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대장 용종에서 cyclooxygenase - 2 와 vascular endothelial growth factor ( VEGF ) 의 발현
이창우(Chang Woo Lee),이구(Goo Lee),김동훈(Dong Hoon Kim),전훈재(Hoon Jai Chun),서정일(Jeong Ill Suh),양창헌(Chang Heon Yang),김수근(Soo Keun Kim),김창덕(Chang Duck Kim),류호상(Ho Sang Ryu),현진해(Jin Hae Hyun),김한겸(Han Kyeon Kim) 대한내과학회 2001 대한내과학회지 Vol.61 No.3
N/A Background : Recent studies showed that non-steroidal antiinflammatory drug may reduce the risk of colorectal cancers. So its potential target, cyclooxygenase (COX)-2 in colorectal cancers has been widely investigated. However, the rate and patterns of COX-2 expression in colorectal polyps have been quite variable among study groups. Furthermore, its role has not been established. The study aim is to investigate the expressions of COX-2 and vascular endothelial growth factor (VEGF) and to evaluate the role of COX-2 in colorectal polyps. Methods : Fifty-seven colorectal polyps from endoscopic polypectomy or surgical resection were enrolled. Polyps were as follows; 9 were hyperplastic polyps, 14 mild, 26 moderate dysplasia, 8 high grade adenomas (5 severe dysplasia, a carcinoma in situ, and two intramucosal carcinomas). They were stained for COX-2 and VEGF by immunohistochemistry. The intensity of staining according to histologic grades and size of polyp was semi-quantitatively assessed. Results : COX-2 was expressed in 18 cases (31.8%) by dysplastic epithelium and 29 cases (50.9%) by interstitial cells. Epithelial COX-2 expressions were significantly related to histologic grades and size, and begun at moderate dysplasia actually. Interstitial COX-2 was little related to histologic grades and size. VEGF was expressed in 35 cases (61.4%). There was close relationship between epithelial COX-2 and VEGF expressions. Conclusion : COX-2 is expressed both in dysplastic epithelium and interstitial cells of colorectal polyps. Our results suggest that epithelial COX-2 expression may be playing a role in tumorigenesis of colorectal polyp, possibly involved in angiogenesis with VEGF.(Korean J Med 61:240-248, 2001)
강창돈(Chang Don Kang),송치욱(Chi Wook Song),구자설(Ja Soul Koo),손수민(Soo Min Sohn),김혜랑(Hye Rang Kim),진윤태(Yoon Tae Jeen),전훈재(Hoon Jai Chun),엄순호(Soon Ho Um),김창덕(Chang Duck Kim),류호상(Ho Sang Ryu),현진해(Jin Hai Hyun) 대한소화기기능성질환·운동학회 2001 Journal of Neurogastroenterology and Motility (JNM Vol.7 No.1
N/A Background/Aims: The competency of the gastroesophageal junction (GEJ) holds the key in unlocking pathophysiologic mechanisms of gastroesophageal reflux disease (GERD). However, a relationship between GERD and the incompetent GEJ has not been established. The aim of our study was to assess the relationship between the shape of the GEJ and gastroesophageal acid reflux. Methods: Forty six patients with reflux symptoms underwent an endoscopy, esophageal manometry and 24-hour esophageal pH monitoring. Patients were placed in 3 groups according to the shape of their GEJ, categorized by a retroflex view of the endoscopy; type I - gastroesophageal fold without a pouch, type II - no pouch and no fold, and type III - a pouch without a fold. Results: In type II and III, LESP was reduced. However, %of time with the pH < 4.0 was increased in type III only. There was a significant correlation between the size of a hiatal hernia and the shape of the GEJ. There was a relationship between the grade of esophagitis and the shape of the GEJ. Conclusions: The retroflex endoscopic finding of the GEJ focusing on the presence or absence of a GE fold and hiatal pouch, could be an indicator of whether a patient has GERD.(Korean Journal of Gastrointestinal Motility 2001;7:29-35)
현진해(Jin Hae Hyun),류호상(Ho Sang Ryu),김창덕(Chang Duck Kim),김혜랑(Hye Rang Kim),박종재(Jong Jae Park),김광희(Kwang Hee Kim) 대한소화기학회 1991 대한소화기학회지 Vol.23 No.4
With progress in diagnostic procedures such as endoscopy and dye method, early diagnosis of esophageal cancer has become possible. Esophageal cancer shows poor prognosis generally, but shows variable outcome according to tumor invasion to underlying tissue. Esophageal cancer not infiltrated beyond submucosal layer without lymphatic invasion shows excellent postoperative outcome because of high curability of early esophageal cancer. We experienced a case of multiple, early esophageal cancer in a asymptomatic patient who visited for general check up, and was diagnosed by endoscopy and surgical specimen. The lesions were a polypoid lesion with irregular erosive surface and slightly elevated lesion on middle and lower esophagus respectively. The histopathologic finding revealed the moderately differentiated squamous carcinoma infiltrated to the level of submucosa. The patient was treated with surgical operation and discharged with cured condition.
