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부산·경남 지역의 일부 패류에 함유된 마비성 패독에 관한 연구
전진호,이종태,김성천,이채언,김준연,김병수,백낙환,Chun, J.H.,Lee, J.T.,Kim, S.C.,Lee, C.U.,Kim, J.Y.,Kim, B.S.,Paik, N.W. 한국패류학회 1986 The Korean Journal of Malacology Vol.2 No.1
The authors carried out paralytic shellfish poison bioassay on the 9 kinds of shellfishes collected from Pusan and Kyungnam areas of Korea from April to July, 1986. The areas are the main producing district of fisheries in Korea and the samples were collected from their producing sites-natural, cultured and marketed. There were little or no PSP in the majority of the shellfishes, but 3 natural (Pusan Il-Kwang $700{\mu}g$, Koje Okpo $648{\mu}g$, Chungmoo Madong $124{\mu}g/100gm$ meat) and 1 marketed (Pusan Chakalchi $490{\mu}g/100gm$ meat) blue mussels contained relatively high PSP only in April. It is considered that there will be a possibility of paralytic shellfish poisoning, and control program for preventing the poisoning is necessary in Korea.
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이종태,손혜숙,문덕환,이채언,김성천,배기택,김준연,김용완,백낙환,Lee, J.T.,Shon, H.S.,Moon, D.H.,Lee, C.U.,Kim, S.C.,Pae, K.T.,Kim, J.Y.,Kim, Y.W.,Paik, N.W. 대한예방의학회 1988 Journal of Preventive Medicine and Public Health Vol.21 No.1
1986년 3월 29일부터 동년 4월 2일까지의 5일간에 걸쳐 부산의 모 폐선 해체 작업장에서 집단적으로 발생하였던 마비성 패류 중독(Paralytic shellfish poisoning)에 대하여 그 독소(Paralytic shelfish poison; PSP) 함유량 및 성상을 보다 정확히 규명하기 위하여 사고 당시 중독의 원인으로 인정되었던 홍합(일명 진주담치, Blue mussel)에서 추출한 PSP에 대하여 동물학적 실험(mouse bioassay, A.O.A.C. method)에 의한 PSP 함유량 산정과 화학적 실험(TLC, IR 및 $^{1}H-NMR$)에 의한 독소성상 분석을 병행하여 다음과 같은 결과를 얻었다. 1. 마비성 패류 중독의 PSP함유량은 패육 100gm당 평균 $1,207.8{\mu}g$이었고, mouse의 평균 치사시간은 5분 16초(4분 51초$\sim$5분 53초)이었다. 2. TLC, IR 및 $^{1}H-NMR$ 등의 화학적 분석 결과 PSP의 주성분은 Gonyautoxin(GTX)류 이었다. The paralytic shellfish poisoning was occurred among 25 laborers who worked at breaking-up of ships in Pusan for 5 days from March 29 to April 2 of 1956. For the purpose of accurately defining the paralytic shellfish poison(PSP) , the authors carried out mouse bioassay and chemical analysis. The results were summarized as follows: 1. The mean amount of Paralytic shellfish toxin was $1,207.8{\mu}g$ Per 100gm meat, and the mean death time of mouse was 5 minutes 16 second. 2. The properties of the PSP were mainly gonyautoxin group by chemical analysis(TLC, IR, $^{1}H-NMR$).
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胃癌에서 Nitrosoureas와 Pyrimidine Analogs의 效果
김예회,김관엽,이혁상,백인욱,백낙환 인제대학교 1980 仁濟醫學 Vol.1 No.1
50명의 진행된 위암환자를 대상으로 nitrosourea계의 항암제인 CCUN 및 pyrimidine analog인 5-FU 또는 ftorafur를 병용하여 23명의 환자(46%)에서 뚜렷한 항암효과를 얻었다. CCNU 및 5-FU 병용요법을 근처적 위절제술이 가능한 환자에서 수술후 보조적 항암요법제로 사용하여 본 결자 재발의 지연내지는 예방하는데 고무적이며 이에 대하여는 보다 많은 환자를 대상으로 장기적인 추적조사가 필요하다고 생각된다. Fifty patients with advanced gastric cancer who were not previously treated with cytotoxic drugs were treaded with CCNU and pyrimidine analogs(fluorouracil or ftorafur). The first group of 38 patients were given CCNU and 5-fluorouracil in combination. The following dose schedule was used: CCNU, 150mg was given by mouth on day 1: 5-FU, 500mg was given intravenously as bolus on days 1 to 4. Each course was repeated at 6 weeks interval. There were18 responders(47%). The median duration of response was 5 months. The second group of 12 patients were treated with CCNU and ftorafur in combination. The dose schedule was as follows: CCNU, 150mg was given on day 1 and retreated at 6 weeks interval. Ftorafur was given by mouth 200mg tid daily until leukocyte count falls below 2,000. There were 5 responders (42%). The duration of reponse ranges from 2 months to 6+mosnths. The combination regimen with CCNU and fluorouracil or its derivative (ftorafur) appears to be very effective for advanced gastric cancer. The result of a preliminary study obtained from trial of the above chemotherapy regimen for patients with stomach cancer as a adjuvant setting is encouraging.
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Sparganum mansoni의 腹腔 및 腹壁皮下寄生 各 1例
심명석,서동엽,장석효,김홍용,백인욱,이혁상,백낙환 인제대학교 1982 仁濟醫學 Vol.3 No.2
Clinical experience with a case of sparganosis in the abdominal wall, and another one in the abdominal cavity is reported. A living larva of the Sparganum mansoni was removed from the subcutaneous tissue of the abdominal wall of the 62 year-old female. Biopsy of a nodule from the serosal surface of the 22-year old male revealed a eosinophilic granulomatous lesion, which contained its dead larva.
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전국 주요 시장에서 시판 중인 진주담치에 함유된 마비성 패독에 관한 조사 연구
이채언,이종태,조규일,정귀원,문덕환,신해림,김공현,배기택,김용완,백낙환 인제대학교 1990 仁濟醫學 Vol.11 No.1
마비성 패독(paralytic shellfish poison)은 강력한 자연계 신경독으로 먹이연쇄를 통해 패류에 축적되며 이를 인간이나 동물이 섭취할 경우 마비성 패류 중독(paralytic shellfish poisoning)을 발생하게 된다. 마비성 패류 중독은 미국, 캐나다 및 일본 등지에서 비교적 호발하고 있으나, 우리나라의 경우 최초의 공식 보고는 1986년 4월 부산지역에서 발생된 집단 중독례로 원인 패류는 진주담치(blue mussel, Mytilus edulis)였다. 본 조사자들은 1989년 4월부터 7월까지 전국 주요 시장 38개소에서 시판 중인 진주담치를 수거하여 mouse bioassay를 이용하여 마비성 패독 함유량을 산정하였기에 보고하고자 한다. Bioassays on paralytic shellfish poison(PSP) in blue mussels(Mytilus edulis) were earned out. The subject matters were collected from 38 markets of 26 places throughout the country, during the period of April to July, 1989. At the time of collection, they were classified into two groups by their sites produced either natural or cultured. As a result, it was identified that two subject matters which were collected from markets of both Boryong and Chinhae contained PSP. The PSP toxicity scores were 47.97㎍/100gm meat in Boryong, 48.84㎍/100gm meat in Chinhae respectively, which are much lower than the level of lethal dose. Hewever it is noticeable that blue mussels in markets contained PSP, which may increase the risk of paralytic shellfish poisoning. From the view point of public health, control measures for preventing paralytic shellfish poisoning are necessary.
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