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백진아 ( Jin Ah Baek ),최영민 ( Young Min Choi ),문신용 ( Shin Yang Moon ) 서울대학교 인구의학연구소 2012 人口醫學硏究論集 Vol.25 No.-
Human embryonic stem cells (hESCs) have great potentials as a source of cells for cell-based therapies and can be used to develop a system such as toxicology and drug discovery. Human ES research is being conducted with a variety of cell lines and culture conditions, however, the consequence of using such conditions would be confuse in scientific improvement. For this reason, the effort for cell stability and safety used in research work has been recognised and developed by international groups worked for stem cell banking. High-quality stem cell lines confirmed by quality assurance/control and ethically sourced are needed for invaluable stem cell researches and therapies.
인간 전분화능 줄기세포 Non-coding RNAs의 기능
백진아 ( Jin Ah Baek ),최영민 ( Young Min Choi ) 서울대학교 인구의학연구소 2015 人口醫學硏究論集 Vol.28 No.-
Human pluripotent stem cells (hPSCs) with the capacity of self-renewal and multilineage differentiation are promising sources for replacement therapies and regeneration medicine. Many researches have been spent to undersrand rhe molecular mechanisms underlying hPSCs mainrenance and pluriporency, and ir is clear rhar borh rranscriprional and epigeneric levels of regularion have crucial roles. Recent research indicares rhar regularorynon-coding RNAs (ncRNAs) are key regulators of hPSCs epigeneric nerwork. For rhis reason, we summarize rhe findings that focus on regulatory ncRNAs of human embryonic stem cells (hESCs) and human induced pluripotent srem cells (hiPSCs).
백진아 ( Jin Ah Baek ),최영민 ( Young Min Choi ),문신용 ( Shin Yong Moon ) 서울대학교 인구의학연구소 2011 人口醫學硏究論集 Vol.24 No.-
The pluripotency and self-renewal of human embryonic stem cells (hESCs) provide appropriate systems for the development of cell replacement therapies. Recent studies have converged on the finding transcription factors, such as Oct4, Sox2, and Nanog, which are served as master regulators in the maintenance of undifferentiated hESC or in early stages of differentiated hESCs. However, downstream targets and signals of these transcription factors for hESC maintenance and regulation are not well characterized. In this study, we summarize the current novel pluripotency markers of hESCs, L1TD1, Banf1, E1B-AP5, POLR3G and L1CAM, that were published in 2011. The identification of novel hESC markers is essential for understanding hESC pluripotency and the mechanisms involved in hESC differentiation and self-renewal.
인간 배아줄기세포와 인간 역분화줄기세포의 유전체 수준 비교
백진아 ( Jin Ah Baek ),최영민 ( Young Min Choi ) 서울대학교 인구의학연구소 2013 人口醫學硏究論集 Vol.26 No.-
Human pluripotent stem cells (hPSCs), which include human embryonic stem cells (hESCs) and human induced pluripotent stem cells (hiPSCs), can self-renew while maintaining the pluripotency. They have been a prime candidate cell source for the development of cell replacement therapies and regenerative medicine. hESCs and hiPSCs are similar in morphology, cell-surface marker and teratoma formation capacity. However, questions remain on whether the epigenetic reprogramming is complete. For this reason, in this study, we compared the transcriptom and epigenetic properties between hESCs and hiPSCs.
초기 계대 인간 배아줄기세포의 해동 후 효율적인 배양 방법
백진아,김희선,설혜원,서진,정주원,윤보애,박용빈,오선경,구승엽,김석현,최영민,문신용,Baek, Jin-Ah,Kim, Hee-Sun,Seol, Hye-Won,Seo, Jin,Jung, Ju-Won,Yoon, Bo-Ae,Park, Yong-Bin,Oh, Sun-Kyung,Ku, Seung-Yup,Kim, Seok-Hyun,Choi, Young-Min,Moon, 대한생식의학회 2009 Clinical and Experimental Reproductive Medicine Vol.36 No.4
목 적: 인간 배아줄기세포 (human embryonic stem cells; hESCs)는 미분화 상태로 무한 증식할 수 있는 자가 증식(self-renewal) 능력과 인체의 모든 세포로 분화할 수 있는 전분화능 (pluripotency)의 특징을 가진 세포로, 손상된 세포를 건강한 세포로 대체하고자 하는 세포치료 (cell therapy) 연구에 활용하기 위한 세포 공급원 (cell source)으로 제시되고 있다. 그러나 인간 배아줄기세포는 확립된 초기에 세포를 안정적으로 배양하고 유지하는 과정이 쉽지 않으며, 특히 동결보존되어 있던 세포를 해동한 후 배양할 때 자연 발생적 분화가 높기 때문에 세포주의 유지에 많은 어려움이 따른다. 본 연구에서는 동결보존되어 있던 초기 계대의 인간 배아줄기세포를 해동하여 다시 배양할 때 자연 발생적 분화 부분을 기계적 분리 방법으로 제거하여 미분화 상태의 세포를 보다 빠르게 확보하기 위한 효율적인 방법에 대해 알아보고자 하였다. 연구방법: 인간 배아줄기세포를 계대 배양한지 4일이 되는 날, 50% 이상의 자연 발생적 분화가 나타난 세포군에서 분화된 부분만을 절개용 유리 피펫 (drawn-out dissecting pasture pipette)을 사용하여 기계적인 방법으로 제거하였다. 이후 지속적으로 배양액을 교환해 주며 세포군의 제거된 부분을 7일째 되는 날까지 관찰하였다. 결 과: 기계적 분리 방법을 사용하여 인간 배아줄기세포의 자연 발생적인 분화 부분을 제거한 빈 공간에 미분화상태의 인간 배아줄기세포가 분열하여 채워지는 것을 관찰하였다. 또한, 이 실험 방법을 연속 두 번 적용하여 배양했을 때 미분화 세포로 회복되는 세포군의 비율이 조금 더 높아지는 것을 확인할 수 있었다. 