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서화규,이강윤,박제민,이병대,문은수,정희정,정영인,김지훈,김학진,문치웅,김태형,김영훈,이영민 대한노인정신의학회 2016 노인정신의학 Vol.20 No.2
Objective:The aim of this study is to determine whether there is any difference in white matter (WM) integrity between Alzheimer’s disease (AD) with metabolic syndrome (MetS) and without MetS. Methods:Altogether, 30 subjects were finally recruited from the Memory Impairment Clinics of Pusan National University Hospital in Korea. All subjects (AD with MetS : n=15, matched AD without MetS for age, gender and year of education : n=15) were underwent 3-tesla magnetic resonance imaging scans of diffusion tensor imaging. Results:The mean fractional anisotropy of the AD with MetS was lower (p<0.05) in right posterior corona radiate, right corticospinal tract and right superior longitudinal fasciculus than that of the AD without MetS. Conclusion:Our findings suggest that WM integrity damage.
아밀로이드 양성인 인지기능저하군에서 APOE ε4 유전형이 내측두엽 위축에 미치는 영향: 자기공명영상 장기연구
김지혜,이영민,이병대,문은수,서화규,김경원,이현지,김학진,박경준,최경운 대한노인정신의학회 2024 노인정신의학 Vol.28 No.1
아밀로이드 양성인 인지기능저하군에서 APOE ε4 유전형이 내측두엽 위축에 미치는 영향: 자기공명영상 장기연구 The Effect of Apolipoprotein E ε4 Genotype on the Medial Temporal Lobe Atrophy in Cognitively Impaired Patients With Amyloid Deposition: 2 Years Longitudinal Magnetic Resonance Imaging Study
A Case of Subacute Psychosis in a Patient With Germ Cell Tumor
김경원,이병대,박제민,이영민,문은수,정희정,서화규,강태욱 대한생물치료정신의학회 2023 생물치료정신의학 Vol.29 No.1
We report a case of subacute psychotic symptoms in a patient with germ cell tumor (GCT). The 32-year-old male patient showed progressive psychotic symptoms with diagnosis of GCT. His psychotic symptoms included delusions of reference and persecution. Brain magnetic resonance imaging, electroencephalography, and laboratory examinations were performed to evaluate any other causes. The clinical, neuroimaging, and laboratory review in this case suggested that the progressively developed psychotic symptoms that led to chronic deterioration were caused by the GCT. This is the case report in which subacute atypical psychotic symptoms in his thirties could develop from a GCT based on previous basic research findings showing the correlations of psychotic symptoms with GCT although it has the limitation of so early speculation.
건강한 노인의 둘째:넷째 손가락 길이 비와 피질하 회백질 부피
박제민,이영민,이강윤,정희정,이병대,문은수,서화규,김경원 대한생물치료정신의학회 2022 생물치료정신의학 Vol.28 No.1
Objectives:This study was aimed to investigate whether 1) sexual dimorphism in subcortical gray matter volumes (GMV) and the length ratio between the second and fourth digits (2D:4D) would be found and 2) 2D:4D would have associated with subcortical GMV in healthy elderly people. Methods:Sixty-two females aged 70.3±6.3 (mean±SD) years and 23 males aged 70.4±4.9 years were recruit ed from the Dementia Clinic in the Pusan National University Hospital. The subjects with the clinical dementia rating scale-sum of boxes (CDR-SB) total score greater than 2.0, any psychiatric or neurological disease, or any pathologic lesion on brain MRI other than micro-angiopathy were excluded. The 2D:4D of the left and right hands were measured 3 times each. Volumetric segmentation of T1-weighted MRI scans was done by Freesurfer software (v7.1.1.1). Results:2D:4Ds of males were smaller than those of females significantly on repeated measures ANOVA. The males’ thalamus, putamen, hippocampus in both hemispheres and the right amygdala were larger than females’. These differences were not significant after controlling for age, education and total intracranial volume (ICV). In the females, the left 2D:4D was negatively correlated with the left hippocampal volume. In the males, 2D:4D was positively correlated with the volumes of ipsilateral or contralateral thalamus, hippocampus, amygdala and accumbens. These correlations were not significant after Bonferroni’s correction, except for the right accumbens. Conclusions:Sexual dimorphism of 2D:4D is preserved in healthy elderly people. There is a significant correlation between the right 2D:4D and GMV of the accumbens in males
