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김연정,장미현,신민철,임백빈,정주호,반건호,백은경,박재형,김이화,김창주,Kim Youn-Jung,Jang Mi-Hyun,Shin Min-Chul,Lim Baek-Vin,Chung Joo-Ho,Bahn Gyun-Ho,Paik Eun-Kyung,Park Jae-Hyung,Kim Ee-Hwa,Kim Chang-Ju 경락경혈학회 2002 Korean Journal of Acupuncture Vol.19 No.1
목적 : 소아의 정신적 및 신체적 발달지연에 사용되고 있는 신기환이 해마의 신경세포 생성에 미치는 영향을 관찰하고자 하였다. 방법 : 신기환이 세포생성에 미치는 영향을 알아보기 위하여 해마 세포인 HiB5에 신기환을 처리, 배양하여 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay를 통해서 세포생성을 관찰하였다. 또한 3주령의 Sprague-Dawley (S-D)계 흰쥐의 중완혈에 신기환 약침을 자침후 해마의 치상회에서 bromodeoxyuridine (BrdU) immunohistochemistry를 시행하여 세포생성을 관찰하였다. 결과 : HiB5 배양세포에서는 신기환을 처리시 배양시간과 농도별로 세포생성율이 증가하였다. 또한, 대조군의 치상회에서 BrdU 양성세포수는 $128.50{\pm}9.53$, 1 mg/kg 신기환 자침군은 $157.08{\pm}10.82$ 및 10 mg/kg 신기환 자침군은 $204.80{\pm}17.68$로 나타났다. 이러한 결과로 신기환은 어린 S-D계 흰쥐의 치상회에서 세포생성을 증가시키는 것으로 사려된다.
Cyclic AMP-PKA System이 억제성 및 흥분성 한약재에 의해 유발된 이온전류에 미치는 영향
김연정,신민철,정주호,이충열,김이화,김창주,Kim Youn-Jung,Shin Min-Chul,Chung Joo-Ho,Lee Choong-Yeol,Kim Ee-Hwa,Kim Chang-Ju 경락경혈학회 2001 대한침구의학회지 Vol.18 No.1
Modulatory effect of cAMP-PKA system on inhibitory- and excitatory herbs-induced ion currents were investigated by nystatin-perforated patch clamp method under voltage-clamp condition. Ion currents induced by Bupleuri radix and Coptidis rhizoma were not affected by cAMP-PKA system. Ion current induced by Ecliptae herba was partially inhibited by cAMP-PKA system. Ion currents induced by Aconiti tuber and Boshniakiae herba were inhibitory modulated and ion current induced by Zingiberis rhizoma was excitatory modulated by cAMP-PKA system. Modulation of cAMP-PKA system on ion currents induced by Ginseng radix was fluctuated. In this results, it can be seen generally that excitatory herbs-induced ion currents were modulated by cAMP-PKA system while cAMP-PKA system did not affect inhibitory herbs-induced ion currents.
소나무 잎과 가지의 정유와 그 성분들의 항산화 및 항노화 작용
김연정(Youn Joung Kim),조봉재(Bong Jae Cho),고명수(Myung Soo Ko),정재민(Jae Min Jung),김희래(Hee Rae Kim),송호선(Ho Sun Song),이지윤(Ji Yun Lee),심상수(Sang Soo Sim),김창종(Chang Jong Kim) 대한약학회 2010 약학회지 Vol.54 No.4
To investigate effects of pine essential oil isolated by steam distillation from Pinus densiflora needles (PN) and twigs (PT) on anti-oxidant and anti-aging activities, the experiments were carried out to determine anti-oxidant and antiaging activities on DPPH radical scavenging activity, NBT/xanthine oxidase-superoxide scavenging activity, silica-induced intracellular H2O2 and hydroxyl radical generation in RAW264.7 cells, hyaluronidase and elastase activities in vitro. Essential oil of PN and PT were contained 0.225 and 0.176 (w/v) %, respectively. PN was contained with 30 kinds of essential oil and its major constituent is α-pinene (21.5%). Further PT was contained with 40 kinds of essential oil and its major constituent is β-pinene (22.4%) in GC/MS assay. Other essential oils of PN were β-pinene, camphene, myrcene, limonene, terpinolene, α-terpineol, bornyl acetate, α-copaene, caryophellene and humulene and PT were α-pinene, camphene, phellandrene, limonene, terpinolene, α-terpineol, bornyl acetate, α-copaene, caryophellene and humulene. The essential oil of PT have more active than that of PN in anti-oxidant activity which has significant DPPH radical and superoxide scavenging activity, and significant inhibitory activities on silica-induced intracellular H2O2 and hydroxyl radical generation, as well as, significantly inhibited elastase and hyaluronidase activities. Further, phellandrene, myrcene and α-pinene have DPPH radical and superoxide scavenging activities, β-pinene, terpinolene, myrcene and phellandrene inhibited silica-induced intracellular H2O2 and hydroxyl radical generations. And also phellandrene and β-pinene inhibited hyaluronidase and elastase activities. In conclusion, the essential oils isolated from PN and PT have anti-oxidant and anti-aging activities.
