초콜릿이 기분에 미치는 영향

김문두,이창인 대한우울조울병학회 2009 우울조울병 Vol.7 No.1

Objectives:We reviewed the relationships between chocolate and mood state. Method:We reviewed chocolate’s constituents and hypotheses that was suggested as the mechanisms of chocolate’s mood altering effects. Results: Orosensory properties of chocolate, carbohydrate, protein, psychoactive substances in chocolate and complex rela- tionships of chocolate with neurotransmitters such as dopamine, serotonin, and opioid could be responsible for ele- vating mood and evoking chocolate cravings. Eating in negative mood state, transient mood stabilizing effect was shown but in case of prolonged use negative mood was maintained. Conclusion:Mood state effects of the cho- colate is thought to be due to other unknown mechanism rather than its antidepressant effect.

임신 여성에서 양극성 기분 장애의 경향과 관련 요인

김문두,서혜진,정영은,이창인,홍성철,박철민,현미열 대한우울조울병학회 2014 우울조울병 Vol.12 No.2

Objectives : This cross-sectional study was aimed to investigate the factors associated with bipolar disorder in pregnant female, including sociodemographic parameters, social support, social conflict, suicidal idea and sleep. Methods : A total of 84 pregnant female were recruited. They filled out self-completing questionnaires on sociodemographic factors, obstetric history, depressive symptoms and bipolarity. Depressive symptoms were assessed using the Korean version of the Edinburgh Postnatal Depression Scale (EPDS). Bipolarity was assessed using the Korean version of the Mood Disorder Questionnaire (K-MDQ). Results : Nineteen participants (22.6%) had positive K-MDQ scores, suggesting the present of bipolarity. Positive EPDS group had twenty subjects (25%) who had depressive symptoms. The diathesis of bipolar disorder was associated with marital dissatisfaction, social conflict, depression and sleep. The multiple logistic regression analysis revealed that the only poor sleep was a risk of bipolarity. Conclusion : Pregnant female with bipolarity were more depressed and sleep problems than those without bipolarity. The results showed that the most important factor of influencing bipolarity was sleep.

차량 시뮬레이터에서의 운전자 시선 추적 및 물체 인식

김규빈(GyuBin Kim),김성민(Sungmin Kim),선민혁(Minhyeok Sun),이지원(Jiwon Lee),현석종(Seokjong Hyeon),이상헌(Sanghun Lee) 한국자동차공학회 2020 한국자동차공학회 학술대회 및 전시회 Vol.2020 No.11

노인우울증에서 Methylphenidate 강화요법의 조기 반응 효과 예측인자

김문두,박용진 대한생물치료정신의학회 2002 생물치료정신의학 Vol.8 No.1

한국 고등학생들의 자살 생각 관련 요인

김문두,정영은,홍성철,이창인,곽영숙,김현주,박원명,윤보현,신지현,현미열 대한정신약물학회 2014 대한정신약물학회지 Vol.25 No.2

Objective The purpose of this study was to evaluate the occurrence of the suicidal ideation and associated factors with selfreportedsuicidal ideation within the last 12 months among Korean high school students. Methods A total of 697 adolescents were recruited from high schools (age range: 15–16 years) in Jeju area. According toexistence of suicidal ideation, they were divided into two groups–suicidal ideation group and non-suicidal ideation group,and the differences between groups in terms of various sociodemographic and clinical characteristics, including depression(Beck Depression Inventory), and health related conditions. Results A total of 187 (26.8%) high school students reported suicidal ideation, and the rate of suicidal attempt was 4.9%(n=34). The associated factors of suicidal ideation were depression [odds ratio (OR)=2.42, p≤0.001], short sleep duration(OR=1.84, p=0.009), current alcohol use (OR=4.94, p≤0.001), self reported poor health (OR=2.10, p=0.004), and schoolbullying (OR=3.06, p=0.002). Conclusion These results may have important implications for the strategies and specified intervention in preventing suicidalideation in Korean high school students. 본 연구 결과, 제주지역 고등학생에서 최근 1년간 자살 사고를 경험한 비율은 26.8%로 조사되었으며, 우울 증상, 음주,흡연, 학교 왕따 경험, 낮은 사회경제적 수준이 자살 사고와밀접한 관련성을 보였다. 청소년의 경우 자살을 예측하기 어렵다는 점을 고려할 때 자살 예방을 위해서는 청소년의 심리적 특성과 자살의 위험 인자에 대한 기본적인 이해가 선행되어야 할 것이다. 특히, 본 연구 결과는 고등학생 자살 문제의예방과 치료에 있어 학교 왕따 문제의 해결, 우울증, 흡연 및알코올 사용 등 신체적, 정신적 건강 문제에 대한 체계적인 관리가 중요함을 시사한다.

노인우울증에서 Methylphenidate 강화요법의 조기 반응 효과 예측인자 : 예비연구

김문두,박용진 대한생물치료정신의학회 2002 생물치료정신의학 Vol.8 No.2

Objects ; The purpose of this study was to review the clinical and biological differences between early onset depression and late onset depression among elderly. Methods ; The author reviewed the medical literature covering the past 25years. Results ; There is strong relationship between late-onset depression and brain abnormality, including subcortical, deep white matter hyperintensity. Late-onset depression also has strong relation with vascular disorder and dementia. Early-onset depression has strong genetic component, while late-onset depression has more environmental component rather than genetic component. Medical burden, life events and stress influence elderly through bidirectional way. Conclusions ; Late-onset depression is heterogeneous disorder. It appears that both type of geriatric depression has different etiology, similar phenomenology. Further investigation will be needed to develop ways to identify geriatric depression in community early in disease course and enhance therapeutic efficacy and speed therapeutic response to avoid serious complication such as suicide and high mortality.

