국내 한의학계에 보고된 흑색종 관련 실험적 연구들의 비교 고찰

권강,김남권,김선영,이동진,김철윤,서형식,Kwon, Kang,Kim, Nam-Kwen,Kim, Sung-Young,Lee, Dong-Jin,Kim, Chul-Yun,Seo, Hyung-Sik 대한한방안이비인후피부과학회 2015 한방안이비인후피부과학회지 Vol.28 No.3

Objective : Melanoma is a very critical and devastating disease. Although many people have depended on surgical operation in melanoma treatment, they have placed importance on non-invasive methods constantly. So we planned to establish a research methodology by analysing existing articles containing conservative melanoma treatments in Journals of Korean Medicine published in Korea.Methods : Using search words of anti-cancer, B16, cancer, lung metastasis, melanoma, metastasis, S-100, SK-MEL, tumor, tyrosinase, we collected 26 articles by searching internet portal sites as following;Using search words of anti-cancer, B16, cancer, lung metastasis, melanoma, metastasis, S-100, SK-MEL, tumor, tyrosinase, we collected 26 articles by searching internet portal sites as following<uri>http://oasis.kiom.re.kr</uri>,<uri>http://www.koreantk.com</uri>,<uri>http://www.riss.kr</uri>,<uri>http://www.dbpia.co.kr</uri>,<uri>http://www.ndsl.kr</uri>,<uri>http://kiss.kstudy.com</uri>,<uri>http://www.naver.com</uri>,<uri>http://www.google.com</uri>.Result : The number of articles is 26 and in the year of 2003, 2004 is ranked the highest number in publication. The journal of acupuncture & moxibustion society ranked the highest(30.8%). 2 and 4 authors ranked the highest(26.9%) in number of authors. T-test ranked the highest(58.1%) in statistics methods. P.O. med indicated in 11 articles and Pharmacopuncture in 15 articles. B16 murine melanoma cell was indicated in 25 articles by cancer-induced methods. In measurement, T cell activity was indicated in 14 articles, NK activity in 4 articles, IL-2 in 6 articles, apoptosis in 1 article, lung metastasis in 14 articles.Conclusion : Considering overall results, it is necessary to diversify cancer-induced methods and measurement methods in experimental melanoma research.

Ramsay Hunt syndrome 환자에 대한 證例報告

권강,박영환,Kwon, Kang,Park, Young-Hwan 대한한방안이비인후피부과학회 2001 한방안이비인후피부과학회지 Vol.14 No.2

Background: Ramsay Hunt syndrome is a disease that cause faical palsy, ear pain, ear vesicle, tinnitus, hardness of hearing by geniculate ganglion herpes. Ramsay Hunt syndrome could be taken two sides view of herpes zoster and facial palsy. In traditional oriental medicine Ramsay Hunt syndrome could be diagnosed as heat and dryness syndromes. Object: These studies are clinical observations about two Ramsay Hunt syndrome patient cases that is recovered under the treatment by herbal-acupuncture therapy and moxibustion. Methods: For treatment in acute state, acupuncture therapy was used and in convalescent stage, herbal acupuncture therapy and moxibustion therapy were used. For diagnosis system, House-Brackmann system, Yanagihara's system used as diagnosis scales. Result&Conclusion: The results as follows. 1. Generally, to treat Ramsay Hunt syndrome, it is knwon that from invasion of virus to period of first effect a short term bring about good result, but in these two cases, though a long term. considerable effect was braught out. 2. In treating two cases, herbal acupuncture therapys what are called CF, JSD were used. satisfactory results was produced.