신기환 약침이 HiB5 해마세포와 어린 Sprague-Dawley계 흰쥐의 치상회 세포생성에 미치는 영향
김연정 ( Youn Jung Kim ),장미현 ( Mi Hyun Jang ),신민철 ( Min Chul Shin ),임백빈 ( Baek Vin Lim ),정주호 ( Joo Ho Chung ),반건호 ( Gyun Ho Bahn ),백은경 ( Eun Kyung Paik ),박재형 ( Jae Hyung Park ),김이화 ( Ee Hwa Kim ),김창주 ( C 대한경락경혈학회 2002 Korean Journal of Acupuncture Vol.19 No.1
목적: 소아의 정신적 및 신체적 발달지연에 사용되고 있는 신기환이 해마의 신경세포 생성에 미치는 영향을 관찰하고자 하였다. 방법: 신기환이 세포생성에 미치는 영향을 알아보기 위하여 해마 세포인 HiB5에 신기환을 처리, 배양하여 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay를 통해서 세포생성을 관찰하였다. 또한 3주령의 Sprague-Dawley (S-D)계 흰쥐의 중완혈에 신기환 약침을 자침후 해마의 치상회에서 bromodeoxyuridine (BrdU) immunohistochemistry를 시행하여 세포생성을 관찰하였다. 결과: HiB5 배양세포에서는 신기환을 처리시 배양시간과 농도별로 세포생성율이 증가하였다. 또한, 대조군의 치상회에서 BrdU 양성세포수는 128.50±9.53, 1 mg/kg 신기환 자침군은 157.08±10.82 및 10 mg/kg 신기환 자침군은 204.80±17.68로 나타났다. 이러한 결과로 신기환은 어린 S-D계 흰쥐의 치상회에서 세포생성을 증가시키는 것으로 사려된다.
김연정 ( Youn Jung Kim ),최식영 ( Sik Young Choi ),김영훈 ( Young-hun Kim ) 한국환경과학회 2019 한국환경과학회지 Vol.28 No.1
Arsenic is among the heavy metals commonly found in aqueous environments. Iron oxide is known as an efficient adsorbent for the arsenic. A new synthetic method was applied to provide iron oxide giving a large specific surface area. The mixing method affects the formation of iron oxide. Ultrasonic waves assisted the formation of very fine iron oxide in an organic phase. The synthesized iron oxide is amorphous type with a high surface area of more than 181.3 m<sup>2</sup>/g. Sorption capacity of the synthesized adsorbent was relatively very high for arsenic and varied depending on the oxidation state of arsenic: a higher capacity was obtained with As(V). Lower solution pH provided a higher sorption capacity for As(V). The competitive effect of co-exist anions such as chloride, nitrate, and sulfate was minimal in sorption capacity of the iron oxide for arsenic.
김연정 ( Kim Youn Jung ),박정숙 ( Park Jung Suk ) 경희대학교 동서간호학연구소 2019 동서간호학연구지 Vol.25 No.1
Purpose: This study aimed to investigate influencing factors on nursing competency of nurses in long-term care hospitals. Methods: A descriptive research design was used with a convenience sample of 150 nurses. Data were collected from Feb 15 to Mar 8, 2017 using self-reported questionnaires and analyzed by descriptive statistics, t-test, ANOVA, Pearson’s correlation coefficient, and multiple regression analysis using the SPSS/WIN 18.0 program. Results: The mean scores of self-efficacy, organizational citizenship behavior and nursing competency were 3.84 out of 5, 3.77 out of 5 and 3.80 out of 5, respectively. Nursing competency was positively correlated with self-efficacy (r=.63, p<.001) and organizational citizenship behavior (r=.64, p<.001). Factors influencing on nursing competency were self-efficacy (β=.38, p<.001), organizational citizenship behavior (β=.37, p<.001) and Clinical career(β=.14, p=.011), which explained 51% of the variance. Conclusion: Based on the finding of this study, it is necessary to develop education and intervention programs in order to increase the nursing competency for nurses in long-term care hospitals.