Ethanol Extract of Inonotus obliquus Inhibits Lipopolysaccharide-Induced Inflammation in RAW 264.7 Macrophage Cells

김호경,김태웅,Deok-Hyo Yoon,Chun-Hoi Kim,Bhushan Shrestha,장우철,So-yeon Lim,Won-Ho Lee,Je-O Lee,Mi-Hee Lim,Geun-Young Kim,최성아,송원옥,Jae-Mo Sung,황기철,Sang-Guk Han 한국식품영양과학회 2007 Journal of medicinal food Vol.10 No.1

Inonotus obliquus(Pers.:Fr.) Pil. is a white rot fungus that belongs to the family Hymenochaetaceae of Ba-sidiomycetes. Extracts and fractions of this fungus have been known to have biological activities, including antimutagenic,anticancer, antioxidative, and immunostimulating effects. Recently, there have been reports that the anti-inflammatory and an-tinociceptive properties of the methanol extract of I. obliquusmay be due to the inhibition of inducible nitric oxide (NO) syn-thase (iNOS) and cyclooxygenase-2 (COX-2) expression via the down-regulation of nuclear factor .B (NF-.B) binding ac-tivity. However, the effects of I. obliquusmediator production have not yet been elucidated. In the present study, a 70% ethanol extract of I. obliquus(IOE70) showedantioxidative effects. We also tested the ability of the I. obliquusextract to inhibit the inflammatory cascades in lipopolysac-charide (LPS)-induced RAW 264.7 macrophage cells. The NO inhibition of IOE70 was better than that of other ethanol ex-tracts from I. obliquus. To investigate the mechanism by which IOE 70 inhibits NO production and iNOS and COX-2 ex-pression, we examined the activations of I.B., Akt, and c-Jun NH2-terminal kinase (JNK) in LPS-activated macrophages.IOE70 markedly inhibited the phosphorylation of I.B.macrophages. Taken together, these experiments demonstrated that IOE70 inhibition of LPS-induced expression of iNOS andCOX-2 protein is mediated by Akt and JNK. Based on our findings, the most likely mechanism that can account for this bi-ological effect of IOE70 involves the inhibition of NF-.B through the phosphatidylinositol 3-kinase/Akt/I.B pathway and theinhibition of JNK activation. Thus, IOE70 might have useful clinical applications in the management of inflammatory dis-eases and may also be useful as a medicinal food.

코로나19로 인한 청소년의 경제적 상태 변화에 따른 한국 청소년의 식생활 및 건강에 미치는 영향

김호경,남형경,Kim, Ho-Kyoung,Nam, Hyong-Kyong 한국산업융합학회 2022 한국산업융합학회 논문집 Vol.25 No.5

This study aims to understand the influence of COVID-19 on youth daily life by analyzing the correlation between youth health and diet according to whether economic status has changed due to COVID-19 and to provide basic data on program construction for the welfare of socially marginalized adolescents. As a result of the study, the proportion of respondents who answered that there was a change in economic status at a high rate for decreased academic performance (p<0.001), stress perception, and suicidal thoughts (p<0.001), and the proportion of decreased number of breakfasts and increased fast food consumption (p<0.001) was also high. These results of the study are thought to be the reason for the increase in adolescents who are alienated due to changes in home conditions due to COVID-19, which is expected to affect the physical and mental health of adolescents who lack communication and guidance, and the increase in delinquents rate due to reduced academic concentration and increased junk food intake. Therefore, through this study, it can be helpful to use basic data for the development of welfare programs such as non-face-to-face as basic data for teenagers alienated from COVID-19.

유전박막을 이용한 금속/반도체 계면 특성 및 결함 연구

김호경,Kim, Ho-Gyeong 한국전기전자재료학회 2018 전기전자재료 Vol.31 No.5

A comparative electrical transport study on Cu/n-type InP Schottky diode measured at 300 and 100 K

김호경,Chan Yeong Jung,Se Hyun Kim,Yunae Cho,김동욱 한국물리학회 2016 Current Applied Physics Vol.16 No.1

Two oxygen plasma treated InP samples with different plasma powers of 100 and 250 W were prepared and a comparative study on the electrical properties of Cu/n-type InP Schottky diode measured at 300 and 100 K was performed to investigate the current transport mechanism in detail. The forward and reverse bias currentevoltage (IeV) characteristics were analyzed with considering various transport models. The fitting to the forward bias IeV characteristics revealed that relatively high ideality factor at 300 K for untreated sample were related with the generation-recombination (GR) current and the large E00 value at 100 K for 100 W plasma treated sample were associated with more significant tunneling effect. The analyses on the reverse bias current characteristics showed the suitable current transport model has changed from thermionic emission (TE) to TE combined with barrier lowering for both untreated and 250 W treated samples and from TE þ BL to thermionic field emission for 100 W treated sample with increasing temperature from 100 to 300 K.

