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엄순호 ( Soon Ho Um ),류호상 ( Ho Sang Ryu ),박미라 ( Mi Ra Park ),이재원 ( Jea Won Lee ),진윤태 ( Yoon Tae Jeen ),전훈재 ( Hoon Jae Chun ),송치욱 ( Chi Wook song ),이상우 ( Sang Woo Lee ),김창덕 ( Chang Duck Kim ),현진해 ( Jin Ha 대한소화기학회 1997 대한소화기학회지 Vol.29 No.6
Background/Aims: Well designed staging system of hepatocellular carcinoma(HCC) is needed for comparative therapeutic studies regarding HCC to be of value. The aim of study is to reevaluate prognostic factors affecting natural history of HCC and to devise a staging system according to prognostic index estimated mathematically Methods: One hundred eighty patients with HCC were analyzed retrospectively. All patients received only conservative treatments. Univariate and multivariate analysis were performed using clinical, biochemical and imaging data obtained at diagnosis. Results: The overall acturial survival rate at 1, 3, 6, 12, 24 months were 74%, 33%, 11%, 7%, 5%, respectively. For significant prognostic variables in the univariate analysis, multivariate survival analysis disclosed that tumor size(p=0.0039), ascites(p=0.0190), total serum bilirubin(p=0.001) were independent prognostic factors. Considering the contribution of each of these factors to prediction of survial, a pronostic index(PI) was defined as a following regression equation. PI=EXP(tumor size×0.1904+ascites×0.4114+Bilirubin×0.0504). According to PI, a new staging system was devised allowing division of patients into three groups with significantly different survival rates(p<0.01). Conclusions: The new staging system for HCC according to PI would be useful for the staratification of HCC patients in the comparative evaluation of various therapeutic modalities.(Korean J Gastroenterol 1997;29:786-796)