국내 한의학 학술지에 게재된 매선요법 관련 논문들의 현황 분석

권강,Kwon, Kang 대한한방안이비인후피부과학회 2014 한방안이비인후피부과학회지 Vol.27 No.4

Objective : To search the trend of studying thread-embedding therapy in Korean medicine academia up to now and to expand the range of using thread-embedding therapy in the future, this study was designed. Methods : Using search portal sites the following; http://oasis.kiom.re.kr, http://www.riss.re.kr, collected 37 articles and devided those three parts and classificated those into four subsection as follows; total analysis, original article, case report. Results : The number of articles are 8 review articles, 14 original articles, 15 case reports. In the year 2013, 14 articles were published and ranked highest(37.8%). The journal of acupuncture & moxibustion medicine society ranked highest(40.5%). 5 persons ranked highest(32.4%) in number of author. Facial beauty care ranked highest(21.6%) in clssification of disease. Remedy item ranked highest(50.0%) in classification of subjects of 8 review articles. No more than 25 persons ranked highest(66.7%) and 6~12months of treatment period ranked highest(33.3%) in 14 original articles. Conclusions : Thread-embedding therapy is considered very useful on various part of Korean medicine clinic. We need to expand application scope of thread-embedding therapy in the future.

국내 한의학 학술지에 게재된 진균 관련 논문들의 경향성 분석

권강,김철윤,이득주,서형식,Kwon, Kang,Kim, Chul-Yun,Lee, Deuk-Joo,Seo, Hyung-Sik 대한한방안이비인후피부과학회 2017 한방안이비인후피부과학회지 Vol.30 No.1

Objectives : Because fungal disease is common and easy to recur, there is need to develop treatment in Korean medical academy. For more intensified study about fungal disease, this article summarized and analyzed tendency of ones in Korean medical journal. Methods : We found 74 articles about fungus in journal of Korean medicine by using 15 Korean keywords and 19 English keywords at internet reference site as follows ; http://oasis.kiom.re.kr, http://www.riss.kr, http://www.dbpia.co.kr, http://www.ndsl.kr, http://kiss.kstudy.com, http://www.naver.com, http://www.google.com. Results : There were 12 articles(16.2%), ranked highest in 2005. Korean Journal of Oriental Physiology & Pathology ranked highest(41.9%). 3 persons ranked highest(23.0%) in number of author. There was 1 descriptive report in original article category. There were 52 In vitro articles and 8 In vivo & In vitro articles in experimental study item. Candida species ranked highest in strain category. There were 4 case reports. Conclusions : There were many experimental studies about fungal diseases, but more clinical research and case reports are necessary to give practical application to patients.

大韓眼耳鼻咽喉皮膚科學會誌에 揭載된 硏究論文들의 傾向性 考察

권강,서형식,Kwon, Kang,Seo, Hyung-sik 대한한방안이비인후피부과학회 2003 한방안이비인후피부과학회지 Vol.16 No.1

Objectives: This study was carried out to analyze and understand the trends of research papers published In the Journal of Oriental Medical Surgery?phthalmology & Otolaryngology Society(JOMSOOS). Methods: We studied the 308 research papers that had been published in JOMSOOS from 1988 Vol. 1. No. 1. to 2002 Vol. 15. No. 2. Our study was developed through the four stages in order to analyze the papers; 1) we analyzed all the papers overall to classify them into three categories; original article. review article and case report. 2) we classified the original articles in terms of methodology. 3) we also analyzed the case reports according to the sort of disease each paper dealt with. 4) we had another statistical approach to each paper to figure out the distribution of diagnoses in detail. Results: We have got the following outcomes from our analysis of the papers in terms of the four stages. 1. Overall Analysis. 1) Classification of 308 research papers between 1988 and 2002: 137 original articles(44.48$\%$), 111 review articles(36.04$\%$), 56 case reports(18.18$\%$). 2) Used language: Korean(99.03$\%$). English(0.97$\%$). 3) The Number of Authors: 2 persons(42.86$\%$). 3 persons(29.87$\%$), 1 person(14.61$\%$). 2. Original Article Analysis 1) Classification of 137 original articles in terms of methodology: 90 experimental studies(65.69$\%$)46 descriptive studies(33.58$\%$), 1 analytic study(0.73$\%$). 2) Classification of the original articles according to the use of statistical methods: No statistical methods(36.42$\%$), Descriptive methods only(1.99$\%$), Not defined(23.18$\%$), t-test(24.50$\%$), ANOVA(3.97$\%$), Multiple comparison(2.65$\%$), Non-parametric test(2.65$\%$), Other methods(1.32$\%$). 3) Classification of 46 descriptive articles in terms of diseases: otorhinolaryngology(43.48$\%$), dermatology(23.91$\%$), ophthalmology(13.04$\%$), facial palsy(13.04$\%$). 4) Classification of descriptive articles in terms of the number of patients: the highest was 'more than 26 but less than 50 persons'(19 articles - 41.30$\%$). 5) Classification of descriptive articles in terms of the period for patients observation: the highest was the time 'more than 9 but less than 12 months(34.78$\%$)' Out of the 34.78$\%$, the number of articles with the patients observed for more than 12 months was 13(28.26$\%$). 3. Case Report Analysis 1) Classification of 56 case reports in terms of the sort of disease: dermatology(44.64$\%$), ophthalmology(19.64$\%$), otorhinolaryngology(14.29$\%$), facial palsy(8.93$\%$). 2) Classification in terms of the number of patients: 1 person(50$\%$), 3 persons(16.07$\%$), 2 persons(14.29$\%$). 4. Diagnosis Distribution of Each Disease. 1) Studies regarding ophthalmology : the percentage of 'strabismus' cases was the highest(33.33$\%$). 2) Studies regarding otorhinolaryngology : nasal inflammation(34.48$\%$), tinnitus(20.69$\%$). 3) Studies regarding dermatology: the percentage of 'allergic skin disease' was the highest(33.33$\%$). Conclusions: We analyzed the trends of research papers that have been published in JOMSOOS in detail. We came to understand the trends of the research through this study. However, we acknowledge that we only adopted the quantitative method out of various possible analysis methods. For further studies, we strongly urge to adopt the qualitative methods as well.

