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      • KCI등재

        최인희 시 연구

        남기택(Nam Ki-taek) 한국비평문학회 2009 批評文學 Vol.- No.32

        The purpose of this article is to examine Choi, In-hee’s poems. Choi, In-hee, a poet from Gangwon-Yeongdong region, composed poems in the 1950s. His poems in Yeojeongbaegcheog( 旅程百尺) depict nature as a world of innocence and peace by means of oriental contemplation. He attempted to find beauty and meaning of life by observing nature. His poetry is characterized by naturalistic tendency and traditional short lyricism. In addition, he pursued the world of Zen which has its roots in Buddhist philosophy. However, he kept a more realistic view as well, standing up to the modern society and its loss of humanity. A case in point is a series of poems composed in the later days of his life as a poet, which feature a prose style and poetic imaginations derived from the real world. In this way, the traditional short lyricism and the modern techniques employed demonstrate the modernity of Choi, In-hee’s poems. When seen from the perspective of Gangwon-Yeongdong regional literature, his poems have a historical value.

      • KCI등재

        백석 시의 '어린이기' 연구

        남기택(Nam Ki-taek) 한국언어문학회 2005 한국언어문학 Vol.54 No.-

        This paper examines the characteristics of Baek Seok's poems with a focus on 'childhood'. The imaginative power found in his poems should be seen from a perspective which is different from the enlightening features in children's literature. It is not like the concepts of children's literature implied by 'sonyen', and existing distinction among genres. While most children's literary works concern 'the children that should be', Baek Seok's poems tend to give shape to 'the modernity that should be'. 'Childhood' in his poem thus effectively encourages the restoration of the community spirit and peaceful order of the past. 'Becoming-child' in his poems represent a manifestation of literary modernity made correspondent to the social modernity of multi-faceted life in reality. Accordingly, this is presumed to be one particular stage of aesthetic modernity reached by 1930's literature. Analyzing 'childhood' in Baek Seok's poem should be seen as part of a work giving a new perspective through which we can revisit from today's standpoint the achievements of his poems as well as the literature in those days in general. Furthermore, it could be a task to reproduce the past with a new perspective and rethink the value of his literature. Through such a task, his poems will have meanings in such a way as to illuminate today's literary landscape and guide directions in which for the literary world of today to move. For this purpose, a close examination need to be conducted of a variety of works and literary activities after the end of the Korean War.

      • KCI등재후보

        신동엽 시의 '지역'과 '저항'

        남기택(Nam Ki-taek) 한국비평문학회 2004 批評文學 Vol.- No.18

        The purpose of this paper is to shed light on the meaning of region and resistance in Shin Dong-yeap's poems. Shin faced poetically his modern surroundings. Therefore, he can be referred to as problematic objects who shared converging and diverging points in looking into and understanding the problems of the modernity reflected in poetry. This paper tries to apply the postcolonialism in broad sense to bis poetic works based on the efforts to resist colonization in various lights.<br/> Colonialism involves not only the direct territorial occupation of another country and the ruthless exploitation of its resources, but also the systemic imposition of the colonizer's culture. If postcolonialism can be defined as an effort to overcome the continuing influence of colonialism, region and resistance is an important element the postcolonial project should handle. Shin's poems tries to show how the colonized and resistance can undermine the colonial hierarchy based on the neo-colonial power.<br/> Shin's view of poetry is characterized by regional attitude and national resistance. The meaning of region and resistance can be called the spirit of postcolonial theory, and Shin's poems are the typical showcase of it. The good examples are poetic attributes as the spirit of the undetermined native place. And his resistance based on the nationalism is a symbol of anti-imperialism. The simple formality deriving from Shin's nationalism is sometimes accompanied by the lack of aesthetic realms. Nonetheless, his spirit and works prove our neo-colonial surroundings and the typical pattern of living in unreasonable modern times by performing effects.

      • SCOPUSKCI등재

        Indole-3-carbinol(I3C) 투여에 의한 7,12-Dimethylbenz[α] anthracene(DMBA) 유발 랫드 유선발암 억제

        강진석,안병우,남기택,최미나,김지영,김대중,장동덕,양기화,Kang, Jin Seok,Ahn, Byeongwoo,Nam, Ki Taek,Choi, Mina,Kim, Ji Young,Kim, Dae Joong,Jang, Dong Deuk,Yang, Ki-Hwa 대한수의학회 2001 大韓獸醫學會誌 Vol.41 No.4

        Indole-3-carbinol (I3C), one component of cruciferous vegetables (the Fammily of Cruciferae), has been shown to exert its chemopreventive effect in liver, colon and mammary tissue before or concurrent exposure of carcinogen, but there have been several evidences that consumption of I3C induced tumor promotion in some tissues. Our studies were investigated to examine the modifying effects of I3C in the 7,12-dimethylbenz[$\alpha$]anthracene (DMBA) induced rat mammary gland tumor model. Fifty-two female Sprague-Dawley rats were randomly divided into five groups. Animals of the group 1 were given the diet containing 100ppm I3C and animals of the groups 2 and 4 were given the diet containing 300ppm I3C from 6 weeks of age. At 7 weeks of age, the animals of the groups 1, 2 and 3 were intubated with DMBA. All amimals were killed at 20 weeks after carcinogen treatment. There were significant increases of food consumption in I3C feeding groups compared with those of basal diet feeding groups. The incidences of the mammary tumors in the group 1, 2 and 3 were 75.0% (9/12), 56.3% (9/16) and 93.8% (15/16), respectively and the average number of tumors of group 1 (DMBA+I3C 100ppm: $2.08{\pm}0.61$) and 2 (DMBA+I3C 300ppm: $1.19{\pm}0.32$) were significantly lower than that of group 3 (DMBA alone: $4.63{\pm}0.72$) at the value of P<0.05 and P<0.001, respectively. In the pathological examination of appearing tumors, most of them were adenocarcinoma. Many epithelial cells of tumors showed strong estrogen receptor (ER) $\alpha$ expression but there were slight difference of ER $\alpha$ expression among the type of tumors. We suggest that pre-initiation treatment of I3C has an inhibitory effects on mammary carcinogenesis induced by DMBA.

