Interstitial Pneumonitis를 동반한 Sj$\ddot{o}$gren's 증후군 1예

박준영,이규락,이상무,김현태,어수택,정연태,김용훈,박춘식,진소영,Park, Jun-Young,Yi, Kyu-Rak,Lee, Sang-Moo,Kim, Hyeon-Tae,Uh, Soo-Taek,Chung, Yeon-Tae,Kim, Yong-Hun,Park, Choon-Sik,Jin, So-Young 대한결핵및호흡기학회 1992 Tuberculosis and Respiratory Diseases Vol.39 No.4

Sj$\ddot{o}$gren's syndrome (SS) is an immunologic disorder characterized by progressive destruction of the exocrine glands due to infiltration of lymphocyte resulting in mucosal and conjunctival dryness accompanied by a variety of autoimmune phenomena. And SS is divided into primary and secondary by accompanying collagen vascular diseases. In Korea, only a few cases of primary SS and primary SS with interstitial pneumonitis have been documented. Recently we experinced a suspected case of primary SS with interstitial pneumonitis diagnosed by sublabial and open lung biopsy, Schirmer's test and slit lamp test.

Apoptotic Effect of Co-Treatment with Valproic Acid and 17AAG on Human Osteosarcoma Cells

박준영,박세진,김인령,박봉수,정성희,고명연,안용우,Park, Jun-Young,Park, Se-Jin,Kim, In-Ryoung,Park, Bong-Soo,Jeong, Sung-Hee,Ko, Myung-Yun,Ahn, Yong-Woo Korean Academy of Orofacial Pain and Oral Medicine 2011 Journal of Oral Medicine and Pain Vol.36 No.1

Valproic acid (VPA) is a well-known anticonvulsive agent and has been used in the treatment of epilepsy for almost 30 years. VPA emerged in 1997 as an antineoplastic agent. And it is known that antitmor activity of VPA is associated with its targeted at histone deacetylases. 17AAG, Inhibition of HSP90 leads to the proteasome degradation of the HSP90 client proteins, such as Akt, Raf/Ras, Erk, VEGF, cyclin D and p53, and causes potent antitumor activity. It is reported that 17AAG-induced HSP90 inhibition results in prevention of cell proliferation and induction of apoptosis in several types of cancer. This study was undertaken to investigate the synergistic apoptotic effect of co-treatment with the histone deacetylases inhibitor, VPA and the HSP90 inhibitor, 17AAG on human osteosarcoma (HOS) cells. Cell viability was evaluated by trypan-blue exclusion. Induction and augmentation of apoptosis were confirmed by Hoechst staining, flow cytometry (DNA hypoploidy and MMP change), Westen blot analysis and immunofluorescent staining. In this study, HOS cells co-treated with VPA and 17AAG showed several lines of apoptotic manifestation such as nuclear condensations, the reduction of MMP, the decrease of DNA content, the release of cytochrome c into cytosol, the translocation of AIF onto nuclei, and activation of caspase-3, caspase-7 and PARP whereas each single treated HOS cells did not. Although the single treatment of 1 mM VPA or 0.5 ${\mu}M$ 17AAG for 48 h did not induce apoptosis, the co-treatment with them induced prominently apoptosis. Therefore our data in this study provide the possibility that combination therapy with VPA and 17AAG could be considered as a novel therapeutic strategy for human osteosarcoma.

