산전 진단된 수신증의 임상 경과 - 단일 기관의 경험 -

김연희,김병주,박문성,양정인,김행수,김병길,배기수,Kim Yeun-Hee,Kim Byoung-Ju,Park Moon-Sung,Yang Jung-In,Kim Haeng-Soo,Kim Pyung-Kil,Pai Ki-Soo 대한소아신장학회 2002 Childhood kidney diseases Vol.6 No.2

목적: 산전 초음파가 널리 이용되면서 태아기의 선천성 요로계의 이상이 발견되는 경우가 점차 증가하고 있다. 수신증의 대부분은 출생 후 1년 내에 자연스럽게 없어지는 생리적 수신증이지만 수술적 교정을 요하는 병적 수신증과의 감별이 쉽지 않다. 본 연구에서는 산전 수신증이 의심되는 환아에서 출생 후 수신증을 확진하여 산전 진단과의 연관성을 비교 분석하고, 산전 수신증의 원인과 자연경과를 이해하여 출생 후 수신증에 대한 대처에 도움을 주고자 본 연구를 시행하였다. 방법: 1994년 9월부터 2001년 8월까지 아주대학교 병원 산과에 등록되어 산전 초음파 검사상 태아 수신증이 의심되었던 환아 119명 중 출생후 실시한 신 초음파 검사에서 수신증이 확진된 91명(121 신단위)을 대상으로 수신증의 원인과 자연경과를 신 초음파 검사와 배설성 신주사 검사로 추적 관찰하였다. 결과: 산전 초음파 검사에서 수신증이 의심되었던 119명의 신생아 중 출생 후 수신증이 확진 되었던 환아는 91명으로 76%였다. 수신증의 원인으로 요관 신우 이행부 협착이 57례(47%)로 가장 많았으며 그 다음으로는 다낭성 이형성신이 12례(10%), 요관 방광 이행부 협착 5례(4%), 방광 요관 역류 5례(4%), 후부요도 판막 2례(2%)등의 눈이었으며 원인을 찾을 수 없었던 경우도 38례(31%)였다. 추적검사에서 47%가 수신증의 완전소식 혹은 호전소견을 보였으며 총 121개의 신 단위 중 10단위가 수술을 받았으며 진단에서 수술까지는 평균 7.2개원이 걸렸다. 결론: 산전 초음파로 발견된 수신증의 대부분은 출생후 수신증으로 확진되었으나 정상인 경우도 있었다. 산전 수신증의 원인으로 요관 신우 이행부 폐쇄가 가장 많았으며 대부분은 비폐색성 수신증이었고, 추적 검사에서 호전되는 경우가 많았다. 그러나 아직까지 신생아 수신증은 정확한 감별진단이 어렵기 때문에 신장기능의 보전을 위해서는 수신증의 정도에 따라 적절한 간격으로 지속적인 관찰을 하는 것이 필요할 것으로 사료된다. Purpose : The detection of hydronephrosis(HN) with antenatal ultrasonography was first reported in the 1970s. Prenatal HN is diagnosed with an incidence of 1:100 to 1:500 on antenatal screening. Recently, the purpose of antenatal screening has changed from simple detection to selection for specific diagnosis-based management. this study is to evaluate the usefulness of antenatal sonography for HN and to investigate the differential causes of HN and their clinical outcomes. Patients and methods : 11,783 live neonates with prenatal ultrasonographic examination at Ajou University School of Medicine, from Sep. 1994 to Aug. 2001 were analyzed. Results and conclusion : Hydronephrosis (>10 mm) was detected in 119 (1.0%) cases antenatally and among these, 91 were proved to have HN postnatally Males were three times more affected than females. Additional imaging studies revealed that ureteropelvic junction obstruction was the most common postnatal diagnosis (47%), followed by multicystic dysplastic kidney, vesicoureteral junction obstruction and vesicoureteral reflux. During 20 months' follow-up(3 to 72 months), 58(48%) renal units showed spontaneous resolution and surgical interventions were necessary in 10 (7.4%) of postnatally confirmed hydronephrotic renal units.

망막중심정맥폐쇄에서 시신경유두부종의 유무에 따른 형광안저혈관조영소견

김연희,김상국.Youn Hui Kim. M.D.. Sang Kook Kim. M.D.. Ph.D. 대한안과학회 2007 대한안과학회지 Vol.48 No.11

Purpose: To investigate the characteristics of fluorescein angiograms (FAG) of the optic nerve head and retina according to the presence of optic nerve head swelling (ONHS) in central retinal vein occlusion (CRVO). Methods: The records of 69 eyes were reviewed, confirmed with the diagnosis of CRVO, and compared for several features according to the presence of ONHS. The best-corrected visual acuities and intraocular pressures were recorded and patterns of retinal hemorrhage were described. The presence of fluorescein filling defects of the optic disc, time till fluorescein started to fill at the optic disc, arteriovenous transit time, and nonperfused areas were assessed using FAG. Results: Forty-one patients without ONHS (group 1) and 28 patients with ONHS (group 2) were included. The mean ages for groups 1 and 2 were 61.4 and 56.9 years, respectively, and there was no significant difference the mean ages between the groups. The fluorescein filling defect of the optic disc was seen more often in group 1 (n=13) than in group 2 (n=2). Marginal irregularity of the foveal avascular zone due to perifoveal capillary drop out was seen significantly more often in group 1 (n=12) than in group 2 (n=2). Conclusions: Fluorescein filling defects of the optic disc and perifoveal capillary drop out were more frequently seen in CRVO patients without ONHS. However, longitudinal studies are needed to confirm the prognostic value of ONHS and the correlation of filling defects with progressive optic neuropathy in CRVO.

