진료비 가감지급의 방향과 과제

김선민,김계숙,김남순,Kim, Sunmean,Kim, Kyesook,Kim, Namsoon 한국의료질향상학회 2006 한국의료질향상학회지 Vol.12 No.2

미국 보건부의 질 향상활동

김선민,김재선,박영희,안미라,김형호,은상준,박건희,Kim, Sun Mean,Kim, Jae Sun,Park, Younghee,Ahn, Mi Ra,Kim, Hyeong-Ho,Eun, Sang Jun,Park, Kunhee,Shin, Youngsoo 한국의료질향상학회 2007 한국의료질향상학회지 Vol.13 No.1

양극산화법에 의한 TiO₂ 나노튜브 어레이의 제조와 성장거동

김선민,김기원,류광선,김유영,조권구,Kim, Seon-Min,Kim, Ki-Won,Ryu, Kwang-Sun,Kim, Yoo-Young,Cho, Kwon-Koo 한국분말야금학회 2011 한국분말재료학회지 (KPMI) Vol.18 No.1

Recently, $TiO_2$ nanotubes have considerably researched because of their novel application about photocatalysis, dye-sensitized solar cells (DSSCs), lithium ion battery, etc. In this work, self-standing $TiO_2$ nanotube arrays were fabricated by anodic oxidation method using pure Ti foil as a working electrode in ethylene glycole with 0.3M $NH_4F$ + $2%H_2O$. Growth behavior of $TiO_2$ nanotube arrays was compared according to temperature, voltage and time. The morphology, structure and crystalline of anodized $TiO_2$ nanotube arrays were observed by FE-SEM (field emission scanning electron microscope) and XRD (X-ray diffraction).

포중익기탕(補中益氣湯)이 알레르기 비염(鼻炎) 유발 마우스에 미치는 효과(效果)

김선민,심성용,변학성,김경준,Kim, Sun-Min,Sim, Sung-Youn,Byun, Hak-Sung,Kim, Kyung-Jun 대한한방안이비인후피부과학회 2005 한방안이비인후피부과학회지 Vol.18 No.3

Objectives: Maier symptoms of allergic rhinitis are nasal obstructions, sneezing and watery rhinorrhea. When exposed to certain allergens, the IgE covered mast cells degranulate and release inflammatory mediators and cytokines which result in a local inflammatory reaction. In many recent studies, molecular biological methods have been used to investigate the role of cytokines in pathogenesis and new therapeutic targets of allergic rhinitis. This experimental study was done to reveal the effects of the Bojungikgi-tang on the allergic rhinitis. We have studied effect of mice on OVA-induced production of IL-4, IL-5, $INF-{\gamma}$ by murine splenocytes and effect of OVA-induced Total IgE and OVA-specific IgE Meterial and Metheds: 21 BALB/c rats were divided into three groups: normal group, control group, experimental group. To induce the allergic rhinitis in control group and experimental group, rats were sentitized intraperitioneally with 0.1% ovalbumin solution 3 times at intervals of 2 weeks. Then intranasal sensitization was performed by diffusing 0.1% ovalbumin solution 3 times at intervals of 2 days for a week. After that time, rats in experimental group were oral administration treated by the Bojuogikgi-tang fer 28 days. We observed changes of IL-4, IL-5, $INF-{\gamma}$, Total IgE and OVA-specific IgE. We used independent-test statistically. Results: 1. In IL-4 study, Bojungikgi-tang treated group didn't show significant differences. 2. In IL-5 study, Bojungikgi-tang treated group shows significant differences. 3. In $INF-{\gamma}$ study, Bojungikgi-tang treated group shows significant differences. 4. In Total IgE, Bojungikgi-tang treated group shows significant differences. 5. In OVA-specific IgE, Bojungikgi-tang treated group didn't show significant differences. According to this result, Bojungikgi-tang was concluded to be effective on lowering the total IgE. Through this. Bojungikgi tang seems to reduce the symptoms of allergic rhinitis. More studies are required to know exact mechanism of Bojungikgi tang to show the anti allergenic effect.

