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기관지 천식에서 Nimesulide의 안정성 및 내인성
나방주,박성주,이식,김신재,최광호,이용철,이양근 의과학연구소 2000 全北醫大論文集 Vol.24 No.1
Background : In most patients with aspirin and non-steroidal anti-inflammatory drug intolerance, anti-inflammatory treatment is a clinical problem. Nimesulide, a newly available anti-inflammatory drug, the safe use of which in aspirin-intolerant patients has been reported anecdotally and is based on its peculiar mechanism of anti-inflammatory action and its weak inhibition of cyclooxygenase. In this study we evaluate the safety and tolerance of a new non-steroidal anti-inflammatory drug, nimesulide(Aulin, Boehringer Mannheim, Italia), in bronchial asthma patients compare with control patients. Material and methods : Total twenty patients(11 bronchial asthma, 9 control patients) were enrolled in this open, non-comparative, monocenter study. The enrolled airway disease patients presented headache, joint pain, pleuritic chest pain, etc. Nimesulide was administered orally at dose of 200㎎ a day(bid) before meals for 7 to 10 days. Other anti-inflammatory drugs were excluded in this study. Results : Successful clinical response observed in 8 asthma patients(72.7%). The tolerance was good in 19 patients(85.0%). Three patients(15.0%) experienced mild epigastric discomfort. Exacerbation of pulmonary symptoms was not developed in both groups. Conclusion : Nimesulide was proved to be effective, safe and tolerable non-steroidal anti-inflammatory drugs in the treatment of the symptoms associated with bronchial asthma.
증예(症例) : Mesangial proliferative golmerulonephritis와 동반된 신정맥 혈전등 1례
고은영 ( En Young Koh ),나방주 ( Bang Joo La ),이식 ( Sik Lee ),김원호 ( Won Ho Kim ),채재건 ( Hae Kun Chae ),강명재 ( Myung Jae Kang ),김원 ( Won Kim ),박성광 ( Sung Kwang Park ),강성귀 ( Sung Kyew Kang ) 전북대학교 의과학연구소 2002 全北醫大論文集 Vol.26 No.1
심부정맥 혈전증(deep thrombosis)는 외과적은 수술, 급성심근경색, 뇌졸중, 하지마비, 암, 그리고 외상 시에 발생할 수 있다. 신증후군도 심부정맥 혈전증 특히, 신정맥 혈전증을 발생시킬 수 있는데 가장 흔하게 동반되는 신증후군으로는 막성사구체병증이 있다. 그러나 mesangial proliferative glomerulonephritis와 병발된 신정맥혈전증은 흔하지 않아 증례보고를 하고자 한다. 본 환자는 신생검에서 mesangial pro-liferative glomerulonephritis로 진단되면서 좌측 대퇴부와 하지의 부종과 통증을 호소하였다. 사지와 신장의 도플러 초음파상 신정맥을 포함하는 하대정맥 내에서 고음영을 보이는 혈전이 관찰되었고, 양측 총장골 정맥(common iliac vein), 외장골 정맥(external iliac vein), 대퇴정맥(femoral vein)등 하지 정맥 혈전으로 막혀있는 소견이 있었다. 항응고제와 스테로이드 요법 후에 정맥내 혈전과 단백뇨가 호전되어 3년째 외래에서 추적관찰중이다. Thrombosis of one or both renal veins occurs in a variety of settings such as trauma, dehydration, extrinsic compression, nephritic syndrome, pregnancy, oral contraceptives or invasion by tumor. Nephrotic syndrome and certain carcinomas seem to predispose to the development of renal vein thrombosis. The most common nephritic syndrome which is associated with renal vein thrombosis is the membranous nephropathy. But, renal thrombosis associated with glomerulonephritis other than membranous is extremely rare. Our patient was diagnosed as mesangial proliferative glomerulonephritis by histologic examination. The patient complained of left flank pain. Doppler ultrasonography revealed contrast-filling defect in the left renal vein. So we have presented a rare case of a renal vein thrombosis in a patient with mesangial proliferative glomerulonephritis.