소아시기에 사시수술을 받은 후 재수술한 환자의 임상 분석

김연희,최미영,Youn Hui Kim,M,D,Mi Young Choi,M,D 대한안과학회 2006 대한안과학회지 Vol.47 No.6

Purpose: To report the clinical characteristics of patients undergoing reoperation after strabismus surgery during childhood. Methods: Sixty-one patients who had undergone strabismus surgery in childhood and later reoperation were included. Age, visual acuity, type of strabismus at the first and second operations and postoperative angle of deviation were analyzed. The causes of reoperation were classified into recurrent, consecutive, or newly developed strabismus. Recurrent strabismus was defined as strabismus developed in the same direction after correction within 10 prism diopters (PD). Consecutive strabismus was defined as strabismus developed in the opposite direction after surgical overcorrection. Results: The mean duration between the first operation and reoperation was 5.6 years. Recurrent exotropia was the most common cause of reoperation. The incidence of vertical strabismus was higher in reoperations than in first operations (4.9 vs 26.2%, P=0.020). Most incidences of vertical strabismus in the reoperation were newly developed after first operation for horizontal strabismus. At the last follow-up, 63.9% had ocular alignment within 10PD in the horizontal plane and within 8PD in the vertical plane. The frequency of amblyopia was 16.4%. Conclusions: Recurrent exotropia was the most common cause of reoperation for strabismus. The incidence of vertical strabismus was higher in reoperations than in first operations.

Oxidative Synthesis of Benzoylpteridines from Benzylpteridines by Potassium Permanganate

김연희,강용한,백대진,Kim, Yeon Hui,Gang, Yong Han,Baek, Dae Jin Korean Chemical Society 2001 Bulletin of the Korean Chemical Society Vol.22 No.2

6- and 7-Benzylpteridine derivatives have been converted to the corresponding 6- and 7-benzoylpteridines by the oxidation reaction with KMnO4. The newly synthesized compounds have been characterized by pKa determinations, UV, and 1H-NMR spectra.

양파 열수추출물의 항산화능 및 인공소화후의 항돌연변이 효과

김연희,손미예,성낙주,Kim Yeon-Hee,Shon Mi-Yae,Sung Nak-Ju 한국생명과학회 2004 생명과학회지 Vol.14 No.6

Antioxidant activity and antimutagenic activities with and without simulated gastric digestion of hot water extracts from white and yellow onions were investigated as compared to BHT and ascorbic acid as control Contents of total phenol and flavonoid in hot water extract of yellow onion were higher than those of white one. The scavenging activity of hydrogen peroxide of both extracts were increased in direct proportion to added their concentration. Antioxidant activity and reducing power of the hot water extract were elevated through analysis of $\beta-carotene-linoleate$ system and were lower than those of BHT and ascorbic acid. Antimutagenic activity after simulated gastric digestion of hot water extract of white and yellow onions was observed against mutagen IG and MNNG on Salmonella typhimurium TA80 and TA100. Extract of yellow onion was higher in antimutagenic activity than that of white one. In conclusion, these results suggested that phenol and flavonoid in hot water extract from yellow and white onions may play an important role in the antioxidant and antimutagenic activities. 양파 열수 추출물의 항산화능 및 인공소화 전과후의 항돌연변이 효과를 BHT와 ascorbic acid와 비교하여 조사하였다. 총 페놀 및 플라보노이드의 함량은 노란색 양파 추출물이 횐색 양파 추출물보다 많았으며, 양파 추출물의 과산화수소 소거능은 농도가 증가함에 따라 비례적으로 증가하였다. $\beta-carotene-linoleate\;system$에서 항산화능과 reducing power는 증가되었으나, BHT와 ascorbic acid보다는 낮았다. 양파열수 추출물의 인공소화 후에 IQ와 MNNG로 처리된 Salmonella typhimurium TA80과 TA100에 대하여 항돌연변이 효과가 나타났으며, 노란색 양파가 횐색 양파보다 높게 나타났다. 결론적으로 양파 추출물을 소화시키면 항산화 및 항돌연변이의 효과는 양파의 페놀과 플라보노이드의 성분 변화에 의한 것으로 판단된다.

