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폐에 발생한 말초 T 세포 림프종의 세침흡인 세포학적 소견 - 1예 보고 -
신옥란,이연수,강창석,김병기,심상인,정은선,Shin, Ok-Ran,Lee, Youn-Soo,Kang, Chang-Suk,Kim, Byung-Kee,Shim, Sang-In,Jung, Eun-Sun 대한세포병리학회 1999 대한세포병리학회지 Vol.10 No.2
Primary non-Hodgkin's lymphoma of the lung is rare among extranodal lymphomas. The most common form is low grade B-cell type originated from the mucosa-associated lymphoid tissue (MALT) of the lung and primary peripheral T cell lymphoma of the lung is extremely rare. We recently experienced a case of fine needle aspiration cytology of primary peripheral T cell lymphoma of the lung in a 39-year-old male patient. The cytologic smears revealed some sheets of reactive epithelial cells, epithelioid histiocytes, and numerous polymorphous population of lymphoid cells composed of small and intermediate sized lymphoid cells and mature lymphocytes. Lymphoid cells were slightly larger than normal mature lymphocytes and showed significant irregularity of nuclear membrane. The internal nuclear structure was marked by chromatin clumping, clear parachromatin areas, and inconspicuous nucleoli. Histopathologically, atypical small lymphocytes infiltrated in the interstitium and alveolar sac. By the immunohistochemical study and molecular biologic study of gene rearrangement, the T cell clonality of atypical lymphoid cells was confirmed.
새열낭종에서 기원한 암종으로 오인된 전이성 편평세포암종 1예
조광재(Kwang Jae Cho),박현진(Hyun Jin Park),신옥란(Ok Ran Shin),이동희(Dong Hee Lee) 대한두경부종양학회 2006 대한두경부 종양학회지 Vol.22 No.1
The existence of primary branchiogenic carcinoma is controversial. In 1950, Martin et al. established four criteria for the diagnosis of primary branchiogenic carcinoma. In 1989, Khafif et al. proposed new modified criteria, which are currently most recognized in the literature. A 54-year-old woman presented the well-defined, fluctuant, painless mass on her left neck and underwent a complete excision under the clinical diagnosis of the branchial cleft cyst. The initial pathological impression was a branchiogenic squamous cell carcinoma. However, it did not coincide with a true primary branchiogenic carcinoma clinically. After the guided biopsy of suspicious areas found a squamous cell carcinoma of the tongue base, the patient was treated by combination chemotherapy with radiotherapy. Thus, we report this case with a review of the literature.
Helicobacter pylori 감염 위상피세포에서 Rosiglitazone이 세포성장과 p27 및 Skp2 발현에 미치는 영향
김성수 ( Sung Soo Kim ),조영석 ( Young Seok Cho ),김형근 ( Hyung Keun Kim ),신옥란 ( Ok Ran Shin ),채현석 ( Hiun Suk Chae ),최명규 ( Myung Gyu Choi ),정인식 ( In Sik Chung ) 대한소화기학회 2010 대한소화기학회지 Vol.55 No.4
Peroxisome proliferator-activated receptorγ (PPARγ)는 핵 수용체로 PPARγ 배위자는 세포주기 조절인자와 세포자멸사에 관련된 인자의 발현에 영향을 미쳐 악성 종양의 성장을 억제할 수 있다. H. pylori 감염에 의한 위샘암의 발생은 위상피세포 증식과 세포자멸사의 불균형이 관여한다. 이에 저자들은 H. pylori 감염 위상피세포에서 rosiglitazone이 세포 성장에 미치는 영향과 p27 단백과 Skp2 단백 발현에 미치는 영향을 보고자 하였다. 대상 및 방법: 위상피세포주인 AGS 세포에 H. pylori를 감염시킨 후 PPARγ 발현은 Western blot을 이용하여 측정하였다. Rosiglitazone을 처리한 후 H. pylori 감염 AGS 세포의 생존율을 측정하였다. H. pylori를 감염시킨 AGS 세포에서 rosiglitazone을 처리한 후 p27 단백과 Skp2 단백 발현은 Western blot을 이용하여 측정하였다. 결과: H. pylori 감염 AGS 세포에서 PPARγ 발현이 증가하였다. Rosiglitazone 처리는 H. pylori 감염 AGS 세포성장을 용량 및 시간 의존적으로 억제하였다. Rosiglitazone은 H. pylori 감염 AGS 세포에서 용량 및 시간 의존적으로 p27 단백 발현을 증가시켰고 Skp2 단백 발현을 감소시켰다. 결론: Rosiglitazone은 H. pylori 감염 AGS 세포의 성장을 억제하였다. 또한 p27 단백 발현을 증가시켰고, 이는 p27 단백분해에 관여하는 Skp2 단백 발현의 감소와 연관이 있었다. 