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Stimulating Effect of Panax Saponins on the $C^{14}$-Leucine Incorporation
한병훈,김종현,한용남,Han, Byung-Hoon,Kim, Chong-Hyun,Han, Yong-Nam 생화학분자생물학회 1973 한국생화학회지 Vol.6 No.2
인삼에서 분리한 Panax Saponin A (protopanaxatriol 계)가 지효성 및 지속성의 anti-inflammatory activity를 나타내는 것은 이마 보고한 바 있다. 이 성분은 mouse의 간 및 혈청에서$C^{14}$-leucine의 동화를 촉진하였고 이 효과를 경시적으로 추구한 결 과 anti-inflammatory activity에 대한 경시적인 실험결과와 동일한 경향을 나타내었다. Maximum incorporation을 일으키는 시점 (투여후 4시간)에서 PSA (1~2 mg/mouse)는 $C^{14}$-leucine의 incorporation을 41 또는 61% 촉진하였고 이 효과는 부신피질 호르몬의 개입이 없이 일어난 것으로 밝혀졌다. Delayed and long-lasting characteristics of stimulating effect of Panax Saponin A, one of protopanaxatriol diglucoside of Korean ginseng, on the incorporation of labeled amino acid into liver and serum protein of mouse appear to be correlated with characteristics of anti-inflammatory activity of the substance. Intraperitoneal administration of PSA (1~2 mg/mouse) enhanced the incorporation rate of labeled amino acid into protein by 41~61% over that of control. At the time of maximum incorporation, The stimulating effect was proved not to be correlated with the intervention of corticak hormone.
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인삼성분 Panax Saponin A 가 흰쥐의 단백합성에 미치는 촉진효과
한병훈,한용남,김종현 ( Byung Hoon Han,Chong Hyun Kim,Yong Nam Han ) 생화학분자생물학회 1973 BMB Reports Vol.6 No.2
Delayed and long-lasting characteristics of stimulating effect of Panax Saponin A, one of protopanaxatriol diglucoside of Korean ginseng, on the incorporation of labeled amino acid into liver and serum protein of mouse appear to be correlated with characteristics of anti-inflammatory activity of the substance. Intraperitoneal administration of PSA (1∼2 ㎎/mouse) enhanced the incorporation rate of labeled amino acid into protein by 41∼61 % over that of control. At the time of maximum incorporation, The stimulating effect was proved not to be correlated with the intervention of cortical hormone.
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일본뇌염 예방접종 후 면역원성 및 중화항체 지속률에 관한 조사: 전향적 다기관 코호트 연구
김동현,홍영진,이훈재,최보율,김창휘,박재옥,강진한,최병준,김종현,안영민,주영란,정영의,한명국,Kim, Dong Hyun,Hong, Young-Jin,Lee, Hoon-Jai,Choi, Bo-Yul,Kim, Chang Hwi,Park, Jae Ock,Kang, Jin Han,Choi, Byung Joon,Kim, Jong Hyun,Ahn, Young Min 대한소아감염학회 2013 Pediatric Infection and Vaccine Vol.20 No.3
목적: 일본뇌염 백신의 면역원성 및 중화항체 지속률을 평가하여 일본뇌염 예방 사업을 위한 토대를 제공하고자 하였다. 방법: 국내 6개 대학병원에 입원한 2-6세의 어린이 중 기초접종력이 확인된 170명을 대상으로 기초접종 완료 경과 기간에 따른 중화항체가를 조사하였다. 결과: 총 170명 중 불활성화 백신 접종군 103명, 생백신 접종군 64명, 교차접종군 3명이었다. 항체검사까지의 기간은 불활성화 백신 17.5개월, 생백신 21.0개월이었고 모두 일본뇌염 방어가 가능한 항체가를 보여 불활성화 백신 322, 생백신 266이었다. 추가접종 후 항체역가 변화는 1-4개월에 가장 높았고 이후 서서히 떨어지는 경향을 보였다. 결론: 불활성화 백신과 생백신의 면역원성과 중화항체 지속률에는 차이가 없고 두 백신 모두 일본뇌염 예방을 위한 적절한 수준의 면역원성을 갖고 있었다. 향후 대규모 표본을 대상으로 더 많은 연구가 필요하다. Purpose: This study aimed to study the antibody response of Japanese encephalitis vaccination in children using different kinds of vaccines (inactivated vaccine, live attenuated vaccine or interchanged) and evaluate the effectiveness of the vaccines to provide the basis of efficient immunization schedule of Japanese encephalitis. Methods: Measurement of the neutralization antibody (NTAb) titers following Japanese encephalitis vaccination using different vaccines for 170 children, 2-6 year of age, who visited six university hospitals and are confirmed by immunization records. Results: Among 170 children who were given primary immunization on Japanese encephalitis, 103 children were given inactivated vaccine, 64 children were given live attenuated vaccine and 3 children were given interchangeably. NTAb titers were more than 1:10 in all children of three groups. The geographic mean antibody titer was 322 in inactivated vaccine group and 266 in live attenuated vaccine group. However, there was no significant difference between two groups. In both groups, the NTAb titer showed the peak at 1-4 months after the third immunization and declined. The NTAb titers of three children who were given two kinds of vaccines alternately were 1:135, 1:632, and 1:2511, respectively. Conclusion: According to the results of this study in children younger than 6 years old, there is no significant difference in effectiveness between inactivated and live attenuated vaccines. However, further studies for the changes of antibody titers for a longer period of time on larger population are required.
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당뇨병성 케톤산증 및 고중성지방혈증으로 인한 급성 췌장염으로 발현한 말단비대증 환자 1예
민용기,이춘영,이문규,이선영,홍성노,김형훈,강보현,강한욱,이병완,박유정,이명식,김광원,김종현 대한내분비학회 2002 Endocrinology and metabolism Vol.17 No.1
Secondary diabetes mellitus caused by increased growth hormone secretion (GH) has well been known. There is a close association between glucose intolerance and GH secretion, and increased GH level itself probably worsens the blood glucose control and lipid profile by increasing glycogenolysis and / or gluconeogenesis and by suppressing lipase activity. We report a case of acromegaly with diabetic ketoacidosis as and hypertriglyceridemia-induced acute pancreatitis. A 38 year old male, previously diagnosed to have acromegaly and diabetes, presented with nausea, vomiting, diffuse abdominal pain and altered mentality. There was no history of drug or alcohol consumption, blood gas analysis showed severe acidosis and urinanalysis for ketone was positive. His serum blood glucose, amylase and lipase levels were 494 ㎎/dL, 331 U/L, and 1288 U/L, respectively (reference values: 70∼110 ㎎/dL, 13∼100 U/L and 13∼190 U/L, respectively). The patient was diagnosed as having diabetic ketoacidosis and acute pancreatitis. With the serum concentration of triglyceride being 1488 ㎎/dL and the absence of any obvious precipitating factors, we considered hypertriglyceridemia to be the cause of acute pancreatitis. He was treated with continuous intravenous insulin infusion, lipid lowering agent, and fluid replacement. After conservative management, general condition gradually improved and his serum amylase, lipase and triglyceride levels were all normalized. GH level was not suppressed under 2 ng/mL during oral glucose loading test, and basal GH and IGF levels were 231 ng/mL and 29.5 ng/mL, respectively. Sella MRI showed a 3.7 ㎝ sized pituitary mass. On the 55th day of admission, transsphenoidal surgery was performed. In immunohistochemical staining, the pathologic tumor specimen was proved to be GH positive pituitary adenoma. This is the first case reported in the English literature of an acromegaly presenting with diabetic ketoacidosis and acute pancreatitis
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