일회성 운동이 골감소증 고령여성의 골대사성 사이토카인 생성에 미치는 영향

김창선 ( Chang-sun Kim ),김효진 ( Hyo-jin Kim ),김지연 ( Ji-yeon Kim ),김지원 ( Ji-won Kim ),임순길 ( Soon-gill Lim ),박동호 ( Dong-ho Park ) 한국운동생리학회(구 한국운동과학회) 2016 운동과학 Vol.25 No.4

PURPOSE: Although overproduction of cytokines from peripheral blood mononuclear cell (PBMC) was associated with the reduction of bone mass, bone metabolic cytokines production according to exercise is still not clear. We aimed to test whether changes in production of bone metabolic cytokines after a bout exercise in osteopenia elderly women. METHOD: Nine osteopenia elderly women (T-score -2.61±0.46; aged 67.67±3.24 years) underwent a bout exercise of 60 %VO₂max (EX group) with a cycle ergometer. To clarify the changes during exercise, we designed repeated measure ANOVA as the sedentary control (CON group) to perform blood sampling without exercise. The concentrations and the mRNA expressions of cytokines were measured before, immediately after and then recovery 60 minutes after exercise. Serum Ca, Pi, Mg, and ALP were also measured at same times. RESULTS: There were no significant changes in the concentrations of serum TNF-alpha, IL-6, IL-1beta, and INF-gamma (NS). Although the mRNA expression of most cytokines also show no significant changes (NS), only TNF-alpha mRNA expression showed significant difference between groups (p=.008). On the other hand, serum Ca showed significant difference between times (p=.002), that of EX group was significantly increased at immediately after exercise compared to baseline (p<.05), and it was decreased at recovery period (p<.01). CONCLUSIONS: These results suggest that a bout exercise of moderate intensity might not be effect on production of bone metabolic cytokines both level of serum and mRNA from PBMC, and induced temporal hypercalcemia.

장기간의 수영운동에 따른 흰쥐의 골염량 및 사료효율의 변화

김창선 ( Chang Sun Kim ) 한국운동영양학회 2008 Physical Activity and Nutrition (Phys Act Nutr) Vol.12 No.1

위상 변위 제어 포워드 다중공진형 컨버터

金昌宣(Chang-Sun Kim),金熙峻(Hee-Jun Kim) 대한전기학회 1995 전기학회논문지 Vol.44 No.8

4주간의 후지체공 자극이 흰쥐의 골밀도 및 Ca대사에 미치는 영향

김창선 ( Chang Sun Kim ),이신언 ( Shin Eon Lee ) 한국운동영양학회 2008 Physical Activity and Nutrition (Phys Act Nutr) Vol.12 No.3

내원시 항상균도말검사상 음성인 환자에서 실시한 PCR검사방법의 유용성에 대한 연구

김창선 ( C. S. Kim ),손형대 ( H. D. Son ),박미란 ( M. R. Park ),서지영 ( J. Y. Seo ),조동일 ( D. I. Cho ),류남수 ( N. S. Rheu ) 대한결핵 및 호흡기학회 1997 Tuberculosis and Respiratory Diseases Vol.44 No.5

청년 주거지원제도와 공공임대주택의 발전방안에 관한 연구 : 청년층의 주거환경만족도를 중심으로

김창선(Kim, Chang Sun),이주호(Lee, Ju Ho),최현일(Choi, Hyun Il) 한국지방공기업학회 2021 한국지방공기업학회보 Vol.17 No.2