이러한 p27 단백 발현 증가가 H. pylori 감염에서 세포 전환율에 미치는 영향과 위암 발생과의 연관성에 대해서는 추후 많은 연구가 필요할 것으로 보인다. Background/Aims: Ligands for peroxisome proliferator-activated receptorγ (PPARγ), a member of the ligand-activated nuclear receptor superfamily, exhibit anti-tumoral effects and are associated with de novo synthesis of proteins involved in regulating the cell cycle and cell survival/death. Helicobacter pylori (H. pylori) is an etiologic agent for gastric adenocarcinoma, and raises the cell turnover of gastric epithelium. The aim of this study was to investigate the effect of PPARγ ligand rosiglitazone on the cell proliferation and the expressions of p27 and Skp2 protein in H. pylori infected gastric epithelial cells. Methods: We examined the expression of PPARγ by Western blot in H. pylori infected AGS human gastric epithelial cells. The effect of rosiglitazone on the survival of H. pylori infected AGS cells was assessed by cell viability assay. After the treatment of rosiglitazone in H. pylori infected AGS cells, the expressions of p27 and Skp2 were assessed by Western blot. Results: The expression of PPARγ protein was increased in H. pylori infected AGS cells. Cell growth was inhibited and decreased in dose-and time-dependent manner in H. pylori infected AGS cells treated with rosiglitazone. A decrease in Skp2 expression and a reciprocal increase in p27 expression were found in dose- and time-dependent manner in H. pylori infected AGS cells treated with rosiglitazone. Conclusions: Rosiglitazone inhibited the growth of H. pylori infected AGS cells. Rosiglitazone attenuated Skp2 expression, thereby promoting p27 accumulation in H. pylori infected human gastric epithelial cells. Further studies will be needed to find the effects of accumulation on cell turnover in H. pylori infection and the role in the H. pylori-associated gastric carcinogenesis. (Korean J Gastroenterol 2010;55:225-231)
조진범(Jin Bum Cho),조항주(Hang Joo Cho),신옥란(Ok Ran Shin),김기환(Kee Hawn Kim),안창혁(Chang Hyeok Ahn),김정수(Jeong Soo Kim),유승진(Seung Jin Yoo),임근우(Keun Woo Lim),김지일(Ji Il Kim) 대한외과학회 2008 Annals of Surgical Treatment and Research(ASRT) Vol.74 No.6
Purpose: A mucocele of the appendix is an uncommon pathology, representing 0.2% to 0.3% of all appendix specimens. It is often diagnosed clinically as a result of its ability to cause signs and symptoms similar to those of acute appendicitis. If it is asymptomatic, it is often detected as an incidental finding during ultrasonography, computed tomography, radiographic examination of the gastrointestinal tract, or laparotomy. The purpose of this study was to identify the clinical features of mucocele of the appendix. Methods: We describe 35 cases of mucocele of the appendix diagnosed at Uijeongbu St. Mary’s hospital between January 1993 and December 2006. We analyzed demographic, clinical, and pathologic data of all the cases. Results: A total of 12 males and 13 females with mean age of 54.7±14.9 years are described. The peak incidence occurred in the seventh decade (34.3%). Sixteen patients presented with symptoms and signs similar to those found in acute appendicitis. Ten patients complained of a palpable mass, 2 patients complained of non-specific abdominal pain, and 7 patients were asymptomatic. Fourteen cases were diagnosed preoperatively, and 3 cases were discovered incidentally. Pathologic examination revealed mucosal hyperplasia in 20% of the cases, cystadenoma in 71%, and cystadenocarcinoma in 9%. The mean age of cystadenocarcinoma patients was older than the mean age of mucosal hyperplasia patients, and the diameter of the appendix was larger in cystadenoma patients than in mucosal hyperplasia patients. Conclusion: The preoperative diagnosis of appendiceal mucocele is very important to make in order to facilitate treatment planning and avoid inadvertent rupture of the mucocele during operation. We recommend more diagnostic studies in cases of suspected mucocele. Mucocele of the appendix must be included in the differential diagnosis of patients with pain in the right iliac fossa, patients older than 40 years of age, patients suffering from long-term symptoms, and patient with a palpable mass in the right iliac fossa.