      • KCI등재

        Evaluation of neutral red uptake and alamar blue assays using hacat cell as a screening test for skin irritancy

        이종권(Jong Kwon Lee),남기택(Ki Taek Nam),김부영(Pu Young Kim) 한국예방수의학회 1999 예방수의학회지 Vol.23 No.3

        인체 피부세포의 배양을 이용한 시험은 피부독성을 평가하는 시험에 유용하게 사용하고 있다. 본 연구는 사람 각질 세포로 알려진 HaCaT 세포를 이용하여 수종의 보습제에 대한 세포독성을 평가하고자 시행하였다. 보습제의 자극 정도에 대한 세포의 독성평가는 Neutral Red Uptake (NRU) assay 방법과 Alamar Blue(AB) assay 방법을 이용하여 평가하였으며, in vivo 시험은 인체 첩포시험을 이용하여 평가하였다. 세포독성을 두 assay로 검증해 본 결과 용량 의존성을 보였다. 인체 첩포시험과 in vitro 시험반응과는 좋은 상관관계를 보였다. In vivo 시험인 인체 첩포시험과 in vitro 시험인 NRU assay의 IC₅₀값과의 상관지수는 0.714를 보였고 또 다른 in vitro 시험인 AB assay의 IC₅₀값과의 상관지수는 0.657을 나타내었다. 본 연구결과 배양된 HaCaT cell을 이용한 AB assay와 NRU assay는 수종의 보습제에 대한 인체 피부의 자극을 예측하는 방법으로 유용하게 사용될 수 있을 것으로 사료된다. Cultured human skin cells have been widely used for assessing the skin irritancy of various humectants. In this study we used HaCaT cell (immortalized human keratinocyte). The irritation potential of humectants was assessed by human skin patch test, the neutral red uptake (NRU) and Alamar Blue (AB) assays. As a result of cytotoxicity assessed by NRU and AB assays, six humectants were seen in a dose dependent manner. There was a relatively good correlation between the in vitro and human patch test scores for the humectants tested. The correlation of NRU assay on the basis of IC₅₀ values with human patch test data yielded a correlation coefficient of r=0.714. The correlation of AB assay data on the basis of IC₅₀ values with human patch test yielded a correlation coefficient of r=0.657. The result of our study suggest that AB and NRU assay using cultured HaCaT cell can be used as an alternative method for screening the dermal irritancy of various humectants. And we found NRU assay would be possible alternative method to evaluate skin irritation potential and was better than the AB assay.

      • KCI등재

        광감작성 시험에서의 동물대체 시험법

        이호 ( Lee Ho ),남기택 ( Nam Ki Taek ),고재숙 ( Koh Jae-sook ),박원재 ( Park Won-jae ) 대한화장품학회 1996 대한화장품학회지 Vol.22 No.1

        동물시험을 최소화 하고, 동물시험에 사용되는 노력과 비용을 줄이기 위해 동일한 동물에서 광독성과 광알러지성을 함께 보는 새로운 방법을 제안하고, in vitro alternatives로서 photostability와 spectrophotometric carbonyl assay의 유용성을 검토하였다. Modified photosensitization model에서는 Ichikawa 방법과는 달리 동물수, 휴식 기간, 첩포 횟수를 단순히하고 폐쇄 첩포를 추가하였다. 방법의 유용성을 보기 위해 Benzocaine, 6-methyl coumarine을 Ichikawa 방법 및 본 시험 방법으로 결과를 비교한 결과 macroscopic, histologic examination에서 비슷한 결과를 얻었다. Photostability 시험에서는 pbotoreactive agent 들이 모두 20%이상의 흡광도 감소를 보여 pbotosensitization potential을 측정하기 위한 전 단계 실험으로서의 가능성을 보여주었고, spectrophotometric carbonyl assay에서는 salmonella를 이용한 광독성 실험에서는 나타나지 않았던 저농도의 Amthracene, Hematoporphyrin에서 조차도 phtotoxic prtential을 보여주어 in vitro alternatives로서의 가능성을 보여주었다. To minimize the use of animals in toxicity testing, and to reduce the cost in vivo test, more rational test method was described which determines, in the same animal, photoxic and photoallergic potential of a substance, and is daptable to routine testing. The other purpose of this study was to investigate the usefulness of in vivo alternatives ; photostability and spectrophotometric carbonyl assay. In this modified photosensitization model, animal numbers and resting periods, the number and method of topical application were simplified. Two positive photoreactive agents, Benzocaine and 6-methyl coumarine, showed a similar photoallergic potential to that of Ichikawa's method. Two sunscreens, Octyl methoxy cinnamate, Butyl methoxyl dibenzoyl methane, hardly showed photoallergic potentials. The photostability test could be used in the step of prescreening of photosensitization potential because most of the photoreactive agents represented the reduction of more than 20% in the absorbance. And photoreactive agents have a high potential of photosensitization in the sddessment of spectrophotometric carbonyl level although two sunscreens have a low possibility of photosensitization. Therefore this method was assumed as a valuable in vivo alternatives in the respect even in the very low concentrations which phototoxicity test using almonella showed no phototoxic potential.

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