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배현우,이소미,김지윤 대한소아혈액종양학회 2017 Clinical Pediatric Hematology-Oncology Vol.24 No.2
We describe our experience regarding metronidazole-induced encephalopathy in a patient with acute lymphoblastic leukemia during chemotherapy. A 17-year-old girl was admitted to our institution with complaints of abdominal pain and mucoid stools. She was diagnosed with acute lymphoblastic leukemia and had been undergoing intensified chemotherapy protocol. During the fifth week of interim maintenance-1 therapy, she developed a fever and complained of chills. On stool examination, stool occult blood was positive and Clostridium difficile toxin A/B test was positive. She was started on metronidazole treatment for possible Clostridium difficile infection and other inflammatory gastrointestinal diseases. Ten days later, the patient complained of dizziness and nausea. A brain MRI was performed to make a differential diagnosis of any chemotherapy-induced CNS complication such as necrotizing leukoencephalopathy. The brain MRI showed features of metronidazole-induced encephalopathy. Metronidazole was discontinued and symptoms started to subside four days after. A follow-up brain MRI performed at four weeks showed that lesions of the dentate nucleus had disappeared.
자흡식 벤츄리 노즐에서의 물-공기 이상유동의 특성에 대한 실험적 연구
배현우,유인수,성재용,이명호 한국생산제조학회 2019 한국생산제조학회지 Vol.28 No.6
Self-entrainment of air occurs when water is supplied through a venturi nozzle with an air hole in its throat. To study the characteristics of air entrainment, the air flow rates and air volume ratio were measured. The flow inside the nozzle was visualized for various diverging angles and water flow rates. The results shows that air entrainment increases with the water flow rate; however, the air volume ratio remains almost constant. Furthermore, air entrainment is the highest at a diverging angle of 40°. As the water flows downstream, an annular, two-phase flow starts to form in the diverging section, changing the flow pattern to a churn flow. This sudden expansion in the diverging section induces a vortex separation that blocks the pathway of air entrainment when air bubbles are present in the vortex.
Treatment Outcomes of Brain metastasis from Papillary Thyroid Cancer
배현우,김석모,김수영,장호진,김법우,이용상,장항석,박정수,Bae, Hyeonwoo,Kim, Seok-Mo,Kim, Soo Young,Chang, Ho Jin,Kim, Bup-Woo,Lee, Yong Sang,Chang, Hang-Seok,Park, Cheong Soo The Korean Society for Head and Neck Oncology 2018 대한두경부 종양학회지 Vol.34 No.1
Background/Objectives: Brain metastasis (BM) is a rare form of distant metastasis with papillary thyroid cancer (PTC). Patients with BM of PTC carry a poor prognosis. The aim of this study was to contribute to the understanding of this disease by analyzing patients with BM of PTC. Materials & Methods: Between March 2003 and December 2013, the patient database was conducted to identify thyroid cancer patients treated. Among the 22,758 thyroid cancer patients, 14 (0.06 %) were identified to have metastasis to the brain during follow-up. The medical records of 14 patients with BM were retrospectively reviewed, focusing on the following: patient characteristics, synchronous or previous distant metastasis, treatments including whole brain radiotherapy (WBRT), stereotactic radiosurgery (SRS) and surgery, and characteristics on radiologic findings, time interval between first diagnosis of primary thyroid cancer and BM and survival after BM. Results: The mean age at initial diagnosis and BM were $50.9{\pm}15.8years$ and $61.3{\pm}12.7years$. The mean duration between initial diagnosis and BM was $10.4{\pm}7.9years$. Patients were treated with varied combinations of surgery, SRS and WBRT except 4 patients who had refused treatment. The median overall survival (OS) time after BM diagnosis was 10 months (range 1 - 19). Patients receiving treatment (WBRT and/or surgery, SRS) had a significant longer median OS of 16.5 months in comparison to 3.5 months for those treated without treatment. (p = 0.005) Conclusion: Patients who received aggressive treatment had a longer OS than those with only supportive care. Treatment such as surgery, SRS and WBRT should be considered in patients with BM.
