure,5 patients for local and regional failure, 26 patients for primary failure and/or distant metastasis, and 2 patient for regional failure and/or distant metastasis. The overall 5-year suwival rate was $57\%;\;37\%$ in RT alone group and $70\%$ in combined treatment group; $55\%$ for node negative and $20\%$ for node positive patients treated with RT alone; $73\%$ for node negative and $77\%$ for node positive patients treated with combined treatment. In conclusion, the combined treatment groups in the treatment of advanced 73 and 74 glottic cancer showed the better results in local control rates and S-year actuarial survival rates than RT alone group. We suggest that total laryngectomy and postoperative RT in the most patients of advanced glottic cancer were performed. However, in cases of node negative patints, RT alone is prefer as a treatment modality over combined surgery and RT since the treatment results were comparable and furthermore functional preservation could be achieved.

Silicoating이 수지접합 수복물의 결합력에 미치는 영향에 관한 실험적 연구

신현수,한동후,이근우,Shin, Hyeon-Soo,Han, Dong-Hu,Lee, Keun-Woo,Lee, Ho-Yong 대한치과보철학회 1989 대한치과보철학회지 Vol.27 No.2

This study investigated the effects of Silicoating procedure on the tensile bond strength of resin-bonded prostheses. The Rexillium III specimens were treated with electrochemical etching and Silicoating procedure, followed by thermocycling and the NNB, Pors-on 4, and Degudent-U specimens were treated with Silicoating procedure. The specimens were debonded in tension with a Tensilon machine. Also, all specimens were observed with SEM, concentration of Si elements was analyzed with EPMA, and the mode of failure was recorded. The results of this study were obtained as follows: 1. In the Rexillium III specimens, the tensile bond strength of the Silicoated specimens was higher than that of the electrochemically etched specimens, and significant differences were observed (P<0.05). 2. The tensile bond strength of electrochemically etched Rexillium III specimens, significant differences were observed between the thermocycled and nonthermocycled specimens (P<0.05), but no significant differences were observed in the Silicoated specimens (P>0.05). 3. The tensile bond strength of the Silicoated specimens decreased NNB, Pors-on 4, Rexillium III, and Degudent-U in that order named. 4. Unlike the electrochemically etched specimens, the Silicoated specimens showed gap-free metal-resin interfaces with SEM. 5. Compared to the electrochemically etched specimens, the Silicoated specimens showed higher concentration of Si elements at the metal-resin interfaces and resin cement. 6. Photographic evaluation (X2) of the fractured sites revealed mainly cohesive failures with the Silicoated specimens, and adhesive failures with the electrochemically etched specimens.

RNA합성장애로 인한 간세포 상해에 대하여

신현수,손태중 慶北大學校 醫科大學 1974 慶北醫大誌 Vol.15 No.1

잡종 숫컷 흰쥐 20마리에 ethionine단독, actinomycin D단독 혹은 ethionine 투여 후 actinomycin D를 투여하고 간세포의 형태적 변화를 관찰한 바를 요약하면 다음과 같다. Ethionine의 투여하면 간세포에는 rER의 확장, sER의 증식 및 확장, ribosome의 rER막으로 부터의 탈락, ribosome의 변성 및 감소, mitochondria의 종창 및 cristae의 소실, 등 세포내 소기관에 주된 변화를 야기하였으며, 심히 변성한 세포에서는 핵이 그 변연의 붙규칙 및 핵질의 응집등의 변화를 나타내는 것도 있었으나 그 정도는 경미하였다. Actinomycin D를 투여하면 세포질 내에는 sER의 심한 증식, ribosome의 탈락 및 변성, rER의 심한 감소, mitochondria의 종창 및 cristae의 소실등 세포질 소기관의 변성 변화에 수반하여,핵의 농축, 핵소체의 분획 및 변성, 핵질의 균일화등 핵의 변화도 뚜렷하였다. Ethionine과 actinomycin D 모두를 투여한 군에 있어서는 상기한 변화들이 더욱 저명하였으며, 여기에 더하여 Golgi complex의 증식 및 큰 lipid droplet의 출현등의 변화도 관찰되었다. 이상의 실험성적으로 보아 ethionine은 핵보다 세포질내 소기관에, actinomycin D는 핵에 일차적으로 작용하며, 이들이 야기한 세포질내 소기관의 형태적인 변화에는 본질적으로 뚜렷한 차이가 없다. Actinomycin D에 의한 핵소체의 분획은 핵소체의 기능적 장애를 시사하는 소견으로 생각되며 세포내 소기관의 변화는 단백합성장애로 인한 효소계의 장애가 주된 영향을 미친 것으로 생각된다. This study was carried out to investigate the ultrastructural changes of rat liver cells induced by administration of a protein synthesis reducing agent, either ethionine or actinomycin D alone, or pretreatment with ethionine followed by actinomycin D. The results were as follow: Ethionine induced main effects on the cytoplasmic organelles such as dilatation of rER, proliferatoin and dilatation of rER, proliferation and dilatation on sER, detachment of ribosome from the rER membrane, degeneration and loss of ribosome, and swelling and loss of cristae of mitochondria. Severely damaged cells showed mild degree of nuclear changes such as irregularity of nuclear magin and condensation of chromatin. Actinomycin D induced main effects on the nucleolus, such as segregation of nucleolar substances into fibrillar and granular components and degenerative changes. Cytoplasmic organelles shows marked increase of sER with marked decrease of rER, shedding and loss of ribosome, and loss of cristae of mitochondria. Both ethionine and actinomycin D treated group showed more marked changes of cytoplasmic organelles and nucleolus. The results suggest that ethionine primarily effects on the cytoplasmi corganelles but actinomycin D primarily effects on the nucleolus. The changes of cytoplatmic organelles are not greatly different between two drugs. The nucleolar changes induced by actinomycin D may reflect deranged function of nucleolus and the degenerative changes of cytoplasmic organelles may be induced by deranged function of enzyme system of the cells.