본 연구는 청년들의 당면한 가장 큰 사회문제인 일자리 문제와 주거문제 해결을 위한 대안으로서 현 정부에서 2020년 도입한 일자리 연계형 지원주택 사업으로서 청년창업지원형 공공임대주택 사업의 발전방안을 모색하고자 하였다. 이를 위해 현재의 청년창업지원형 공공임대주택 추진 현황을 살펴보고, 청년층을 대상으로 한 청년창업지원형 공공임대주택 공급방안에 대한 요구와 현재의 주거환경만족도를 분석하였다. 청년창업지원형 공공임대주택 공급에 대한 고려사항은 임대료를 가장 핵심적 과제로, 대중교통접근성을 중요한 요인으로 인식하고 있으며, 공간의 형태는 30평 이상의 넓은 공간을 요구하는 반면, 형태는 오피스텔 구조로 요구하고 있어 업무와 주거의 통합을 요구하는 것으로 파악되었다. 한편, 현재의 주거환경만족도는 성별에 따라서는 쾌적성이 뚜렷한 차이를 보이는 가운데, 창업동기 이유에 따라 안정성, 쾌적성, 경제성에 대한 만족도에 차이를 보이고 있는 것으로 나타났다. 또한 소득이 낮을수록 환경에 대한 평가는 안정성과 경제성에 대하여 관대한 평가를 하고 있으며, 학력에 따라 유의미한 차이는 나타나지 않았다. 이에 창업지원 공공임대주택의 입지적 요소는 다양한 사회적 활동 요소가 복합적으로 고려되어야 하며, 주택의 공간 구성 또한 수요자의 욕구에 따라 다양하게 설계되는 것이 필요하다. 마지막으로 주거비 지원 방식에 있어서 창업자금의 부담을 완화 측면에서 주거비 지원 방식의 활용을 함께 고려하는 것이 필요하다. As an alternative to solving the job problem and housing problem, which are the biggest social problems facing young people, this study sought to develop public rental housing project of the youth start-up support. Considering the supply of youth start-up-supported public rental housing, rent is the most important task, public transportation access is recognized as an important factor, and the form of space requires more than 30 pyeong of space, while the form requires an officetel structure, requiring integration of work and housing. On the other hand, it was found that the current satisfaction with the residential environment showed a clear difference in comfort depending on gender, and the satisfaction with stability, comfort, and economic feasibility depending on the reason for the motivation for start-up. In addition, the lower the income, the more generous the evaluation of the environment is about stability and economic feasibility, and there was no significant difference depending on the educational background. Accordingly, the locational elements of start-up support public rental housing must be considered in combination with various social activity factors, and the spatial composition of the house also needs to be designed in various ways according to the needs of consumers. Finally, in terms of easing the burden of start-up funds in the housing cost support method, it is necessary to consider the use of the housing cost support method together.

인체 감지 제어 기능을 갖는 UV LED Bar의 최적 설계

김창선(Chang Sun Kim,)이재학(Jae Hak Lee,)고영진(Young Jin Goh) 한국전자통신학회 2017 한국전자통신학회 논문지 Vol.12 No.6

본 논문에서는 다용도로 사용 가능한 UV LED 바의 최적설계를 하였다. UV LED는 자외선을 방출하기 때문에 사용목적상 일정하게 자외선을 방출하는 것이 중요하다. 일정한 자외선이 방출되기 위해서는 동작 가능 입력 전압 범위 내에서 정전류원으로 구동되어야 하고 자외선 활용 특성 상 자외선 방출 유지 시간이 길기 때문에 방열이 특히 중요하다. 따라서 소비전력이 최소화 되도록 설계해야 한다. 또한 인체 보호가 필수적이기 때문에 거리 감지 센서와 블루투스를 이용해 인체 감지 여부에 따라 동작할 수 있게 알고리즘을 구성하였다. 자외선 UVA를 방출하기 위해 365nm UV LED 3개가 직렬로 사용되었으며 입력 전압 12V와 정전류 500mA에서 동작하며 효율은 87.5%, 소비전력은 6.006W이다. 그리고 자외선 조사량은 루트론 계측기로 측정하였을 경우 10cm 거리에서 5.35mW/cm2으로 측정 되었다. In this paper, it is performed the optimal design of the UV LED bar which can be used variously. The UV LED Bar emits ultraviolet rays, so it is important to emit ultraviolet rays constantly for the purpose of use. In order to emit a certain amount of ultraviolet rays as ever, the ultraviolet ray emission should be driven by a constant current source within the operable input voltage range. And also the heat dissipation is particularly important because of the long ultraviolet emission retention time due to the UV utilization characteristics. In addition, since human body protection is essential, the algorithm is configured to operate according to human body detection using distance sensor and Bluetooth. Three 365nm UV LEDs were used in series to emit ultraviolet UVA, operating at the constant current of 500mA with an efficiency of 87.5% and a power consumption of 6.006W. The ultraviolet radiation dose was measured at 5.35 mW / cm2 at the distance of 10 cm when measured by the Lutron ultraviolet measuring instruments.

