정상면역을 가진 성인에서 발생한 식도 방선균증

김현수 ( Hyun Soo Kim ),천종운 ( Jong Woon Cheon ),김민수 ( Min Su Kim ),정창길 ( Chang Kil Jung ),김경록 ( Kyung Rok Kim ),최재원 ( Jae Won Choi ),강동우 ( Dong Woo Kang ),김선영 ( Sun Young Kim ) 대한소화기학회 2013 대한소화기학회지 Vol.61 No.2

Hyun Soo Kim, Jong Woon Cheon, Min Su Kim, Chang Kil Jung, Kyung Rok Kim, Jae Won Choi, Dong Woo Kang and Sun Young Kim1 Departments of Internal Medicine and Pathology1, DongKang Medical Center, Ulsan, Korea Actinomycosis is a chronic suppurative disease and caused by Actinomycosis species, principally Actinomyces israelii, which are part of the normal inhabitant on the mucous membrane of the oropharynx, gastrointestinal tract, and urogenital tract. It usually affects cervicofacial, thoracic and abdominal tissue. Cervicofacial type has the highest percentage of occurrence with 50%. Actinomycosis frequently occurs following dental extraction, jaw surgery, chronic infection or poor oral hygiene. It may also be considered as an opportunistic infection in immunocompromised patients such as malignancy, human immunodeficiency virus infection, diabetes mellitus, steroid usage or alcoholism. But, actinomycosis rarely occurs in adults with normal immunity and rare in the esophagus. We report an unusual case of esophageal actinomycosis which was developed in a patient with normal immunity and improved by therapy with intravenous penicillin G followed oral amoxicillin, and we also reviewed the associated literature.

Sn 함침-티타니아 나노입자와 나노튜브에 놓인 2-Chlorophenol 광 분해 성능

김현수,이가영,박선민,강미숙,Kim, Hyun Soo,Lee, Gayoung,Park, Sun-Min,Kang, Misook 한국세라믹학회 2012 한국세라믹학회지 Vol.49 No.5

This study focuses on the difference of photocatalytic activity depending on crystal structure type of nanoparticles ($TiO_2$) and nanotubes (TNT). The photodecomposition of 2-chlorophenol on the synthesized $TiO_2$, Sn-impregnated $TiO_2$, TNT, and Snimpregnated TNT were evaluated. The characteristics of the synthesized photocatalyts, TNT, Sn/TNT, $TiO_2$, and Sn/$TiO_2$ were analyzed by X-ray diffraction (XRD), transmission electron microscopy (TEM), and UV-Visible spectroscopy (UV-Vis), and cyclic voltammeter (CV). The water-suspended 2-chlorophenol photodegradation over $TiO_2$ (anatase structure) catalyst was better than that over pure TNT. Particularly, the water-suspended 2-chlorophenol of 10 ppm was perfectly decomposed within 4 h over Sn/$TiO_2$ photocatalyst.

제주도 밭작물 용수사용량 분석

김현수,이영일,강봉균,송창길,전택기,Kim Hyeon Soo,Lee Yong Il,Kang Bong Kyoon,Song Chang Khil,Jun Taek Ki 한국관개배수위원회 2005 한국관개배수논문집 Vol.12 No.1

This study was carried out to obtain basic data for the agricultural water development project in Jeju-do. In this study, Jeju-do was divided into four regions considering the precipitation and soil characteristics. Water used for irrigation of the major

다목적 유전자알고리즘을 이용한 첨단기술산업 시설물의 스마트 미진동제어

김현수,강주원,김영식,Kim, Hyun-Su,Kang, Joo-Won,Kim, Young-Sik 한국공간구조학회 2013 한국공간구조학회지 Vol.13 No.2

Reduction of microvibration is regarded as important in high-technology facilities with high precision equipments. In this paper, smart control technology is used to improve the microvibration control performance. Mr damper is used to make a smart base isolation system amd fuzzy logic control algorithm is employed to appropriately control the MR damper. In order to develop optimal fuzzy control algorithm, a multi-objective genetic algorithm is used in this study. As an excitation, a train-induced ground acceleration is used for time history analysis and three-story example building structure is employed. Microvibration control performance of passive and smart base isolation systems have been investigated in this study. Numerical simulation results show that the multi-objective genetic algorithm can provide optimal fuzzy logic controllers for smart base isolation system and the smart control system can effectively reduce microvibration of a high-technology facility subjected to train-induced excitation.

