정상인과 파킨슨병 환자에서 [I-123]IPT SPECT를 이용한 도파민 재섭취부위의 영상화

손형선,김의녕,이경진,나형균,손병철,최창락,Sohn, Hyung Sun,Kim, Euy Neyng,Lee, Kyung Jin,Rha, Hyung Keun,Son, Byung Chul,Choi, Chang Rhack 대한신경외과학회 2001 Journal of Korean neurosurgical society Vol.30 No.3

Objective : Dopamine transporter concentrations have been known to decrease in Parkinson's disease(PD). The aim of the present study was to evaluate the correlation between SPECT measurements of [I-123]N-(3-iodopropene-2-yl)-$2{\beta}$-carbomethoxy-$3{\beta}$-(4-chlorophenyl) tropane(IPT) as an imaging agent for measuring changes in transporter concentrations with PD. Patients and Methods : IPT labelled with $4.87{\pm}1.29mCi$($180.19{\pm}47.73MBq$) of [I-123] was intravenously injected into 23 patients(age : $58{\pm}12$) with PD and three normal controls(NC)(age : $37{\pm}7$) as bolus. Brain SPECT were then performed at 1 hour and 2 hours after injection on a double headed camera. The statistical parameters were the contrast ratio of left basal ganglia(BG) and right basal ganglia to occipital cortex(OCC) per milli curies of injected radiotracer at 1 hour and 2 hours. The correlations were evaluated between these parameters and Hoehn-Yahr classification of the patients. Results : The(BG - OCC)/OCC/mCi ratios at 1 hour and 2 hours for PD and NC were $0.14{\pm}0.07$ and $0.27{\pm}0.07$(1 hour) and $0.12{\pm}0.07$ and $0.34{\pm}0.04$(2 hour), respectively. The(BG - OCC)/OCC/mCi ratios of Parkinson's disease were decreased with higher grade of Hoehn-Yahr classification of the patients. The ratio between BG and OCC for PD were clearly separated from NC and may be useful outcome measures for clinical diagnosis. Conclusion : The findings suggest that IPT may be a very useful tracer for early diagnosis and treatment of PD and study of dopamine re-uptake site.

태전모반 (太田母斑) 에 대한 유전학적 ( 빈도를 중심으로 ) 및 임상적 연구

황선욱(Sun Wook Hwang),정태복(Tae Bock Chung),손형선(Hyung Son Sohn),김영표(Young Pio Kim) 대한피부과학회 1984 대한피부과학회지 Vol.22 No.1

The clinical observation was done on 126 patients of Ota's nevus, 113 of whom were seen at Department of Dermatology, Chonnam National University Hospital from January 1973 through July 1983, and 13 of whom were found among 45, 87l male and female students of high school in Kwangju City, Korea. The results obtained were as follows: 1. The incidence of male and female students of Ota's nevus were respectively 0. 013% and 0.043%, with the incidence,as a whole being 0.03%, whereas the frequency of Ota's nevus among the outpatients was 0. 24% with the ratio of male to female being 1: 2. 67. 2. There was only one family of familial occurrence, in which 2 sisters were involved among 5 siblings. 3. Thirty three percent of Ota's nevus showed the onset at birth. 4. According to Tanino's classification, our patients showed that Type II was 41.7% and then Type Ia, III, Ib, and IV being respectively 33. 3%, 16. 7, 4.2, and 4. 2%. 5. Seleral involvement was 54. 2%, especially in type III and Type II. 6. The color was increased in 54%, especially Type II by internal and external factors such as fatigue, warm temperature, menstruation and cold temperature. 7. The color intensification was prominent at the age of 10 to 14.

정상 한국인의 모발성장에 관한 연구

김영표(Young Pio Kim),나해철(Hae Cherl Nah),황선욱(Sun Wook Hwang),전인기(Inn Ki Chun),손형선(Hyung Son Sohn) 대한피부과학회 1984 대한피부과학회지 Vol.22 No.1

The hair growth of the scalp is influenced by many systemic and local factors. So the study of standard hair growth rate is very important for the diagnosis and treatment of some pathological conditions. That study has not been done well in Korea. The present study was to establish the standard hair growth rate of the scalp of healthy Koreans at different ages. The investigations were carried out on 509 individuals of both sexes whose ages ranged between 2 and 69 years. The subjects were grouped according to 5 age periods. The results of this study were as follows: 1. The mean value of the daily scalp hair growth rate was 0. 401+ 0. 037mm. 2. The daily hair growth rate of each groups were as follows: under 10 years of age; 0. 367+0.032mm, in the teenagers; 0.419,+0. 032mm, in the twenties0.398+0.037mm, in the thirties and fourties; 0. 394+0. 034mm, above 50 years of age 0. 386+029mm. 3. Sex differences of each age groups in the scalp hair growth were not statistically significant.