인간체외수정시술시 다낭성난포종 난포액이 정자의 운동성에 미치는 영향

김연희,이상훈,허민,Kim, Yeon-Hee,Lee, Sang-Hoon,Hur, Min 대한생식의학회 2000 Clinical and Experimental Reproductive Medicine Vol.27 No.2

Objective: The purpose of this study was to evaluate the effect of polycystic ovarian follicular fluid on sperm motility in human in vitro fertilization (IVF). Methods: From May, 1998 to July, 1999, 55 patients who complained of infertility were involved in this study. We obtained ovarian follicular fluids from the patients by ultrasono-guided aspiration. Subjects were divided into two groups. 20 patients who had polycystic ovarian disease were belong to study group, and 25 patients who had normal ovarian follicular fluid were belong to control group. The follicular fluid dilution was done with Ham's fluid as 10%, 20%, 50%, 100%. The sperm motility was analyzed by CASA at 6hr and 12hr after incubation in follicular fluids. Results: The levels of average path velocity (VAP) in all concentration fluid didn't show significant difference between study and control group. The other parameters including curvilinear velocity (VCL), amplitude of lateral head displacement (ALH), and linerity (LIN) were didn't show any significant difference between both groups. Conclusion: PCOD fluid had seemed to have an adverse effect on the sperm biological function. But, this study showed that PCOD fluid had no different effect on sperm motility with normal follicular fluid.

CONTENT PRISM / KIPA 비지니스 상담회

김연희,Kim, Yeon-Hui 한국데이터베이스진흥원 2003 디지털콘텐츠 Vol.8 No.-

8월 25일부터 26일까지 양일간 대만 타이페이에서 한국-대만 콘텐츠/솔루션 비지니스 상담회가 진행될 예정이다. 대만의 디지털콘텐츠진흥센터(DCIPO)와 소프트웨어산업협회(CISA)의 후원으로 개최되는 비지니스 상담회로 온라인게임, 모바일게임, 인터넷콘텐츠와 솔루션 등의 업체들의 참여가 기대된다. 이미 한류열풍이 거세게 불고 있는 대만에서는 이미 엔씨소프트의 '리니지', 그라비티의 '라그나로크' 등이 선풍적인 인기를 끌고 있다.

Penicillium verruculosm 의 Endo - β - 1 , 4 - Glucanase 의 정제 및 특성

김연희,조남철,김강화,최원기,전순배,이용규,정기철 ( Yeon Hi Kim,Nam Chul Cho,Won Ki Choi,Kang Hwa Kim,Soon Bai Chun,Yong Kyu Lee,Ki Chul Chung ) 생화학분자생물학회 1992 BMB Reports Vol.25 No.2

Two endoglucanase(EG, 1,4-β-D-glucan glucanohydrolase, EC 3.2.1.4) were purified from culture broth of P. verruculosum by ammonium sulfate precipitation, and HPLC-phenyl, HPLC-DEAE and HPLC gel filtration column chromatography. Purified enzymes were estimated to have molecular weight of 40 kDA(EG II), and 58 kDa(EG III) by SDS-PAGE and of 120 kDa(EG II), 140 kDa(EG III) by HPLC gel filtration. The optimal pH and temperature for these enzymes were found to be 4∼5 and 50-60℃, respectively. EG II and EG III hydrolyze carboxymethylcellulose but can not hydrolyze p-Nitrophenyl-α-D-glucoside and crystalline cellulose such as cotton, Avicel, filter paper. The hydrolytic products of CMC catalyzed by the enzyme were cellobiose, glucose and oligosaccharides. From the similarity in amino acid composition and elution profiles of tryptic peptides of EG II and EG III and cross reactivity of antibodies against the enzymes, it is suggested that amino acid sequences of these two EGs are very similar.

성인의 눈꺼풀결막에 발생한 랑거한스세포 조직구증식증 1례

김연희,최미영,김석형,Youn Hui Kim,Mi Young Choi,Seok Hyung Kim 대한안과학회 2007 대한안과학회지 Vol.48 No.3

Purpose: To report a case of isolated Langerhans cell histiocytosis (LCH) in the palpebral conjunctiva of an adult patient. Methods: A 39-year-old male presented with a mass of one month`s duration on the palpebral conjunctiva of his left upper lid. The lesion had gradually progressed. The mass was non-tender, relatively well circumscribed, yellowish white, flat, firm, and 5 mm×8 mm in size. Otherwise, the ophthalmic examination was completely normal, including the anterior and posterior segments. Based on the clinical picture, an infiltrative/neoplastic lesion was suspected. Incision biopsy was performed to obtain a diagnosis for proper management. Results: The histopathologic examination of the lesion showed an intensive proliferation of monotonous and histiocytoid cells beneath the epidermis. Immunohistochemical study revealed that the tumor cells were positively stained in the cytoplasm with anti CD1A antibody and anti S-100 antibody. The patient was then referred to the Oncology Department for evaluation. A detailed systemic examination, and the laboratory and radiologic investigations ruled out systemic involvement. The diagnosis of isolated LCH was finally made. Three months later, the lesion underwent remission without any treatment. Conclusions: This rare disorder may also present as a solitary lesion on the palpebral conjunctiva in adults, and so it should be kept in mind during the differential diagnosis of a conjunctival mass in an adult.

건강교육 : 여고생들의 체중조절 관심도에 영향을 미치는 요인에 관한 연구

김연희,홍양자 ( Yeon Hee Kim,Yang Ja Hong ) 한국체육학회 1992 국제스포츠 학술대회 Vol.1992 No.-