상시 교량 모니터링을 위한 저전력 IoT 센서 및 클라우드 기반 데이터 융합 변위 측정 기법 개발

박준영,신준식,원종빈,박종웅,박민용,Park, Jun-Young,Shin, Jun-Sik,Won, Jong-Bin,Park, Jong-Woong,Park, Min-Yong 한국전산구조공학회 2021 한국전산구조공학회논문집 Vol.34 No.5

It is important to develop a digital SOC (Social Overhead Capital) maintenance system for preemptive maintenance in response to the rapid aging of social infrastructures. Abnormal signals induced from structures can be detected quickly and optimal decisions can be made promptly using IoT sensors deployed on the structures. In this study, a digital SOC monitoring system incorporating a multimetric IoT sensor was developed for long-term monitoring, for use in cloud-computing server for automated and powerful data analysis, and for establishing databases to perform : (1) multimetric sensing, (2) long-term operation, and (3) LTE-based direct communication. The developed sensor had three axes of acceleration, and five axes of strain sensing channels for multimetric sensing, and had an event-driven power management system that activated the sensors only when vibration exceeded a predetermined limit, or the timer was triggered. The power management system could reduce power consumption, and an additional solar panel charging could enable long-term operation. Data from the sensors were transmitted to the server in real-time via low-power LTE-CAT M1 communication, which does not require an additional gateway device. Furthermore, the cloud server was developed to receive multi-variable data from the sensor, and perform a displacement fusion algorithm to obtain reference-free structural displacement for ambient structural assessment. The proposed digital SOC system was experimentally validated on a steel railroad and concrete girder bridge. 사회기반 시설물의 노후화에 대응해 이상 징후를 파악하고 유지보수를 위한 최적의 의사결정을 내리기 위해선 디지털 기반 SOC 시설물 유지관리 시스템의 개발이 필수적인데, 디지털 SOC 시스템은 장기간 구조물 계측을 위한 IoT 센서 시스템과 축적 데이터 처리를 위한 클라우드 컴퓨팅 기술을 요구한다. 본 연구에서는 구조물의 다물리량을 장기간 측정할 수 있는 IoT센서와 클라우드 컴퓨팅을 위한 서버 시스템을 개발하였다. 개발 IoT센서는 총 3축 가속도 및 3채널의 변형률 측정이 가능하고 24비트의 높은 해상도로 정밀한 데이터 수집을 수행한다. 또한 저전력 LTE-CAT M1 통신을 통해 데이터를 실시간으로 서버에 전송하여 별도의 중계기가 필요 없는 장점이 있다. 개발된 클라우드 서버는 센서로부터 다물리량 데이터를 수신하고 가속도, 변형률 기반 변위 융합 알고리즘을 내장하여 센서에서의 연산 없이 고성능 연산을 수행한다. 제안 방법의 검증은 2개소의 실제 교량에서 변위계와의 계측 결과 비교, 장기간 운영 테스트를 통해 이뤄졌다.

전극평형전위차 가스 센싱 메커니즘을 적용한 일산화탄소 소형 전위차센서의 특성 향상에 관한 연구

박준영,김지현,박가영,Park, Jun-Young,Kim, Ji-Hyun,Park, Ka-Young,Wachsman, Eric D. 한국세라믹학회 2010 한국세라믹학회지 Vol.47 No.1

Based on the differential electrode equilibria approach, potentiometric YSZ sensors with semiconducting oxide electrodes for CO detection are developed. To improve the selectivity, sensitivity and response-time of the sensor, our strategy includes (a) selection of an oxide with a semiconducting response to CO, (b) addition of other semiconducting materials, (c) addition of a catalyst (Pd), (d) utilization of combined p- and n-type electrodes in one sensor configuration, and (e) optimization of operating temperatures. Excellent sensing performance is obtained by a novel device structure incorporating $La_2CuO_4$ electrodes on one side and $TiO_2$-based electrodes on opposite substrate faces with Pt contacts. The resulting response produces additive effects for the individual $La_2CuO_4$ and $TiO_2$-based electrodes voltages, thereby realizing an even higher CO sensitivity. The device also is highly selective to CO versus NO with minor sensitivity for NO concentration, compared to a notably large CO sensitivity.