목과(木瓜)의 Adjuvant 관절염(關節炎)에 대한 실험적(實驗的) 연구(硏究)

권강,박기철,손승현,박희수,Kwon, Kang,Park, Ki-Chul,Sohn, Seong-Hyun,Park, Hee-Soo 대한약침학회 2003 Journal of pharmacopuncture Vol.6 No.2

9Objective : We carried out this experimental study in order to investigate the effect of Chaenomelis Fructus(木瓜) extract and herbal-acupuncture on the arthritis induced by injecting Freund's complete adjuvant Method : 1. We categorized SD-rats into five groups as followings. (1) Control: Without any Treat (2) Treat I: treated by acupuncture (3) Treat II: treated by drinking 5% saline (4) Treat III: treated by drinking Chaenomelis Fructus(木瓜) extract (5) Treat IV: treated by Chaenomelis Fructus(木瓜) herbal-acupuncture 2. We established ten items for decision of experimental results as followings Edema rate, Pain endurance, WBC, Hemoglobin, Platelet, Total protein, Albumin, Globulin, RA factor, CRP Results : The groups that showed significant effects compared with Contol group were explained as followings. 1. Edema rate : Treat I , Treat III 2. Pain endurance : Treat I, Treat IV 3. WBC : Treat IV 4. Hemoglobin : Treat III 5. Plat99elet : Treat IV 6. Total protein : Treat I, Treat IV 7. Albumin : None 8. Globulin : Treat I, Treat IV 9. RA factor : Treat I, Treat IV 10. CRP : Treat IV Conclusion : Observing above experimental results, we can guess that the effects of acupuncture and Chaenomelis Fructus(木瓜) herbal-acupuncture on Freund's adjuvant arthritis are more superior than other ways. In addition, we can find that the latter is more better than the former in effect by two items(platelet, CRP).

Neutron irradiation effect of poly-Si1?xMnx semiconductors grown by MBE

권강,임영언,이성원,김도진,김효진,손재민,강영환,김봉구,김창수,류현,오상준 한국물리학회 2006 Current Applied Physics Vol.6 No.3

The neutron irradiation effect of polycrystalline Si1xMnx semiconductor thin films has been studied. The Si1xMnx semiconductor thin films were grown on SiO2/(100)Si substrate at 400 C by using a MBE. The as-grown specimens are irradiated by the fast neutrons of 0.82 MeV in a neutron research reactor at KAERI. After neutron irradiation, the electrical resistivities of neutron-irradiated specimens increase with the irradiation amount, while the saturation magnetizations decrease. Hall analysis reveals that the mobility of neutron- irradiated specimen decreases remarkably. The XRD and TEM analyses show that the phase transformation is not induced by the neutron irradiation.