Technetium-99m sestamibi 스캔으로 진단된 종격동 부갑상선 선종 1예

이광우,손형선,송기호,손호영,차봉연,강성구,이성희,한원희 대한내분비학회 1996 Endocrinology and metabolism Vol.11 No.2

We present a patient with primary hyperparathyroidism in whom preoperative Tc-99m sestarnibi scanning cleary demonstrated mediastinal parathyroid adenoma. After resection of tumor through median sternotomy, he was restored to the normocalcemia. This case suggests that Tc-99m sestamibi scanning may be a useful method in the preoperative localization of mediastinal parathyroid adenoma(1 Kor Soc Endocrinol 11:227~232, 1996).

스포로트리쿰증에 관한 임상적 관찰

김영표,정인기,손형선 대한피부과학회 1979 大韓皮膚科學會誌 Vol.17 No.6

Observations of 50 sporotrichosis patients, who were confirmed by dinical, histopathological and mycological examination, were made in the department of Dermatology at Chon-nam University Hospital for the twelve year period from 1967 to 1978. The results obtained were as follows; 1. During this period, out of a total of 39, 594 outpatients, there were 50 cases of sporotrichosis for an average of 0. 13 percent. The highest incidence was in 1970 with 7 cases, however, there was no period with a particularly marked increase in the occurrence of the disease. 2. Half of all the cases occurred in the third and fourth decades of life. The male to female ratio was 2. 3:1. 3. Occupationally, the greatest percent were farmers, 36 cases(72%), and the next highest, unemployed. 4. In Kwang-ju an.d surrounding 6 counties, there were 25 cases which were widely scattered thraughout Chonnam province and the southern tip of Chonbuk province. 5. The initial lesion appeared on the upper extremities in 39 cases, particularly the right hand, and the lower extremities in 9 cases. 6. Of the total patients, there were 24 cases(48%) with a history of trauma before the onset of the disease. Of those cases, the disease appeared between I and 2 weeks. after trauma in 10 cases(41.7%) and between 2 and 3 weeks in 8 cases(33.3%). 7. The duration of the skin lesions before initial examination was 2 months in 12 cases(24%) and 3 months in 14 cases(28%). 8. Forty six percent of the total cases visited our department in spring, showing a higher incidence than any other season. The highest monthly incidence was in May, when there were 13 cases. 9. Of the total, 42 cases(84%) were cutaneous lymphatic type, while 8 cases(16%), localized cutaneous type.

동종골수이식 후 발생한 비갑상선질환 증후군에서 사이토카인의 혈청 농도의 변화 및 비갑상선질환 증후군이 이식 후 예후에 미치는 영향

안병영,이광우,민우성,손형선,손호영,차봉연,강무일,윤건호,강성구,오기원,이원영,손현식,신완식,김춘추 대한내분비학회 2000 Endocrinology and metabolism Vol.15 No.2

Background : Alteration of thyroid hormone parameters are frequently observed in sick patients and commonly known as nonthyroidal illness syndrome(NTIS) or euthyroid sick syndrome(ESS). NTIS is seen in starvation, surgery, severe illness, and also bone marrow transplantation(BMT). The degree of reduction in thyroid hormone parameters correlated with the severity of NTIS and might predict the prognosis of underlying illness. Recently, particular attention is focused on the role of cytokines in developing the NTIS. This prospective study was designed to assess the relationship of serum thyroid hormone parameters and serum cytokine levels before and in the short-term follow-up after allogeneic BMT in order to predict patients outcome. Methods : Included 80 patients that were mainly leukemia and severe aplastic anemia. Serum thyroid hormone parameters and serum cytokine levels were measured before and 7, 14, 21, 28 days and 3, and 6 months after BMT. Results : Near-all patients experienced significant decrease of thyroid hormone levels and also significant increase of cytokine levels after BMT. After post-BMT 3 weeks, the serum cytokine levels were negatively correlated with the serum T3 and T4 levels, but not with the serum TSH levels. The patients treated with high-dose steroid or total-body irradiation tended to show lower levels of TSH and more delayed recovery compared to non-treated patients. The patients died after BMT represented generally lower levels of all thyroid hormone parameters than survival patients during entire follow-up period. Conclusion : Development of NTIS is associated with higher probability of fatal outcome after BMT and has prognostic relationship in this group of patients. Increased levels of cytokines, especially IL-6 and TNF-?, are often found in post-BMT NTIS patients and correlated with the changes in the levels of thyroid hormone parameters(J Kor Soc Endocrinol 15:214-225, 2000).