천음속 회전익에서의 누설유동

박준영,정희택,백제현,Park, Jun-Young,Chung, Hee-Taeg,Baek, Je-Hyun 대한기계학회 2003 大韓機械學會論文集B Vol.27 No.1

It is known that tip clearance flows reduce the pressure rise, flow range and efficiency of the turbomachinery. So, the clear understanding about flow fields in the tip region is needed to efficiently design the turbomachinery. The Navier-Stokes code with the proper treatment of the boundary conditions has been developed to analyze the three-dimensional steady viscous flow fields in the transonic rotating blades and a numerical study has been conducted to investigate the detail flow physics in the tip region of transonic rotor, NASA Rotor 67. The computational results in the tip region of transonic rotors show the leakage vortices, leakage flow from pressure side to suction side and their interaction with a shock. Depen ding on the operating conditions, toad distributions and the position of shock-wave on the blade surface are very different close to the blade tip of the transonic compressor rotor. The load distribution and the shock-wave position close to the blade tip had the close relationship with the starting position of leakage vortex and the direction of leakage flow.

탄산화 건자재 제조를 위한 석탄 비산회의 탄산화

박준영,김유택,김현정,Park, Jun-Young,Kim, Yoo-Taek,Kim, Hyun-Jung 한국결정성장학회 2012 한국결정성장학회지 Vol.22 No.3

이산화탄소($CO_2$)를 폐기물에 안정하게 고정화시키기 위하여 탄산화 가능한 알칼리 토금속인 Ca와 Mg 성분을 다량 포함한 석탄재에 CO2를 저장하여 건자재의 제조 가능성을 연구하였다. 초기 실험으로는 Ca 산화물과 수화물을 사용하였으며, $CO_2$ 저장 반응기로는 Autoclave를 사용하여 일정한 압력과 온도에서 조성을 변화시켜 탄산화를 시행하였다. 탄산화 된 시편의 무게변화율, X-선 회절분석 및 시차열분석을 통하여 관찰한 결과 $Ca^{2+}$의 이온용출 반응에 의해 탄산화가 진행되었음을 확인할 수 있었다. 10 $kgf/cm^2$의 압력과 $120^{\circ}C$에서 10분간 온도를 유지한 분위기에서 폐기물자원 원료에 15 % 이상의 탄산화율을 얻는 것이 가능할 것으로 판단되었다. Carbon dioxide ($CO_2$) could be stored in the form of Ca and Mg compounds including alkaline earth metal by carbonation. The possibility of $CO_2$ storage was tested by using desulfurized ash from fluidized bed type boiler as raw material. Autoclave was used for maintaining the reaction pressure and temperature for the carbonation. The analysis of weight change rate, XRD, and TG/DTA proved that more than 15 % of carbonation rate was obtained under 10 $kgf/cm^2$ and $120^{\circ}C$-10 min.

회원작품 - 목은재(木隱齋)

