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포스터 발표 : 담도,췌장 ; 췌장암에서의 Clusterin 발현과 세포사멸에 관한 연구
김진용 ( Jin Yong Kim ),이홍식 ( Hong Sik Lee ),김영선 ( Young Sun Kim ),전훈재 ( Hoon Jae Jun ),엄순호 ( Soon Ho Um ),이상우 ( Sang Woo Lee ),최재현 ( Jae Hyun Choi ),김창덕 ( Chang Duck Kim ),류호상 ( Ho Sang Ryu ),현진해 ( Jin 대한소화기학회 2002 대한소화기학회 춘계학술대회 Vol.2002 No.-
〈목적〉 췌장암은 조기 진단이 어렵고 항암제치료 및 방사선 치료에 반응도가 매우 낮아 5년 생존율이 약1-3%에 불과할 정도를 치료가 어려운 종양이다. 췌장암이 일반적으로 항암 치료에 반응이 낮은 이유는 아직 규명되고 있지 않으나 췌장암세포가 항암제 및 방사선 치료에 의해 유발되는 세포사멸에 대한 저항력이 큰 것이 가능성으로 제시되고 있다. Clusterin은 세포사멸, 조직재생, 세포 부착등의 여러 가지 생물학적 기능을 갖고 있는 glycoprotei
진단에서 38mg 저용량 요소(13C-urea) 캡슐을 이용한 요소호기검사의 유용성
전훈재 ( Jeon Hun Jae ),김용식 ( Kim Yong Sig ),진윤태 ( Jin Yun Tae ),김한겸 ( Kim Han Gyeom ),현진해 ( Hyeon Jin Hae ),정인식 ( Jeong In Sig ),최명규 ( Choe Myeong Gyu ),김상우 ( Kim Sang U ),이인석 ( Lee In Seog ),박경신 ( Park 대한소화기학회 2003 대한소화기학회 추계학술대회 Vol.2003 No.-
<목적> Helicobacter pylori 감염의 비침습적 기준 진단법인 요소호기검사법(UBT)은 1987년 개발된 이후 진단기기의 개선과 요소용량, 검사시간, 시험식 등의 다양한 인자를 포함한 연구를 통해 진단의 정확도 및 편리성이 개선되어 왔다. 그러나 요소 75mg을 복용 후 30분에 호기를 채취하는 기존의 방법은 요소가 고가이며 검사 시간이 오래 걸리는 단점이 있다. 저자들은 최근 국내 바이오벤처인 ㈜메디켐스에서 개발, 상용화를 진행 중인, 요
담석췌장염의 진단과 치료에서 조기 내시경적 시술의 유용성
김진용,이홍식,김창덕,류호상,현진해 대한소화기내시경학회 1998 Clinical Endoscopy Vol.18 No.1
Background/Aims: Gallstone pancreatitis has showed higher mortality and morbidity rate as compared to other causes of pancreatitis, and the proper timing of endoscopic retrograde cholangiopancreatography (ERCP) and endoscopic sphincterotomy (EST) is still controversial. But recent several trials reveals early ERCP/EST is safe procedure and can reduce mortality and complication rate in gallstone pancreatitis. Methods: To assess the safety and effectiveness of early ERCP/EST, we perfomed ERCP and EST, if necessary, in 40 cases of acute gallstone pancreatitis. Results: 1) Early ERCP group (in 72 hours) were 27 cases, delayed group were 13 cases, and 11 early EST group, 16 delayed EST group. No statistically significant difference was found between two groups in blood chemistry and the severity of pancreatitis according to Ranson's criteria, respectively. No remarkable complication due to ERCP or EST was noted, and the hospital days were shorter in early ERCP/EST group with statistical significance, 2) Duodenoscopic findings show 14 normal papillae, 20 papillary edema, hemorrhagic and lacerated papillae in 6 cases. Conclusion: In cases of gallstone pancreatitis, early ERCP and EST is considered as a safe and effective treatment modality.
권용대,이홍식,박철희,진윤태,전훈재,이상우,최재현,김창덕,류호상,현진해 대한간학회 2003 Clinical and Molecular Hepatology(대한간학회지) Vol.9 No.1
Auto-immune hepatitis is a chronic necroinflammatory liver disorder that is characterized by hypergamma-globulinemia, auto-antibodies in serum, and, on histological examination, the presence of periportal hepatitis. Although it can be associated with a number of other auto-immune diseases, Sjo¨gren’s syndrome is rarely associated with auto-immune hepatitis. We herein report an unusual case of auto-immune hepatitis associated with primary Sjo¨gren’s syndrome. A 39-year-old woman was admitted to our hospital due to jaundice. Laboratory data showed negative viral hepatitis marker, increased serum IgG level, positive anti-nuclear antibody, and an increased rheumatoid factor titer. The patient had no history of taking medications and alcohol. Based on characteristic clinical features, live biopsy findings, positive Schirmer’s test, and salivary scintigraph, she was diagnosed as having auto-immune hepatitis and Sjo¨gren’s syndrome. The patient achieved complete remission with steroid monotherapy.
이정용,이홍식,김창덕,류호상,현진해 대한소화기내시경학회 1997 Clinical Endoscopy Vol.17 No.5
Background/Aims: Pancreas divisum is a congenital anomaly caused by failure of fusion of the ventral and dorsal pancreatic anlagen during the sixth and seventh week of gestation. With widespread use of endoscopic retrograde cholangiopancreatography(ERCP), pancreas divisum is being detected with increasing frequency. Pancreas divisum is the most common congenital pancreatic anatomic variant, occuring in approximately 4.7 - 14% of necropsy series and has been demonstrated 1.3-6.7% of patients undergoing ERCP, The condition is seen least frequently in Asian(1-2%). It has been postulated that this anomaly may be a cause of obstructive pancreatic pain and pancreatitis on the basis of impaired drainage through the minor papilla. But there is a controversy as to whether pancreas divisum is associated with an increased incidence of pancreatitis. This study is performed to evaluate the clinical presentation and significance of pancreas divisum. Methods: 27 cases of pancreas divisum detected among 1,718 ERCP examinations performed from June, 1993 to December, 1996 at our institution were critically analyzed. Results: Overall incidence of pancreas divisum was 1.6%. Among them, 13 cases(48.1%) were classified as complete type, 14 cases(51.9%) were classified as incomplete type. There was a significantly high incidence of pancreatitis, 22.2% in pancreas divisum compared with 5.6% in fused pancreas. Pancreas divisum was misdiagnosed as pancreatic head mass on radiological imaging study in 4 cases(25%). Conclusions: Pancreas divisum may be predispose to development of pancreatitis, and that its presence may lead to misinterpretation of ultrasonographic and CT scan findings.