창출(蒼朮) 에탄올 추출물이 비만세포 매개 염증반응에 미치는 영향

김선민,김경준,Kim, Sun-Min,Kim, Kyung-Jun 대한한방안이비인후피부과학회 2011 한방안이비인후피부과학회지 Vol.24 No.1

Objective : Atractyloides Chinensis Rhizome (ACR) is widely used in oriental medicine as a remedy for an inflammation and an allergic disease. However, as yet there is no clear explanation of how ACR affects the production of inflammatory cytokine. This study was to determine the effects of ACR on the mast cell-mediated inflammatory responses. Method : The amount of inflammatory cytokine production induced by the phorbol myristate acetate (PMA) plus calcium ionophore(A23187) in the human mast cell line (HMC-1) incubated with various concentrations of ACR was measured. The TNF-${\alpha}$ protein levels were analysised by Western blots. The TNF-${\alpha}$, IL-6 and IL-8 secreted protein levels were measured by the ELISA assay. The TNF-${\alpha}$, IL-6 and IL-8 mRNA levels were measured by the RT-PCR analysis. NF-${\kappa}$B, phospho-I${\kappa}$B and MAPKs were examined by Western blot analysis. The NF-${\kappa}$B promoter activity was examined by a luciferase assay. Results : 1. The expressions of TNF-${\alpha}$ and TNF-${\alpha}$ mRNA were decreased dose-dependently at 0.05-0.2mg/$m\ell$ of ACR and significantly decreased at 0.2mg/$m\ell$. 2. The expressions of IL-6 and IL-6 mRNA were decreased dose-dependently at 0.05-0.2mg/$m\ell$ of ACR and significantly decreased at 0.2mg/$m\ell$. 3. The expressions of IL-8 and IL-8 mRNA were decreased dose-dependently at 0.05-0.2mg/$m\ell$ of ACR and significantly decreased at 0.2mg/$m\ell$ specially. 4. The expressions of Phosphorylated-JNK were decreased, not p38, ERK 5. The expressions of NF-${\kappa}$B were decreased dose-dependently at 0.1-0.2mg/$m\ell$ of ACR. The expressions of Phosphorylated I${\kappa}$B were significantly decreased at 0.2mg/$m\ell$. In addition, ACR suppressed PMA plus A23187-induced NF-${\kappa}$B promoting activity. Conclusion : It is suggested that ACR should suppress through inhibition of NF-${\kappa}$B activity and cytokine production.

『동의수세보원사상초본권(東醫壽世保元四象草本卷)』에서의 양생(養生)에 관(關)한 고찰(考察)

김선민,송일병,Kim, Sun-min,Song, Il-byung 사상체질의학회 2000 사상체질의학회지 Vol.12 No.1

1. 연구목적 "동의수세보원사상초본권"의 내용 중에서 무병장수(無病長壽)를 하기 위한 양생(養生)은 어떠한 방법들이 있는가 조사해 보았다. 2. 방법 "동의수세보원사상초본권"에 기재된 글 중에서 예방적 사고방식 및 올바른 생활습관에 관하여 서술된 내용을 고찰하였다. 3. 결과 (1) 섭생(攝生)과 정신적 안정이 약(藥)보다 중요하니 조양(調養)하여 본상지기(本常之氣)를 50%이상(以上) 올려놓아 자발적으로 나아지려고 하는 항병력(抗病力)을 도와주면 병(病)을 관리하는 정신으로 편소지장(偏小之臟)의 취약점을 극복할 수 있으니 약(藥)의 중용(中庸)이 필요하다. 2) 주색(酒色)과 사노교착(思盧膠着)이 병(病)의 원인이 되므로 주색재권(酒色財權)의 중용(中庸), 성정(性情)의 중용(中庸), 인사(人事)의 능(能) 부능(不能)의 중용(中庸)을 통한 사상인(四象人)의 건강유지 방법과 치료정신을 제시하였다. 3) 자폭자엽(自暴自葉)하지 않고 주어진 여건에서 최선을 다하려는 긍정적인 자세와 희노애락(喜怒哀樂)을 중(中)과 절(節)에 맞춰서 크게 어긋나지 않게 노력하고 안빈락도(安貧樂道)하고 극기(克己)하는 생활속에서 복(壽)과 수(壽)를 누릴 수 있다. 4) 일반론적(一般論的) 지행(知行)으로서의 명지성행(明知誠行)보다 체질론적(體質論的) 지행(知行)으로서의 선사경행(善思敬行)으로 이기해물(利己害物)되지 않게 호심술(好心術)을 발휘하여 살아가는 것이 득수(得數)의 요인이 된다. Purpose This study is carried out to investigate the way of preservation of health. Method I studied the archives of the preventive way of thinking and upright habit of life expressed in the Dongyi Suse Bowon Sasang Chobonguen Result & Conclusion 1. For taking car of one's health and keeping quiet of emotion is more important than drug, we have to be cautious in extravagant use of drug. 2. For the preservation of health, it is recommended to observe moderation in liquor, sex, property, authority and discretion. 3. It is necessary for a man to do his best and to control emotion. 4. It had better engage in philanthropy than egoism.