소뇌와 정신분열병

김문두,강병조 대한생물치료정신의학회 1999 생물치료정신의학 Vol.5 No.1

소뇌는 주로 운동기능에만 관여하는 뇌구조인 것으로 생각되어왔고, 균형의 장애와 운동조정의 장애만이 소뇌 질환의 유일한 병리적 징후라고 여겨졌다. 그러나 소뇌가 운동영역만을 조정하고 통합하는 것은 아니라는 새로운 연구들이 보고되고 있다. 주의집중, 감각변별, 언어성 학습과 언어성 기억, 작업기억, 그리고 복잡한 문제 해결 등과 같은 다양한 인지처리과정 등이 이러한 소뇌의 부가적인 기능으로 생각된다. 또한, 소뇌병변이 있는 환자들이 보이는 증상들은 정신분열병의 대부분의 증상들을 설명할 수 있다. 이에 우리는 소뇌의 구조적, 기능적 해부학을 간략히 요약하고, 소뇌가 정신분열증의 증상 형성에 미치는 영향을 보고한 문헌들을 고찰하여 보았다.

제주도 농촌지역 주민들의 음주습관과 우울증상 및 스트레스

김문두 대한신경정신의학회 2004 신경정신의학 Vol.43 No.1

Objectives:Stress has been known as one of the main reasons for drinking. Depression also is a risk factor for people to have alcohol related problem. Despite of high correlation between depression and stress, little study has been done to see the simultaneous effect of depression and stress to alcohol dependence. We tried to investigate the prevalences of depressive symptom, stress and alcohol dependence among Jeju rural population. Also, we have tried to find a relationship of alcohol dependence with depressive symptom and stress. Methods:The study subjects were 1,086, 531 (48.9%) male and 555 (51.1%) female living in rural Jeju area. We collected data through face-to face interviews in 2002. With the data we investigated the prevalences of alcohol dependence, depression and stress using CAGE, Alcohol use disorder identification test (AUDIT), Beck Depression Inventory (BDI), and Psychosocial Well Being Index Short Form (SF-PWI). Results:1) The prevalence of alcohol dependence in rural Jeju area is 22.3% in male, 3.6% in female. The prevalence of depressive symptom is 14.9% in male, 18.4 in female. The prevalence of moderate distress is 70.8% in male, 67.5% in female. The prevalence of severe distress is 16.7% in male, 26.7% in female. 2) In relationship between stress and alcohol dependence, odds ratio of moderate distress is 7.76 (95% CI 1.86-32.35), severe distress is 17.29 (95% CI 3.95-75.60) in male, and the odd ratio of depressive symptom is 2,96 (95% CI 1.12-7.84) in female. 3) Multiple logistic regression analysis showed that the risk factors for male alcohol dependence were potential stress (OR=8.15 95% CI 1.91-34.65), and stress risk (OR= 22.47 95% CI 4.86-103.704). The risk factor for female alcohol dependence was depressive symptom (OR=3.42 95% CI1.10-10.56). Conclusion:Compared with national survey result, the prevalence of alcohol dependence in rural Jeju area is relatively low. Stress in male, depressive symptom in female proved to be strong risk factors. This suggests that we can apply coping strategies to stress in male alcoholics, and treat depression in female alcoholics for improving their mental health.

조발성 우울증과 만발성 우울증의 임상적, 생물학적인 차이

김문두,박용진 대한생물치료정신의학회 2002 생물치료정신의학 Vol.8 No.1

한국형 양극성 장애 약물치료 알고리듬 2014 : 노인

김문두,박원명,이정구,윤보현,정영은,정종현,손인기,심세훈,왕희령,우영섭,전덕인,서정석,신영철,민경준 대한우울조울병학회 2014 우울조울병 Vol.12 No.2

Objectives : In this study, we evaluated the treatment strategies of geriatric bipolar disorders of Korean Medication Algorithm Project for Bipolar Disorder (KMAP-BP) 2014. Method : Sixty-four psychiatrists of the review committee who have vast clinical experiences in treating bipolar disorders completed the survey. This survey was composed of 56 main questionnaires of which the contents covered from overall treatment strategies to treatment strategies under the specific situations. The executive committee analyzed the results and discussed the final production of algorithm. Results : In geriatric bipolar disorder, the first-line treatment option for acute manic episode is monotherapy with atypical antipsychotic or mood stabilizer, and combination of mood stabilizer and an atypical antipsychotic. The first-line treatment option for acute bipolar depressive episode was combination of mood stabilizer and an atypical antipsychotic, monotherapy with atypical antipsychotic, and combination of atypical antipsychotics and lamotrigine. Valproate and lithium are chosen for the preferred mood stabilizer, and among atypical antipsychotics, aripiprazole, quetiapine, and olanzapine were preferred. Conclusion : In KMAP-BP 2014, the recommendation for treatment option in geriatric bipolar disorder was newly introduced. We expect this algorithm will be helpful in the treatment of geriatric bipolar disorder.