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감궁탕이 사람의 갑상선세포에서 Fas 매개성 apoptosis에 미치는 영향
남경수,손옥례,김미경,김철호,소명숙,전병훈,손윤희,Nam Kyung Soo,Son Ok Lye,Kim Mee Kyung,Kim Cheorl Ho,So Myung Suk,Jeon Byung Hun,Shon Yun Hee 대한동의생리학회 2005 동의생리병리학회지 Vol.19 No.3
Inflammatory cytokine, abundantly produced in Hashimoto's thyroiditis, induced Fas expression in normal thyrocytes. We determined that susceptibility to Fas-activated apoptosis could be influenced by inflammatory cytokine and investigated a potential role of Gamgung-tang (GGT, Glycyrrhizae Radix, black beans, Angelicae Radix and Cnidii Rhizoma) in the thyroid follicular cells. $IL-1\beta$ was able to induce Fas expression in normal thyrocytes. GGT inhibited $IL-1\beta-induced$ Fas expression. Thyroid follicular cells were found to undergo DNA fragmentation with the inflammatory cytokines. GGT inhibited DNA fragmentation in a dose-dependent manner. These results suggest that GGT inhibit Fas-mediated apoptosis in thyroid follicular cells, therefore, may have therapeutic potential in the treatment of autoimmune chronic thyroiditis.
천궁이 유방암세포 증식, Nitric Oxide 생성 및 Ornithine Decarboxylase 활성에 미치는 영향
남경수,손옥례,이경화,조현정,손윤희 한국생약학회 2004 생약학회지 Vol.35 No.4
The efect of water extract from Cnidii Rhizoma (CRW) on proliferation of human breast cancer cells, nitric oxideproduction, nitric oxide synthase expression, and ornithine decarboxylase activity was tested. CRW inhibited the growth of bothestrogen-dependent MCF-7 and estrogen-independent MDA-MB-231 human breast cancer cels. Lipopolysacharide-inducednitric oxide (NO) production was significantly reduced by CRW at the concentration of 0.5, 1.0 and 5.0 mg/ml. Expresion ofinducible nitric oxide synthase (iNOS) was also suppressed with the treatment of CRW in Raw 264.7 cells. CRW inhibitedinduction of ornithine decarboxylase by 12-O-tetradecanoylphorbol-13-acetate, a key enzyme of polyamine biosynthesis, whichis enhanced in tumour promotion. Therefore, CRW is worth further investigation with respect to breast cancer chemopreventionor therapy.
생약혼합물이 사이토카인에 의한 갑상선세포의 Apoptosis에 미치는 영향
남경수,손옥례,김미경,박인경,김철호,조현국,전병훈,손윤희 한국생약학회 2005 생약학회지 Vol.36 No.2
Apoptosis plays an important role in autoimmune chronic (Hashimoto,s) thyroiditis, a disorder that often results in hypothyroidism. The goal of this study was to induce apoptosis by the combination of inflammatory cytokines, interferon (IFN)-γ and tumor necrosis factor (TNF)-α, and to investigate a potential role of medicinal plants in the thyroid follicular cells (FRTL) in vitro. The apoptosis was evaluated by cellular viability, DNA fragmentation, and terminal deoxynucleotidyl transferase-mediated deoxy-UTP nick end labeling (TUNEL) assay. Extract of Gamgung-tang (GGT, Glycyrrhizae Radix, black beans, Angelicae Radix, and Cnidii Rhizoma) (0.3~9.0 mg/ml) was shown to maintain the viability of cells treated with IFN-γ (100 U/ml) and TNF-α (0.5 ng/ml). FRTL cells were found to undergo DNA fragmentation with the inflammatory cytokines.The extract of GGT inhibited DNA fragmentation in dose-dependent manner. The cells with TUNEL-positive nuclei were detected with IFN-γ and TNF-α treatment. The number of TUNEL-positive cells decreased with the treatment of extract of GGT. These results indicate that medicinal plants inhibit the occurrence of apoptosis in thyroid follicular cells, therefore, may have therapeutic potential in the treatment of autoimmune chronic thyroiditis.