蚯蚓藥鍼이 비만쥐의 지질강하능, 항산화능, 전염증성 Cytokines 농도에 미치는 영향

권강,박희수 대한침구의학회 2010 대한침구의학회지 Vol.27 No.2

Objectives : This study was designed to investigate effects of Lumbricus pharmacopuncture (LP) on the lipid lowering, anti-oxidative activity and concentration of proinflammatory cytokines in rat fed high fat diet. Methods : Sprague-Dawley male rats were fed high fat diet for 8 weeks and experimental groups were divided into 4 groups as follows : Control, Lumbricus Jungwan (CV12) pharmacopuncture (T Ⅰ), Lumbricus Joksamni (ST36) pharmacopuncture (T Ⅱ), Lumbricus Jungwan (CV12) and Joksamni (ST36) pharmaco- puncture (T Ⅲ). Results : The levels of plasma FFA, TG, total cholesterol, LDL-C, TBARS, IL-1β, IL-6, TNF-α and liver total cholesterol, TG, TBARS, SOD, catalase, IL-6 in more than one LP group were significantly lower than those of Control groups. The level of IL-10 in one of LP groups was significantly higher than that of Control group. Conclusions : As the results were shown, LP treatment have considerable effects on lipid lowering, anti-oxidative activity and concentration of proinflammatory cytokines in rat fed high fat diet.

돌발성 난청 환자 3례에 대한 임상적 고찰

권강,최관호,박재영,위종성,박희수,박영환,Kwon, Kang,Choi, Kwan-Ho,Park, Jae-Young,Owi, Jong-Sung,Park, Hee-Soo,Park, Young-Hwan 대한한방안이비인후피부과학회 2002 한방안이비인후피부과학회지 Vol.15 No.2

Backgrounds : sudden sensorineural hearing loss is defined as a disease that has abrupt onset of sensorineural hearing loss without definite cause. In some cases, this disease cause tinnitus, vertigo, headache addition to hearing loss. In traditional oriental medicine, sudden sensorineural hearing loss is could be diagnosed as deficiency of Yang-Gi(陽氣). Objects & Methods : This study is clinical observation about three sudden sensorineural hearing loss cases. For diagnosing in these cases, pure tone audiometry was used. For treatment, acupuncture, herbal-medicine and moxibustion therapy were used. Results & Conclusions : as follows. 1. Generally, in this disease, the shorter the whole period from the time that occurs to the time that starts to treat is, the more the results are better. The research shows that short-term case is more efficient than the other long-term two cases in the aspects of symptoms and pure tone audiometry . 2. In making a diagnosis of sudden sensorineural hearing loss and measuring the effect, subjective symptoms generally correspond to the improvement of pure tone audiometry, but not completely. Therefore, in treating patients, the doctor must consider these both aspects and keep the balance.

이드반응이 동반된 족부백선 환자 치험 1례

권강,김철윤,이동진,김남권,서형식,Kwon, Kang,Kim, Chul-Yun,Lee, Dong-Jin,Kim, Nam-Kwen,Seo, Hyung-Sik 대한한방안이비인후피부과학회 2015 한방안이비인후피부과학회지 Vol.28 No.1

Objective : This study was carried out to find out the effect of Korean medical treatments on tinea pedis with id reaction. Method : We treated a 33-year-old man was afflicted with tinea pedis complicating id reaction with herbal medicine, acupuncture, ointment, wet-dressing and steam treatment. After treatments, we measured the status of scales, fissures and the degree of pruritus. We followed up symptom changes by taking pictures and compared before and after. Result & Conclusion : Three days after admission, erythema occurred at upper and lower limbs and the degree of pruritus increased by id reaction. As tinea pedis improved, id reaction decreased, too. Consequently, both sites of primary lesions of tinea pedis and secondary id reactions were significantly improved, and accompanied symptoms were resolved simultaneously.