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Inhibition of Various K+ Current by Ofloxacin in Neonatal rat Ventricular Myocytes
박상웅,오승범,구재웅,성동준 한국웰니스학회 2018 한국웰니스학회지 Vol.13 No.3
Fluoroquinolones are among the most widely used broad-spectrum antibiotics. Although ofloxacin is deemed to be relatively safe, whether side effects occur in the heart is unclear. This pilot study investigated the effect of ofloxacin on various K+ channel currents as well as L-type Ca2+ channel currents. The various K+currents were examined with a voltage pulse protocol using multi-step pulses, with a step to-120mV followed by a depolarizing step to +50mV and then to –40mV from holding potential of –80mV. L-type Ca2+ currents were measured at 0mV after prepulse to –40mV. Ofloxacin inhibited the various K+ currents, with IC50 values of 850μM for IKir, 6.8μM for IKs, and 0.4μM for IKr. Ofloxacin did not affect the L-type Ca2+ currents. We suggest that potential cardiac side effects, such as action potential prolongation and arrhythmia, maybe induced by ofloxacin.
박상웅 한국산학기술학회 2024 한국산학기술학회논문지 Vol.25 No.7
현재 국내에서 연구개발되는 정밀유도무기체계의 시험평가 수량을 결정하는 핵심요소는 군의 요구성능(Requirement of Capability, ROC)상에 명시된 명중률이다. ROC에서 제시된 명중률은 무기체계 소요결정 간 제시된 기준이며, 달성여부는 단순히 시험을 통해 획득된 명중률(명중 수/시험발수)에 근거하여 합격/불합격을 판정하고 있다. 이러한 수량산정 기준 및 명중률 판정 기준은 시험발사수량과 실제 양산수량의 차이가 커질수록 시험수량의 대표성이 줄어들어 정확한 결과를 얻기 어려운 문제가 있으며 또한 시험의 성공여부에 따라 실패 시 과도한 재시험수량이 요구된다. 이러한 평가 방법은 일부 시제품에 대한 시험결과를 전체로 확대해석하여 실제 장비의 명중률에 대한 불신을 야기할 수 있다. 따라서 본 연구는 방위사업청 선행연구 수행지침에 따라 선행연구 조사·분석 수행과정에서 유도무기의 시험사격수량을 종합적으로 분석하고자 하였다. 이를 위해 관련내용에 대한 기존 연구자료를 분석하였고 그에 따른 신뢰수준과 명중률을 파라미터로 활용하여 사격수량 추정방안을 소개한 후, 국내·외 유도무기 사격수량 및 비용을 사례로 활용하여 적절한 신뢰수준을 제시하였다. 위 결과를 바탕으로 무기체계의 특성을 고려한 유도탄 사격시험 수량을 도출하였으며 최종적으로 최근 전력화가 완료된 유도무기체계의 사례와 비교분석하여 추후 활용 가능성을 확인하였다. The number of test evaluations of a precision-guided weapon system currently researched and developed in Korea is determined by the accuracy rate specified in the military's Requirement of Capability (ROC). The accuracy rate presented in the ROC is the criterion used to make decisions about the weapon system. The number of hits/test launches obtained through the test determines whether the system passes or fails. The criteria for determining the quantity and accuracy rate present a challenge in that the representativeness of the test quantity declines as the discrepancy between the number of test launches and the actual quantity for mass production increases. This makes it challenging to obtain accurate results. Furthermore, a substantial number of retests are required in the event of failure, contingent on the success or failure of the test. This evaluation method may reduce confidence in the accuracy rate of actual equipment by expanding and analyzing the test results for some prototypes as a whole. Therefore, this study aimed to comprehensively analyze the number of test shots of guided weapons in the process of conducting prior research and analysis in accordance with the Defense Acquisition Program Administration's guidelines for conducting prior research. A suitable level of confidence was demonstrated by presenting domestic and foreign guided weapon firing quantity and cost as examples after analyzing existing research data on the relevant content and introducing a method for estimating the number of shots fired using the confidence level and accuracy rate as parameters. Finally, the potential for future use was confirmed by comparing and analyzing the case of a guided weapon system with the above results, considering the characteristics of the weapon system.
Facilitation of serotonin-induced contraction of rat mesenteric artery by ketamine
박상웅,노현주,김정민,김보경,조성일,김윤수,우남식,김성훈,배영민 대한약리학회 2016 The Korean Journal of Physiology & Pharmacology Vol.20 No.6
Ketamine is an anesthetic with hypertensive effects, which make it useful for patients at risk of shock. However, previous ex vivo studies reported vasodilatory actions of ketamine in isolated arteries. In this study, we reexamined the effects of ketamine on arterial tones in the presence and absence of physiological concentrations of 5-hydroxytryptamine (5-HT) and norepinephrine (NE) by measuring the isometric tension of endothelium-denuded rat mesenteric arterial rings. Ketamine little affected the resting tone of control mesenteric arterial rings, but, in the presence of 5-HT (100~200 nM), ketamine (10~100 μM) markedly contracted the arterial rings. Ketamine did not contract arterial rings in the presence of NE (10 nM), indicating that the vasoconstrictive action of ketamine is 5-HT-dependent. The concentration-response curves (CRCs) of 5-HT were clearly shifted to the left in the presence of ketamine (30 μM), whereas the CRCs of NE were little affected by ketamine. The left shift of the 5-HT CRCs caused by ketamine was reversed with ketanserin, a competitive 5-HT2A receptor inhibitor, indicating that ketamine facilitated the activation of 5-HT2A receptors. Anpirtoline and BW723C86, selective agonists of 5-HT1B and 5-HT2B receptors, respectively, did not contract arterial rings in the absence or presence of ketamine. These results indicate that ketamine specifically enhances 5-HT2A receptor-mediated vasoconstriction and that it is vasoconstrictive in a clinical setting. The facilitative action of ketamine on 5-HT2A receptors should be considered in ketamine-induced hypertension as well as in the pathogenesis of diseases such as schizophrenia, wherein experimental animal models are frequently generated using ketamine.