다목적 유전자 알고리즘을 이용한 아웃리거 댐퍼의 최적설계

김현수,윤성욱,강주원,Kim, Hyun-Su,Yoon, Sung-Wook,Kang, Joo-Won 한국공간구조학회 2014 한국공간구조학회지 Vol.14 No.4

Recently, a concept of damped outrigger system has been proposed for tall buildings. Structural characteristics and design method of this system were not sufficiently investigated to date. In this study, control performance of damped outrigger system for building structures subjected to seismic excitations has been investigated. And optimal design method of damped outrigger system has been proposed using multi-objective genetic algorithm. To this end, a simplified numerical model of damped outrigger system has been developed. State-space equation formulation proposed in previous research was used to make a numerical model. Multi-objective genetic algorithms has been employed for optimal design of the stiffness and damping parameters of the outrigger damper. Based on numerical analyses, it has been shown that the damped outrigger system control dynamic responses of the tall buildings subjected to earthquake excitations in comparison with a traditional outrigger system.

적응형 스마트 공유 TMD의 MIMO 제어알고리즘개발

김현수,강주원,Kim, Hyun-Su,Kang, Joo-Won 한국공간구조학회 2015 한국공간구조학회지 Vol.15 No.2

A shared tuned mass damper (STMD) was proposed in previous research for reduction of dynamic responses of the adjacent buildings subjected to earthquake loads. A single STMD can provide similar control performance in comparison with two traditional TMDs. In previous research, a passive damper was used to connect the STMD with adjacent buildings. In this study, a smart magnetorheological (MR) damper was used instead of a passive damper to compose an adaptive smart STMD (ASTMD). Control performance of the ASTMD was investigated by numerical analyses. For this purpose, two 8-story buildings were used as example structures. Multi-input multi-output (MIMO) fuzzy logic controller (FLC) was used to control the command voltages sent to two MR dampers. The MIMO FLC was optimized by a multi-objective genetic algorithm. Numerical analyses showed that the ASTMD can effectively control dynamic responses of adjacent buildings subjected to earthquake excitations in comparison with a passive STMD.

준능동 아웃리거 댐퍼시스템의 진동제어 성능평가

김현수,강주원,Kim, Hyun-Su,Kang, Joo-Won 한국공간구조학회 2015 한국공간구조학회지 Vol.15 No.4

Damped outrigger systems have been proposed as a novel energy dissipation system to protect tall buildings from severe earthquakes and strong wind loads. In this study, semi-active damping devices such as magnetorheological (MR) dampers instead of passive dampers are installed vertically between the outrigger and perimeter columns to achieve large and adaptable energy dissipation. Control performance of semi-active outrigger damper system mainly depends on the control algorithm. Fuzzy logic control algorithm was used to generate command voltage sent to MR damper. Genetic algorithm was used to optimize the fuzzy logic controller. An artificial earthquake load was generated for numerical simulation. A simplified numerical model of damped outrigger system was developed. Based on numerical analyses, it has been shown that the semi-active damped outrigger system can effectively reduce both displacement and acceleration responses of the tall building in comparison with a passive outrigger damper system.

소 사육단계 HACCP 지정 및 사후관리 체계

김현수,Kim, Hyeon-Su 한국낙농육우협회 2007 낙농·육우 Vol.27 No.10

단일기관에서 이중 질량 분석법(tandem mass spectrometry technology)을 이용한 선천성 대사이상 검사의 위양성율에 대한 연구

김현수,신손문,고선영,이연경,박성원,Kim, Hyunsoo,Shin, Son Moon,Ko, Sun Young,Lee, Yeon Kyung,Park, Sung Won 대한유전성대사질환학회 2016 대한유전성대사질환학회지 Vol.16 No.1

