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라명재(Myung Jae Ra),김광진(Kwang Jin Kim),오영돈(Young Don Oh) 대한산부인과학회 1999 Obstetrics & Gynecology Science Vol.42 No.12
Leiomyomas of the vagina is a rare tumor, with 300 cases reported in the world literature. We experienced a case of leiomyoma of the vagina, and present it with a brief review of the literatures.
김종호 ( Chong Ho Kim ),라명재 ( Myung Jae Ra ),문영진 ( Young Jin Moon ),황정혜 ( Jeong Hyae Hwang ),김승룡 ( Seung Ryong Kim ),황윤영 ( Youn Yeoung Hwang ) 대한산부인과학회 1997 Obstetrics & Gynecology Science Vol.40 No.12
Korean hemorrhagic fever complicated during pregnancy are rare. Korean hemorrhagic fever is a disease characterized by fevers, capillary dilatation, leakage of blood leading to hemorrhagic manifestations, and in severe cases, shock and renal tubular disease or acute respiratory failure. We experienced one case of pregnancy complicated with Korean hemorrhagic fever, so we report the case with brief review of the literatures.
김승룡,문영진,황정혜,신중식,최중섭,안명주,라명재,나영정 대한부인종양 콜포스코피학회 1996 Journal of Gynecologic Oncology Vol.7 No.4
Primary carcinoma of the fallopian tube is an extremely rare malignancy of the female genital tract. We have experienced two cases of primary carcinoma in the fallopian tube. One case with huge mass which was diagnosed incidentally on the basis of the biopsy findings, and the other case of the 3 years follow-up. We reported the cases with a brief review of the concemed literatures.
자궁경부암 환자에 있어 telomerase 활성도의 임상측명
김승룡,김경태,조삼현,황윤영,문형,유중배,김기성,라명재 대한산부인과학회 1997 Obstetrics & Gynecology Science Vol.40 No.4
A current hypothesis gaining prominence proposes that activation of the telomerase is necessarey for cells to become immortal, or be capable of proliferating indefinitely. The theory suggersts that that almost all cancer cells must attain immortality for progression to malingnant state and, hence, require activation of telomerase. To assess the role of telomerase in the development of mailignant transformation of the uterine cervical carcinoma, telomerase activeiy was measured by using a recently developed sensitive RPR-based telomerase assay(telomeric repeat amplification protocol; TRAP)in benign uterine condition and invasive uterine cervical carcinoma tissues revealed to be telomerase positive (14/16, 88%) which represents a characteristic 6 bp ladder pattern, while none of the 4 cervical tissues with the nonspecific pathologic findings or just chronic cervictis which were obtained by simple bysterenctomy under the diagnoses of benign myoma or uterine prolapse showed any telomerase actiovity. These findings suggest that this enzyme activity may play a key role in the establishment and progression of the uterine cervical carcinoma. This activity of telomerase may influence from the initial stage of tumorigenesis of uterine cervical carcinoma because poitive findings were noticed from the early stage (stage (i 1a1) to the advanced stage. The results of neoadjuvant chemotherpy which were revealed in final histopathologic specimens following radical hysterectomuy, pelvic and raraaortic lymph nodes dissection (suggestion by Rosen et al,) were one grade IV wiht telomerase poistive, 2 grade III with all positivie, 5grade II with 3 positive 2 negative. The two cases of pelvic lymph node metastasis belong to the group of grade II and their activeities of telomerase were 1 positive and 1negative. The situation of apoptosis induced by antineoplastic chemotherapy has not been related to that of telomerase activeity. Furthemore, the late recurrences has been noticed over 5years follow-up following neoadjuvant chemotherapy and radical surgery for the management of the high risk group of patients (not shown in this study) This measn that the nowday`s regimen for induction tumoricidals may have been operating as dual effects (partial restoring and redamaging) to the cell cycle chekpoint. Therefore if telomerase inhibitor will be applied combined whit the induction chemotherapy, unexpected benefits mignt be obtained for the patient with the advanced uterine cervical carcinoma.