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만성 간질환 환자에서 간 섬유화 평가에 대한 간 탄력도 측정의 유용성
김은선 ( Eun Sun Kim ),서연석 ( Yeon Seok Seo ),이광균 ( Kwang Gyun Lee ),박상훈 ( Sanghoon Park ),권용대 ( Yong Dae Kwon ),금보라 ( Bora Keum ),김용식 ( Yong Sik Kim ),진윤태 ( Yoon Tae Jeen ),전훈재 ( Hoon Jai Chun ),김창덕 ( Ch 대한내과학회 2008 대한내과학회지 Vol.74 No.3
Background/Aims: Accurate assessment of liver fibrosis is very important for predicting the prognosis of patients with chronic liver diseases. Liver biopsy is still considered the gold-standard for assessing liver fibrosis. However, it is an invasive procedure with several limitations such as its questionable outcomes. Recent studies have suggested that liver stiffness measurement (LSM) using Fibroscan is noninvasive and useful for assessing liver fibrosis. This study was performed to evaluate the efficacy of LSM for evaluating liver fibrosis in patients with chronic liver diseases. Methods: We prospectively enrolled 93 patients with chronic liver diseases, as confirmed by liver biopsy. The patients underwent liver biopsy and LSM. The METAVIR liver fibrosis stages of the biopsy specimens were assessed by an experienced pathologist. LSM was performed by Fibroscan. The efficacy of LSM and the optimal cutoff values for assessment of the fibrosis stage were determined by a receiver-operating characteristics (ROC) curve analysis. Results: LSM was well correlated with the fibrosis stage (Kendall correlation coefficient: 0.58; p<0.001). The areas under the ROC curves were 0.871 (95% CI, 0.715-0.924) for the patients with significant fibrosis (F≥2), 0.874 (0.761-0.929) for the patients with severe fibrosis (F≥3) and 0.894 (0.792-0.956) for the patients with cirrhosis (F=4). The optimal LSM cutoff values for F ≥2, F ≥3 and F=4 were 6.9, 11.75 and 14.5 kPa, respectively. Conclusions: LSM was a simple, effective method for assessing liver fibrosis in patients with chronic liver diseases. Its use for the follow up and management of these patients could be of great interest and so further investigation is required. (Korean J Med 74:264-270, 2008)
김은선(Eun Sun Kim),금보라(Bo Ra Keum),서연석(Yeon Seok Seo),이홍식(Hong Sik Lee),전훈재(Hoon Jai Chun),박성철(Sung Chul Park),박낙순(Nark Soon Park),김동곤(Dong Gon Kim),나재운(Jae Woon Nah),진윤태(Yoon Tae Jeen),조혜진(Hye Jin Cho) 한국고분자학회 2014 폴리머 Vol.38 No.3
위장관 종양 조직이 스텐트 내로 성장하는 것을 방지하는 피막형 스텐트가 개발되어 널리 사용되고 있으나 위산에 의한 막의 분해로 인해 스텐트 폐쇄나 파손이 있다. 이에 본 연구에서는 위산 환경하에서 막의 성분과 재질 농도에 따른 피막형 스텐트의 물성 변화와 안정성을 살펴보고자 하였다. 스텐트 막의 재질은 실리콘과 폴리우레탄을 사용하였고, 각각의 농도를 15%, 18%, 20%로 하여 제작된 스텐트를 pH 1.2 산성 용액에서 18주 동안 3주 간격으로변화를 관찰하였다. 피막을 분석한 결과 동일 농도에서 비교하였을 때 실리콘이 폴리우레탄보다 두껍고 균일하게코팅되었다. 인공 위액에 의한 폴리우레탄 피막의 분해가 실리콘 피막에 비해 심하였다. 반경 방향 팽창력의 크기는실리콘 피막이 폴리우레탄 피막에 비해 상대적으로 컸다. 반경 방향 팽창력과 변형 회복력 모두 인공 위액에서의침잠 기간이 경과함에 따라 점차 감소하였고, 폴리우레탄 피막 스텐트에서 감소율이 더 컸다. 결론적으로 실리콘 피막이 폴리우레탄에 비해 위산에 대해 안정성이 높음을 알 수 있었다. In membrane covered stent, occlusion and fracture from membrane degradation by gastric acid sometimesoccurred. Therefore, we investigated the physical properties of membrane covered stent according to its ingredient andconcentration in gastric acid environment. Membrane covered stents consisted of silicone and polyurethane with 15%,18%, 20% concentrations were used. After incubating stents in a condition of pH 1.2, we checked any changes at every3 weeks for 18 weeks. The changes of membrane surface, radial expansion and recovery force of stent were investigated. Coating thickness increased proportionally to an increase in ingredient concentration. Surface was evenly coated with siliconecompared to the case with polyurethane and its homogeneity was excellent in a high concentration. Degradationwas much severe in the case of polyurethane. The radial force of silicone was higher than polyurethane, and the decreaseof radial and recovery force was higher in the case of polyurethane. In conclusion, high concentration of silicone membranewas more stable than polyurethane in acid environment of in vitro study.
AOP를 이용한 신뢰성 있는 서비스 어플리케이션의 SOA 기반 프레임워크
김은선(Eun-Sun Kim),이재정(Jae-Jeong Lee),이병정(Byung-Jeong Lee) 한국IT서비스학회 2011 한국IT서비스학회지 Vol.10 No.2
Loosely coupled properties of SOA(Service Oriented Architecture) services do not guarantee that service applications always work properly. Service errors may also influence other services of SOA. These characteristics adversely affect software reliability. Therefore, it is a challenge to effectively manage system change and errors for operating services normally. In this study, we propose a SOA based framework using AOP(Aspect Oriented Programming) for reliable service applications, AOP provides a way to manipulate cross-cutting concerns such as logging, security and reliability and these concerns can be added to applications through weaving process. We define a service specification and an aspect specification for this framework. This framework also includes service provider, requester, repository, platform, manager, and aspect weaver to handle changes and exceptions of applications. Independent Exception Handler is stored to exhibited external Aspect Service Repository. When exception happened, Exception Handler is linked dynamically according to aspect rule that is defined in aspect specification and offer function that handle exception alternate suitable service in systematic error situation. By separating cross-cutting concerns independently, we expect that developer can concentrate on core service implementation and reusability, understanding, maintainability increase. Finally, we have implemented a prototype system to demonstrate the feasibility of our framework in case study.
김은선 ( Eun Sun Kim ) 대한주산의학회 2013 Perinatology Vol.24 No.4
Infectious complications such as necrotizing enterocolitis (NEC) or neonatal sepsis are main causes of mortality and disability in very low birth weight infants (VLBWIs). Because preterm infants are exposed to too unfavorable environment to promote appropriate intestinal colonization, pathologic organisms can easily colonize and host defense systems are also down-regulated in preterm gut, causing infectious complications such as NEC. To promote appropriate intestinal microbiota, probiotics have been studied for potential benefits by increasing mucosal barrier function, reducing intestinal pathogens, up-regulating immune system balancing inflammation. Large randomized controlled trials have shown favorable effects of probiotics on preterm NEC and mortality. Meta-analysis of clinical trials showed consistent evidence of probiotics uses in preterm infants. However, adequate type, dose, timing, and duration of probiotics have not been standardized for clinical applications. Inaddition, other interventions promoting preterm intestinal micobiota and immunity, such as prebiotics or lactoferrin, are on studies in combination with probiotics. More clinical trials should be added for the evidence based clinical use of probiotics in preterm infants.