브로거 운동을 병행한 산전운동프로그램이 임산부의 허리 통증 및 균형에 미치는 영향 단일 사례 연구

김선민,장상훈,Kim, Sun Min,Jang, Sang Hun 대한물리치료과학회 2021 대한물리치료과학회지 Vol.28 No.1

Background: The purpose of this study was to effect of prenatal exercise program combined with Brugger's exercise on low back pain and balance in pregnant women. Design: A Single-Subject Study. Methods: This study was applied to 28 weeks of pregnant women who complained of low back pain for a total of 4 weeks. A total of 10 prenatal exercise programs in this study consists of sessions, and each session was applied with a Bruger exercise for 1 minute before the start. For the fatigue and safety of pregnant women, a break for 1 minute was provided for each session and was conducted under the supervision of the therapist The visual analogue scale (VAS), Oswestry disability index (ODI), and static balance (BT-4) were measured to evaluate the pregnant women's low back pain and balance ability before and after the intervention Results: The change in back pain after the intervention was VAS 5 before the intervention, but the VAS gradually decreased at 4 weeks after the intervention. Reduced to VAS 2 after 4 weeks of intervention. The Oswestry Disability Index (ODI) was 54%, which was at the level of severe disability, but the dysfunction index gradually decreased 4 weeks after intervention, reaching 19% in 4 weeks, and there were no problems with daily life. As for the static balance ability, the sway area and the sway distance values gradually decreased after the intervention in both the eyes open and closed state, showing an improvement in the static balance ability of pregnant women after the intervention than before the intervention. Conclusion: The prenatal exercise program combined with Brugger's exercise was effective to improve low back pain and static balance in pregnant women. The result of this study may helpful as basic data for obstetric physical therapy.

오픈신경망 포맷을 이용한 기계학습 모델 변환 및 추론

김선민,한병현,허준영,Kim, Seon-Min,Han, Byunghyun,Heo, Junyeong 한국인터넷방송통신학회 2021 한국인터넷방송통신학회 논문지 Vol.21 No.3

최근 다양한 분야에 인공지능 기술이 도입되고, 학계 관심이 늘어남에 따라 다양한 기계학습 모델들이 여러 프레임워크에서 운용되고 있다. 하지만 이러한 프레임워크들은 서로 다른 데이터 포맷을 가지고 있어, 상호운용성이 부족하며 이를 극복하기 위해 오픈 신경망 교환 포맷인 ONNX가 제안되었다. 본 논문에서는 여러 기계학습 모델을 ONNX로 변환하는 방법을 설명하고, 통합된 ONNX 포맷에서 기계학습 기법을 판별할 수 있는 알고리즘 및 추론 시스템을 제안한다. 또한, ONNX 변환 전·후 모델의 추론 성능을 비교하여 ONNX 변환 간 학습 결과의 손실이나 성능 저하가 없음을 보인다. Recently artificial intelligence technology has been introduced in various fields and various machine learning models have been operated in various frameworks as academic interest has increased. However, these frameworks have different data formats, which lack interoperability, and to overcome this, the open neural network exchange format, ONNX, has been proposed. In this paper we describe how to transform multiple machine learning models to ONNX, and propose algorithms and inference systems that can determine machine learning techniques in an integrated ONNX format. Furthermore we compare the inference results of the models before and after the ONNX transformation, showing that there is no loss or performance degradation of the learning results between the ONNX transformation.

