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자궁 경부에 발생한 Adenoma Malignum 1예
동서연,임명철,이주희,허주엽 대한산부인과학회 2002 Obstetrics & Gynecology Science Vol.45 No.11
1870년 Gusserow에 의해서 처음으로 보고된 adenoma malignum은 자궁경부 선암의 1~3%를 차지하는 드문 형태로 minimal deviation adenocarcinoma라고도 하며 조직학적으로 잘 분화되어 양성에 가까운 모양을 보인다. 내경관 (endocervical canal)의 원주상피에서 유래하여 자궁경부 기질 깊숙이 자라 들어가는 경우가 많아 임상적으로 진단이 어려울 뿐 아니라 종양표지자 검사에서도 정상소견을 보이고 초음파나 자기공명촬영 등에서도 특징적인 소견이 없으며 병리학적으로도 거의 정상에 가까운 조직학적 소견과 매우 드문 빈도 때문에 수술 전에는 진단이 어려워서 적절한 치료시기를 놓치고 암이 진행된 후에야 발견되는 경우도 많다. 가장 흔한 증상은 점액성 질분비물이며 종종 Peutz-Jeghers syndrome이나 난소의 점액성 종양과 동반되어 나타나기도 한다. 저자들은 최근 본원 산부인과에 점액성 질분비물을 주소로 내원한 42세 여자환자에서 수술 전 검사상 모두 정상소견으로 질 초음파 및 컴퓨터 단층 촬영에서 자궁경부에 발생한 다발성 나보시안 낭종으로 진단되었으나 증상의 악화로 전자궁적출술 시행 후 조직학적 소견상 "adenoma malignum"으로 진단된 예를 치험하였기에 간단한 문헌 고찰과 함께 이를 보고하는 바이다. Adenoma malignum (minimal deviation adenocarcinoma) is a rare, extremely well-differentiated form of invasive cervical adenocarcinoma. The name derives from the deceptively benign epithelial cells that line the glands of this neoplasm. The presence of architectural disorder with irregular, abnormally shaped invasive glands sometimes surrounded by a desmoplastic stromal response or demonstrating vascular and perineural invasion may be the only features establishing its malignant nature. Despite its bland appearance, adenoma malignum may carry a poor prognosis. Because of its rarity, and possibly because diagnostic changes are subtle and may be missed, there are few reports. A case of adenoma malignum of the uterine cervix is presented with a brief review of the literatures.
Expression of MTA1 and nm23H1 protein in ovarian carcinomas in relation to lymph node metastasis
동서연,김윤영,기경도,이종민,이선경,박용구 대한부인종양학회 2008 Journal of Gynecologic Oncology Vol.19 No.1
Objective:Cancer metastasis is a complex process involving a sequential series of multi-step genetic events, which produces an imbalance between stimulatory and inhibitory genes for metastasis. Presently, we examined the expression of metastatic tumor antigen 1 (MTA1) and nonmetastatic protein 23 homologue H1 (nm23-H1) proteins in metastasized epithelial ovarian cancer cells. Methods:Fifty-one primary epithelial ovarian tumors and corresponding lymph nodes (LNs) were examined immunohistochemically for expression of MTA1 and nm23-H1. Expression of these proteins was statistically evaluated. Results:The frequency of MTA1 expression was 30.3% (10/33) in stage III/IV LNs but was absent (0/18) in stage I/II LNs (p=0.01). MTA1 expression was observed in 50% (6/12) of metastasizing LNs but in only 10.3% (4/39) of non-metastasizing LNs (p=0.01). In contrast with MTA1, nm23-H1 expression was evident in 16 of 18 (88.9%) stage I/II ovarian cancer tissue samples but only in 20 of 33 (60.6%) stage III/IV tissues (p=0.05), and nm23-H1 production was also observed in 75.6% (34/45) of ovarian cancer tissue with residual tumors under 2 cm in diameter, but in 2/6 (33.3%) of cancer tissue with residual tumors exceeding 2 cm in diameter (p=0.03). Conclusion:The degree of expression and imbalance of MTA1 and nm23H1 are correlated with ovarian cancer LN metastasis. Objective:Cancer metastasis is a complex process involving a sequential series of multi-step genetic events, which produces