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Meta-analysis를 이용한 UVB 조사량에 따른 피부암 발생 위해도의 예측 연구
신동천,이종태,양지연,Shin, D.C.,Lee, J.T.,Yang, J.Y. 대한예방의학회 1998 예방의학회지 Vol.31 No.1
성층권의 오존층 파괴로 수반되는 부작용에는 우주의 자외선이 차단되지 않고 지구표면에까지 도달하는 것을 들 수 있다. 이로 인하여 생태계 파괴를 비롯하여 기후이상 및 인체 건강장애 발생의 가능성이 높아진다고 알려져 있다. 특히 자외선 노출로 인한 피부암 발생에 관한 여러 연구결과가 보고 되었으며 이에 대한 종합적이고 신뢰성 있는 재평가 필요성이 대두되었으며 유사한 연구의 국내 수행이 제시되는 때이다. 이에 메타분석이라는 방법을 통하여 신뢰성있는 BAF 값을 추정하여 보고 이 지수를 국내 자료에 적용하여 국내 피부암 발생의 변화 양상을 자외선 증가와 함께 추정하여 보았다. 3개국의 자료를 일원화하여 추정된 UVB 계수는 지수함수 모델에 의해서는 $2.07\times10^{-6}$으로, 멱함수 모델에 의해서는 2.49로 산출되었으며, 이들 모두 통계적으로 유의한 것으로 나타났으며, 이 계수로부터 BAF 값을 추정한 결과, 서울 일부 지역에서의 UVB 조사량이 1% 증가되면, 피부암 발생률은 지수함수 모델에서는 1.90%, 멱함수 모델에서는 2.51%가 증가되는 것으로 산출되었으며, 이 연구에서 적용한 메타분석의 방법으로 제시된 위해도는 비교적 신뢰도가 높을 것으로 추정된다. 현재 우리나라에서의 비흑색종 피부암 발생율이 백만명당 11명이라고 가정할 때, UVB 조사량이 1% 증가됨으로 인해 국내 비흑색종 피부암 발생율은 백만명당 11.1명$\sim$11.3명으로 증가되는 것으로 예측된다. 이렇게 낮은 수준의 위해도에도 불구하고 자외선 노출이 피부암 발생의 원인적 요인이라는 것이 밝혀진 지금, 이에 대한 불필요한 노출을 가능한 삼가고 계속적인 관심을 두어야 할 것이다. Under experimental conditions, UVB radiation, a type of ultra violet radiation, has shown to .elate with the occurrence of skin erythema (sun-burn) in human and skin cancer in experimental animal. Cumulative exposure to UVB is also believed to be at least partly responsible for the 'aging' process of the skin in human. It has also been observed to have an effect of altering DNA (deoxyribonucleic acid). UVB radiation is both an initiator and a promoter of non-melanoma skin cancer. Meta-analysis is a new discipline that critically reviews and statistically combines the results of previous researches. A recent review of meta-analysis in the field of public health emphasized its growing importance. Using a meta-analysis in this study, we explored more reliable dose-response relationships between UVB radiation and skin cancer incidence. We estimated skin cancer incidence using measured UVB radiation dose at a local area of Seoul (Shin chou-dong). The studies showing the dose-response relationships between UVB radiation and non-melanoma skin cancer incidence were searched and selected for a meta-analysis. The data for 7 reported epidemiological studies of three counties (USA, England, Australia) were pooled to estimated the risk. We estimated rate of incidence change of skin cancer using pooled data by meta-analysis method, and exponential and power models. Using either model, the regression coefficients for UVB did not differ significantly by gender and age. In each analysis of variance, non-melanoma skin cancer incidence after removing the gender and age and UVB effects was significant (p>0.01). The coefficients for UVB dose were estimated $2.07\times10^{-6}$ by the exponential model and 2.49 by the power model. At a local area of Seoul (Shinchon-Dong), BAF value were estimated 1.90 and 2.51 by the exponential and power model, respectively. The estimated BAP value were increased statistical power than that of primary studies that using a meta-analysis method.