Family Based Genome-Wide Association Analysis of Schizophrenia in a Korean Population: A Pilot Study
배소정,이병대,박제민,이영민,문은수,정희정,서화규,김경원,오하영 대한생물치료정신의학회 2023 생물치료정신의학 Vol.29 No.1
Objectives: Schizophrenia (SPR) is the most devastating mental illness that causes severe deterioration in social and occupational functioning, but, the aetiology remains unknown. The aim was to identify patterns of association and segregation for genetic variants and to identify the genes and signalling pathways that determine the risk of developing SPR, through a family-based Genome-wide association study. Methods: We have recruited 27 probands(with SPR) with their parents and siblings whenever possible. DNA was extracted from blood sampling of 58 individuals in 27 families and analysed in an Illumina core exome single nucleotide polymorphism (SNP) array. A family-based association test was used to derive SNP association values across all chromosomes. Results: Although none of the final 800,000 SNPs reached the genome-wide significant threshold of 5×10-8, the most significant 3 SNPs were within the 10-5-10-7. Conclusions: This confirms that SPR is not monogenic but results as a consequence of interactions between multiple host genes and possibly also environmental factors. The present approach provides novel insights into the mechanisms underlying SPR and raises the possibility of identifying individuals at risk of acquiring this condition. In this study, several possible susceptibility genes have been identified that are linked to a range of different pathways, which could reflect the mind-body interaction that is included in the psychiatric genomics consortium.
알츠하이머병에서 APOE e4 유전형과 인지기능, 뇌 부피, 당 대사량 그리고 뇌 아밀로이드 침착과의 연관성
윤원배,이영민,박제민,이병대,문은수,서화규,김경원,김유준,이현지,김학진,박경준,최경운 대한노인정신의학회 2023 노인정신의학 Vol.27 No.1
Objective: The purpose of this study is to investigate the association of the apolipoprotein E (APOE) e4 genotype with cognition, brain volume, glucose metabolism, and amyloid deposition in patients with Alzheimer disease (AD). Methods: This is cross-sectional study of 69 subjects with AD. All subjects were divided into carriers and non-carriers of the e4 allele. Forty APOE e4 carriers and 29 APOE e4 non-carriers underwent neuropsychological, structural magnetic resonance imaging, [18F]fluorodeoxyglucose positron emission tomography scans (PET) and [18F]florbetaben amyloid PET. Analysis of covariance was conducted to compare the differences on cognition, brain volume, glucose metabolism and amyloid deposition between APOE e4 carriers and non-carriers after controlling demographics. Results: APOE e4 carriers had 50% lower scores of Seoul Verbal Learning Test (delayed recall) compared to non-carriers (0.88±1.65 vs. 1.76±1.75, p<0.05). However, APOE e4 carriers performed better on other cognitive tests than non-carriers (Korean version of Boston Naming Test [11.04±2.55 vs. 9.66±2.82, p<0.05], Rey Complex Figure Test [25.73±8.56 vs. 20.15±10.82, p<0.05], and Stroop test [color response] [48.28±26.33 vs. 31.56±27.03, p<0.05]). APOE e4 carriers had slightly smaller hippocampal volume than non-carriers (3.09±0.38 vs. 3.32±0.38, p<0.05), but greater total brain cortical thickness (1.45±1.55 vs. 1.37±1.24, p<0.05). Amyloid deposition did not differ significantly between APOE e4 carriers and non-carriers, and no significant difference in glucose metabolism was found between groups. Conclusion: We found that APOE e4 genotype is associated with cognition, brain volume in AD, suggesting that APOE e4 genotype could play an important role in the underlying pathogenesis of AD.