결 론: 동결되어 있던 초기 계대 인간 배아줄기세포의 해동 후, 자연 발생적 분화에 의해 미분화 상태를 유지하는 세포의 수가 적어 계대를 유지 하기가 어려울 때 이와 같은 기계적 분리 방법을 사용하여 자연 발생적 분화 부분을 제거한 후 배양을 지속하는 것이 단기간 내에 미분화 상태를 유지하는 인간 배아줄기세포의 양적 확보를 위한 효율적인 방법이라고 사료된다. Objective: Human embryonic stem cells (hESCs) have the capacity to differentiate into all of the cell types and therefore hold promise for cell therapeutic applications. In order to utilize this important potential of hESCs, enhancement of currently used technologies for handling and manipulating the cells is required. The cryopreservation of hESC colonies was successfully performed using the vitrification and slow freezing-rapid thawing method. However, most of the hESC colonies were showed extremely spontaneous differentiation after freezing and thawing. In this study, we were performed to rapidly collect of early passage hESCs, which was thawed and had high rate of spontaneously differentiation of SNUhES11 cell line. Methods: Four days after plating, partially spontaneously differentiated parts of hESC colony were cut off using finely drawn-out dissecting pipette, which is mechanical separation method. Results: After separating of spontaneously differentiated cells, we observed that removed parts were recovered by undifferentiated cells. Furthermore, mechanical separation method was more efficient for hESCs expansion after thawing when we repeated this method. The recovery rate after removing differentiated parts of hESC colonies were 55.0%, 74.5%, and 71.1% when we have applied this method to three passages. Conclusion: Mechanical separation method is highly effective for rapidly collecting and large volumes of undifferentiated cells after thawing of cryopreserved early passage hESCs.
항과립구 항체 골수스캔을 이용한 다발성 골수종 병변의 평가 - 단순골 X-선검사 및 골스캔과의 비교
김동환,이재태,백진호,정진태,현동우,천경아,이영학,손상균,송홍석,이규보 ( Dong Hwan Kim,Jae Tae Lee,Jin Ho Baek,Jin Tae Jung,Dong Woo Hyun,Kyung Ah Chun,Young Hak Lee,Sang Kyun Sohn,Hong Seok Song,Kyu Bo Lee ) 대한핵의학회 1998 핵의학 분자영상 Vol.32 No.4
Purpose: Simple X-ray study and bone scan have limiitations for early diagnosis of bone or bone marrow lesions in multiple myeloma. The purpose of this study was to evaluate the diagnostic usefulness of bone marrow imrnunoscintigraphy using anti-granulocyte monoclonal antibody for the evaluation of bone involvement I:n multiple myeloma. Materials and Methods: In 22 patients (Male: 15, Female: 7) with multiple myeloma, we perforrned whole-body immunoscintigraphy using ' Tc-labelled antigranulocyte antibody (BW 250/183, Scintimum Granulozyt CIS, France) and compared the findings with those of simple bone radiography and Tc-MDP bone scan. Abnonnal findings in bone marrow scintigraphy were, considered to be present in case of expansion of peripheral bone marrow or focal photan defect in axial bones. Results: Marrow expansion was noted in 15 of 22 patients (68%). Focal photon defects were found in 18 patients (82%). While one (33%) of 3 patients with Stage II disease showed focal defects in bone marrow scan, abnormal focal defects were observed in 17 of 19 (90%) patients with Stage III. Among 124 focal abnormal sites which were observed in bone marrow scan, bone scan or simple bone radiography, bone rnarrow scan detected 92 sites (74%), whereas 82 sites (66%) were observed in simple bone radiography(58 sites, 47%) or bone scan(40 sites, 32%). Fifty-one (41%) out of 124 bone lesions were detected by bone marrow scan only, and located mostly in thoracolumbar spine. Conclusion: Bone marrow scan using Tc-labelled antigranulocyte antibody seems to be a more sensitive procedure for the detection of pathologic bone lesions than simple bone X-ray ar bone sean in patients with multiple myeloma. (Korean J Nucl Med 1998;32:354-64)
인성일 ( Sung Il In ),백진아 ( Jin Ah Baek ),박경숙 ( Kyung Sook Park ),방동식 ( Dong Sik Bang ),이은소 ( Eun So Lee ) 대한피부과학회 2008 대한피부과학회지 Vol.46 No.5
Background: Macrophage migration inhibitory factor (MIF) is a unique protein, participating in inflammation, immune response, and cell growth. Previous reports showed that MIF-polymorphisms are associated with an increased risk for various inflammatory diseases. Objective: This study was designed to investigate the effect of MIF polymorphisms on Behcet`s disease (BD). Methods: A total of 362 patients with BD and 290 healthy controls were genotyped. We also performed RT-PCR analysis, ELISA, and immunohistochemical stain for MIF. Results: We could not find statistically significant differences in the genotype frequencies of the MIF-794[CATT]5-8 repeat polymorphism or MIF-173 G>C polymorphism between BD patients and controls. Immunohistochemical analysis showed that MIF protein was diffusely distributed throughout epidermis and subcutaneous fat tissue from the skin lesions of patients with BD and erythema nodosum. Conclusion: Contrary to earlier reports, serum MIF levels were decreased in patients with BD, and the prescence of polymorphisms in the MIF promoter region was not associated with disease susceptibility. Nevertheless, MIF may play a role in cutaneous inflammation in BD. (Korean J Dermatol 2008;46(5):611∼618)