박정수,이효민,정용,신동천,노재훈,문영한,Park, J.S.,Lee, H.M.,Chung, Y.,Shin, D.C.,Roh, J.H.,Moon, Y.H. 대한예방의학회 1992 Journal of Preventive Medicine and Public Health Vol.25 No.1
This study was conducted to investigate the mechanism of protective effect by sodium selenite in methylmercuric chloride neurotoxicity, increasing intracellular $Ca^{2+}$concentration of the neuron. Methylmercuric chloride of 3mg/kg of body weight was administered simultaneously with sodium selenite of 5mg/kg and pretreatment of sodium selenite via intraperitoneal injection to rats. Also, effect of methylmercuric chloride($25{\mu}M,\;50{\mu}M,\;100{\mu}M$) and sodium selenite($200{\mu}M$) on free intrasynaptosomal $Ca^{2+}$ concentration were studied using the fluorescent $Ca^{2+}$ indicator fura -2 in vitro. After the treatment, at 6, 24, and 48 hours later, mercury in the cerebral cortex, liver and kidney tissues, succlnic dehydrogenase activities, adenosin-5'-triphosphate concentration, acetylcholinesterase activities, and intracellular $Ca^{2+}$ concentration in the cerebral cortex were determined in vivo. Cerebral synaptosomes of rats were incubated with methylmercuric chloride and sodium selenite in Hepes buffer for 10 minutes and free intrasynaptosomal $Ca^{2+}$ concentration were measured with fura-2 in vitro. The results were summarized as follows ; 1. The combined administration of $CH_3HgCl$ and $Na_2SeO_3$ and pretreatment of $Na_2SeO_3$ according to time significantly more increased in the cerebral cortex and decreased in the liver, kidney mercury concentrations compared to the administration of $CH_3HgCl$ only. 2. The combined administration of $CH_3HgCl$ and $Na_2SeO_3$ and pretreatment of $Na_2SeO_3$ increased more succinic dehydrogenase and acetylcholinesterase activities compared to the administration of $CH_3HgCl$ only. Particularly pretreatment of $Na_2SeO_3$ significantly more compared to the administration of $CH_3HgCl$ only. The concentration of adenosine-5'-triphosphate in $Na_2SeO_3$ treatment groups revealed a favourable effect compared to the administration of $CH_3HgCl$ only. 3. Intracellular $Ca^{2+}$ concentration in administration of $CH_3HgCl$ only was increased significantly more than control group in all test hours but was increased significantly more at 48 hours only after treatment in combined administration of $CH_3HgCl$ and $Na_2SeO_3$ and pretreatment of $Na_2SeO_3$ according to time interval more decreased significantly intracellular $Ca^{2+}$ concentration compared to the administration of $CH_3HgCl$ only. 4. Free intrasynaptosomal $Ca^{2+}$ concentration in the combined administration of $CH_3HgCl$ and $Na_2SeO_3$ was decreased ($24%{\sim}40%$) significantly more than the administration of $CH_3HgCl$ only. From the above results, the specific dosage of $Na_2SeO_3$ decreased increment of intracellular $Ca^{2+}$ concentration induced by administration of $CH_3HgCl$. These findings suggest the protective mechanism of $Na_2SeO_3$ on the neurotoxicity of $CH_3HgCl$.
김호현,이재영,양지연,이준상,신동천,정혜웅,임영욱,Kim, H.H.,Lee, J.Y.,Yang, J.Y.,Lee, J.S.,Shin, D.C.,Jung, H.W.,Lim, Y.W. Korea National University of Agriculture and Fishe 2010 현장농업연구지 = Journal of practical agricultural resear Vol.12 No.1
유엔환경기구는 잔류성유기오염물질(persistent organic pollutants, POPs)의 생산 및 유통을 억제하기 위한 국제금지협약을 2001년 5월 22일 채택하였다. 이 협약은 151개 승인국 중 59개국으로부터 비준을 얻어 2004년 5월 17일 발효되었다. 한국은 2001년 10월 4일 승인한 이후 본 협약의 비준에 대비하여 등재된 물질에 대한 체계적인 조사를 시행하였다. 문헌 및 사례조사를 통하여 특정면제품목의 가능성이 chlordane, dichloro diphenyl trichloroethane (DDT), hexachlorobenzenes (HCB), heptachlor, polychlorinated biphenyls (PCBs)에서 발견되었다. 하지만 보다 상세한 추후 조사에 의하여 특정면제품목의 작성 없이 본 협약에 가입할 수 있게 되었다.