방과후 아동지도 정책

신현수 한국아동학회 1997 한국아동학회 학술발표논문집 Vol.1997 No.12

성령의 복음 사역

신현수 평택대학교 2002 論文集 Vol.- No.-

물체 파지점 검출 향상을 위한 분할 기반 깊이 지도 조정

신현수,무하마드 라힐 아파잘,이성온 한국로봇학회 2024 로봇학회 논문지 Vol.19 No.1

Robotic grasping in unstructured environments poses a significant challenge, demanding precise estimation of gripping positions for diverse and unknown objects. Generative Grasping Convolution Neural Network (GG-CNN) can estimate the position and direction that can be gripped by a robot gripper for an unknown object based on a three-dimensional depth map. Since GG-CNN uses only a depth map as an input, the precision of the depth map is the most critical factor affecting the result. To address the challenge of depth map precision, we integrate the Segment Anything Model renowned for its robust zero-shot performance across various segmentation tasks. We adjust the components corresponding to the segmented areas in the depth map aligned through external calibration. The proposed method was validated on the Cornell dataset and SurgicalKit dataset. Quantitative analysis compared to existing methods showed a 49.8% improvement with the dataset including surgical instruments. The results highlight the practical importance of our approach, especially in scenarios involving thin and metallic objects.

프레임간 연동벡터 검출을 위한 고속 알고리즘 ( A Fast Algorithm for Interframe Motion Vector Detection )

신현수,양경호,이충웅 대한전자공학회 1989 대한전자공학회 학술대회 Vol.1989 No.11

단층촬영법을 이용한 느티나무, 팽나무, 은행나무 노거수의 건강도 측정

신현수,김민영,전형국,유지호,김종갑 경상대학교 농업생명과학연구원 2017 농업생명과학연구 Vol.51 No.6

This study was investigated to the internal risk of old trees of Zelkova serrata, Celtis sinensisand Gingo biloba by internal tomography. The proportion of healthy area of trunk was generallyhigh in order of Celtis sinensis, Zelkova serrata and Gingo biloba. The proportion of infectionarea of trunk was generally high in order of G. biloba, Z. serrata and C. sinensis. Theproportion of cavity area of trunk was generally high in order of G. biloba, Z. serrata and C. sinensis. In the case of G. biloba, it did not show the indication of cavity part externally, butthere was the system of the internal risk. The old trees are apt to be broken and fallen thetrunk by increase in the cavity area. Therefore, it is necessary to sean the internal risk bytomography and this internal tomography can be applied to conservation and management of theold trees. 느티나무, 팽나무, 은행나무 노거수를 대상으로 수간 내부 건강도 단층촬영을 통해 수목의 내부 피해도를 조사하였다. 단층촬영 결과, 전반적으로 수간 내부의 건강부위 비율은 팽나무>느티나무>은행나무의 순으로 나타났고, 부후부위는 은행나무>느티나무>팽나무의 순으로 나타났으며, 공동부위는 은행나무>느티나무>팽나무의 순으로 나타났다. 은행나무의 경우 외관상으로는 공동부위가 나타나지 않았지만내부적으로는 부후가 진행된 수목도 있었다. 공동부위의 증가로 수간 부러짐 등의 피해가 나타날 수 있으므로 수간 내부 단층촬영을 통해 내부 부후 상황을 정밀하게 조사·분석함으로써 노거수의 생육상태를 파악할 수 있으며, 내부단층촬영은 노거수 보호관리에도 응용될 수 있을 것이다.