TMS가 확산되고 검사가 많아짐에 따라 위양성 건수도 증가하고 있다. 본 연구에서는 2012년 1월 1일부터 2014년 12월 31일까지 단일 기관에서 출생한 신생아를 대상으로 시행한 TMS의 위양성율을 조사하고 관련된 요인들을 분석하였다. 총 검사 대상자 중 남아는 8,942명(51.7%), 여아는 8,350명(48.3%)이었고, 평균 제태연령은 $38.6{\pm}1.7$주 였다. 평균 출생 체중은 $3,155.6{\pm}502.4g$, 평균 출생 신장은 $49.1{\pm}2.9cm$, 평균 체질량지수는 $13.0{\pm}3.8kg/m^2$ 이었다. 질식 분만은 9,713 (56.2%)건, 제왕절개는 7,579 (43.8%)건이었다. 평균 검사 시행일은 $2.8{\pm}1.1$일이었다. 위양성을 포함하여 TMS에서 양성으로 확인된 224명은 전체 대상자의 1.3%였다. 다중 로지스틱 회귀분석을 통해 분석한 결과 27주 이하의 초미숙아에서 위양성으로 나타날 odds ratio가 6.957 (95% CI: 1.273-38.008), 1,000 g 이하의 극저체중아에서 5.616 (95% CI: 1.134-27.820)로 나타났다. 위양성 대상자들 중에서는 지방산 대사이상 질환(fatty acid oxidation dis-orders)이 104명(47%), 아미노산 이상질환(amino-acidopathy)가 75명(34%), 유기산 이상 질환(organic aciduria)가 43명(19%)이었다. 전국적인 자료를 모아 평가한다면 국내 발생률에 대한 정확한 평가 및 접근이 가능할 것으로 생각한다. Objective: Newborn screening leads to improved treatment and disease outcomes, but false-positive newborn screening results may impact include parental stress and anxiety, perception of child as unhealthy, parent-child relationship dysfunction, and increased infant hospitalizations. The purpose of this study was to investigate of the false positive rates and the causative factors of false positive results in Tandem Mass Spectrometry (TMS) in single center. Methods: Records were reviewed for all 18,872 subjects who were born in Cheill General Hospital, during January 1st, 2012 to December 31st, 2014. 17,292 neonates (91.62%) were tested for tandem mass screening almost in 2-5th day of life. Newborn babies whose first results were abnormal had been tested repeatedly by same methods in 7-14 day. If the results were abnormal again, further evaluation was performed. TMS analysis included data for the 43 disorders screened for using TMS broken down into three categories: fatty acid oxidation disorders, organic acidurias, and aminoacidopathies. The impact of several factors on increased false positive rates was analyzed using a multivariate analysis: time from birth to sample collection, birth weight, birth height, BMI, gender, gestational age, delivery type. Results: Males of the subjects were 8942 (51.7%), female 8350 (48.3%), the mean gestational age was $38.6{\pm}1.7$ weeks, the average birth weight $3,155.6{\pm}502.4g$, the average birth height $49.1{\pm}2.9cm$, and the average BMI $13.0{\pm}3.8(kg/m^2)$. Vaginal delivery cases were 9713 (56.2%), caesarean section 7,579 (43.8%). The average date of the inspection was $2.8{\pm}1.1$ days. 224 cases were identified as TMS positive. All the subjects were false positive (222/17,292, 1.30%) except 2 cases (1 male; benign phenylketonuria and 1 female; Short chain acyl-CoA dehydrogenase deficiency). The false positive rates were 0.61% in fatty acid oxidation disorders, 0.25% in organic acidurias, and 0.45% in aminoacidopathies. In our study, the date of inspection got late, the false positive rates got higher. Because almost the cases of late test date were in treatment in neonatal intensive care unit so their test date was affected by their medical conditions. False positive rate was higher in extreme immaturity${\leq}27$ weeks than newborns of gestational age >27 weeks [OR=6.957 (CI=1.273-38.008), p<0.025] and extremely low birth weight<1,000 g than newborns of birthweight ${\geq}1,000g$ [OR=5.616 (CI=1.134-27.820), p<0.035]. Conclusion: False positive rate of TMS was 1.30% in Cheil General Hospital. Lower gestational age and birth weight impacted on increased false positive rates. Better understanding of factors that influence the reporting of screening tests, and the ability to modify these important factors, may improve the screening process and reduce the need for retesting. of screening tests, and the ability to modify these important factors, may improve the screening process and reduce the need for retesting.

Poly-TPD/PVK 이중 박막 정공수송층 구조의 양자점발광다이오드

김현수,이도형,김바다,황보람,김창교,Kim, Hyun Soo,Lee, Do Hyung,Kim, Bada,Hwang, Bo Ram,Kim, Chang Kyo 한국전기전자재료학회 2019 전기전자재료학회논문지 Vol.32 No.5

A poly[bis(4-butypheny)-bis(phenyl)benzidine] (poly-TPD) and poly(9-vinylcarbazole) (PVK) bilayer was employed as a hole transport layer (HTL) in solution-processed CdSe/ZnS quantum dot light-emitting diodes (QLEDs). The thickness of the PVK layer spin-coated onto the poly-TPD layer, whose thickness was fixed to 40 nm, was varied, with PVK layer thicknesses of 0 nm, 35 nm, 45 nm, and 55 nm. Because the thickness of the PVK can determine the hole transport properties of the HTL, a PVK thickness that maximizes the performance of the HTL for the QLEDs was investigated. By employing the optimized PVK thickness of 45 nm, the current efficiency of the QLED exhibited a 1.74 times improvement when compared with that of the QLED with poly-TPD based HTL without PVK. This was mainly attributed to the decrease in the energy barrier between the HTL and the quantum dot (QD) emitting layer (EML).