박현진(Hyun Jin Park),김홍래(Hong Rae Kim),신옥란(Ok Ran Shin),조광재(Kwang Jae Cho) 대한두경부종양학회 2005 대한두경부 종양학회지 Vol.21 No.1
Leiomyosarcoma of the larynx is very rare, and rarely been described in reference to the head and neck region. This tumor occurs mainly in the uterus, the gastrointestinal track, and the retroperitoneum. There have been 24 previously reported cases of this tumor involving the larynx in the literature. Histologic diagnosis remains extremely difficult. A case of leiomyosarcoma of the larynx, treated by total laryngectomy, is reported. We discuss the clinical presentation, diagnosis, and treatment of leiomyosarcoma with a review of the literature.
요관에 발생한 평활근육종 분화를 보인 육종양 요로상피암
임광일(Kwang Il Yim),이용석(Young Seok Lee),구영미(Young Mi Ku),신옥란(Ok Ran Shin) 대한비뇨기종양학회 2010 대한비뇨기종양학회지 Vol.8 No.2
Sarcomatoid urothelial carcinoma is a rare malignant tumor with a poor prognosis. We experienced a case of sarcomatoid urothelial carcinoma of the ureter that protruding into the urinary bladder in 55-year old woman. She underwent total nephrouretectomy with bladder cuff resection. Pathologically, the mass consisted of high grade urothelial cell carcinoma component and sarcomatoid cell component and we could find transitional zone of two cell groups. In immunohistochemical study, sarcomatoid cell group showed positive reactions for smooth muscle actin and vimentin. Therefore sarcomatoid cell component showed leiomyosarcomatous differentiation, so we can diagnosed this tumor as sarcomatoid urothelial carcinoma with heterologous elements of leiomyosarcoma.
이성학 ( Sung Hak Lee ),이희중 ( Hee Joong Lee ),장하균 ( Ha Kyun Chang ),박태철 ( Tae Chul Park ),신옥란 ( Ok Ran Shin ),이교영 ( Kyo Young Lee ) 대한산부인과학회 2009 Obstetrics & Gynecology Science Vol.52 No.9
Non-Hodgkin lymphoma can involve the female genital tract usually as a manifestation of systemic disease, the vast majority of cases being B cell lineage. We report here one case of nasal type NK/T cell lymphoma arising in the uterus, of a 45-year-old Korean woman. The endometrium and myometrium showed diffuse infiltrative mass with hemorrhage and necrosis. Microscopic examination of the tumor revealed medium-sized atypical lymphoid cells. The tumor cells were positive for cytoplasmic CD3 and CD56, and were negative for vimentin, CD10, smooth muscle actin and desmin. Furthermore, In situ hybridization analysis for Epstein-Barr virus (EBV) RNA was positive. The histopathologic and immunohistochemical findings were consistent with extranodal nasal type NK/T cell lymphoma. We report this case to illustrate that NK/T cell lymphomas can involve, and rarely arise in, the gynecologic tract.
최수경 ( Soo Kyoung Choi ),이윤희 ( Youn Hee Lee ),이진희 ( Jinhee Lee ),박선호 ( Seon Ho Park ),김미희 ( Mi Hee Kim ),신옥란 ( Ok Ran Shin ),조영석 ( Young Seok Cho ) 대한내과학회 2015 대한내과학회지 Vol.89 No.3
Giardia lamblia infection, giardiasis, is the leading waterborne diarrhea-causing disease. It is common in most countries of the world, including South Korea and Japan. Giardia lamblia can cause asymptomatic infection but also acute abdominal discomfort with diarrhea. In addition, it may lead to chronic diarrhea associated with villous atrophy and impaired epithelial barrier in the small intestine. In the present case, a 45-year-old woman presented with lower abdominal discomfort in the absence of diarrhea. Colonoscopy showed diffuse mucosal edema, erythema, and erosions with exudate in the cecum and ascending colon. Colonoscopic biopsy and stool examination revealed trophozoites of Giardia lamblia. Colitis resolved after metronidazole therapy. Our case suggests that giardiasis should be included in the differential diagnosis of colitis, even if the patient does not present with diarrhea. (Korean J Med 2015;89:312-316)