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김의배,박용,박세종,김대식,김지원,서희연,성화정,최인근,박경화,오상철,최철원,김병수,김열홍,김준석,신상원,김철용,정광윤 대한암학회 2008 Cancer Research and Treatment Vol.40 No.4
Purpose: The rate of second primary lung cancer development for patients with head and neck cancer (HNC) has been noted. The aim of our study was to evaluate the incidence and clinical features of suspected second primary lung cancer that developed in patients with primary HNC. Materials and Methods: We conducted a retrospective study of 469 patients who were newly diagnosed with HNC at the Korea University Medical Center between January 2000 and December 2006. Results: A total of 469 patients were included (389 men and 80 women). Eighteen patients (3.8%) had suspected second primary lung cancers. Statistically significant clinical variables for lung cancer development included the origin site for the primary HNC (oro-hypopharynx and larynx) (p=0.048), abnormal chest x-ray findings (p=0.027) and the histological HNC type (squamous cell carcinoma) (p=0.032). When the second primary lung cancers were combined with HNCs, the adjusted overall survival of patients with a second primary lung cancer was 16 months (p<0.001). Conclusions: Considering the relative risk factors for a second primary lung cancer developing in patients with HNC, advanced diagnostic tools, such as chest CT or PET CT scan, should be applied for the early detection of a second primary lung cancer.
김의배 ( Eui Bae Kim ),정승원 ( Soung Won Jeong ),장재영 ( Jae Young Jang ),이세환 ( Sae Hwan Lee ),김상균 ( Sang Gyune Kim ),김영석 ( Young Seok Kim ),김홍수 ( Hong Soo Kim ),김부성 ( Boo Sung Kim ),장아람 ( A Ram Jang ) 대한간암학회 2012 대한간암학회지 Vol.12 No.2
Hepatocellular carcinoma (HCC) is the sixth most common tumor worldwide and the third leading cause of tumor mortality. The majority of tumors are diagnosed when advanced and then a 5-year survival rate of HCC is below 5%. However, recent progress in the diagnosis and treatment of HCC has made it possible for the patient to survive longer, and as a result, distant metastasis from HCC has increased and attracted more attention than before. HCC can be metastasized to all organs through blood and lymphatic channel. Of the various metastatic sites, the most common site is the lungs, followed by the lymph nodes, musculoskeletal, adrenal and omentum. Also, spleen, small bowel, large bowel and esophagus can be invloved. Brain metastasis can be occurred rarely, and then it is regarded to oncologic emergency. We report a patient who present with brain metastasis of progressing HCC despite of treatment.
김의배 ( Eui Bae Kim ),이태희 ( Tae Hee Lee ) 대한내과학회 2013 대한내과학회지 Vol.84 No.1
Superior mesenteric artery syndrome (SMAS) is an uncommon disease resulting from compression of the third portion of the duodenum by the superior mesenteric artery. Typical symptoms of SMAS are anorexia, nausea, vomiting, early satiety, abdominal pain and postprandial fullness. The diagnosis requires radiologic studies in patients with symptoms suggestive of SMAS. Radiologic studies include upper gastrointestinal barium study, angiography, abdominal ultrasound, endoscopic ultrasound, computed tomography (CT), and magnetic resonance imaging. The SMA angle to the aorta is normally 45° (range, 38-56°), whereas in SMAS, that SMA angle is decreased to 6 to 25°. Additionally, the distance between the SMA and the aorta normally ranges from 10 to 20 mm, whereas in SMAS this distance is decreased to 2 to 8 mm. Recently SMAS diagnosis has been most commonly confirmed by CT. Therapy of SMAS includes weight gain to increase the aortomesenteric angle, but surgery is indicated in symptomatic patients when conservative management failed. To date, laparoscopic duodenojejunostomy seems to be a first-choice surgical options. (Korean J Med 2013;84:28-36)
박용,김지원,김대식,김의배,박세종,박진용,최우석,송종규,서희연,오상철,김병수,박종재,김열홍,김준석 대한암학회 2008 Cancer Research and Treatment Vol.40 No.3
Purpose: Bone Morphogenetic Proteins (BMPs) are members of the TGF-β superfamily and it has been demonstrated that BMPs enhance migration, invasion and metastasis. The purpose of this study was to identify the association between the serum BMP-2 level and the progression status of gastric cancer. Materials and Methods: Fifty-five patients with metastatic gastric cancer (metastatic disease group), six patients with early gastric cancer without lymph node metastasis (the EGC group), and ten healthy control subjects were enrolled in this study. The serum BMP-2 level was quantified by use of a commercially available ELISA kit. In EGC group patients and patients with metastatic disease, whole blood was obtained before endoscopic mucosal resection and before the commencement of a scheduled cycle of systemic chemotherapy, respectively. Results: No significant difference in the mean serum BMP-2 levels was observed between the control subjects and the EGC group patients (87.95 pg/ml for the control subjects and 84.50 pg/ml for the EGC group, p=1.0). However, the metastatic disease group patients had a significantly higher level of serum BMP (179.61 pg/ml) than the control subjects and EGC group patients (87.95 pg/ml for the control subjects and 84.50 pg/ml for the EGC group, p<0.0001). Moreover, the mean serum BMP-2 level from patients with a bone metastasis was significantly higher than the mean serum BMP-2 level from patients without a bone metastasis (204.73 pg/ml versus 173.33 pg/ml, p=0.021). Conclusions: BMP-2 seems to have a role in progression to metastatic disease in gastric cancer, especially in the late stage of tumorigenesis, including invasion and metastasis. BMP-2 may facilitate bone metastasis in gastric cancer. To confirm these findings, further studies are required with tissue specimens and the use of a cancer cell line.
서희연,신봉경,김석진,김병수,김의배,김지원 대한암학회 2009 Cancer Research and Treatment Vol.41 No.2
Multicentric Castleman disease (MCD) is a rare lymphoproliferative disorder. Although MCD pathogenesis is unclear, studies have suggested that human herpesvirus 8 (HHV-8) may be associated with the disorder. Recent reports have identified MCD cases without viral infection. A 43-year-old woman presented to our hospital for fever and myalgia of 6 months’ duration. The complete blood count revealed an elevated leukocyte count (15.1x103/uL) and a decreased hemoglobin level of 10.0 g/dL. The C-reactive protein level was elevated at 276.5 mg/L. Thoracic computed tomography (CT) scans revealed bilateral axillary lymphadenopathy. There was no evidence of HHV-8, human immunodeficiency virus (HIV), or Mycobacterium infection. Histologic evaluation of a lymph node biopsy from the left axilla yielded a diagnosis of MCD. Cyclophosphamide, adriamycin, vincristine, and prednisone (CHOP) were administered for a total of 4 cycles. The patient’s fever and lymphadenopathy resolved after the course of chemotherapy. She has been in complete remission for 24 months at this writing. As previously reported, this case report suggests that MCD can develop without viral infection. CHOP chemotherapy may be an effective treatment option for newly diagnosed MCD patients.