현진해(Jin Hai Hyun),류호상(Ho Sang Ryu),이중건(Choong Keun Lee),김창덕(Chang Duck Kim),박균철(Kyun Chul Park),조인식(In Sik Cho),김의경(Eui Kyeong Kim),김남성(Nam Seong Kim),이재동(Jae Dong Lee) 대한소화기학회 1988 대한소화기학회지 Vol.20 No.3
It is common to define double primary cancer as the case of primary malignant tumors of different histologic site origins in each other. Etiology of double primary cacer is not known exactly but there are many contributing factors and theories about double primary cancer development. Owing to advancement of diagnostic procedure, reported cases of double primary malignant tumors have been increased in number. But occurance rate of multiple prirnary malignant tumors is relatively rare. We report the two cases, which we have confirmed double promary malignant tumors of different site origins such as esophageal squamous cell carcinoma and stomach adenocarcinoma with gastric fiberoptic endoscopic biopsy.
송훤택(Hwun Taig Song),김창덕(Chang Duck Kim),류호상(Ho Sang Ryu),현진해(Jin Hae Hyun) 대한소화기학회 1994 대한소화기학회지 Vol.26 No.5
N/A Gastric cancer is the leading cause of cancer death in Korea. The high mortality rate of gas- tric cancer is partly attributed to its late detection and the perfomance of surgery at an advanced stage of disease. So, its early detection and treatment of gastric carcinoma will im- prove the current unfavourable prognosis of gastric cancer. Progress in diagnostic endoscopy has made it possible to detect the early gastric cancer which has excellent postoperative out- come because of its high curability. In this retrospective study, 181 cases of early gastric cancer which have been resected at the Korea University Anam Hospital from January, 1982 to December 1992 were reviewed with emphasis on incidence, macroscopic classification, clinical significance, and prognosis in order to elucidate the clincal picture of early gastric cancer. The proportion of early gastric cancer was 8.1% of all gastric cancer and 0.29% of total patients who underwent gastrofiberscopy. The ratio of male to female was 1.8: 1, and the peak age of incidence was 6th decade(35.4%). The lesion was most commonly found in antrum(51.1%) and lesser cur- vature side(73.1%). EGC type II< was the most common macroscopic type(31.3%). The size of lesion was mostly less than 3cm(68.1%) and the larger lesions showed the higher rate of in- vasion to submucosa and lymph node metastasis. The percentage of lymph node metastasis was much higher in lesion infiltrating to submucosa(20.0%) than mucosa confined cancer. According to cancer cell type, tubular adenocarcinoma was most common(74.8%). There was no correlation between cancer cell type and the incidence of lymph node metastasis. The diag- nostic accuracy by gastrofiberscopic observation was 83.5%. The 5 year survival rate of total early gastric cancer patient was 94.2%.(Korean J Gastroenterol 1994; 26: 789 799)
엄순호 ( Soon Ho Um ),류호상 ( Ho Sang Ryu ),박미라 ( Mi Ra Park ),이재원 ( Jea Won Lee ),진윤태 ( Yoon Tae Jeen ),전훈재 ( Hoon Jae Chun ),송치욱 ( Chi Wook song ),이상우 ( Sang Woo Lee ),김창덕 ( Chang Duck Kim ),현진해 ( Jin Ha 대한소화기학회 1997 대한소화기학회지 Vol.29 No.6
Background/Aims: Well designed staging system of hepatocellular carcinoma(HCC) is needed for comparative therapeutic studies regarding HCC to be of value. The aim of study is to reevaluate prognostic factors affecting natural history of HCC and to devise a staging system according to prognostic index estimated mathematically Methods: One hundred eighty patients with HCC were analyzed retrospectively. All patients received only conservative treatments. Univariate and multivariate analysis were performed using clinical, biochemical and imaging data obtained at diagnosis. Results: The overall acturial survival rate at 1, 3, 6, 12, 24 months were 74%, 33%, 11%, 7%, 5%, respectively. For significant prognostic variables in the univariate analysis, multivariate survival analysis disclosed that tumor size(p=0.0039), ascites(p=0.0190), total serum bilirubin(p=0.001) were independent prognostic factors. Considering the contribution of each of these factors to prediction of survial, a pronostic index(PI) was defined as a following regression equation. PI=EXP(tumor size×0.1904+ascites×0.4114+Bilirubin×0.0504). According to PI, a new staging system was devised allowing division of patients into three groups with significantly different survival rates(p<0.01). Conclusions: The new staging system for HCC according to PI would be useful for the staratification of HCC patients in the comparative evaluation of various therapeutic modalities.(Korean J Gastroenterol 1997;29:786-796)
현진해(Jin Hai Hyun),류호상(Ho Sang Ryu),김창덕(Chang Duck Kim),심경보(Kyung Bo Shin) 대한소화기학회 1988 대한소화기학회지 Vol.20 No.2
N/A The purpose of the present syudy is to determine whether the serum concentration can represent as a tumor marker of gastric cancer, the extent of gastric cancer, and can reflect the liver metastasis of gastric cancer. The fasting serum copper concentration was measured in 8 healthy adult as normal controls, 26 gastric cancer and 55 patients with other cancer. The results were as follow: 1) The serum copper concentration was 120.25+25.12 mcg/dl in normal controls and 153+39.56 mcg/dl in patient with gastric cancer. 2) The serum copper concentrations of advanced gastric cancer patients (with liver metastasis) was markedly elevated than normal control, but not in patients with stageIIl gastric cancer. 3) The serum copper concentrations was more than 130 mcg/dl in most patients of stage llI gastric cancer and more than 150 mcg/dl in most patients of stage III gastric cancer and more than 150 mc/dl in stage IV gastric cancer (liver metastasis) patients. 4) The serum copper concentrations of lung and bile ductular cancer were more elevated than that of other malignancies. This results that serum copper concentration seems to be a simple and reliable tumor marker for the extent as well as liver metastasis of gastric cancer.