피이드포워드 보상기를 갖는 강인한 선형 다변수 최적 모델 추종 서보계의 구성에 관한 연구

황창선(C.S. HWANG),김정택(C.T. KIM),김동완(D.W. KIM),김문수(M.S. KIM),이경홍(K.H. LEE) 대한전기학회 1993 대한전기학회 학술대회 논문집 Vol.1993 No.7

흰쥐의 후지체공에 따른 앞다리와 뒷다리의 골밀도 차이

김창선(Chang-sun Kim) 한국생활환경학회 2011 한국생활환경학회지 Vol.18 No.3

Mechanical forces play a pivotal role in maintaining bone mass. Tail-suspension has long been employed to induce a pattern of osteopenia in rats and it has been used as a ground-based model for the spaceflight. This study was designed to clarify the change of BMD between the fore- and hind-limb induced by non-weight-bearing, eighteen 7-week-o1d female spraque-dawley rats completed tail-suspension for 2-week. After a week of stabilization, rats were randomly divided into three groups: before tail-suspension group (n=6, before), non-suspension control group (n=6, Con) and tail-suspension group (n=6, Sus). The rats were fed standard lab chow (CRF-l, Charles River, Japan) and water ad libitum while Con group were pair fed with the appropriate suspension rats for control of caloric intake. At before and after 2-week suspension, rats were sacrificed and femur and humerus were removed for analysis of bone mineral density (BMD) by dual energy X-ray absorptionmetry (DEXA, Lunar DPXL, DSA). Serum and twenty four hours urinary calcium (Ca) and phosphate (P) were determined by biochemical markers of bone metabolism. BMD of femur in the Con group were increased in approximately 16.5% as compared with that of the before group (p<.001), but that of the Sus group did not increased, and showed approximately 11.2% lower than that of the Con group(p<.01). However, BMD of humerus in the both group showed no difference between the Con and the Sus group(NS). Similarly, BMC of femur in the Con group were increased in approximately 45.5% as compared with that of the before group (p<.001), but that of the Sus group was small, and showed approximately 14.5% lower than that of the Con group (p<.01). However, BMC of humerus in the both group showed no difference between the Con and the Sus group (NS). The femur weight of the Sus group was decreased approximately in 8% as compared to the Con group (p<.05), but the humerus weight showed no difference between the Con and the Sus group. On the other hand, the serum Ca concentration and twenty four hours urinary Ca excretion between the Con and the Sus group showed similar levels. Twenty four hours urinary P excretion of the Sus group, however, dynamically decreased approximately 50% lower than that of the Con group (P<.05) while serum P concentration was increased (p<.001). These results suggest that the bone loss was occurred mainly a part of non-weight bearing, and that disturbed P homeostasis in this process.

8주간의 필라테스 운동은 부위 특이적으로 요추 및 하지 부위의 골밀도를 향상 시킨다

김창선 ( Chang Sun Kim ),김지연 ( Ji Yeon Kim ),김효진 ( Hyo Jin Kim ) 한국운동생리학회 2015 운동과학 Vol.24 No.4

PURPOSE: Pilates exercise has been shown to improve core stability, strength, flexibility, muscle coordination and posture, but its effects on BMD and bone metabolism were unknown. The purpose of this study was to examine the effects of 8 weeks of Pilates exercise on BMD and bone metabolism in female university students. METHODS: Eighteen subjects, aged 21.65±2.45 yrs, were randomly assigned into two groups: Pilates exercise group (Pilates, n=9) and non-exercise control group (Control, n=9). The subjects in the Pilates group participated in the mat Pilates exercise program for 60 minutes a day, 3 days per week for 8 weeks. Total body and lumbar vertebral BMD were measured by dual energy X-ray apsorptionmetry (DEXA) before and after experience period. The blood samples were also collected before and after exercise, then the following variables were examined as bone metabolic markers in serum: osteocalcin (OC), c-terminal telopeptide of type 1 collagen (CTx), insulin-like growth factor type 1 (IGF-1) and growth hormone (GH). RESULTS: Although total body BMD in the Pilates group was not shown to be significantly different before and after period, legs BMD and lumbar vertebral BMD (L2-L4) significantly improved approximately 0.9% and 1.6%, respectively in the Pilates group (p<.05). L1 BMD (p<.05), L2 BMD (p<.05), L3 BMD (p<.05), L1-2 BMD (p<.01), L1-3 BMD (p<.001), L1-4 BMD (p<.01) and L2-3 BMD (p<.001) also significantly increased after period in Pilates group. However, serum OC, CTx, IGF-1 and GH did not show significant differences between pre-and post-periods in all groups CONCLUSIONS: These results suggest that prolonged mat Pilates exercise site-specifically improves legs and lumbar vertebral BMD, but it did not affect total body BMD. These site-specific improvement of BMD was independent of GH and IGF-1.