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문상원,김혜선,송혜정,최홍규,박종태,김흥중,장현선,박주철,Moon, Sang-Won,Kim, Hye-Sun,Song, Hyun-Jung,Choi, Hong-Kyu,Park, Jong-Tae,Kim, Heung-Joong,Jang, Hyun-Seon,Park, Joo-Cheol 대한치주과학회 2006 Journal of Periodontal & Implant Science Vol.36 No.2
For the regeneration of periodontal tissues, the microenvironment for new attachment of connective tissue fibers should be provided, At this point of view, cementum formation in root surface plays a key role for this new attachment. This study was performed to figure out which factor promotes differentiation of cementoblast Considering anatomical structure of tooth, we selected the cells which may affect the differentiation of cementoblast - Ameloblast, OD11&MDPC23 for odontoblasts, NIH3T3 for fibroblsts and MG63 for osteoblasts. And OCCM30 was selected for cementoblast cell line. Then, the cell lines were cultured respectively and transferred the conditioned media to OCCM30. To evaluate the result, Alizarin red S stain was proceeded for evaluation of mineralization. The subjected mRNA genes are bone sialoprotein(BSP), alkaline phosphate(ALP) , osteocalcin(OC), type I collagen(Col I), osteonectin(SPARC ; secreted protein acidic and rich in cysteine). Expression of the gene were analysed by RT-PCR, The results were as follows: 1. For alizarin red S staining, control OCCM30 didn't show any mineralized red nodules until 14 days. But red nodules started to appear from about 4 days in MDPC-OCCM30 & OD11-OCCM30. 2. For results of RT-PCR, ESP mRNAs of control-OCCM30 and others were expressed from 14 days, but in MDPC23-OCCM30 & OD11-OCCM30 from 4 days. Like this, the gene expression of MDPC23-OCCM30 & OD11-OCCM30 were detected much earlier than others. 3. For confirmation of odontoblast effect on cementoblast, conditioned media of osteoblasts(MG63) which is mineralized by producing matrix vesicles didn't affect on the mineralized nodule formation of cementoblasts(OCCM30). This suggest the possibility that cementoblast mineralization is regulated by specific factor in dentin matrix protein rather than matrix vesicles. Therefore, we proved that the dentin/odontoblast promotes differentiation/mineralization of cementoblasts. This new approach might hole promise as diverse possibilities for the regeneration of tissues after periodontal disease.
문상원,김지완,이동현,김영창,김영복,이상진 대한골대사학회 2012 대한골대사학회지 Vol.19 No.2
As a result of aging population, the incidence of pelvic insufficiency fracture has been increasing. Pain-related immobility caused by pelvic insufficiency fractures may result in a serious dependency and high mortality with preexisting comorbidities. We present two cases of pelvic insufficiency fracture in elderly patients which had good clinical outcome by parathyroid hormone 1-34(teriparatide) treatment as well as a literature review.
문상원 한국재산법학회 2008 한국재산법학회 학술대회 자료집 Vol.2008 No.1
국가배상법은 그 주체가 국가로 한정되는 손해배상 책임에 관한 내용을 담고 있다. 그러나 주체를 한정하는 법률 규정이라 하여 그 기본적인 법리가 일반 손해배상의 법리와 전혀 다른 의미를 가지는 것인지 또한 그에 따른 별개의 규율 체계를 가져야 하는 것인지 의문이 제기 되었다. 따라서 여기서는 국가배상법을 일반 민사법과 비교하여 보고, 더 구체적으로 들어가 다른 특별사법인 자동차손해배상보장법과의 관계에 대해서도 논의해 보도록 한다. 마지막으로 국가배상법의 특별사법으로서의 성격에 대한 평가를 해보고, 특히 국가배상법의 규정에 대하여 일반 손해배상의 제도와 별다른 근거없이 특별한 해석을 시도한 판례의 태도의 문제점을 알아봄으로써 향후 국가배상 제도의 법적인 문제와 개선책에 대한 논의의 필요성을 제기하고자 한다.
정상안 및 황반 질환에서 스펙트럼 영역 빛간섭단층촬영(3D-OCT 1000)의 황반 두께 및 부피 반복성
문상원,이정민,송유미,조희윤,이병로,Sang Won Moon,Jung Min Lee,You Mi Song,Hee Yoon Cho,Byung Ro Lee 대한안과학회 2010 대한안과학회지 Vol.51 No.4
Purpose: To evaluate the repeatability of macular thickness and total macular volume measurements made using spectral domain optical coherence tomography (OCT) in normal subjects and subjects with macular disease. Methods: Among a total of 108 subjects, there were 50 normal subjucts, 20 patients with diabetic macular edema, 10 patients with retinal vein occlusion, 15 patients with age-related macular degeneration, and 13 subjects with other conditions. Two serial macular measurements were obtained from each subject by a single experienced examiner using spectral domain OCT. The repeatability of the measurements was evaluated by comparing two consecutive foveal and perifoveal thickness measurements and total macular volume measurements. The intraclass correlation coefficient was also calculated to evaluate the repeatability of measurements made in normal and macular disease subjects. Result: Spectral domain OCT measurements of macular thickness and macular volume were found to be consistent. Measurements of normal subjects were the most consistent, followed by measurements of patients with age-related macular degeneration, retinal vein occlusion, and diabetic macular edema. Conclusions: Although measurements made using spectral domain OCT were repeatable across all subjects, they were more consistent in normal subjects than in patients with macular disease. The differences in repeatability should be considered in the context of diseased pathologic anatomy. Physicians should remain cautious when using these measurements for clinical evaluation. J Korean Ophthalmol Soc 2010;51(4):524-531