박준영,Park, Jun-Young 대한건축사협회 2009 建築士 Vol.2009 No.6

냉동 중 신선 소고기패티의 안정성 평가를 위한 정향 첨가 효과

박준영,양한술,Park, Jun-Young,Yang, Han-Sul 한국축산식품학회 2020 축산식품과학과 산업 Vol.9 No.2

Y-90 microsphere 로부터 생성되는 제동복사선의 차폐를 위한 차폐체 개발 연구

박준영,Park, Jun Young 대한핵의학기술학회 2019 핵의학 기술 Vol.23 No.1

본 연구는 고에너지의 베타선을 방출하는 Y-90 미세구의 경동맥방사선색전술 시 발생되는 제동복사선에 의한 불필요한 외부피폭을 줄이고자 텅스텐 차폐체를 개발하였다. 본 연구에서는 다양한 용량(1 GBq, 2 GBq, 4 GBq)의 $SIR-Spheres^{(R)}$ Y-90 미세구를 사용하여, 텅스텐 차폐체 표면으로부터 10 cm, 50 cm, 100 cm인 곳에서 GM tube식 디지털 서베이미터로 선량률을 측정하였다. 텅스텐 차폐체 표면 10 cm 위치에서 차폐율을 분석한 결과 4 GBq의 $SIR-Spheres^{(R)}$ Y-90 미세구의 경우 90.9%, 2 GBq의 경우 88.9%, 1 GBq의 경우 88.8%의 차폐율을 보였고, 표면 50 cm 위치에서 차폐율은 4 GBq의 $SIR-Spheres^{(R)}$ Y-90 미세구의 경우 89.2%, 2 GBq의 경우 87.5%, 1GBq의 경우 86.3%로 나타났다. 텅스텐 차폐체 표면 100 cm 위치에서 텅스텐 차폐체는 평균 75.1%의 차폐율을 보이는 것으로 확인할 수 있었다. 높은 용량이 함유된 $SIR-Spheres^{(R)}$ Y-90 미세구의 경동맥방사선색전술시 방사선 작업종사자와 선원간의 거리가 짧고, 작업시간이 길기 때문에 제동복사선에 의한 피폭에 노출될 수 있다. 본 연구를 통해 개발된 텅스텐 차폐체는 향후 임상에서 경동맥방사선색전술 시 제동복사선에 의한 외부피폭을 줄이는데 활용될 수 있을 것이라 기대 된다. Purpose Yttrium-90 (Y-90) is high-energy beta emitters ($E{\beta}$, max = 2.28 MeV) with the mean penetration depth of 2.5 mm in tissue. Radioactive microspheres containing Y-90 is widely used for the transarterial radioembolization of hepatocellular carcinoma. However, bremsstrahlung radiation from Y-90 can cause the external radiation exposure to medical staff who handle the Y-90 microspheres. In this study, shielding device for Y-90 microspheres was developed to minimize the external radiation exposure. Materials and Methods Y-90 microsphere shielding device was made from 6 mm thicknesses of tungsten including the lead glass window. Radiation shielding ability of Y-90 microsphere shielding device was evaluated using 4 GBq of $SIR-Spheres^{(R)}$ Y-90 microspheres. The bremsstrahlung radiation was measured using radiation survey meter. Results The mean radiation dose of Y-90 microspheres in acrylic shield was $261.7{\pm}2.3{\mu}Sv/h$ (n=5) at 10 cm away from the shield. With the additional tungsten shielding device, it was $23.7{\pm}1.3{\mu}Sv/h$ (n=5). Thus, the bremsstrahlung radiation dose was decreased by 90.9%. At 50 cm away from the shield, bremsstrahlung radiation was reduced by 89.2% after using tungsten shielding device. Conclusion During the preparation and radioembolization of Y-90 microsphere, medical staff are exposed to external radiation. In this study, we demonstrated that the use of tungsten shielding device devices significantly reduced the amount of bremsstrahlung radiation. Y-90 microsphere tungsten shielding device can be highly effective in reducing the bremsstrahlung radiation.

압전효과를 이용한 압인방식의 휴대용 피부탄력 측정장치

박준영,김명남,Park, Jun-Young,Kim, Myoung Nam 한국멀티미디어학회 2022 멀티미디어학회논문지 Vol.25 No.9

In this paper, we proposed and developed a new portable skin elasticity measuring device based on the indentation method using piezoelectric effect. The proposed device is designed to minimize the uncertainty caused by the layer structure of the skin when measuring the elasticity of the skin. And, we developed a piezoelectric-based thin-film pressure sensor that can measure quantitatively and quickly during repeated measurement as a device sensor. To confirm the effectiveness of the proposed measuring device, it was compared with the experimental results of the conventional measuring devices under the same experimental conditions, and statistical correlation analysis was performed between the experimental data of the proposed measuring device and the experimental data of the conventional measuring devices. As a result of the correlation analysis, it was confirmed that the proposed measuring device had a high correlation with the conventional measuring devices. Therefore, it was confirmed that the proposed skin elasticity measuring device was effective.