체감의이인탕(體感薏苡仁湯) 복용(服用)과 전침시술(電鍼施術)이 체지방(體脂肪) 감소(減少)에 미치는 효과(效果) (한방치료((韓方治療)의 부분비만(部分肥滿) 개선(改善) 효과(效果))

김선민,김길수,Kim, Sun-Min,Kim, Kil-Soo 한방비만학회 2002 한방비만학회지 Vol.2 No.1

Background & Methods: In order to study the effect of electro-lipolysis-acupuncture, 57 outpatients who have had herbal medication in Kirin Oriental Hospital were devided to two groups; acupuncture-treated group(46) vs non-acupuncture-treated group(11) Acupuncture-treated group was given electro-lipolysis-acupuncture at least two times a week and administered with herbal diet medication, whereas non-acupuncture-treated group was administered only with herbal diet medication. Results: Mean age, body weight and BMI of these two group at the start point of the treatment were $27.22({\pm}7.64)\;vs \;29.09({\pm}8.73),\;67.76({\pm}9.34)\;vs\;67.00({\pm}10.69),\;and\;26.20({\pm}3.02)\;vs\;26.14({\pm}4.10)$ in the order of acupuncture-treated and non-acupuncture groups. After one month of treatment, change rate of body weight, BMI, total fat, percentage of fat was significantly higher in acupuncture-treated group. Also the change rate of arm circumference, hip circumference and thigh circumference was significantly higher in acupuncture-treated group. The change rate of abdominal circumference and WHR of acupuncture-treated group was higher than that of non-acupuncture-treated group with no statistical significance. The circumference reduction rate according to herbal dieting program was higher in this order, abdomen, arms, chest, thighs and hips. On the other hand, chest circumference change rate over weight loss rate, which is the portion no acupuncture treatment was given to, and AMC change rate was higher in non-acupuncture-treated group. Conclusion: These results imply that herbal dieting program combined with electro-lipolysis-acupuncture is more effective on reducing body fat, size reduction of localized obesity and preservation of muscle than herbal prescription only dieting program.