닭과 돼지에서 분리한 Salmonella Typhimurium의 항생제 내성 특성 분석
문자영 ( Ja Young Moon ),김원경 ( Won Kyong Kim ),이건희 ( Kun Hee Lee ),나방주 ( Bang Ju Na ),고재천 ( Jae Cheon Go ),심균섭 ( Kyun Seob Sim ),( Patil Trupti A ),허진 ( Jin Hur ) 한국동물위생학회 2016 한국동물위생학회지 (KOJVS) Vol.39 No.1
Fifty and forty two Salmonella enterica subspecies enterica serovar 52 Typhimurium (ST) strains were isolated from chicken and pigs, respectively, collected from markets throughout Korea from 2008 to 2011. The isolates were investigated for the presence of antimicrobial resistance and multi-drug patterns. All 50 ST isolates from chicken and 42 ST isolates from pigs were resistant to at least one of 13 antibiotics used in this study, 92.0% of ST isolates from chicken and 88.1% of ST isolates from pigs were resistant to three or more antimicrobials. As many as 3 isolates of ST isolates from chicken were resistant to 11 of 13 antimicrobials tested in this study. Only one isolate of ST isolates from pigs was resistant to 10 of 13 antimicrobials. The ACSSuT resistance phenotype was observed in 34% of the 50 isolates and 23.8% of the 42 isolates. Especially, 1 isolate from pigs had the ACSSuTAu. The high rate of antimicrobial-resist and multi-drug resistant (MDR) ST isolation may give rise to crucial public health problems. Therefore, control of antimicrobial use, and continuous monitoring of antimicrobial resistance and MDR patterns among Salmonella isolates in chicken and pig farms is necessary to ensure public health.
김원(Won Kim),임철수(Cheol Su Lim),성미정(Mi Jung Sung),김성훈(Sung Hoon Kim),문상옥(Sang Ok Moon),이식(Sik Lee),나방주,박성광(Sung Kwang Park),강성귀(Sung Kyew Kang),김형진(Hyung Jin Kim),고규영(Gou Young Koh) 대한신장학회 2002 Kidney Research and Clinical Practice Vol.21 No.4
목 적 : Apoptosis를 억제하는 약물이나 성장인자는 세포생존효과가 있으므로 cisplatin 또는 adriamycin에 의해서 유도된 apoptosis에서 vascular endothelial growth factor(VEGF)와 angiopoietin-1(Ang1)의 세포생존효과를 보고자 하였다. 방 법: 항암제인 adriamycin 또는 cisplatin을 사구체 내피세포에 투여하여 apoptosis을 유발시키고, VEGF와 Ang1을 투여하여 apoptosis 억제 효과와 신호전달과정을 관찰하고자 하였다. 결 과 : 사구체 내피세포에서 adriamycin과 cisplatin은 농도에 의존적으로 apoptosis을 유발하였다. VEGF는 5 ng/mL 이상의 농도에서 adriamycin에 의해서 유도된 apoptosis에 억제 효과가 있었고, Ang1은 50 ng/mL 이상의 농도에서 adriamycin에 의해서 유도된 apoptosis 억제 효과가 있었다. 그리고 VEGF(20 ng/mL)와 Ang1(100 ng/mL)은 cisplatin 500, 1,000, 2,000 ng/mL 각각의 농도에서 apoptosis를 억제하였다. Ang1 또는 VEGF를 단독으로 투여하는 경우보다는 Ang1와 VEGF를 같이 투여하는 경우에 있어서 apoptosis 억제 효과가 더 높았다. 한편 Ang1와 VEGF의 apoptosis에 억제 효과는 phosphatidylinositol 3`-kinase/Akt를 통하여 신호전달이 이루어졌다. 결 론 : Adriamycin 또는 cisplatin을 투여할 때 VEGF와 Ang1을 전처치하거나 같이 투여하면 apoptosis를 줄임으로서 신손상을 예방하거나 치료할 수 있는 가능성을 제시할 수 있었다. Background : Because glomerular endothelium play a pivotal role in the renal diseases, damage of glomerular endothelial cells lead to progression of glomerular sclerosis and decrement of renal function. Apoptotic damage of cells is an important mechanism in renal disease. Therefore, several growth factors that have antiapoptotic effect may have a protective role in maintaining a renal function in apoptotic cell injury. Methods : The present study evaluated whether cisplatin or adriamycin induce apoptosis in glomerular endothelial cells. We also evaluated the antiapoptotic effect of angiopoietin-1 and VEGF in cisplatin or adriamycin- induced apoptosis. Results : Cisplatin or adriamycin induced apoptosis in glomerualr endothelial cell in dose dependent manner. Angiopoietin-1 and VEGF produced antiapoptotic effect in cisplatin or adriamycin-induced apoptosis in a dose dependent manner. The antiapoptotic effect of angiopoietin-1 was more potent than that of VEGF in glomerualr endothelial cells. Wortmannin, a phosphatidylinositol 3`-kinase inhibitor decrease the angiopoietin-1 or VEGF-induced antiapoptotic effect. Conclusion : These results suggest that angiopoietin-1 and VEGF may be a strong survival factor for the glomerular endothelial cells in the cisplatin or adriamycin-induced apoptosis through phosphatidylinositol 3`-kinase/Akt. Therefore, pretreatment of angiopoietin-1 and VEGF could play a beneficial role for maintaining normal glomerular endothelial cell integrity before and during systemic cisplatin or adriamycin therapy.