an imbalance between stimulatory and inhibitory genes for metastasis. Presently, we examined the expression of metastatic tumor antigen 1 (MTA1) and nonmetastatic protein 23 homologue H1 (nm23-H1) proteins in metastasized epithelial ovarian cancer cells. Methods:Fifty-one primary epithelial ovarian tumors and corresponding lymph nodes (LNs) were examined immunohistochemically for expression of MTA1 and nm23-H1. Expression of these proteins was statistically evaluated. Results:The frequency of MTA1 expression was 30.3% (10/33) in stage III/IV LNs but was absent (0/18) in stage I/II LNs (p=0.01). MTA1 expression was observed in 50% (6/12) of metastasizing LNs but in only 10.3% (4/39) of non-metastasizing LNs (p=0.01). In contrast with MTA1, nm23-H1 expression was evident in 16 of 18 (88.9%) stage I/II ovarian cancer tissue samples but only in 20 of 33 (60.6%) stage III/IV tissues (p=0.05), and nm23-H1 production was also observed in 75.6% (34/45) of ovarian cancer tissue with residual tumors under 2 cm in diameter, but in 2/6 (33.3%) of cancer tissue with residual tumors exceeding 2 cm in diameter (p=0.03). Conclusion:The degree of expression and imbalance of MTA1 and nm23H1 are correlated with ovarian cancer LN metastasis.
동서연 ( Seo Yun Tong ),임명철 ( Mung Chul Lim ),이주희 ( Ju Hee Lee ),허주엽 ( Chu Yeop Huh ) 대한산부인과학회 2002 Obstetrics & Gynecology Science Vol.45 No.12
Adenoma malignum (minimal deviation adenocarcinoma) is a rare, extremely well-differentiated form of invasive cervical adenocarcinoma. The name derives from the deceptively benign epithelial cells that line the glands of this neoplasm. The presence of arc
동서연 ( Seo Yun Tong ),김여홍 ( Yea Hong Kim ),전철수 ( Chul Su Chon ),장미경 ( Mi Kyung Chang ),최응환 ( Eung Whan Choe ),김승보 ( Seung Bo Kim ) 대한산부인과학회 2002 Obstetrics & Gynecology Science Vol.45 No.11
Mature cystic teratoma of the ovary is the most common ovarian germ cell tumor and almost benign, but malignant transformation occurs in less than 2% of benign mature teratoma. Of the malignancies arising in teratomas, squamous cell carcinoma is the most
동서연 ( Dong Seo Yeon ),이선경 ( Lee Seon Gyeong ),이주희 ( Lee Ju Hui ),김승보 ( Kim Seung Bo ) 대한산부인과학회 2003 Obstetrics & Gynecology Science Vol.46 No.5
Primary squamous cell carcinoma of the endometrium is extremely rare malignancy. In 1928 Fluhmann proposed three criteria to establish the diagnosis : (1) no coexisting endometrial adenocarcinoma, (2) no connection between the endometrial tumor and the squamous epithdlium of the cervix, and (3) no squamous cell carcinoma of the cervix present> Historically, this malignancy has been associate with short survival (<24 months) despite complete surgical exirpation, with or without pre- or postoperative external beam irradiation. In the a case of endmetrial squamous cell carcinoma is presented with a review of related current knowledge.
동서연 ( Dong Seo Yeon ),김여홍 ( Kim Yeo Hong ),허주엽 ( Heo Ju Yeob ),양문호 ( Yang Mun Ho ) 대한산부인과학회 2003 Obstetrics & Gynecology Science Vol.46 No.11
The coexistence of mucinous ovarian and appendiceal tumors in associated with pseudomyxoma peritonei is well established. But, ovarian and appendiceal mucinous tumors occur without involvement of other organs is unusual. When the two lesions are morpholog