배현우,도기덕,김인호,장성열 한국해양공학회 2022 韓國海洋工學會誌 Vol.36 No.4
The process-based XBeach model has numerous empirical parameters because of insufficient understanding of hydrodynamics and sediment transport on the nearshore; hence, it is necessary to calibrate parameters to apply to various study areas and wave conditions. Therefore, the calibration process of parameters is essential for the improvement of model performance. Generally, the trial-and-error method is widely used; however, this method is passive and limited to various and comprehensive parameter ranges. In this study, the Generalized Likelihood Uncertainty Estimation (GLUE) method was used to estimate the optimal range of three parameters (gamma, facua, and gamma2) using morphological field data collected in Maengbang beach during the four typhoons that struck from September to October 2019. The model performance and optimal range of empirical parameters were evaluated using Brier Skill Score (BSS) along with the baseline profiles, sensitivity, and likelihood density analysis of BSS in the GLUE tools. Accordingly, the optimal parameter combinations were derived when facua was less than 0.15 and simulated well the shifting shape, from crescentic sand bar to alongshore uniform sand bars in the surf zone of Maengbang beach after storm impact. However, the erosion and accretion patterns nearby in the surf zone and shoreline remain challenges in the XBeach model.
다수의 공동 배열을 가진 가이드 그릴 형상이 공진기 흡입 유동에 미치는 영향
배현우(Hyunwoo Bae),성재용(Jaeyong Sung),이동훈(Dong Hoon Lee) 한국가시화정보학회 2016 한국가시화정보학회 학술발표대회 논문집 Vol.2016 No.12
In this study, the intake flows through guide grills consisting of multi cavities above a resonator have been investigated by 3-D numerical simulations. The flows are assumed to be compressible, unsteady, and turbulent. To analyze the effect of the cavity array structures on the guide grill, aligned and staggered structures are considered. For each structure, the amount of intake mass flow rate through the cavity is compared. The results show that the net mass flow rate through the cavity has a positive or negative value depending on the position of cavity, which denotes intake and outtake flows through a cavity. These intake and outtake flows are sequentially generated in the array of the cavity. In case of the aligned cavity array, there are also found cavities which have neither intake nor outtake flow.
열차 주행 시 터널 벽면에서의 속도장 및 압력분포 해석
배현우(Hyunwoo Bae),성재용(Jaeyong Sung) 한국철도학회 2014 한국철도학회 학술발표대회논문집 Vol.2014 No.10
열차가 터널 내부에서 주행할 때, 터널 벽면에 높은 속도를 가지는 유동장과 강한 압력파가 발생하게 된다. 이는 진동 및 소음을 발생시키고, 터널 내에서 발생하는 먼지를 플랫폼으로 이동시켜 승객들에게 불편을 유발한다. 본 연구에서는 진동 및 소음문제를 개선하고자 터널에서 열차가 주행 시 벽면에서 생기는 속도장 및 압력분포를 해석하였다. 터널내 유동은 2차원 압축성 난류 모델을 이용하여 수치해석 하였다. 난류모델로는 RNG모델을 사용하였고, 움직이는 열차에는 sliding method와 layering method를 적용하였다. 그 결과 터널내 열차 주행에 의해 열차 속도의 2배 이상의 유체 속도장이 벽면 근처에 형성되었으며, 강한 음압이 나타남을 알 수 있었다. When the train passes through a tunnel, high velocity and strong pressure fields are formed on the tunnel wall. These effects generate vibration, noise and make dust transported to platform. And then, the effects cause inconvenience to passengers. In this study, for improving vibration and noise problem, velocity and pressure fields on the tunnel wall during passing through tunnel are solved using Ansys-Fluent software. Flow in the tunnel is computed by using two-dimensional, compressible, turbulence model. As a turbulence model, RNG k-ε model is applied. To implement the train motion, sliding meshes are used. As a result, there forms strong flow velocity more than twice the train speed accompanying with strong negative pressure by the subway train passing.