Characterization of Conduction Mechanism in Cu Schottky Contacts to p-type Ge

김호경,Se Hyun Kim,Chan Yeong Jung 한국전기전자재료학회 2014 Transactions on Electrical and Electronic Material Vol.15 No.6

Germanium (Ge) is a promising material for next generation nanoelectronics and multiple junction solar cells. This work investigated the electrical properties in Cu/p-type Ge Schottky diodes, using current-voltage (I-V )measurements. The Schottky barrier heights were 0.66, 0.59, and 0.70 eV from the forward ln(I)-V, Cheung, and Nordemethods, respectively. The ideality factors were 1.92 and 1.78 from the forward ln(I)-V method and Cheung method,respectively. Such high ideality factor could be associated with the presence of an interfacial layer and interface statesat the Cu/p-Ge interface. The reverse-biased current transport was dominated by the Poole-Frenkel emission ratherthan the Schottky emission.

유통한약 품질규격 모니터링 연구

김호경,천진미,이아영,이혜원,최지현,장설,고병섭,Kim, Ho-Kyoung,Chun, Jin-Mi,Lee, A-Young,Lee, Hye-Won,Choi, Ji-Hyun,Jang, Seol,Ko, Byoung-Seob 한국한의학연구원 2005 한국한의학연구원논문집 Vol.11 No.2

This study was investigated to determine the quality control of Oriental medicine from stores dealing in Oriental medicine around Seoul and Daegu. We tested total 120 samples that widely used 15 species in herbal medicine (Lycii Fructus, Platycodi Radix, Angelicae Gigantis Radix and 12 others) being collected from Oriental medicine clinic, pharmacy, Oriental pharmacy, Oriental medical hospital and Oriental drug store. We have estimated Oriental medicine by K.P. (Korean Pharmacopoeia), K.H.P(Korean Herbal Pharmacopoeia) and announcement of KFDA. The items of examination were identification, purity, loss on drying, ash, acid insoluble ash, extract content, essential oil content, assay, heavy metal limit, and pesticides residue(BHC, DDT, Aldrin, Endrin, Dieldrin). As a result, 20 samples in total 120 samples were not satisfied with the standard and 7 species in total 15 species were not satisfied with the standard. Identification test, extract content test and pesticides residue(BHC, DDT, Aldrin, Endrin, Dieldrin) were satisfied with the standard. The result will be the basic data for the quality control of Oriental medicine.

유자의 항 Influenza 바이러스 A형 활성에 관한 연구

김호경,고병섭,전원경,Kim, Ho-Kyoung,Ko, Byoung-Seob,Jeon, Won-Kyung 한국생약학회 2000 생약학회지 Vol.31 No.1

To evaluate anti-influenza virus activity of 113 specimens of Korean traditional medicine both water and methanol extracts were examined using haemagglutination inhibition test. The water extract from Citrus junos was found to inhibit influenza virus A/Taiwan/l/86(H1N1). The survival rates of virus were determined by in situ cellular enzyme-linked immunosorbent assay. The water extract of Citrus junos was fractionated by chromatographic separating using Amberlite XAD-4, 40% MeOH and 60% MeOH layer had antiviral activity. The half inhibition concentration $(IC_{50})$ of 40% MeOH layer on survival of influenza virus was $MIC>361.5{\mu}g/ml$ and $IC_{50}$ value of fr. 40-4 fractionated from 40% MeOH layer was $677.19{\mu}g/ml$. These results suggested that the fractions of Citus junos have potent anti-influenza A virus activity.

$550^{\circ}C$에서의 2.25Cr-1Mo 강 용접부의 고온 균열성장 거동에 관한 연구

김호경,정강,정진성,Kim, Ho-Kyung,Chung, Kang,Chung, Chin-Sung 대한용접접합학회 2001 대한용접·접합학회지 Vol.19 No.3

Both creep deformation and creep crack growth experiments have been conducted on 2.25Cr-1Mo steel weldment in order to provided an information on residual life prediction of structural component weldment containing a crack. The stress exponent of creep deformation equation for the base metal and weldment at 823k were found to be 10.2 and 7.3, respectively. These two values could be assumed that dislocation climb processes are controlling the creep deformation of both materials. The creep rate of the weldment was very low, compared with that of base metal under the same applied stress. Whereas the creep crack growth rate of the weldment was almost twice higher than that of base metal under the fixed value of $C^*$. This may indicate that the weldment is stronger than the base metal in view of creep deformation and is brittle during creep crack growth due to the intrinsic microstructure of banite and relatively higher and Mn contents.

알루미늄 고용체 합금의 고온변형 거동에 관한 연구

김호경,Kim, Ho-Gyeong 대한기계학회 1997 大韓機械學會論文集A Vol.21 No.2

The creep characteristics of an Al-5wt.% Ag alloy including the stress exponent, the activation energy for creep and the shape of the creep curve were investigated at a normalized shear stress extending from $ 10^{-5}{\;}to{\;}3{\times}10^{-4}$ and in the temperature range of 640-873 K, where silver is in solid solution. The experimental results shows that the stress exponent is 4.6, the activation energy is 141 kJ/mole, and the stacking fault energy is $180{\;}mJ/m^2$, suggesting that the creep behavior of Al-5 wt.% Ag is similiar to that reported for pure aluminum, and that under the current experimental conditions, the alloy behaves as a class II(metal class). The above creep characteristics obtained for Al-5 wt.% Ag are discussed in the light of prediction regarding deformation mechanisms in solid solution alloys.

가스의 공급체계와 향후 전망

김호경,Kim, Ho-Gyeong 한국화재보험협회 1990 防災와 保險 Vol.47 No.-