정신병적 증상을 동반한 알츠하이머병에서 앞쪽뇌량 부피의 감소: 자기공명영상 단면연구
이현지,이영민,박제민,이병대,문은수,정희정,서화규,김경원,김학진,박경준,최경운 대한노인정신의학회 2022 노인정신의학 Vol.26 No.1
Objective: Although previous studies have shown association between anterior corpus callosum (ACC) and various psychotic disorder, the effect of ACC on development on psychotic symptoms in Alzheimer’s disease (AD) is still unclear. The purpose of this study is to investigate the association of ACC with the development of psychosis in patients with AD. Methods: This is a hospital based cross-sectional study of 241 AD patients. The main outcome measure is the volume of ACC that were measured as regions of interest with magnetic resonance imaging and the FreeSurfer analysis at baseline. Analysis of covariance and Logistic regression analysis conducted to assess the association between the volume of ACC and the presence of psychosis in AD, adjusting for age, education, Clinical Dementia Rating-Sum of Boxes, and total intracranial volume. Results: We found that the volume of ACC is significantly reduced in AD with psychosis (AD+P) compared to AD without psychosis (AD-P) (774.27±142.96 vs. 833.09±142.04, p=0.005). The volume of ACC associated with the presence of psychosis in AD (odds ratio=0.995; 95% confidence interval=0.993-0.997; p=0.006). Conclusion: We have found that reduced volume of ACC in AD+P, suggesting that ACC might play an important role in the underlying pathogenesis of development of psychotic symptoms in AD.
손성미,이영민,박제민,이병대,문은수,정희정,서화규,김경원,김학진,박경준,최경운 대한노인정신의학회 2022 노인정신의학 Vol.26 No.1
Objective: This study examined the volume of choroid plexus across AD without delusion (AD-D), AD with paranoid delusion (AD+PD), and AD with misidentification delusion (AD+MD). Methods: This is a hospital based cross-sectional study of patients with AD. The main outcome measure is the volume of choroid plexus that were measured as regions of interest with magnetic resonance imaging and the FreeSurfer analysis at baseline. Analysis of covariance (ANCOVA) was conducted to compare the differences on the volume of choroid plexus across AD-D, AD+PD, and AD+MD after controlling demographics. Results: There was no volume difference in the both choroid plexus between AD-D and AD+D. However, the volumes of both choroid plexus were significantly reduced in AD+MD compared to AD+PD. Conclusion: Our study demonstrates that AD+MD has significantly reduced volumes of choroid plexus compared to AD+PD. These findings suggest that AD+MD and AD+PD may have different pathophysiological mechanisms related to neuroimmune responses in the choroid plexus
기억장애성 경도인지장애 환자의 양전자방출단층촬영검사에서 아밀로이드 침착이 해마 대사량에 미치는 영향 : 예비연구
김기옥,이영민,박제민,이병대,문은수,정희정,김수연,이강윤,서화규,김학진,박경준,문치웅,김지훈,정영인 대한생물치료정신의학회 2019 생물치료정신의학 Vol.25 No.3
Objectives:Most studies of hippocampal metabolism(HM) in amnestic mild cognitive impairment(aMCI) gave inconsistent results. Our objective was to evaluate the effect of amyloid-beta(Aβ) status on hippocampal metabolism in aMCI. Methods:Overall, 23 aMCI underwent three-dimensional magnetic resonance imaging(MRI), 18F-fluorodeoxyglucose-positron emission tomography(18FDG-PET) and 18F-Fluorbetaben amyloid positron emission tomography (amyloid-PET). According to Aβ status on amyloid PET, 23 aMCI were classified as either Aβ+aMCI(N=13) or Aβ-aMCI(N= 10). The primary outcome was HM using 18FDG-PET and we investigate the difference on HM between Aβ+aMCI and Aβ-aMCI using analysis of variance(ANOVA) model, after controlling hippocampal volume. Results:We found that HM was more decreased in Aβ+aMCI than Aβ-aMCI. This result was not changed after controlling hippocampal volume. Conclusion:Our findings suggest that Aβ+ is associated with decreased HM, regardless of hippocampal volume, in aMCI.
Various Psychiatric Manifestation in DiGeorge Syndrome (22q11.2 Deletion Syndrome): A Case Report
Giok Kim,Eun Soo Moon,Je Min Park,Byung Dae Lee,Young Min Lee,Hee Jeong Jeong,Soo Yeon Kim,Kang Yoon Lee,서화규 대한정신약물학회 2020 CLINICAL PSYCHOPHARMACOLOGY AND NEUROSCIENCE Vol.18 No.3
This case report aimed to describe various psychiatric manifestation and treatment course in a patient with DiGeorge syndrome. Psychiatric symptoms and treatment course in a female patient with DiGeorge syndrome were described. This patient showed psychotic symptoms, mood symptoms, and intellectual disability. As well as various psychiatric symptoms, treatment response and sensitivity of side effect by antipsychotics were different from typical characteristics in psychiatric disorders. This case suggests that the genetic defect in DiGeorge syndrome might have a great association with psychiatric problems and response of antipsychotics.