만주족과 인삼

김선민,Kim, Seonmin 고려인삼학회 2019 인삼문화 Vol.1 No.-

만주족의 선조인 여진족은 그들이 거주하는 만주의 자연환경에 따라 채집과 수렵활동을 주된 생계수단으로 삼았다. 여진족의 거주지는 대부분 삼림이 울창하고 하천이 발달하여 다양한 동식물의 서식지로는 적합했지만 농경에는 맞지 않았다. 여진족 사회조직 역시 채집과 수렵활동에 적합한 방식으로 형성되었고 그것은 이후 청나라 고유의 사회 군사조직인 팔기제도로 발전했다. 한편 채집과 수렵으로 획득한 자연자원을 주변의 농경사회과 교환하는 일은 여진 사회의 발전에 절대적으로 중요했다. 인삼을 비롯한 만주의 자연자원을 중원의 한인들과 교역하는 일은 오래전부터 있었지만, 대외무역이 여진 사회에 근본적인 변화를 초래할 만큼 확대된 것은 16세기의 현상이었다. 당시 외부에서 유입된 은은 중국 내지의 경제를 활성화시키고 나아가 만주를 비롯한 명의 변경지역의 경제에도 큰 영향을 미쳤다. 만주의 자연환경에 기초한 수렵 채집활동이 16세기에 이르러 중원에서 유입된 은과 조우하여 변경 사회를 자극했고, 분산되어 있던 여진 부락은 경쟁과 통일의 과정을 거쳐 마침내 만주족으로 변모하여 1636년 청나라를 건설하기에 이르렀다. 1644년 만주족은 중원 정복에 성공하고 북경으로 수도를 옮겼다. 중원으로 들어간 후에도 청황실의 만주족은 만주 인삼의 가치를 잊지 않았을 뿐만 아니라 그 이익을 독점하기 위해 많은 노력을 기울였다. 17세기 말까지 만주 인삼은 만주족의 제도인 팔기를 중심으로 운영되었다. 만주에 주둔한 팔기 병사들은 민간인의 출입을 통제하여 인삼의 생산지를 한인의 접근으로부터 보호했다. 만주 인삼의 채취는 황실 내무부, 부트하 울라 총관, 성경상삼기 등 황제에게 직속된 기구에서 담당했다. 이들은 부트하 병정이나 팔기 병정을 파견하여 지정된 장소에서 정해진 액수의 인삼을 채취하여 납부하게 했다. 황실의 귀족만이 만주에 사람을 보내 인삼을 채취할 수 있는 특권을 누렸고, 그조차 엄격히 제한되었다. 18세기도 만주의 인삼은 여전히 국가에 의해 독점적으로 관리되었다. 청의 인삼 정책은 황실의 발상지인 만주와 그 자연자원을 민간인의 침탈로부터 보호하고 만주족 고유의 전통을 유지한다는 원칙에 따라 운영되었다. 동시에 만주의 인삼은 국가의 중요한 재정 수입원으로 개발되었다. 국가가 필요한 만큼의 수입을 징수하기 위해서는 인삼을 대량으로 채취해야 했는데, 부트하 병정이나 팔기 병정을 파견하는 것만으로는 안정적인 인삼세수를 기대할 수 없었다. 그 결과 상인들이 인삼업에 개입하기 시작했고 청의 인삼 정책은 이후 점점 더 상인에 의존하는 방향으로 발전해갔다. 청대 인삼의 국가 독점은 1853년에 공식적으로 중단되었지만, 부유한 상인이 채삼인을 고용하고 인삼을 대신 납부하는 현상은 18세기에 이미 나타나고 있었다. 청대 만주족의 인삼 독점은 사실상 한인 상인의 참여로 유지되었다고 할 수 있다. The Jurchens, the ancestors of the Qing Manchus, had lived scattered in Manchuria and had made their living mostly on ginseng gathering and animal hunting. Their residential areas, rich with deep forest and numerous rivers, provided great habitation for all kinds of flora and fauna, but not so proper for agriculture. Based on their activities of foraging and hunting, the Jurchens developed a unique social organization that was later transformed into the Banner System, the most distinctive Qing military institution. By the sixteenth century, that the external trade brought considerable changes to Jurchen society. A huge amount of foreign silver, imported from Japan and South America to China, first invigorated commercial economy in China proper, and later caused a huge influence on Ming frontier regions, including Manchuria. In the late sixteenth century when the tradition of foraging and hunting encountered with silver economy, the Jurchen tribes became unified after years of competition and transformed themselves into the Manchus to build the Qing empire in 1636. In 1644 the Manchus succeeded in conquering the China Proper and moved into Beijing. Even after that, the Manchu imperial court never forgot the value of Manchurii ginseng; instead, they paid great efforts to monopolize this profitable root. Until the late seventeenth century, the Qing court used the Banner System to manage Manchurian ginseng. The banner soldiers stationed in Manchuria checked unauthorized civilian entrances in this frontier and protected its ginseng producing mountains from the Han Chinese people. All the process of ginseng gathering was managed by the institutions under the direct control of the imperial court, such as the Imperial Household Department, the Butha Ula Office, and the Three Upper Banner in Shengjing. Banner soldiers were dispatched to the given mountains, collect the given amount of ginseng, and send them to the imperial court in Beijing. The state monopoly of ginseng was maintained throughout the eighteenth and nineteenth centuries under the principle that Manchuria and its natural resources should be guarded from civilian encroachment. At the same time, Manchurian ginseng was considered as an important source of state revenue. The imperial court and financial bureau wanted to collect ginseng as much as they needed. By the late seventeenth century as the ginseng management by the banner soldiers failed in securing the ginseng tax, the Qing court began to invite civil merchants to ginseng business. During the eighteenth century the Qing ginseng policy became more dependent on civil merchants, both their money and management. In 1853 the Qing finally ended the ginseng monopoly, but it was before the early eighteenth century that wealthy merchants hired ginseng gatherers and paid ginseng tax to the state. The Qing monopoly of ginseng was in fact maintained by the active participation of civil merchants in the ginseng business.